Abstract
The normal thyroid is a bilobed gland, connected by an isthmus. It is encased by a thin capsule, which does not strip easily and contains sizable venous channels. The weight of normal thyroid in the United States ranges from 10 to 20 g. The follicle is the functional unit of the thyroid and averages about 20 μm in diameter. A thyroid lobule consists of 20–40 follicles bound together by a thin sheath of connective tissue and supplied by a lobular artery. The thyroid follicles are formed by a single layer of low cuboidal epithelium (Fig. 21.1). The nucleus of the follicular cell is round to ovoid in shape; it is usually centrally placed with an inconspicuous nucleolus.
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References
Dozois RR, Beahrs OH (1977) Surgical anatomy and technique of thyroid and parathyroid surgery. Surg Clin North Am 57:647–661
Akimova RN, Zotikov LA (1969) An electron microscope study of thyroid gland cells under normal conditions and during the carcinogenic process in golden hamsters. Vopr Onkol 15:68–75
Mansberger AR Jr, Wei JP (1993) Surgical embryology and anatomy of the thyroid and parathyroid glands. Surg Clin North Am 73:727–746
Miller FR (2003) Surgical anatomy of the thyroid and parathyroid glands. Otolaryngol Clin North Am 36:1–7, vii
Zampi G, Bianchi S, Amorosi A, Vezzosi V (1994) Thyroid cancer: anatomy and pathologic histology. Chir Ital 46:4–7
Kondalenko VF, Kalinin AP, Odinokova VA (1970) Ultrastructure of the normal and pathologic human thyroid gland. Arkh Patol 32:25–34
Nesland JM, Sobrinho-Simoes M, Johannessen JV (1987) Scanning electron microscopy of the human thyroid gland and its disorders. Scanning Microsc 1:1797–1810
Sugiyama S (1971) The embryology of the human thyroid gland including ultimobranchial body and others related. Ergeb Anat Entwicklungsgesch 44:3–111
Kovalenko AE (1999) Contemporary concepts of embryology and surgical anatomy of the thyroid gland. Klin Khir 8:38–42
Gibson W, Peng T, Croker B (1980) C-cell nodules in adult human thyroid: a common autopsy finding. Am J Clin Pathol 73:347–351
Wolfe H, DeLellis R, Voelkel E, Tashjian A (1975) Distribution of calcitonin containing cells in the normal neonatal human thyroid gland: a correlation of morphology with peptide content. J Clin Endocrinol Metab 41:1076–1081
Baschieri L, Castagna M, Fierabracci A, Antonelli A, Del Guerra P, Squartini F (1989) Distribution of calcitonin- and somatostatin-containing cells in thyroid lymphoma and in Hashimoto’s thyroiditis. Appl Pathol 7:99–104
Dhillon AP, Rode J, Leathem A, Papadaki L (1982) Somatostatin: a paracrine contribution to hypothyroidism in Hashimoto’s thyroiditis. J Clin Pathol 35:764–770
O’Toole K, Fenoglio-Preiser C, Pushparaj N (1985) Endocrine changes associated with the human aging process. III. Effect of age on the number of calcitonin immunoreactive cells in the thyroid gland. Hum Pathol 16:991–1000
Guyetant S, Rousselet MC, Durigon M et al (1997) Sex-related C cell hyperplasia in the normal human thyroid: a quantitative autopsy study. J Clin Endocrinol Metab 82:42–47
Harach H (1986) Solid cell nests of the human thyroid in early stages of postnatal life. Acta Anat (Basel) 127(2):62–264
Harach H (1988) Solid cell nests of the thyroid. J Pathol 155:191–200
Harach HR (1987) Mixed follicles of the human thyroid gland. Acta Anat (Basel) 129:27–30
Baloch ZW, LiVolsi VA (1999) Oncocytic lesions of the neuroendocrine system. Semin Diagn Pathol 16:190–199
Weiss ML, Deckart H, Pilz R, Deckart E, Kleinau E (1984) Oncocytes in thyroid gland aspirates – differential diagnostic problem: tumor/thyroiditis. Radiobiol Radiother (Berl) 25:765–768
Mikhailov IG, Vasil’ev NB, Smirnova EA (1980) Comparative quantitative electron-microscopic study of the nucleoli of human thyroid oncocytes and follicular cells. Arkh Patol 42:32–36
Mitchell JD, Kirkham N, Machin D (1984) Focal lymphocytic thyroiditis in Southampton. J Pathol 144:269–273
Kabel PJ, Voorbij HA, van der Gaag RD, Wiersinga WM, de Haan M, Drexhage HA (1987) Dendritic cells in autoimmune thyroid disease. Acta Endocrinol Suppl (Copenh) 281:42–48
Nakamura Y, Watanabe M, Matsuzuka F, Maruoka H, Miyauchi A, Iwatani Y (2004) Intrathyroidal CD4+ T lymphocytes express high levels of Fas and CD4+ CD8+ macrophages/dendritic cells express Fas ligand in autoimmune thyroid disease. Thyroid 14:819–824
Katz AD, Hachigian M (1988) Thyroglossal duct cysts. A thirty year experience with emphasis on occurrence in older patients. Am J Surg 155:741–744
Sturgis EM, Miller RH (1993) Thyroglossal duct cysts. J La State Med Soc 145:459–461
Topf P, Fried MP, Strome M (1988) Vagaries of thyroglossal duct cysts. Laryngoscope 98:740–742
Allard R (1982) The thyroglossal cyst. Head Neck Surg 5:134–140
Baughman R (1972) Lingual thyroid and lingual thyroglossal tract remnants. Oral Surg Oral Med Oral Pathol 34:781–798
Heshmati HM, Fatourechi V, van Heerden JA, Hay ID, Goellner JR (1997) Thyroglossal duct carcinoma: report of 12 cases. Mayo Clin Proc 72:315–319
Apel RL, Asa SL, Chalvardjian A, LiVolsi VA (1994) Intrathyroidal lymphoepithelial cysts of probable branchial origin [see comments]. Hum Pathol 25:1238–1242
Carpenter GR, Emery JL (1976) Inclusions in the human thyroid. J Anat 122:77–89
Harach HR, Vujanic GM, Jasani B (1993) Ultimobranchial body nests in human fetal thyroid: an autopsy, histological, and immunohistochemical study in relation to solid cell nests and mucoepidermoid carcinoma of the thyroid. J Pathol 169:465–469
LiVolsi VA (1990) Surgical pathology of the thyroid. Saunders, Philadelphia
Rosai J, Carcangui ML, DeLellis RA (1992) Tumors of the thyroid gland, vol 3rd series, Fascicle 5. Armed Forces Institute of Pathology, Washington, DC
Hathaway BM (1965) Innocuous accessory thyroid nodules. Arch Surg 90:222–227
Baloch Z, LiVolsi VA (2002) Pathology of the thyroid gland. Churchill Livingston, Philadelphia
Gerard-Marchant R (1964) Thyroid follicle inclusions in cervical lymph nodes. Arch Pathol Lab Med 77:637–643
Roth L (1965) Inclusions of nonneoplastic thyroid tissue within cervical lymph nodes. Cancer 18:105–111
Meyer J, Steinberg L (1969) Microscopically benign thyroid follicles in cervical lymph nodes. Cancer 24:301–311
Bataskis J, Nishiyama R, Schmidt R (1963) “Sporadic goiter syndrome”: a clinicopathologic analysis. Am J Clin Pathol 30:241–251
Johnson J (1949) Adenomatous goiters with and without hyperthyroidism. Arch Surg 59:1088–1099
Struder H, Ramelli F (1982) Simple goiter and its variants: euthyroid and hyperthyroid. Endocr Rev 3:40–61
Weaver D, Batsakis J, Nishiyama R (1969) Relationship of iodine to “lymphocytic goiter”. Arch Surg 98:183–185
Brown R, Jackson I, Pohl S, Reichlin S (1978) Do thyroid stimulating immunoglobulins cause nontoxic and toxic multinodular goiter? Lancet 1:904–906
Gaitan E, Nelson NC, Poole GV (1991) Endemic goiter and endemic thyroid disorders. World J Surg 15:205–215
Braverman LE (2001) The physiology and pathophysiology of iodine and the thyroid. Thyroid 11:405
Ghossein RA, Rosai J, Heffess C (1997) Dyshormonogenetic goiter: a clinicopathologic study of 56 cases. Endocr Pathol 8:283–292
Rosenthal D, Carvalho-Guimaraes DP, Knobel M, Medeiros-Neto GA (1990) Dyshormonogenetic goiter: presence of an inhibitor of normal human thyroid peroxidase. J Endocrinol Invest 13:901–904
Bala TS, Janardanasarma MK, Raghunath M (1996) Dietary goitrogen-induced changes in the transport of 2-deoxy-D-glucose and amino acids across the rat blood–brain barrier. Int J Dev Neurosci 14:575–583
Fenwick GR, Griffiths NM (1981) The identification of the goitrogen (−)5-vinyloxazolidine-2-thione (goitrin), as a bitter principle of cooked brussels sprouts (Brassica oleracea L. var. gemmifera). Z Lebensm Unters Forsch 172:90–92
Gabrilove JL, Dorrance WR, Soffer LJ (1952) Effect of corticotropin, cortisone and desoxycorticosterone on thyroid weight of the goitrogen-treated rat. Am J Physiol 169:565–567
Amdisen A, Jensen SE, Olsen T, Schou M (1968) Development of goiter during lithium treatment. Ugeskr Laeger 130:1515–1518
Maloof F, Wang CA, Vickery AL Jr (1975) Nontoxic goiter-diffuse or nodular. Med Clin North Am 59:1221–1232
Struder H, Peter H, Gerber H (1987) Morphologic and functional changes in developing goiters. In: Hall R, Kobberling J (eds) Thyroid disorders associated with iodine deficiency and excess. Raven, New York
Murray D (1998) The thyroid gland. Blackwell Science, Malden
Barsano C, DeGroot L (1979) Dyshormonogenetic goiter. Baillieres Clin Endocrinol Metab 8:145–165
Medeiros-Neto G, Bunduki V, Tomimori E et al (1997) Prenatal diagnosis and treatment of dyshormonogenetic fetal goiter due to defective thyroglobulin synthesis. J Clin Endocrinol Metab 82:4239–4242
Ramelli F, Studer H, Bruggisser D (1982) Pathogenesis of thyroid nodules in multinodular goiter. Am J Pathol 109:215–223
Fialho NJ, de Oliveira CA (1971) Colloid goiter (observations on 100 operated and treated cases). Rev Bras Med 28:314–326
