Real-Time 3D Ultrasound Guided Interventional System for Cardiac Stem Cell Therapy with Motion Compensation

  • Vijay Parthasarathy
  • Charles Hatt
  • Zoran Stankovic
  • Amish Raval
  • Ameet Jain
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6891)


This paper describes a clinically translatable interventional guidance platform to improve the accuracy and precision of stem cell injections into a beating heart. The proposed platform overlays live position of an injection catheter onto a fusion of a pre-procedural MR roadmap with real-time 3D transesophageal echocardiography (TEE). Electromagnetic (EM) tracking is used to initialize the fusion. The fusion is intra-operatively compensated for respiratory motion using a novel algorithm that uses peri-operative full volume ultrasound images. Validation of the system on a moving heart phantom produced a landmark registration accuracy of 2.8 ± 1.45mm. Validation on animal in vivo data produced an average registration accuracy of 2.2 ± 1.8 mm; indicating that it is feasible to reliably and robustly fuse the MR road-map with catheter position using 3D ultrasound in a clinical setting.


Stem cell therapy Motion compensation 3D TEE EM tracking Image fusion Interventional cardiology 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Vijay Parthasarathy
    • 1
  • Charles Hatt
    • 2
  • Zoran Stankovic
    • 3
  • Amish Raval
    • 2
  • Ameet Jain
    • 1
  1. 1.Philips Research North AmericaBriarcliff ManorUSA
  2. 2.University of Wisconsin Medical SchoolMadisonUSA
  3. 3.Philips Research EindhovenThe Netherlands

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