Plant Hormones and Metabolites as Universal Vocabulary in Plant Defense Signaling

  • Dirk Balmer
  • Brigitte Mauch-ManiEmail author
Part of the Signaling and Communication in Plants book series (SIGCOMM, volume 14)


Plants are sessile organisms exposed to a highly dynamic environment, and physiological flexibility including the rapid activation of suitable defense responses is crucial for their survival. Plants are confronted with an armada of pathogens and pests, and throughout the ongoing evolutionary arms race with these attackers, they have developed a sophisticated chemical signaling system, which allows them to activate highly specific and targeted defense responses. In this context, plant hormones and secondary metabolites play a pivotal role: they serve as signals in an intricate local and systemic communication network. This chapter presents recent insights into the vocabulary used by plants to fend off pathogens and pests.


Salicylic Acid Azelaic Acid Induce Systemic Resistance Chemical Regulator Jasmonic Acid Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors were supported by the National Centre of Competence in Research (NCCR) “Plant Survival” and by SNF Grant 31003A-120197, both research programs of the Swiss National Science Foundation. We also thank Ana Slaughter for critical reading of the manuscript. We apologize to our colleagues who could not be cited in this review due to space restrictions.


  1. Anderson JP, Badruzsaufari E, Schenk PM, Manners JM, Desmond OJ, Ehlert C, Maclean DJ, Ebert PR, Kazan K (2004) Antagonistic interaction between abscisic acid and jasmonate-ethylene signaling pathways modulates defense gene expression and disease resistance in Arabidopsis. The Plant Cell 16:3460–3479PubMedCrossRefGoogle Scholar
  2. Attaran E, Zeier TE, Griebel T, Zeier J (2009) Methyl salicylate production and jasmonate signaling are not essential for systemic acquired resistance in Arabidopsis. The Plant Cell 21:954–971PubMedCrossRefGoogle Scholar
  3. Bari R, Jones JD (2009) Role of plant hormones in plant defense responses. Plant Molecular Biology 69:473–488PubMedCrossRefGoogle Scholar
  4. Buchanan RB, Gruissem W, Jones RL (2002) Biochemistry and molecular biology of plants. American Society of Plant Physiologists, RockvilleGoogle Scholar
  5. Cao H, Glazebrook J, Clark JD, Volko S, Dong X (1997) The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats. Cell 88:57–63PubMedCrossRefGoogle Scholar
  6. Cao FY, Yoshioka K, Desveaux D (2011) The roles of ABA in plant-pathogen interactions. J Plant Res, in press (doi: 10.1007/s10265-011-0409-y)Google Scholar
  7. Chanda B, Xia Y, Mandal MK, Yu K, Sekine KT, Gao QM, Selote D, Hu Y, Stromberg A, Navarre D, Kachroo A, Kachroo P (2011) Glycerol-3-phosphate is a critical mobile inducer of systemic immunity in plants. Nat Genet, in press (doi:10.1038/ng.789)Google Scholar
  8. Chen H, Wilkerson CG, Kuchar JA, Phinney BS, Howe GA (2005) Jasmonate-inducible plant enzymes degrade essential amino acids in the herbivore midgut. Proc Natl Acad Sci USA 102:19237–19242PubMedCrossRefGoogle Scholar
  9. Chinchilla D, Zipfel C, Robatzek S, Kemmerling B, Nürnberger T, Jones JD, Felix G, Boller T (2007) A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence. Nature 448:497–500PubMedCrossRefGoogle Scholar