Greer MA, Studer H, Kendall JW (1967) Studies on the pathogenesis of colloid goiter. Endocrinology 81:623–632
Nair K (1951) Adenoma of thyroid; simple adenomatous goiter. Antiseptic 48:716–724
Hirosawa H, Noguchi M, Sakata N, Tanaka S, Miyazaki I (1983) Adenoma or adenomatous goiter with the clinical symptoms of hyperthyroidism. Horumon To Rinsho 31(Suppl):95–98
Apel RL, Ezzat S, Bapat BV, Pan N, LiVolsi VA, Asa SL (1995) Clonality of thyroid nodules in sporadic goiter. Diagn Mol Pathol 4:113–121
Hicks DG, LiVolsi VA, Neidich JA, Puck JM, Kant JA (1990) Clonal analysis of solitary follicular nodules in the thyroid. Am J Pathol 137:553–562
Miller JM (1975) Plummer’s disease. Med Clin North Am 59:1203–1216
LiVolsi VA (1994) The pathology of autoimmune thyroid disease: a review. Thyroid 4:333–339
Margolick JB, Hsu SM, Volkman DJ, Burman KD, Fauci AS (1984) Immunohistochemical characterization of intrathyroid lymphocytes in Graves’ disease. Interstitial and intraepithelial populations. Am J Med 76:815–821
Misaki T, Konishi J, Nakashima T et al (1985) Immunohistological phenotyping of thyroid infiltrating lymphocytes in Graves’ disease and Hashimoto’s thyroiditis. Clin Exp Immunol 60:104–110
Totterman TH (1978) Distribution of T-, B-, and thyroglobulin-binding lymphocytes infiltrating the gland in Graves’ disease, Hashimoto’s thyroiditis, and de Quervain’s thyroiditis. Clin Immunol Immunopathol 10:270–277
Misaki T, Konishi J, Arai K et al (1987) HLA-DR antigen expression on intrathyroidal lymphocytes and thyrocytes in Hashimoto’s thyroiditis and Graves’ disease: an immunohistological study. Endocrinol Jpn 34:257–262
Weetman AP, Gunn C, Hall R, McGregor AM (1985) Thyroid autoantigen-induced lymphocyte proliferation in Graves’ disease and Hashimoto’s thyroiditis. J Clin Lab Immunol 17:1–6
Brinkane A, Ounadi-Corbille W, Bellamy J, Leroy-Terquem E (2004) Hyperplasia of the thymus in Graves’ disease. A case report. Rev Pneumol Clin 60:239–241
Kawai K, Tamai H, Mori T et al (1993) Thyroid histology of hyperthyroid Graves’ disease with undetectable thyrotropin receptor antibodies. J Clin Endocrinol Metab 77:716–719
Hirota Y, Tamai H, Hayashi Y et al (1986) Thyroid function and histology in forty-five patients with hyperthyroid Graves’ disease in clinical remission more than ten years after thionamide drug treatment. J Clin Endocrinol Metab 62:165–169
Cassano C (1971) Dyshormonogenetic goiter caused by altered synthesis of thyroglobulin. Recenti Prog Med 50:9–23
Vickery AL Jr (1981) The diagnosis of malignancy in dyshormonogenetic goitre. Clin Endocrinol Metab 10:317–335
Roti E, Uberti ED (2001) Iodine excess and hyperthyroidism. Thyroid 11:493–500
Strauss A, Trujillo M (1986) Lithium-induced goiter and voice changes. J Clin Psychopharmacol 6:120–121
Mizukami Y, Funaki N, Hashimoto T, Kawato M, Michigishi T, Matsubara F (1988) Histologic features of thyroid gland in a patient with bromide-induced hypothyroidism. Am J Clin Pathol 89:802–805
Imai C, Kakihara T, Watanabe A et al (2002) Acute suppurative thyroiditis as a rare complication of aggressive chemotherapy in children with acute myelogeneous leukemia. Pediatr Hematol Oncol 19:247–253
Lambert MJ 3rd, Johns ME, Mentzer R (1980) Acute suppurative thyroiditis. Am Surg 46:461–463
Golshan MM, McHenry CR, de Vente J, Kalajyian RC, Hsu RM, Tomashefski JF (1997) Acute suppurative thyroiditis and necrosis of the thyroid gland: a rare endocrine manifestation of acquired immunodeficiency syndrome. Surgery 121:593–596
Leesen E, Janssen L, Smet M, Breysem L (2001) Acute suppurative thyroiditis. JBR-BTR 84:68
Hnilica P, Nyulassy S (1985) Plasma cells in aspirates of goitre and overt permanent hypothyroidism following subacute thyroiditis. Preliminary report. Endocrinol Exp 19:221–226
Weetman AP, Smallridge RC, Nutman TB, Burman KD (1987) Persistent thyroid autoimmunity after subacute thyroiditis. J Clin Lab Immunol 23:1–6
Greene J (1971) Subacute thyroiditis. Am J Med 51:97–108
Bastenie P, Bonnyns M, Neve P (1972) Subacute and chronic granulomatous thyroiditis. In: Bastenie PA, Er-mans AM (eds) Thyroiditis and thyroid function, clinical, morphological and physiological studies. Pargamon Press, Oxford, pp 69–97
Cordray JP, Nys P, Merceron RE, Augusti A (2001) Frequency of hypothyroidism after De Quervain thyroiditis and contribution of ultrasonographic thyroid volume measurement. Ann Med Intern (Paris) 152:84–88
Harach HR, Williams ED (1990) The pathology of granulomatous diseases of the thyroid gland. Sarcoidosis 7:19–27
Meachim G, Young M (1963) DeQuervain’s subacute granulomatous thyroiditis: histological identification and incidence. J Clin Pathol 16:189–199
Carney JA, Moore SB, Northcutt RC, Woolner LB, Stillwell GK (1975) Palpation thyroiditis (multifocal granulomatour folliculitis). Am J Clin Pathol 64:639–647
Harach HR (1993) Palpation thyroiditis resembling C cell hyperplasia. Usefulness of immunohistochemistry in their differential diagnosis. Pathol Res Pract 189:488–490
Mizukami Y, Michigishi T, Kawato M et al (1982) Chronic thyroiditis: thyroid function and histologic correlations in 601 cases. Hum Pathol 23:980
Hayashi Y, Tamai H, Fukata S et al (1985) A long term clinical, immunological, and histological follow-up study of patients with goitrous chronic lymphocytic thyroiditis. J Clin Endocrinol Metab 61:1172–1178
Roitt IM, De Carvalho LC (1982) The immunological basis of autoimmune disease. Ciba Found Symp 90:22–34
Podleski WK (1971) Quantitative distribution of IgG, IgM and IgA immunoglobulins in lymphocytic thyroiditis of the Hashimoto type. Arch Immunol Ther Exp 19:431–438
Tomer Y, Ban Y, Concepcion E et al (2003) Common and unique susceptibility loci in Graves and Hashimoto diseases: results of whole-genome screening in a data set of 102 multiplex families. Am J Hum Genet 73:736–747
Fatourechi V, McConahey WM, Woolner LB (1971) Hyperthyroidism associated with histologic Hashimoto’s thyroiditis. Mayo Clin Proc 46:682–689
Mizukami Y, Michigishi T, Hashimoto T et al (1988) Silent thyroiditis: a histologic and immunohistochemical study. Hum Pathol 19:423–431
Aozasa M, Amino N, Iwatani Y et al (1989) Intrathyroidal HLA-DR-positive lymphocytes in Hashimoto’s disease: increases in CD8 and Leu7 cells. Clin Immunol Immunopathol 52:516–522
Iwatani Y, Amino N, Mori H et al (1983) T lymphocyte subsets in autoimmune thyroid diseases and subacute thyroiditis detected with monoclonal antibodies. J Clin Endocrinol Metab 56:251–254
Iwatani Y, Hidaka Y, Matsuzuka F, Kuma K, Amino N (1993) Intrathyroidal lymphocyte subsets, including unusual CD4+ CD8+ cells and CD3loTCR alpha beta lo/-CD4-CD8- cells, in autoimmune thyroid disease. Clin Exp Immunol 93:430–436
Weetman AP, Volkman DJ, Burman KD et al (1986) The production and characterization of thyroid-derived T-cell lines in Graves’ disease and Hashimoto’s thyroiditis. Clin Immunol Immunopathol 39:139–150
McIntosh RS, Watson PF, Weetman AP (1997) Analysis of the T cell receptor V alpha repertoire in Hashimoto’s thyroiditis: evidence for the restricted accumulation of CD8+ T cells in the absence of CD4+ T cell restriction. J Clin Endocrinol Metab 82:1140–1146
Kossev P, Livolsi V (1999) Lymphoid lesions of the thyroid: review in light of the revised European-American lymphoma classification and upcoming World Health Organization classification. Thyroid 9:1273–1280
Lam KY, Lo CY, Kwong DL, Lee J, Srivastava G (1999) Malignant lymphoma of the thyroid. A 30-year clinicopathologic experience and an evaluation of the presence of Epstein-Barr virus. Am J Clin Pathol 112:263–270
Baloch ZW, Solomon AC, LiVolsi VA (2000) Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases. Mod Pathol 13:802–807
Katz SM, Vickery AL Jr (1974) The fibrous variant of Hashimoto’s thyroiditis. Hum Pathol 5:161–170
Papi G, Corrado S, Carapezzi C, De Gaetani C, Carani C (2003) Riedel’s thyroiditis and fibrous variant of Hashimoto’s thyroiditis: a clinicopathological and immunohistochemical study. J Endocrinol Invest 26:444–449
LiVolsi VA (1993) Postpartum thyroiditis. The pathology slowly unravels. Am J Clin Pathol 100:193–195
Weetman AP, Fung HY, Richards CJ, McGregor AM (1990) IgG subclass distribution and relative functional affinity of thyroid microsomal antibodies in postpartum thyroiditis. Eur J Clin Invest 20:133–136
Papi G, Corrado S, Carapezzi C, Corsello SM (2003) Postpartum thyroiditis presenting as a cold nodule and evolving to Graves’ disease. Int J Clin Pract 57:556–558
Williams ED, Doniach I (1962) The post-mortem incidence of focal thyroiditis. J Pathol Bacteriol 83:255–264
Weaver DR, Deodhar SD, Hazard JB (1966) A characterization of focal lymphocytic thyroiditis. Cleve Clin Q 33:59–72
Vollenweider R, Stolkin I, Hedinger C (1982) Focal lymphocytic thyroiditis and iodized salt prophylaxis. Comparative studies on goiter specimens at the Institute of Pathology of Zurich University. Schweiz Med Wochenschr 112:482–488
Bogazzi F, Bartalena L, Gasperi M, Braverman LE, Martino E (2001) The various effects of amiodarone on thyroid function. Thyroid 11:511–519
