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Analysis of Gray Matter in AD Patients and MCI Subjects Based Voxel-Based Morphometry

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Brain Informatics (BI 2011)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 6889))

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Abstract

In recent years, pathological researches of mild cognitive impairment (MCI) subjects and the Alzheimer’s disease (AD) patients have gained a great deal of attention. In this study, we used the voxel-based morphometry (VBM) method to analyze the Magnatic Resonance Imaging (MRI) data of gray matter volumes in 98 normal controls (NCs), 91 AD patients and 113 MCI subjects. The measurements of gray matter volumes were calculated for each of the three groups respectively. We found that compared with MCI subjects, AD patients had further atrophy in the following brain regions: right insula, left hippocampus, right fusiform and bilateral middle temporal gyrus. Compared with NCs, AD patients and MCI subjects shared some abnormal brain regions such as bilateral parahippocampal gyrus, bilateral hippocampus, left amygdala and left fusiform. The results provided additional evidences to support the viewpoint that MCI is the transitional stage between normal aging and AD.

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Author information

Authors and Affiliations

  1. The School of Information Science and Engineering, Lanzhou University, Lanzhou, China

    Zhijun Yao, Bin Hu, Lina Zhao & Chuanjiang Liang

  2. School of Computing, Telecomminications and Networks, Birmingham City University, Birmingham, UK

    Bin Hu

Authors
  1. Zhijun Yao
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  2. Bin Hu
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  3. Lina Zhao
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  4. Chuanjiang Liang
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Editor information

Editors and Affiliations

  1. School of Information Science and Engineering, Feiyun Lou Building, Lanzhou University, Tianshui South Road 222, 730000, Lanzhou, Gansu, China

    Bin Hu

  2. Department of Computer Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR

    Jiming Liu

  3. Chinese Academy of Sciences, Institute of Biophysics, 15 Datun Road, Chaoyng District, 100101, Beijing, China

    Lin Chen

  4. Department of Life Science and Informatics, Maebashi Institute of Technology, 460-1 Kamisadori-Cho, 371.0816, Maebashi-City, Japan

    Ning Zhong

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© 2011 Springer-Verlag Berlin Heidelberg

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Yao, Z., Hu, B., Zhao, L., Liang, C. (2011). Analysis of Gray Matter in AD Patients and MCI Subjects Based Voxel-Based Morphometry. In: Hu, B., Liu, J., Chen, L., Zhong, N. (eds) Brain Informatics. BI 2011. Lecture Notes in Computer Science(), vol 6889. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23605-1_22

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  • DOI: https://doi.org/10.1007/978-3-642-23605-1_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-23604-4

  • Online ISBN: 978-3-642-23605-1

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