  10. de Torres-Zabala M, Truman W, Bennett MH, Lafforgue G, Mansfield JW, Egea PR, Bögre L, Grant M (2007) Pseudomonas syringae pv. tomato hijacks the Arabidopsis abscisic acid pathway to cause disease. EMBO J 26:1434–1443PubMedCrossRefGoogle Scholar
  11. Dean JV, Delaney SP (2008) Metabolism of salicylic acid in wild-type, ugt74f1 and ugt74f2 glucosyl-transferase mutants of Arabidopsis thaliana. Physiologia Plantarum 132:417–425PubMedCrossRefGoogle Scholar
  12. Degenhardt DC, Refi-Hind S, Stratmann JW, Lincoln DE (2010) Systemin and jasmonic acid regulate constitutive and herbivore-induced systemic volatile emissions in tomato, Solanum lycopersicum. Phytochemistry 71:2024–2037PubMedCrossRefGoogle Scholar
  13. Glazebrook J, Chen W, Estes B, Chang HS, Nawrath C, Métraux JP, Zhu T, Katagiri F (2003) Topology of the network integrating salicylate and jasmonate signal transduction derived from global expression phenotyping. The Plant Journal 34:217–228PubMedCrossRefGoogle Scholar
  14. Göhre V, Robatzek S (2008) Breaking the barriers: microbial effector molecules subvert plant immunity. Annual Review of Phytopathology 46:189–215PubMedCrossRefGoogle Scholar
  15. Heil M, Silva Bueno JC (2007) Within-plant signaling by volatiles leads to induction and priming of an indirect plant defense in nature. Proc Natl Acad Sci USA 104:5467–5472PubMedCrossRefGoogle Scholar
  16. Hind SR, Pulliam SE, Veronese P, Shantharaj D, Nazir A, Jacobs NS, Stratmann JW (2011) The COP9 signalosome controls jasmonic acid synthesis and plant responses to herbivory and pathogens. The Plant Journal 65:480–491PubMedCrossRefGoogle Scholar
  17. Jones JD, Dangl JL (2006) The plant immune system. Nature 444:323–329PubMedCrossRefGoogle Scholar
  18. Jung HW, Tschaplinski TJ, Wang L, Glazebrook J, Greenberg JT (2009) Priming in systemic plant immunity. Science 324:89–91PubMedCrossRefGoogle Scholar
  19. Kandoth PK, Ranf S, Pancholi SS, Jayanty S, Walla MD, Miller W, Howe GA, Lincoln DE, Stratmann JW (2007) Tomato MAPKs LeMPK1, LeMPK2 and LeMPK3 function in the systemin-mediated defense response against herbivorous insects. Proc Natl Acad Sci USA 104:12205–12210PubMedCrossRefGoogle Scholar
  20. Kemmerling B, Schwedt A, Rodriguez P, Mazzotta S, Frank M, Qamar SA, Mengiste T, Betsuyaku S, Parker JE, Müssig C, Thomma BP, Albrecht C, de Vries SC, Hirt H, Nürnberger T (2007) The BRI1-associated kinase 1, BAK1, has a brassinolide-independent role in plant cell-death control. Current Biology 17:1116–1122PubMedCrossRefGoogle Scholar
  21. Koornneef A, Leon-Reyes A, Ritsema T, Verhage A, Den Otter FC, van Loon LC, Pieterse CM (2008) Kinetics of salicylate-mediated suppression of jasmonate signaling reveal a role for redox modulation. Plant Physiology 147:1358–1368PubMedCrossRefGoogle Scholar
  22. Krishna P (2003) Brassinosteroid-mediated stress responses. J Plant Growth Regul 22:289–297PubMedCrossRefGoogle Scholar
  23. Leon-Reyes A, Spoel SH, De Lange ES, Abe H, Kobayashi M, Tsuda S, Millenaar FF, Welschen RA, Ritsema T, Pieterse CM (2009) Ethylene modulates the role of NONEXPRESSOR OF PATHOGENSIS-RELATED GENES1 in cross talk between salicylate and jasmonate signaling. Plant Physiology 149:1797–1809PubMedCrossRefGoogle Scholar