Smyrk T, Goellner J, Brennan M, Carney J (1987) Pathology of the thyroid in amiodarone associated thyrotoxicosis. Am J Surg Pathol 11:197–204
Katsikas D, Shorthouse A, Taylor S (1976) Riedel’s thyroiditis. Br J Surg 63:929–931
Arnott E, Greaves D (1965) Orbital involvement in Riedel’s thyroiditis. Br J Ophthalmol 491:1–5
Bartholomew L, Cain J, Woolner L, Utz D, Ferris D (1963) Sclerosing cholangitis. Its possible association with Riedel’s struma and fibrous retroperitonitis. N Engl J Med 269:8–12
Davies D, Furness P (1984) Riedel’s thyroiditis with multiple organ fibrosis. Thorax 39:959–960
Rao C, Ferguson G, Kyle V (1973) Retroperitoneal fibrosis associated with Riedel’s struma. Can Med Assoc J 108:1019–1021
Schwaegerle S, Bauer T, Esselstyn C (1988) Riedel’s thyroiditis. Am J Clin Pathol 90:715–722
Papi G, Corrado S, Cesinaro AM, Novelli L, Smerieri A, Carapezzi C (2002) Riedel’s thyroiditis: clinical, pathological and imaging features. Int J Clin Pract 56:65–67
Casoli P, Tumiati B (1999) Hypoparathyroidism secondary to Riedel’s thyroiditis. A case report and a review of the literature. Ann Ital Med Int 14:54–57
Meij S, Hausman R (1978) Occlusive phlebitis, a diagnostic feature in Riedel’s thyroiditis. Virchows Arch [A] 377:339–349
Harach HR, Williams ED (1983) Fibrous thyroiditis – an immunopathological study. Histopathology 7:739–751
Dahlgren M, Khosroshahi A, Nielsen GP, Deshpande V, Stone JH (2010) Riedel’s thyroiditis and multifocal fibrosclerosis are part of the IgG4-related systemic disease spectrum. Arthritis Care Res (Hoboken) 62:1312–1318
Cheuk W, Chan JK (2010) IgG4-related sclerosing disease: a critical appraisal of an evolving clinicopathologic entity. Adv Anat Pathol 17:303–332
Fragoulis GE, Moutsopoulos HM (2010) IgG4 syndrome: old disease, new perspective. J Rheumatol 37:1369–1370
Baloch ZW, Feldman MD, LiVolsi VA (2000) Combined Riedel’s disease and fibrosing Hashimoto’s thyroiditis: a report of three cases with two showing coexisting papillary carcinoma. Endocr Pathol 11:157–163
Cetta F, Montalto G, Petracci M, Fusco A (1997) Thyroid cancer and the Chernobyl accident. Are long-term and long distance side effects of fall-out radiation greater than estimated? J Clin Endocrinol Metab 82:2015–2017
Carr RF, LiVolsi VA (1989) Morphologic changes in the thyroid after irradiation for Hodgkin’s and non-Hodgkin’s lymphoma. Cancer 64:825–829
Aizawa T, Watanabe T, Suzuki N et al (1998) Radiation-induced painless thyrotoxic thyroiditis followed by hypothyroidism: a case report and literature review. Thyroid 8:273–275
Avetisian IL, Gulchiy NV, Demidiuk AP, Stashuk AV (1996) Thyroid pathology in residents of the Kiev region, Ukraine, during pre- and post-Chernobyl periods. J Environ Pathol Toxicol Oncol 15:233–237
Nishiyama K, Kozuka T, Higashihara T, Miyauchi K, Okagawa K (1996) Acute radiation thyroiditis. Int J Radiat Oncol Biol Phys 36:1221–1224
Lindsay S, Dailey M, Jones M (1954) Histologic effects of various types of ionizing radiation on normal and hyperplastic human thyroid glands. J Clin Endocrinol Metab 14:1179–1219
Goldsmith JD, Lai ML, Daniele GM, Tomaszewski JE, LiVolsi VA (2000) Amyloid goiter: report of two cases and review of the literature. Endocr Pract 6:318–323
Hamed G, Heffess CS, Shmookler BM, Wenig BM (1995) Amyloid goiter. A clinicopathologic study of 14 cases and review of the literature. Am J Clin Pathol 104:306–312
Pastolero GC, Asa SL (1994) Drug-related pigmentation of the thyroid associated with papillary carcinoma. Arch Pathol Lab Med 118:79–83
Gordon G, Sparano B, Kramer A, Kelly R, Latropoulos M (1984) Thyroid gland pigmentation and minocycline therapy. Am J Pathol 117:98–109
LiVolsi VA, Feind CR (1976) Parathyroid adenoma and nonmedullary thyroid carcinoma. Cancer 38:1391–1393
Mai KT, Landry DC, Thomas J et al (2001) Follicular adenoma with papillary architecture: a lesion mimicking papillary thyroid carcinoma. Histopathology 39:25–32
LiVolsi VA (1996) Well differentiated thyroid carcinoma. Clin Oncol (R Coll Radiol) 8:281–288
LiVolsi VA, Baloch ZW (2004) Follicular neoplasms of the thyroid: view, biases, and experiences. Adv Anat Pathol 11:279–287
LiVolsi VA, Merino MJ (1994) Worrisome histologic alterations following fine-needle aspiration of the thyroid (WHAFFT). Pathol Annu 29:99–120
Oyama T, Vickery AL Jr, Preffer FI, Colvin RB (1994) A comparative study of flow cytometry and histopathologic findings in thyroid follicular carcinomas and adenomas. Hum Pathol 25:271–275
Harlow SP, Duda RB, Bauer KD (1992) Diagnostic utility of DNA content flow cytometry in follicular neoplasms of the thyroid. J Surg Oncol 50:1–6
Carney JA, Ryan J, Goellner JR (1987) Hyalinizing trabecular adenoma of the thyroid gland. Am J Surg Pathol 11:583–591
Chetty R, Beydoun R, LiVolsi VA (1994) Paraganglioma-like (hyalinizing trabecular) adenoma of the thyroid revisited. Pathology 26:429–431
LiVolsi VA (2000) Hyalinizing trabecular tumor of the thyroid: adenoma, carcinoma, or neoplasm of uncertain malignant potential? Am J Surg Pathol 24:1683–1684
Fonseca E, Nesland J, Sobrinho-Simoes M (1997) Expression of stratified epithelial type cytokeratins in hyalinizing trabecular adenoma supports their relationship with papillary carcinoma of the thyroid. Histopathology 31:330–335
Papotti M, Volante M, Giuliano A et al (2000) RET/PTC activation in hyalinizing trabecular tumors of the thyroid. Am J Surg Pathol 24:1615–1621
Hazard JB, Kenyon R (1954) Atypical adenoma of the thyroid. Arch Pathol 58:554–563
Fukunaga M, Shinozaki N, Endo Y, Ushigome S (1992) Atypical adenoma of the thyroid. A clinicopathologic and flow cytometric DNA study in comparison with other follicular neoplasms. Acta Pathol Jpn 42:632–638
Lang W, Georgii A, Atay Z (1977) Differential diagnosis between atypical adenoma and follicular carcinoma of the thyroid gland (author’s transl). Verh Dtsch Ges Pathol 61:275–279
Carcangiu ML, Steeper T, Zampi G, Rosai J (1985) Anaplastic thyroid carcinoma. A study of 70 cases. Am J Clin Pathol 83:135–158
LiVolsi VA (1992) Papillary neoplasms of the thyroid. Pathologic and prognostic features. Am J Clin Pathol 97:426–434
Mazzaferi E, Young R (1981) Papillary thyroid carcinoma: a 10-year follow-up report of the impact of therapy in 576 patients. Am J Med 70:511–518
Furlan JC, Bedard YC, Rosen IB (2004) Clinicopathologic significance of histologic vascular invasion in papillary and follicular thyroid carcinomas. J Am Coll Surg 198:341–348
Mills SE, Allen MS Jr (1986) Congenital occult papillary carcinoma of the thyroid gland. Hum Pathol 17:1179–1181
Schottenfeld D, Gershman ST (1977) Epidemiology of thyroid cancer – part II. Clin Bull 7:98–104
Williams ED, Doniach I, Bjarnason O, Michie W (1977) Thyroid cancer in an iodide rich area: a histopathological study. Cancer 39:215–222
Harach HR, Escalante DA, Day ES (2002) Thyroid cancer and thyroiditis in Salta, Argentina: a 40-yr study in relation to iodine prophylaxis. Endocr Pathol 13:175–181
Petrova GV, Tereshchenko VP, Avetis’ian IL (1996) The dynamics of thyroid diseases in the inhabitants of Kiev and Kiev Province after the accident at the Chernobyl Atomic Electric Power Station. Lik Sprava 5:67–70
Ron E, Kleinerman RA, Boice JD, LiVolsi VA, Flannery JT, Fraumeni JF (1987) A population-based case–control study of thyroid cancer. J Natl Cancer Inst 79:1–12
Pacini F, Vorontsova T, Molinaro E et al (1999) Thyroid consequences of the Chernobyl nuclear accident. Acta Paediatr Suppl 88:23–27
Tamimi DM (2002) The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol 10:141–146
Nikiforova MN, Caudill CM, Biddinger P, Nikiforov YE (2002) Prevalence of RET/PTC rearrangements in Hashimoto’s thyroiditis and papillary thyroid carcinomas. Int J Surg Pathol 10:15–22
Hunt JL, Baloch Z, Barnes EL et al (2003) Loss of heterozygosity of tumor suppressor genes in cytologically atypical areas in Hashimoto’s thyroiditis. Am J Surg Pathol 27:159–166
La Vecchia C, Ron E, Franceschi S et al (1999) A pooled analysis of case–control studies of thyroid cancer III Oral contraceptives, menopausal replacement therapy and other female hormones. Cancer Causes Control 10:157–166
Diaz NM, Mazoujian G, Wick MR (1991) Estrogen-receptor protein in thyroid neoplasms. An immunohistochemical analysis of papillary carcinoma, follicular carcinoma, and follicular adenoma. Arch Pathol Lab Med 115:1203–1207
Cetta F, Montalto G, Gori M, Curia MC, Cama A, Olschwang S (2000) Germline mutations of the APC gene in patients with familial adenomatous polyposis-associated thyroid carcinoma: results from a European cooperative study. J Clin Endocrinol Metab 85:286–292
Harach HR, Soubeyran I, Brown A, Bonneau D, Longy M (1999) Thyroid pathologic findings in patients with Cowden disease. Ann Diagn Pathol 3:331–340
Haggitt RC, Reid BJ (1986) Hereditary gastrointestinal polyposis syndromes. Am J Surg Pathol 10:871–887
Cetta F, Toti P, Petracci M et al (1997) Thyroid carcinoma associated with familial adenomatous polyposis. Histopathology 31:231–236
