A New Web-Based Integration Tool for the Development of in Silico Experiments of Cardiac Electrophysiology

Abstract

Computational modeling of cardiac electrophysiology demands multidisciplinary groups and a growing number of simulation software to validate new models with experimental data. These in silico experiments are very often composed of legacy tools developed by different researchers and based on different technologies. Therefore, they tend to be very hard to reproduce or extend. This paper presents the FISIOCOMP Environment, a web-based tool that simplifies the simulation process by allowing legacy tools to be easily integrated, documented and used in the development of new in silico experiments. In addition, a study case is presented, where a legacy command line tool for simulating cardiac electrophysiology models is integrated in a new userfriendly web application that allows one to perform sensitivity analysis of the model’s parameters. This new web application is then used to support the study of some pathological changes observed by in vitro experiments performed with ventricular cardiac myocytes extracted from infected mice that are in the acute phase of Chagas’ Disease.