  24. Li L, Li C, Lee GI, Howe GA (2002) Distinct roles for jasmonate synthesis and action in the systemic wound response of tomato. Proc Natl Acad Sci USA 99:6416–6421PubMedCrossRefGoogle Scholar
  25. Llorente F, Muskett P, Sánchez-Vallet A, López G, Ramos B, Sánchez-Rodríguez C, Jordá L, Parker J, Molina A (2008) Repression of the auxin response pathway increases Arabidopsis susceptibility to necrotrophic fungi. Molecular Plant 1:496–509PubMedCrossRefGoogle Scholar
  26. Mauch-Mani B, Mauch F (2005) The role of abscisic acid in plant-pathogen interactions. Current Opinion in Plant Biology 8:409–414PubMedCrossRefGoogle Scholar
  27. Melotto M, Underwood W, Koczan J, Nomura K, He SY (2006) Plant stomata function in innate immunity against bacterial invasion. Cell 126:969–980PubMedCrossRefGoogle Scholar
  28. Morrissey JP, Osbourn AE (1999) Fungal resistance to plant antibiotics as a mechanism of pathogenesis. Microbiology and Molecular Biology Reviews 63:708–724PubMedGoogle Scholar
  29. Mur LA, Laarhoven LJ, Harren FJ, Hall MA, Smith AR (2008) Nitric oxide interacts with salicylate to regulate biphasic ethylene production during the hypersensitive response. Plant Physiology 148:1537–1446PubMedCrossRefGoogle Scholar
  30. Murphy AM, Carr JP (2002) SA has cell-specific effects on Tobacco mosaic virus replication and cell-to-cell movement. Plant Physiology 128:552–563PubMedCrossRefGoogle Scholar
  31. Nagpal P, Ellis CM, Weber H, Ploense SE, Barkawi LS, Guilfoyle TJ, Hagen G, Alonso JM, Cohen JD, Farmer EE, Ecker JR, Reed JW (2005) Auxin responsive factors ARF6 and ARF8 promote jasmonic acid production and flower maturation. Development 132:4107–4118PubMedCrossRefGoogle Scholar
  32. Nakashita H, Yasuda M, Nitta T, Asami T, Fujioka S, Arai Y, Sekimata K, Takatsuto S, Yamaguchi I, Yoshida S (2003) Brassinosteroid functions in a broad range of disease resistance in tobacco and rice. The Plant Journal 33:887–898PubMedCrossRefGoogle Scholar
  33. Nambara E, Marion-Poll A (2005) Abscisic acid biosynthesis and catabolism. Annual Review of Plant Biology 56:165–185PubMedCrossRefGoogle Scholar
  34. Navarro L, Dunoyer P, Jay F, Arnold B, Dharmasiri N, Estelle M, Voinnet O, Jones JD (2006) A plant miRNA contributes to antibacterial resistance by repressing auxin signaling. Science 312:436–439PubMedCrossRefGoogle Scholar
  35. Navarro L, Bari R, Achard P, Lisón P, Nemri A, Harberd NP, Jones JD (2008) DELLAs control plant immune responses by modulation the balance of jasmonic acid and salicylic acid signaling. Current Biology 18:650–655PubMedCrossRefGoogle Scholar
  36. Padmanabhan MS, Kramer SR, Wang X, Culver JN (2008) Tobacco mosaic virus replicase-auxin/indole acetic acid protein interactions: reprogramming the auxin response pathway to enhance virus infection. Journal of Virology 82:2477–2485PubMedCrossRefGoogle Scholar
  37. Park SW, Kaimoyo E, Kumar D, Mosher S, Klessig DF (2007) Methyl salicylate is a critical mobile signal for plant systemic acquired resistance. Science 318:113–116PubMedCrossRefGoogle Scholar
  38. Penninckx IA, Thomma BP, Buchala A, Métraux JP, Broekaert WF (1998) Concomitant activation of jasmonate and ethylene response pathways is required for induction of a plant defensin gene in Arabidopsis. The Plant Cell 10:2103–2113PubMedGoogle Scholar