Cetta F, Olschwang S, Petracci M et al (1998) Genetic alterations in thyroid carcinoma associated with familial adenomatous polyposis: clinical implications and suggestions for early detection. World J Surg 22:1231–1236
Cetta F, Chiappetta G, Melillo RM et al (1998) The ret/ptc1 oncogene is activated in familial adenomatous polyposis-associated thyroid papillary carcinomas. J Clin Endocrinol Metab 83:1003–1006
Dahia PL, Marsh DJ, Zheng Z et al (1997) Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res 57:4710–4713
Wirtzfeld DA, Petrelli NJ, Rodriguez-Bigas MA (2001) Hamartomatous polyposis syndromes: molecular genetics, neoplastic risk, and surveillance recommendations. Ann Surg Oncol 8:319–327
Meshikhes AW, Butt MS, Al-Saihati BA (2004) Combined parathyroid adenoma and an occult papillary carcinoma. Saudi Med J 25:1707–1710
Dralle H, Altenahr E (1979) Pituitary adenoma, primary parathyroid hyperplasia and papillary (non-medullary) thyroid carcinoma. A case of multiple endocrine neoplasia (MEN). Virchows Arch A Pathol Anat Histol 381:179–187
Carcangiu ML, Zampi G, Rosai J (1985) Papillary thyroid carcinoma: a study of its many morphologic expressions and clinical correlates. Pathol Annu 20(Pt 1):1–44
Francis IM, Das DK, Sheikh ZA, Sharma PN, Gupta SK (1995) Role of nuclear grooves in the diagnosis of papillary thyroid carcinoma. A quantitative assessment on fine needle aspiration smears. Acta Cytol 39:409–415
Riazmontazer N, Bedayat G (1991) Psammoma bodies in fine needle aspirates from thyroids containing nontoxic hyperplastic nodular goiters. Acta Cytol 35:563–566
Hunt JL, Barnes EL (2003) Non-tumor-associated psammoma bodies in the thyroid. Am J Clin Pathol 119:90–94
Hosoya T, Sakamoto A, Kasai N, Sakurai K (1983) Nodal psammoma body in thyroid cancer as an indicator of cancer metastasis to the lymph node. Gan No Rinsho 29:1336–1339
Mancini A, Rabitti C, Conte G, Gullotta G, De Marinis L (1993) Lymphocytic infiltration in thyroid neoplasms. Preliminary prognostic assessments. Minerva Chir 48:1283–1288
Gomez Saez JM, Gomez Arnaiz N, Sahun de la Vega M, Soler Ramon J (1997) Prevalence and significance of lymphocyte infiltration in papillary carcinoma of the thyroid gland. An Med Interna 14:403–405
Ruiz-Velasco R, Waisman J, Van Herle AJ (1978) Cystic papillary carcinoma of the thyroid gland. Diagnosis by needle aspiration with transmission electron microscopy. Acta Cytol 22:38–42
de los Santos ET, Keyhani-Rofagha S, Cunningham JJ, Mazzaferri EL (1990) Cystic thyroid nodules. The dilemma of malignant lesions. Arch Intern Med 150:1422–1427
Namba H, Matsuo K, Fagin JA (1990) Clonal composition of benign and malignant human thyroid tumors. J Clin Invest 86:120–125
Fusco A, Chiappetta G, Hui P et al (2002) Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer. Am J Pathol 160:2157–2167
Hunt JL, LiVolsi VA, Baloch ZW et al (2003) Microscopic papillary thyroid carcinoma compared with clinical carcinomas by loss of heterozygosity mutational profile. Am J Surg Pathol 27:159–166
Petkov R, Gavrailov M, Mikhailov I, Todorov G, Kutev N (1995) Differentiated thyroid cancer – a study of the pathomorphological variants in 216 patients. Khirurgiia 48:11–12
Akslen LA, LiVolsi VA (2000) Prognostic significance of histologic grading compared with subclassification of papillary thyroid carcinoma [see comments]. Cancer 88:1902–1908
Paessler M, Kreisel FH, LiVolsi VA, Akslen LA, Baloch ZW (2002) Can we rely on pathologic parameters to define conservative treatment of papillary thyroid carcinoma? Int J Surg Pathol 10:267–272
Santini L, Pezzullo L, D’Arco E, De Rosa N, Guerriero O, Salza C (1989) Lymph node metastases from an occult sclerosing carcinoma of the thyroid. A case report. Ital J Surg Sci 19:277–279
Akslen LA, LiVolsi VA (2000) Poorly differentiated thyroid carcinoma – it is important. Am J Surg Pathol 24:310–313
Tachikawa T, Kumazawa H, Kyomoto R, Yukawa H, Yamashita T, Nishikawa M (2001) Clinical study on prognostic factors in thyroid carcinoma. Nippon Jibiinkoka Gakkai Kaiho [J Otorhinolaryngol Soc Jpn] 104:157–164
Mazzaferri EL (1987) Papillary thyroid carcinoma: factors influencing prognosis and current therapy. Semin Oncol 14:315–332
Prasad ML, Pellegata NS, Huang Y, Nagaraja HN, Chapelle Ade L, Kloos RT (2005) Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Mod Pathol 18:48–57
Casey MB, Lohse CM, Lloyd RV (2003) Distinction between papillary thyroid hyperplasia and papillary thyroid carcinoma by immunohistochemical staining for cytokeratin 19, galectin-3, and HBME-1. Endocr Pathol 14:55–60
Cheung CC, Ezzat S, Freeman JL, Rosen IB, Asa SL (2001) Immunohistochemical diagnosis of papillary thyroid carcinoma. Mod Pathol 14:338–342
Eimoto T, Naito H, Hamada S, Masuda M, Harada T, Kikuchi M (1987) Papillary carcinoma of the thyroid. A histochemical, immunohistochemical and ultrastructural study with special reference to the follicular variant. Acta Pathol Jpn 37:1563–1579
van Hoeven KH, Kovatich AJ, Miettinen M (1998) Immunocytochemical evaluation of HBME-1, CA 19–9, and CD-15 (Leu-M1) in fine-needle aspirates of thyroid nodules. Diagn Cytopathol 18:93–97
Baloch ZW, Abraham S, Roberts S, LiVolsi VA (1999) Differential expression of cytokeratins in follicular variant of papillary carcinoma: an immunohistochemical study and its diagnostic utility. Hum Pathol 30:1166–1171
Baloch ZW, LiVolsi VA (2002) The quest for a magic tumor marker: continuing saga in the diagnosis of the follicular lesions of thyroid. Am J Clin Pathol 118:165–166
Batistatou A, Zolota V, Scopa CD (2002) S-100 protein+ dendritic cells and CD34+ dendritic interstitial cells in thyroid lesions. Endocr Pathol 13:111–115
Hiasa Y, Nishioka H, Kitahori Y et al (1991) Immunohistochemical detection of estrogen receptors in paraffin sections of human thyroid tissues. Oncology 48:421–424
Khan A, Baker SP, Patwardhan NA, Pullman JM (1998) CD57 (Leu-7) expression is helpful in diagnosis of the follicular variant of papillary thyroid carcinoma. Virchows Arch 432:427–432
Miettinen M, Karkkainen P (1996) Differential reactivity of HBME-1 and CD15 antibodies in benign and malignant thyroid tumours. Preferential reactivity with malignant tumours. Virchows Arch 429:213–219
Zedenius J, Auer G, Backdahl M et al (1992) Follicular tumors of the thyroid gland: diagnosis, clinical aspects and nuclear DNA analysis. World J Surg 16:589–594
Grieco M, Santoro M, Berlingieri MT et al (1990) PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell 60:557–563
Santoro M, Rosati R, Grieco M et al (1990) The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas. Oncogene 5:1595–1598
Santoro M, Dathan NA, Berlingieri MT et al (1994) Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. Oncogene 9:509–516
Inaba M, Umemura S, Satoh H et al (2003) Expression of RET in follicular cell-derived tumors of the thyroid gland: prevalence and implication of morphological type. Pathol Int 53:146–153
Nikiforov YE (2002) RET/PTC rearrangement in thyroid tumors. Endocr Pathol 13:3–16
Jhiang SM, Cho JY, Furminger TL et al (1998) Thyroid carcinomas in RET/PTC transgenic mice. Recent Results Cancer Res 154:265–270
Fischer AH, Bond JA, Taysavang P, O’Eugene B, Wynford-Thomas D (1998) Papillary thyroid carcinoma oncogene (RET/PTC) alters the nuclear envelope and chromatin structure. Am J Pathol 153:1443–1450
Fusco A, Santoro M, Grieco M et al (1995) RET/PTC activation in human thyroid carcinomas. J Endocrinol Invest 18:127–129
Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H, Fagin JA (1997) Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. Cancer Res 57:1690–1694
Bounacer A, Wicker R, Schlumberger M, Sarasin A, Suarez HG (1997) Oncogenic rearrangements of the ret proto-oncogene in thyroid tumors induced after exposure to ionizing radiation. Biochimie 79:619–623
Wirtschafter A, Schmidt R, Rosen D et al (1997) Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto’s thyroiditis [see comments]. Laryngoscope 107:95–100
Sheils O, Smyth P, Finn S, Sweeney EC, O’Leary JJ (2002) RET/PTC rearrangements in Hashimoto’s thyroiditis. Int J Surg Pathol 10:167–168; discussion 168–169
Elisei R, Romei C, Vorontsova T et al (2001) RET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults. J Clin Endocrinol Metab 86:3211–3216
Cohen Y, Xing M, Mambo E et al (2003) BRAF mutation in papillary thyroid carcinoma. J Natl Cancer Inst 95:625–627
Nikiforova MN, Kimura ET, Gandhi M et al (2003) BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas. J Clin Endocrinol Metab 88:5399–5404
Soares P, Trovisco V, Rocha AS et al (2004) BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas. Virchows Arch 444:572–576
Puxeddu E, Moretti S, Elisei R et al (2004) BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas. J Clin Endocrinol Metab 89:2414–2420
Begum S, Rosenbaum E, Henrique R, Cohen Y, Sidransky D, Westra WH (2004) BRAF mutations in anaplastic thyroid carcinoma: implications for tumor origin, diagnosis and treatment. Mod Pathol 17(11):1359–1363
Barzon L, Masi G, Boschin IM et al (2008) Characterization of a novel complex BRAF mutation in a follicular variant papillary thyroid carcinoma. Eur J Endocrinol 159:77–80
Namba H, Nakashima M, Hayashi T et al (2003) Clinical implication of hot spot BRAF mutation, V599E, in papillary thyroid cancers. J Clin Endocrinol Metab 88:4393–4397
Xing M (2005) BRAF mutation in thyroid cancer. Endocr Relat Cancer 12:245–262
Xing M, Tufano RP, Tufaro AP et al (2004) Detection of BRAF mutation on fine needle aspiration biopsy specimens: a new diagnostic tool for papillary thyroid cancer. J Clin Endocrinol Metab 89:2867–2872
Nikiforov YE, Steward DL, Robinson-Smith TM et al (2009) Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules. J Clin Endocrinol Metab 94:2092–2098
Mazzaferri EL (1999) An overview of the management of papillary and follicular thyroid carcinoma. Thyroid 9:421–427
Kjellman P, Learoyd DL, Messina M et al (2001) Expression of the RET proto-oncogene in papillary thyroid carcinoma and its correlation with clinical outcome. Br J Surg 88:557–563
Basolo F, Molinaro E, Agate L et al (2001) RET protein expression has no prognostic impact on the long-term outcome of papillary thyroid carcinoma. Eur J Endocrinol 145:599–604
Cetta F, Gori M, Raffaelli N, Baldi C, Montalto G (1999) Comment on clinical and prognostic relevance of Ret-PTC activation in patients with papillary thyroid carcinoma. J Clin Endocrinol Metab 84:2257–2258
Kim JY, Cho H, Rhee BD, Kim HY (2002) Expression of CD44 and cyclin D1 in fine needle aspiration cytology of papillary thyroid carcinoma. Acta Cytol 46:679–683
Takeuchi Y, Daa T, Kashima K, Yokoyama S, Nakayama I, Noguchi S (1999) Mutations of p53 in thyroid carcinoma with an insular component. Thyroid 9:377–381
Basolo F, Caligo MA, Pinchera A et al (2000) Cyclin D1 overexpression in thyroid carcinomas: relation with clinico-pathological parameters, retinoblastoma gene product, and Ki67 labeling index. Thyroid 10:741–746
Lee A, LiVolsi VA, Baloch ZW (2000) Expression of DNA topoisomerase IIalpha in thyroid neoplasia. Mod Pathol 13:396–400
Tallini G, Garcia-Rostan G, Herrero A et al (1999) Downregulation of p27KIP1 and Ki67/Mib1 labeling index support the classification of thyroid carcinoma into prognostically relevant categories. Am J Surg Pathol 23:678–685
DeLellis RA, Lloyd RD, Heitz PU, Eng C (2004) WHO: pathology and genetics. Tumours of endocrine organs. In: Kleihues P, Sobin LE (eds) WHO classification of tumours. IARC Press, Lyon
Rodriguez JM, Moreno A, Parrilla P et al (1997) Papillary thyroid microcarcinoma: clinical study and prognosis. Eur J Surg 163:255–259
Hay ID, Grant CS, van Heerden JA, Goellner JR, Ebersold JR, Bergstralh EJ (1992) Papillary thyroid microcarcinoma: a study of 535 cases observed in a 50-year period. Surgery 112:1139–1146; discussion 1146–1137
Braga M, Graf H, Ogata A, Batista J, Hakim NC (2002) Aggressive behavior of papillary microcarcinoma in a patient with Graves’ disease initially presenting as cystic neck mass. J Endocrinol Invest 25:250–253
Fernandez-Real JM, Ricart W (1999) Familial papillary thyroid microcarcinoma. Lancet 353:1973–1974
Lupoli G, Vitale G, Caraglia M et al (1999) Familial papillary thyroid microcarcinoma: a new clinical entity. Lancet 353:637–639
Lindsay S (1960) Carcinoma of the thyroid gland: a clinical and pathologic study of 239 patients at the University of California Hospital. Charles C Thomas, Springfield
Chen KTC, Rosai J (1977) Follicular variant of thyroid papillary carcinoma: a clinicopathologic study of six cases. Am J Surg Pathol 1:123–130
LiVolsi VA, Asa SL (1994) The demise of follicular carcinoma of the thyroid gland. Thyroid 4:233–236
Baloch ZW, Gupta PK, Yu GH, Sack MJ, LiVolsi VA (1999) Follicular variant of papillary carcinoma. Cytologic and histologic correlation. Am J Clin Pathol 111:216–222
Baloch Z, LiVolsi VA, Henricks WH, Sebak BA (2002) Encapsulated follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 118:603–605; discussion 605–606
Tielens ET, Sherman SI, Hruban RH, Ladenson PW (1994) Follicular variant of papillary thyroid carcinoma. A clinicopathologic study. Cancer 73:424–431
Liu J, Singh B, Tallini G et al (2006) Follicular variant of papillary thyroid carcinoma: a clinicopathologic study of a problematic entity. Cancer 107:1255–1264
Baloch ZW, Livolsi VA (2002) Follicular-patterned lesions of the thyroid: the bane of the pathologist. Am J Clin Pathol 117:143–150
Mizukami Y, Nonomura A, Michigishi T, Ohmura K, Noguchi M, Ishizaki T (1995) Diffuse follicular variant of papillary carcinoma of the thyroid. Histopathology 27:575–577
Ivanova R, Soares P, Castro P, Sobrinho-Simoes M (2002) Diffuse (or multinodular) follicular variant of papillary thyroid carcinoma: a clinicopathologic and immunohistochemical analysis of ten cases of an aggressive form of differentiated thyroid carcinoma. Virchows Arch 440:418–424
Williams ED, Abrosimov A, Bogdanova TI, Roasi J, Sidorov Y, Thomas GA (2000) Two proposals regarding the terminology of thyroid tumors. Guest editorial. Int J Surg Pathol 8:181–183
Albores-Saavedra J, Gould E, Vardaman C, Vuitch F (1991) The macrofollicular variant of papillary thyroid carcinoma: a study of 17 cases. Hum Pathol 22:1195–1205
Giordano TJ, Kuick R, Thomas DG et al (2005) Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS, and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis. Oncogene 24:6646–6656
Wreesmann VB, Ghossein RA, Hezel M et al (2004) Follicular variant of papillary thyroid carcinoma: genome-wide appraisal of a controversial entity. Genes Chromosomes Cancer 40:355–364
Zhu Z, Gandhi M, Nikiforova MN, Fischer AH, Nikiforov YE (2003) Molecular profile and clinical-pathologic features of the follicular variant of papillary thyroid carcinoma. An unusually high prevalence of ras mutations. Am J Clin Pathol 120:71–77
Johnson TH, Lloyd R, Thompson NW, Beierwalters WH, Sisson JC (1988) Prognostic implications of the tall cell variant of papillary carcinoma. Am J Surg Pathol 12:22–27
Sobrinho-Simoes M, Sambade C, Nesland JM, Johannessen JV (1989) Tall cell papillary carcinoma. Am J Surg Pathol 13:79–80
Bronner MP, LiVolsi VA (1991) Spindle cell squamous carcinoma of the thyroid: an unusual anaplastic tumor associated with tall cell papillary cancer. Mod Pathol 4:637–643
Prendiville S, Burman KD, Ringel MD et al (2000) Tall cell variant: an aggressive form of papillary thyroid carcinoma. Otolaryngol Head Neck Surg 122:352–357
Jobran R, Baloch ZW, Aviles V, Rosato EF, Schwartz S, LiVolsi VA (2000) Tall cell papillary carcinoma of the thyroid: metastatic to the pancreas [in process citation]. Thyroid 10:185–187
Terry J, John S St, Karkowski F et al (1994) Tall cell papillary thyroid cancer: incidence and prognosis. Am J Surg 168:459–461
Sobrinho-Simoes M, Nesland JM, Johannessen JV (1988) Columnar-cell carcinoma. Another variant of poorly differentiated carcinoma of the thyroid. Am J Clin Pathol 89:264–267
Chan JK (1990) Papillary carcinoma of thyroid: classical and variants. Histol Histopathol 5:241–257
Wenig BM, Thompson LDR, Adair CF, Shmookler B, Heffess CF (1998) Thyroid papillary carcinoma of columnar cell type. A clinicopathologic study of 16 cases. Cancer 82:740–753
Evans HL (1996) Encapsulated columnar-cell carcinoma of the thyroid. A report of four cases suggesting a favorable outcome. Am J Surg Pathol 20:1205–1211
Apel RL, Asa SL, LiVolsi VA (1995) Papillary Hurthle cell carcinoma with lymphocytic stroma. “Warthin-like tumor” of the thyroid. Am J Surg Pathol 19:810–814
Baloch ZW, LiVolsi VA (2000) Warthin-like papillary carcinoma of the thyroid. Arch Pathol Lab Med 124:1192–1195
Chan JKC, Tsui MS, Tse CH (1987) Diffuse sclerosing variant of papillary thyroid carcinoma. A histological and immunohistochemical study of three cases. Histopathology 11:191–201
Peix JL, Mabrut JY, Van Box Som P, Berger N (1998) Thyroid cancer in children and adolescents. Clinical aspects, diagnostic problems and special therapeutics. Ann Endocrinol (Paris) 59:113–120
Santoro M, Thomas GA, Vecchio G et al (2000) Gene rearrangement and Chernobyl related thyroid cancers. Br J Cancer 82:315–322
Soares J, Limbert E, Sobrinho-Simoes M (1989) Diffuse sclerosing variant of papillary thyroid carcinoma. A clinicopathologic study of 10 cases. Pathol Res Pract 185:200–206
Nikiforov YE, Erickson LA, Nikiforova MN, Caudill CM, Lloyd RV (2001) Solid variant of papillary thyroid carcinoma: incidence, clinical-pathologic characteristics, molecular analysis, and biologic behavior. Am J Surg Pathol 25:1478–1484
Thomas GA, Bunnell H, Cook HA et al (1999) High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant. J Clin Endocrinol Metab 84:4232–4238
Sywak M, Pasieka JL, Ogilvie T (2004) A review of thyroid cancer with intermediate differentiation. J Surg Oncol 86:44–54
Vergilio J, Baloch ZW, LiVolsi VA (2002) Spindle cell metaplasia of the thyroid arising in association with papillary carcinoma and follicular adenoma. Am J Clin Pathol 117:199–204