  39. Pieterse CM, Leon-Reyes A, Van der Ent S, Van Wees SC (2009) Networking by small-molecule hormones in plant immunity. Nature Chem Biol 5:308–316CrossRefGoogle Scholar
  40. Pré M, Atallah M, Champion A, De Vos M, Pieterse CM, Memelink J (2008) The AP2/ERF domain transcription factor ORA59 integrates jasmonic acid and ethylene signals in plant defense. Plant Physiology 147:1347–1357PubMedCrossRefGoogle Scholar
  41. Ryan CA, Pearce G (2001) Polypeptide hormones. Plant Physiology 125:65–68PubMedCrossRefGoogle Scholar
  42. Sakakibara H, Kasahara H, Ueda N, Kojima M, Takei K, Hishiyama S, Asami T, Okada K, Kamiya Y, Yamaya T, Yamaguchi S (2005) Agrobacterium tumefaciens increases cytokinin production in plastids by modifying the biosynthetic pathway in the host plant. Proc Natl Acad Sci USA 102:9972–9977PubMedCrossRefGoogle Scholar
  43. Schenk PM, Kazan K, Wilson I, Anderson JP, Richmond T, Somerville SC, Manners JM (2000) Coordinated plant defense responses in Arabidopsis revealed by microarray analysis. Proc Natl Acad Sci USA 97:11655–11660PubMedCrossRefGoogle Scholar
  44. Shah J (2009) Plants under attack: systemic signals in defence. Current Opinion in Plant Biology 12:459–464PubMedCrossRefGoogle Scholar
  45. Shannon CE, Weaver W (1949) The mathematical theory of communication. University of Illinois Press, ChampaignGoogle Scholar
  46. Siemens J, Keller I, Sarx J, Kunz S, Schuller A, Nagel W, Schmülling T, Parniske M, Ludwig-Müller J (2006) Transcriptome analysis of Arabidopsis clubroots indicate a key role for cytokinins in disease development. Molecular Plant–Microbe Interactions 19:480–494PubMedCrossRefGoogle Scholar
  47. Spoel SH, Dong X (2008) Making sense of hormone crosstalk during plant immune response. Cell Host & Microbe 3:348–351CrossRefGoogle Scholar
  48. Spoel SH, Koornneef A, Claessens SM, Korzelius JP, Van Pelt JA, Mueller MJ, Buchala AJ, Métraux JP, Brown R, Kazan K, van Loon LC, Dong X, Pieterse CM (2003) NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol. The Plant Cell 15:760–770PubMedCrossRefGoogle Scholar
  49. Staswick PE (2008) JAZing up jasmonate signaling. Trends in Plant Science 13:66–71PubMedCrossRefGoogle Scholar
  50. Tada Y, Spoel SH, Pajerowska-Mukthar K, Mou Z, Song J, Wang C, Zuo J, Dong X (2008) Plant immunity requires conformational changes of NPR1 via S-nitrosylation and thioredoxins. Science 321:952–956PubMedCrossRefGoogle Scholar
  51. Thorpe MR, Ferrieri AP, Herth MM, Ferrieri RA (2007) 11C-imaging: methyl jasmonate moves in both phloem and xylem, promotes transport of jasmonate, and of photoassimilate even after proton transport is decoupled. Planta 226:541–551PubMedCrossRefGoogle Scholar
  52. Ton J, Mauch-Mani B (2004) Beta-amino-butyric acid-induced resistance against necrotrophic pathogens is based on ABA-dependent priming for callose. The Plant Journal 38:119–130PubMedCrossRefGoogle Scholar
  53. Ton J, Pieterse CMJ, van Loon LC (2006) The relationship between basal and induced resistance in Arabidopsis. In: Tuzun S, Bent E (eds) Multigenic and induced systemic resistance in plants. Springer, New York, pp 197–224CrossRefGoogle Scholar
  54. Ton J, Flors V, Mauch-Mani B (2009) The multifaceted role of ABA in disease resistance. Trends Plant Sci 14:310–317PubMedCrossRefGoogle Scholar