Dickersin G, Vickery AL Jr, Smith S (1980) Papillary carcinoma of the thyroid, oxyphil cell type, “clear cell” variant: a light and electron microscopic study. Am J Surg Pathol 4:501–509
Berho M, Suster S (1997) The oncocytic variant of papillary carcinoma of the thyroid: a clinicopathologic study of 15 cases. Hum Pathol 28:47–53
Bisi H, de Camargo RY, Longatto Filho A, Fernandes VS (1993) Thyroid papillary carcinoma lipomatous type: report of two cases. Pathologica 85:761–764
Schroder S, Bocker W (1985) Lipomatous lesions of the thyroid gland: a review. Appl Pathol 3:140–149
Chan JK, Carcangiu ML, Rosai J (1991) Papillary carcinoma of thyroid with exuberant nodular fasciitis-like stroma. Report of three cases. Am J Clin Pathol 95:309–314
Cameselle-Teijeiro J, Chan JK (1999) Cribriform-morular variant of papillary carcinoma: a distinctive variant representing the sporadic counterpart of familial adenomatous polyposis-associated thyroid carcinoma? Mod Pathol 12:400–411
Hirokawa M, Kuma S, Miyauchi A et al (2004) Morules in cribriform-morular variant of papillary thyroid carcinoma: immunohistochemical characteristics and distinction from squamous metaplasia. APMIS 112:275–282
Xu B, Yoshimoto K, Miyauchi A et al (2003) Cribriform-morular variant of papillary thyroid carcinoma: a pathological and molecular genetic study with evidence of frequent somatic mutations in exon 3 of the beta-catenin gene. J Pathol 199:58–67
Franssila KO, Ackerman LV, Brown CL, Hedinger CE (1985) Follicular carcinoma. Semin Diagn Pathol 2:101–122
Tollefson HR, Shah JP, Huvos AG (1973) Follicular carcinoma of the thyroid. Am J Surg 126:523–528
Wade JS (1975) The aetiology and diagnosis of malignant tumours of the thyroid gland. Br J Surg 62:760–764
Jorda M, Gonzalez-Campora R, Mora J, Herrero-Zapatero A, Otal C, Galera H (1993) Prognostic factors in follicular carcinoma of the thyroid. Arch Pathol Lab Med 117:631–635
Segal K, Arad A, Lubin E, Shpitzer T, Hadar T, Feinmesser R (1994) Follicular carcinoma of the thyroid. Head Neck 16:533–538
Crile G, Pontius K, Hawk W (1985) Factors influencing the survival of patients with follicular carcinoma of the thyroid gland. Surg Gynecol Obstet 160:409–412
Schmidt RJ, Wang CA (1986) Encapsulated follicular carcinoma of the thyroid: diagnosis, treatment, and results. Surgery 100:1068–1077
Evans HL (1984) Follicular neoplasms of the thyroid. A study of 44 cases followed for a minimum of 10 years with emphasis on differential diagnosis. Cancer 54:535–540
Thompson LD, Wieneke JA, Paal E, Frommelt RA, Adair CF, Heffess CS (2001) A clinicopathologic study of minimally invasive follicular carcinoma of the thyroid gland with a review of the English literature. Cancer 91:505–524
Carcangiu ML (1997) Minimally invasive follicular carcinoma. Endocr Path 8:231–234
Shaha AR, Loree TR, Shah JP (1995) Prognostic factors and risk group analysis in follicular carcinoma of the thyroid. Surgery 118:1131–1136; discussion 1136–1138
Moore JH Jr, Bacharach B, Choi HY (1985) Anaplastic transformation of metastatic follicular carcinoma of the thyroid. J Surg Oncol 29:216–221
D’Avanzo A, Treseler P, Ituarte PH et al (2004) Follicular thyroid carcinoma: histology and prognosis. Cancer 100:1123–1129
Jakubiak-Wielganowicz M, Kubiak R, Sygut J, Pomorski L, Kordek R (2003) Usefulness of galectin-3 immunohistochemistry in differential diagnosis between thyroid follicular carcinoma and follicular adenoma. Pol J Pathol 54:111–115
Collini P, Sampietro G, Rosai J, Pilotti S (2003) Minimally invasive (encapsulated) follicular carcinoma of the thyroid gland is the low-risk counterpart of widely invasive follicular carcinoma but not of insular carcinoma. Virchows Arch 442:71–76
Kahn NF, Perzin KH (1983) Follicular carcinoma of the thyroid: an evaluation of the histologic criteria used for diagnosis. Pathol Annu 18:221–253
Udelsman R, Westra WH, Donovan PI, Sohn TA, Cameron JL (2001) Randomized prospective evaluation of frozen-section analysis for follicular neoplasms of the thyroid. Ann Surg 233:716–722
Leteurtre E, Leroy X, Pattou F et al (2001) Why do frozen sections have limited value in encapsulated or minimally invasive follicular carcinoma of the thyroid? Am J Clin Pathol 115:370–374
Paphavasit A, Thompson GB, Hay ID et al (1997) Follicular and Hurthle cell thyroid neoplasms. Is frozen-section evaluation worthwhile? Arch Surg 132:674–678; discussion 678–680
Johannessen JV, Sobrinho-Simoes M (1982) Follicular carcinoma of the human thyroid gland. An ultrastructural study with emphasis on scanning electron microscopy. Diagn Histopathol 5:113–127
Backdahl M (1985) Nuclear DNA, content and prognosis in papillary, follicular, and medullary carcinomas of the thyroid. Karolinska Medical Institute, Stockholm
Papotti M, Rodriguez J, Pompa RD, Bartolazzi A, Rosai J (2005) Galectin-3 and HBME-1 expression in well-differentiated thyroid tumors with follicular architecture of uncertain malignant potential. Mod Pathol 18(4):541–546
Rosai J (2003) Immunohistochemical markers of thyroid tumors: significance and diagnostic applications. Tumori 89:517–519
Kroll TG, Sarraf P, Pecciarini L et al (2000) PAX8-PPAR[gamma] 1 fusion in oncogene human thyroid carcinoma. Science 289:1357–1360
Marques AR, Espadinha C, Catarino AL et al (2002) Expression of PAX8-PPAR gamma 1 rearrangements in both follicular thyroid carcinomas and adenomas. J Clin Endocrinol Metab 87:3947–3952
Gustafson KS, LiVolsi VA, Furth EE, Pasha TL, Putt ME, Baloch ZW (2003) Peroxisome proliferator-activated receptor gamma expression in follicular-patterned thyroid lesions. Caveats for the use of immunohistochemical studies. Am J Clin Pathol 120:175–181
Esapa CT, Johnson SJ, Kendall-Taylor P, Lennard TW, Harris PE (1999) Prevalence of Ras mutations in thyroid neoplasia. Clin Endocrinol 50:529–535
Basolo F, Pisaturo F, Pollina LE et al (2000) N-ras mutation in poorly differentiated thyroid carcinomas: correlation with bone metastases and inverse correlation to thyroglobulin expression. Thyroid 10:19–23
Capella G, Matias-Guiu X, Ampudia X, de Leiva A, Perucho M, Prat J (1996) Ras oncogene mutations in thyroid tumors: polymerase chain reaction- restriction-fragment-length polymorphism analysis from paraffin- embedded tissues. Diagn Mol Pathol 5:45–52
Grebe SK, McIver B, Hay ID et al (1997) Frequent loss of heterozygosity on chromosomes 3p and 17p without VHL or p53 mutations suggests involvement of unidentified tumor suppressor genes in follicular thyroid carcinoma. J Clin Endocrinol Metab 82:3684–3691
Matsuo K, Tang SH, Fagin JA (1991) Allelotype of human thyroid tumors: loss of chromosome 11q13 sequences in follicular neoplasms. Mol Endocrinol 5:1873–1879
Nesland JM, Sobrinho-Simoes MA, Holm R, Sambade MC, Johannessen JV (1985) Hurthle-cell lesions of the thyroid: a combined study using transmission electron microscopy, scanning electron microscopy, and immunocytochemistry. Ultrastruct Pathol 8:269–290
Gonzalez-Campora R, Herrero-Zapatero A, Lerma E, Sanchez F, Galera H (1986) Hurthle cell and mitochondrion-rich cell tumors. A clinicopathologic study. Cancer 57:1154–1163
Thompson N, Dun E, Batsakis J, Nishiyama R (1974) Hürthle cell lesions of the thyroid gland. Surg Gynecol Obstet 139:555–560
Gundry S, Burney R, Thompson N, Lloyd R (1983) Total thyroidectomy for Hürthle cell neoplasm of the thyroid gland. Arch Surg 118:529–553
Bronner M, LiVolsi V (1988) Oxyphilic (Askanazy/Hurthle cell) tumors of the thyroid: microscopic features predict biologic behavior. Surg Pathol 1:137–150
Carcangiu ML, Bianchi S, Savino D, Voynick IM, Rosai J (1991) Follicular Hurthle cell tumors of the thyroid gland. Cancer 68:1944–1953
Chen H, Nicol TL, Zeiger MA et al (1998) Hurthle cell neoplasms of the thyroid: are there factors predictive of malignancy? Ann Surg 227:542–546
Janser JC, Pusel J, Rodier JF, Navarrete E, Rodier D (1989) Hurthle cell tumor of the thyroid gland. Analysis of a series of 33 cases. J Chir (Paris) 126:619–624
Kanthan R, Radhi JM (1998) Immunohistochemical analysis of thyroid adenomas with Hurthle cells. Pathology 30:4–6
Bronner MP, Clevenger CV, Edmonds PR, Lowell DM, McFarland MM, LiVolsi VA (1988) Flow cytometric analysis of DNA content in Hurthle cell adenomas and carcinomas of the thyroid. Am J Clin Pathol 89:764–769
Schark C, Fulton N, Yashiro T et al (1992) The value of measurement of ras oncogenes and nuclear DNA analysis in the diagnosis of Hurthle cell tumors of the thyroid. World J Surg 16:745–751; discussion 752
Bouras M, Bertholon J, Dutrieux-Berger N, Parvaz P, Paulin C, Revol A (1998) Variability of Ha-ras (codon 12) proto-oncogene mutations in diverse thyroid cancers. Eur J Endocrinol 139:209–216
Maximo V, Soares P, Lima J, Cameselle-Teijeiro J, Sobrinho-Simoes M (2002) Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hurthle cell tumors. Am J Pathol 160:1857–1865
Variakojis D, Getz ML, Paloyan E, Straus FH (1975) Papillary clear cell carcinoma of the thyroid gland. Hum Pathol 6:384–390
Carcangiu ML, Sibley RK, Rosai J (1985) Clear cell change in primary thyroid tumors. A study of 38 cases. Am J Surg Pathol 9:705–722
Lam KY, Lo CY (1998) Metastatic tumors of the thyroid gland: a study of 79 cases in Chinese patients. Arch Pathol Lab Med 122:37–41
Sakamoto A, Kasai N, Sugano H (1983) Poorly differentiated carcinoma of the thyroid. Cancer 52:1849–1855
Carcangiu ML, Zampi G, Rosai J (1984) Poorly differentiated (“insular”) thyroid carcinoma. A reinterpretation of Langhans’ “wuchernde Struma”. Am J Surg Pathol 8:655–668
Flynn SD, Forman BH, Stewart AF, Kinder BK (1988) Poorly differentiated (“insular”) carcinoma of the thyroid gland: an aggressive subset of differentiated thyroid neoplasms. Surgery 104:963–970
Palestini N, Papotti M, Durando R, Fortunato MA (1993) Poorly differentiated “insular” carcinoma of the thyroid: long-term survival. Minerva Chir 48:1301–1305
Rivera M, Ghossein RA, Schoder H, Gomez D, Larson SM, Tuttle RM (2008) Histopathologic characterization of radioactive iodine-refractory fluorodeoxyglucose-positron emission tomography-positive thyroid carcinoma. Cancer 113:48–56
Volante M, Collini P, Nikiforov YE et al (2007) Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach. Am J Surg Pathol 31:1256–1264
Venkatesh YS, Ordonez NG, Schultz PN, Hickey RC, Goepfert H, Samaan NA (1990) Anaplastic carcinoma of the thyroid. A clinicopathologic study of 121 cases. Cancer 66:321–330
Dumitriu L, Stefaneanu L, Tasca C (1984) The anaplastic transformation of differentiated thyroid carcinoma. An ultrastructural study. Endocrinologie 22:91–96
Chang TC, Liaw KY, Kuo SH, Chang CC, Chen FW (1989) Anaplastic thyroid carcinoma: review of 24 cases, with emphasis on cytodiagnosis and leukocytosis. Taiwan Yi Xue Hui Za Zhi 88:551–556
LiVolsi VA, Brooks JJ, Arendash-Durand B (1987) Anaplastic thyroid tumors. Immunohistology. Am J Clin Pathol 87:434–442
Berry B, MacFarlane J, Chan N (1990) Osteoclastomalike anaplastic carcinoma of the thyroid. Diagnosis by fine needle aspiration cytology. Acta Cytol 34:248–250
Wan SK, Chan JK, Tang SK (1996) Paucicellular variant of anaplastic thyroid carcinoma. A mimic of Reidel’s thyroiditis. Am J Clin Pathol 105:388–393
Giuffrida D, Attard M, Marasa L et al (2000) Thyroid carcinosarcoma, a rare and aggressive histotype: a case report. Ann Oncol 11:1497–1499
Donnell CA, Pollock WJ, Sybers WA (1987) Thyroid carcinosarcoma. Arch Pathol Lab Med 111:1169–1172
Miettinen M, Franssila KO (2000) Variable expression of keratins and nearly uniform lack of thyroid transcription factor 1 in thyroid anaplastic carcinoma. Hum Pathol 31:1139–1145
Sahoo M, Bal CS, Bhatnagar D (2002) Primary squamous-cell carcinoma of the thyroid gland: new evidence in support of follicular epithelial cell origin. Diagn Cytopathol 27:227–231
Harach HR, Day ES, de Strizic NA (1986) Mucoepidermoid carcinoma of the thyroid. Report of a case with immunohistochemical studies. Medicina 46:213–216
Arezzo A, Patetta R, Ceppa P, Borgonovo G, Torre G, Mattioli FP (1998) Mucoepidermoid carcinoma of the thyroid gland arising from a papillary epithelial neoplasm. Am Surg 64:307–311
Wenig BM, Adair CF, Heffess CS (1995) Primary mucoepidermoid carcinoma of the thyroid gland: a report of six cases and a review of the literature of a follicular epithelial-derived tumor. Hum Pathol 26:1099–1108
Chan JK, Albores-Saavedra J, Battifora H, Carcangiu ML, Rosai J (1991) Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia. A distinctive low-grade malignancy arising from the metaplastic follicles of Hashimoto’s thyroiditis. Am J Surg Pathol 15:438–448
Chan JK, Rosai J (1991) Tumors of the neck showing thymic or related branchial pouch differentiation: a unifying concept. Hum Pathol 22:349–367
Iwasa K, Imai MA, Noguchi M et al (2002) Spindle epithelial tumor with thymus-like differentiation (SETTLE) of the thyroid. Head Neck 24:888–893
Ahuja AT, Chan ES, Allen PW, Lau KY, King W, Metreweli C (1998) Carcinoma showing thymiclike differentiation (CASTLE tumor). AJNR Am J Neuroradiol 19:1225–1228
Bayer-Garner IB, Kozovska ME, Schwartz MR, Reed JA (2004) Carcinoma with thymus-like differentiation arising in the dermis of the head and neck. J Cutan Pathol 31:625–629
Roka S, Kornek G, Schuller J, Ortmann E, Feichtinger J, Armbruster C (2004) Carcinoma showing thymic-like elements – a rare malignancy of the thyroid gland. Br J Surg 91:142–145
Nose V (2008) Familial non-medullary thyroid carcinoma: an update. Endocr Pathol 19(4):226–240
Dotto J, Nose V (2008) Familial thyroid carcinoma: a diagnostic algorithm. Adv Anat Pathol 15:332–349
Kraimps JL, Bouin-Pineau MH, Amati P et al (1997) Familial papillary carcinoma of the thyroid. Surgery 121:715–718
Fenton PA, Clarke SE, Owen W, Hibbert J, Hodgson SV (2001) Cribriform variant papillary thyroid cancer: a characteristic of familial adenomatous polyposis. Thyroid 11:193–197
Goto M, Miller RW, Ishikawa Y, Sugano H (1996) Excess of rare cancers in Werner syndrome (adult progeria). Cancer Epidemiol Biomarkers Prev 5:239–246
Blumenthal GM, Dennis PA (2008) PTEN hamartoma tumor syndromes. Eur J Hum Genet 16:1289–1300
Hazard JB, Hawk WA, Crile G (1959) Medullary (solid) carcinoma of the thyroid. A clinicopathologic entity. J Clin Endocrinol Metab 19:152–161
Williams ED (1965) A review of 17 cases of carcinoma of the thyroid and pheochromocytoma. J Clin Pathol 18:288–292
Williams ED (1966) Histogenesis of medullary carcinoma of the thyroid. J Clin Pathol 19:114–118
Block MA, Horn RC, Miller JM, Barrett JL, Brush BE (1967) Familial medullary carcinoma of the thyroid. Ann Surg 166:403–412
Albores-Saavedra J, LiVolsi VA, Williams ED (1985) Medullary carcinoma. Semin Diagn Pathol 2:137–146
Wolfe HJ, Melvin KE, Cervi-Skinner SJ et al (1973) C-cell hyperplasia preceding medullary thyroid carcinoma. N Engl J Med 289:437–441
Mulligan LM, Kwok JB, Healey CS et al (1993) Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature 363:458–460
Hofstra RM, Landsvater RM, Ceccherini I et al (1994) A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma [see comments]. Nature 367:375–376
Mulligan LM, Eng C, Healey CS et al (1994) Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC. Nat Genet 6:70–74
Uribe M, Fenoglio-Preiser CM, Grimes M, Feind C (1985) Medullary carcinoma of the thyroid gland. Clinical, pathological and immunohistochemical features with review of the literature. Am J Surg Pathol 9:577–594
Wolfe HJ, Delellis RA (1981) Familial medullary thyroid carcinoma and C cell hyperplasia. Clin Endocrinol Metab 10:351–365
Leboulleux S, Baudin E, Travagli JP, Schlumberger M (2004) Medullary thyroid carcinoma. Clin Endocrinol (Oxf) 61:299–310
Williams E, Karim S, Sandler M (1968) Prostaglandin secretion by medullary carcinoma of the thyroid: a possible cause of the associated diarrhea. Lancet 1:22–23
Kakudo K, Miyauchi A, Ogihara T et al (1982) Medullary carcinoma of the thyroid with ectopic ACTH syndrome. Acta Pathol Jpn 32:793–800
Sipple JH (1961) The association of pheochromocytoma with carcinoma of the thyroid gland. Am J Med 31:163–166
Jansson S, Hansson G, Salander H, Stenstrom G, Tisell L (1984) Prevalence of C-cell hyperplasia and medullary thyroid carcinoma in a consecutive series of pheochromocytoma patients. World J Surg 8:493–500
Eng C (1996) RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirschsprung’s disease. Semin Med Beth Israel Hosp (Boston) 335:943–951
Eng C (1999) RET proto-oncogene in the development of human cancer. J Clin Oncol 17:380–393
Eng C, Clayton D, Schuffenecker I et al (1996) The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA 276:1575–1579
Kebebew E, Ituarte PH, Siperstein AE, Duh QY, Clark OH (2000) Medullary thyroid carcinoma: clinical characteristics, treatment, prognostic factors, and a comparison of staging systems. Cancer 88:1139–1148
Kambouris M, Jackson CE, Feldman GL (1996) Diagnosis of multiple endocrine neoplasia [MEN] 2A, 2B and familial medullary thyroid cancer [FMTC] by multiplex PCR and heteroduplex analyses of RET proto-oncogene mutations. Hum Mutat 8:64–70
Nakata S, Okugi H, Saitoh Y, Takahashi H, Shimizu K (2001) Multiple endocrine neoplasia type 2B. Int J Urol 8:398–400
Nguyen L, Niccoli-Sire P, Caron P et al (2001) Pheochromocytoma in multiple endocrine neoplasia type 2: a prospective study. Eur J Endocrinol 144:37–44
Marsh DJ, Zheng Z, Arnold A et al (1997) Mutation analysis of glial cell line-derived neurotrophic factor, a ligand for an RET/coreceptor complex, in multiple endocrine neoplasia type 2 and sporadic neuroendocrine tumors. J Clin Endocrinol Metab 82:3025–3028
Borrello MG, Smith DP, Pasini B et al (1995) RET activation by germline MEN2A and MEN2B mutations. Oncogene 11:2419–2427
Eng C, Smith DP, Mulligan LM et al (1994) Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours. Hum Mol Genet 3:237–241
Cohen EG, Shaha AR, Rinaldo A, Devaney KO, Ferlito A (2004) Medullary thyroid carcinoma. Acta Otolaryngol 124:544–557