  55. Truman W, Bennett MH, Kubigsteltig I, Turnbull C, Grant M (2007) Arabidopsis systemic immunity uses conserved defense signaling pathways and is mediated by jasmonates. Proc Natl Acad Sci USA 104:1075–1080PubMedCrossRefGoogle Scholar
  56. van Loon LC, Geraats BP, Linthorst HJ (2006) Ethylene as a modulator of disease resistance in plants. Trends in Plant Science 11:184–191PubMedCrossRefGoogle Scholar
  57. Verberne MC, Hoekstra J, Bol JF, Linthorst HJ (2003) Signaling of systemic acquired resistance in tobacco depends on ethylene perception. The Plant Journal 35:27–32PubMedCrossRefGoogle Scholar
  58. Vernooij B, Friedrich L, Morse A, Reist R, Kolditz-Jawhar R, Ward E, Uknes S, Kessmann H, Ryals J (1994) SA is not the translocated signal responsible for inducing SAR but is required in signal transduction. The Plant Cell 6:959–965PubMedGoogle Scholar
  59. Vlot AC, Klessig DF, Park SW (2008) Systemic acquired resistance: the elusive signal(s). Current Opinion in Plant Biology 11:436–442PubMedCrossRefGoogle Scholar
  60. Vlot AC, Dempsey DA, Klessig DF (2009) Salicylic acid, a multifaceted hormone to combat disease. Annual Review of Phytopathology 47:177–206PubMedCrossRefGoogle Scholar
  61. Walters DR (2010) Plant defense: warding off attack by pathogens, herbivores, and parasitic plants. Blackwell Publishing Ltd, OxfordGoogle Scholar
  62. Wang KL, Li H, Ecker JR (2002) Ethylene biosynthesis and signaling networks. The Plant Cell 14(Suppl):S131–151PubMedGoogle Scholar
  63. Wang D, Pajerowska-Mukhtar K, Culler AH, Dong X (2007) Salicylic acid inhibits pathogen growth in plants through the repression of the auxin signaling pathway. Current Biology 17:1784–1790PubMedCrossRefGoogle Scholar
  64. Wasilewska A, Vlad F, Sirichandra C, Redko Y, Jammes F, Valon C, Frei dit Frey N, Leung J (2008) An update on abscisic acid signaling in plants and more. Molecular Plant 1:198–217PubMedCrossRefGoogle Scholar
  65. Wasternack C (2007) Jasmonates: an update on biosynthesis, signal transduction and action in plant stress response, growth and development. Annals of Botany 100:681–697PubMedCrossRefGoogle Scholar
  66. Weingart H, Ullrich H, Geider K, Völksch B (2001) The role of ethylene production in virulence of Pseudomonas syringae pvs. glycinea and phaseolicola. Phytopathology 91:511–518PubMedCrossRefGoogle Scholar
  67. Yasuda M, Ishikawa A, Jikumaru Y, Seki M, Umezawa T, Asami T, Maruyama-Nakashita A, Kudo T, Shinozaki K, Yoshida S, Nakashita H (2008) Antagonistic interaction between systemic acquired resistance and the abscisic acid-mediated abiotic stress response in Arabidopsis. The Plant Cell 20:1678–1692PubMedCrossRefGoogle Scholar
  68. Zhang ZQ, Li Q, Li Z, Staswick PE, Wang M, Zhu Y, He Z (2007) Dual regulation role of GH3.5 in salicylic acid and auxin signaling during Arabidopsis-Pseudomonas syringae interaction. Plant Physiology 145:450–64PubMedCrossRefGoogle Scholar
  69. Zhang S, Wei Y, Lu Y, Wang X (2009) Mechanisms of brassinosteroids interacting with multiple hormones. Plant Signaling & Behavior 4:1117–1120CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of Biology, Laboratory of Molecular and Cell BiologyUniversity of NeuchâtelNeuchâtelSwitzerland

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