Asa SL (1997) C-cell lesions of the thyroid. Pathol Case Rev 2:210–217
Abrosimov A (1996) Histologic and immunohistochemical characterization of medullary thyroid carcinoma. Arkh Patol 58:43–48
Alevizaki M, Dai K, Grigorakis SI, Legon S, Souvatzoglou A (1994) Amylin/islet amyloid polypeptide expression in medullary carcinoma of the thyroid: correlation with the expression of the related calcitonin/CGRP genes. Clin Endocrinol (Oxf) 41:21–26
Dominguez-Malagon H, Delgado-Chavez R, Torres-Najera M, Gould E, Albores-Saavedra J (1989) Oxyphil and squamous variants of medullary thyroid carcinoma. Cancer 63:1183–1188
Harach HR, Williams ED (1983) Glandular (tubular and follicular) variants of medullary carcinoma of the thyroid. Histopathology 7:83–97
Huss LJ, Mendelsohn G (1990) Medullary carcinoma of the thyroid gland: an encapsulated variant resembling the hyalinizing trabecular (paraganglioma-like) adenoma of thyroid. Mod Pathol 3:581–585
Landon G, Ordonez NG (1985) Clear cell variant of medullary carcinoma of the thyroid. Hum Pathol 16:844
Mendelsohn G, Baylin SB, Bigner SH, Wells SA Jr, Eggleston JC (1980) Anaplastic variants of medullary thyroid carcinoma: a light-microscopic and immunohistochemical study. Am J Surg Pathol 4:333–341
Kos M, Separovic V, Sarcevic B (1995) Medullary carcinoma of the thyroid: histomorphological, histochemical and immunohistochemical analysis of twenty cases. Acta Med Croatica 49:195–199
DeLilles RA, Rule AH, Spiler F et al (1978) Calcitonin and carcinoembryonic antigen as tumor markers in medullary thyroid carcinoma. Am J Clin Pathol 70:587
Hirsch MS, Faquin WC, Krane JF (2004) Thyroid transcription factor-1, but not p53, is helpful in distinguishing moderately differentiated neuroendocrine carcinoma of the larynx from medullary carcinoma of the thyroid. Mod Pathol 17:631–636
Matsubayashi S, Yanaihara C, Ohkubo M et al (1984) Gastrin-releasing peptide immunoreactivity in medullary thyroid carcinoma. Cancer 53:2472
Roth KA, Bensch KG, Hoffman AR (1987) Characterization of opioid peptides in human thyroid medullary carcinoma. Cancer 59:1594
Komminoth P, Roth J, Saremasiani P et al (1994) Polysialic acid of the neural cell adhesion molecule in the human thyroid: a marker for medullary carcinoma and primary C-cell hyperplasia. An immunohistochemical study on 79 thyroid lesions. Am J Surg Pathol 18:399
Ruppert JM, Eggleston JC, de Bustros A, Baylen SB (1986) Disseminated calcitonin-poor medullary thyroid carcinoma in a patient with calcitonin-rich primary tumor. Am J Surg Pathol 10:513–518
Randolph GW, Maniar D (2000) Medullary carcinoma of the thyroid. Cancer Control 7:253–261
Giuffrida D, Ferrau F, Bordonaro R et al (2000) Medullary carcinoma of the thyroid: diagnosis and therapy. Clin Ter 151:29–35
Gimm O, Sutter T, Dralle H (2001) Diagnosis and therapy of sporadic and familial medullary thyroid carcinoma. J Cancer Res Clin Oncol 127:156–165
Gilliland FD, Hunt WC, Morris DM, Key CR (1997) Prognostic factors for thyroid carcinoma. A population-based study of 15,698 cases from the Surveillance, Epidemiology and End Results (SEER) program 1973–1991. Cancer 79:564–573
Randolph GW (1996) Medullary carcinoma of the thyroid: subtypes and current management. Compr Ther 22:203–210
Brierley J, Tsang R, Simpson WJ, Gospodarowicz M, Sutcliffe S, Panzarella T (1996) Medullary thyroid cancer: analyses of survival and prognostic factors and the role of radiation therapy in local control. Thyroid 6:305–310
Schroder S, Bocker W, Baisch H et al (1988) Prognostic factors in medullary thyroid carcinomas. Survival in relation to age, sex, stage, histology, immunocytochemistry, and DNA content. Cancer 61:806–816
Albores-Saavedra J, Gorraez de la Mora T, de la Torre-Rendon F, Gould E (1990) Mixed medullary-papillary carcinoma of the thyroid: a previously unrecognized variant of thyroid carcinoma. Hum Pathol 21:1151–1155
Giove E, Renzulli G, Lorusso C, Merlicco D, Iacobone D (2004) Mixed medullary and follicular carcinoma of the thyroid: report of one case. Ann Ital Chir 75:251–256; discussion 257
Kashima K, Yokoyama S, Inoue S et al (1993) Mixed medullary and follicular carcinoma of the thyroid: report of two cases with an immunohistochemical study. Acta Pathol Jpn 43:428–433
LiVolsi VA (2004) Mixed follicular medullary thyroid carcinoma. Diagn Cytopathol 31:434; author reply 435
Beressi N, Campos JM, Beressi JP et al (1998) Sporadic medullary microcarcinoma of the thyroid: a retrospective analysis of eighty cases. Thyroid 8:1039–1044
Guyetant S, Dupre F, Bigorgne JC et al (1999) Medullary thyroid microcarcinoma: a clinicopathologic retrospective study of 38 patients with no prior familial disease. Hum Pathol 30:957–963
Albores-Saavedra JA, Krueger JE (2001) C-cell hyperplasia and medullary thyroid microcarcinoma. Endocr Pathol 12:365–377
Kaserer K, Scheuba C, Neuhold N et al (2001) Sporadic versus familial medullary thyroid microcarcinoma: a histopathologic study of 50 consecutive patients. Am J Surg Pathol 25:1245–1251
Mizukami Y, Kurumaya H, Nonomura A et al (1992) Sporadic medullary microcarcinoma of the thyroid. Histopathology 21:375–377
Sironi M, Cozzi L, Pareschi R, Spreafico GL, Assi A (1999) Occult sporadic medullary microcarcinoma with lymph node metastases. Diagn Cytopathol 21:203–206
Russo F, Barone Adesi TL, Arturi A et al (1997) Clinico-pathological study of microcarcinoma of the thyroid. Minerva Chir 52:891–900
Yamauchi A, Tomita Y, Takakuwa T et al (2002) Polymerase chain reaction-based clonality analysis in thyroid lymphoma. Int J Mol Med 10:113–117
Ghazanfar S, Quraishy MS, Essa K, Muzaffar S, Saeed MU, Sultan T (2002) Mucosa associated lymphoid tissue lymphoma (Maltoma) in patients with cold nodule thyroid. J Pak Med Assoc 52:131–133
Takano T, Miyauchi A, Matsuzuka F, Yoshida H, Kuma K, Amino N (2000) Diagnosis of thyroid malignant lymphoma by reverse transcription-polymerase chain reaction detecting the monoclonality of immunoglobulin heavy chain messenger ribonucleic acid. J Clin Endocrinol Metab 85:671–675
Neri A, Aldovini D, Leonardi E, Giampiccolo M, Pedrolli C (1990) Primary angiosarcoma of the thyroid gland. Presentation of a clinical case. Recenti Prog Med 81:318–321
Tsugawa K, Koyanagi N, Nakanishi K et al (1999) Leiomyosarcoma of the thyroid gland with rapid growth and tracheal obstruction: a partial thyroidectomy and tracheostomy using an ultrasonically activated scalpel can be safely performed with less bleeding. Eur J Med Res 4:483–487
Chan YF, Ma L, Boey JH, Yeung HY (1986) Angiosarcoma of the thyroid. An immunohistochemical and ultrastructural study of a case in a Chinese patient. Cancer 57:2381–2388
Diaz-Arias AA, Bickel JT, Loy TS, Croll GH, Puckett CL, Havey AD (1992) Follicular carcinoma with clear cell change arising in lingual thyroid. Oral Surg Oral Med Oral Pathol 74:206–211
LiVolsi VA, Perzin KH, Savetsky L (1974) Carcinoma arising in median ectopic thyroid (including thyroglossal duct tissue). Cancer 34:1303–1315
Doshi SV, Cruz RM, Hilsinger RL Jr (2001) Thyroglossal duct carcinoma: a large case series. Ann Otol Rhinol Laryngol 110:734–738
Cignarelli M, Ambrosi A, Marino A, Lamacchia O, Cincione R, Neri V (2002) Three cases of papillary carcinoma and three of adenoma in thyroglossal duct cysts: clinical-diagnostic comparison with benign thyroglossal duct cysts. J Endocrinol Invest 25:947–954
Fih J, Moore R (1963) Ectopic thyroid tissue and ectopic thyroid carcinoma. Ann Surg 157:212–222
Devaney K, Snyder R, Norris HJ, Tavassoli FA (1993) Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. Int J Gynecol Pathol 12:333–343
Kdous M, Hachicha R, Gamoudi A et al (2003) Struma ovarii. Analysis of a series of 7 cases and review of the literature. Tunis Med 81:571–576
Rosenblum NG, LiVolsi VA, Edmonds PR, Mikuta JJ (1989) Malignant struma ovarii. Gynecol Oncol 32:224–227
Koo HL, Jang J, Hong SJ, Shong Y, Gong G (2004) Renal cell carcinoma metastatic to follicular adenoma of the thyroid gland. A case report. Acta Cytol 48:64–68
Matias-Guiu X, LaGuette J, Puras-Gil AM, Rosai J (1997) Metastatic neuroendocrine tumors to the thyroid gland mimicking medullary carcinoma: a pathologic and immunohistochemical study of six cases. Am J Surg Pathol 21:754–762
Baloch ZW, LiVolsi VA (1999) Tumor-to-tumor metastasis to follicular variant of papillary carcinoma of thyroid. Arch Pathol Lab Med 123:703–706
Lloyd RV (2004) Endocrine pathology: differential diagnosis and molecular advances. Humana Press, Totowa
Bronner MP, Hamilton R, LiVolsi VA (1994) Utility of frozen section analysis on follicular lesions of the thyroid. Endocr Pathol 5:154–161
Paessler M, LiVolsi VA, Baloch ZW (2001) Role of ultrafast Papanicolaou-stained scrape preparations as an adjunct to frozen sections in the surgical management of thyroid lesions. Endocr Pract 7:89–94
Rodriguez JM, Parrilla P, Sola J et al (1994) Comparison between preoperative cytology and intraoperative frozen- section biopsy in the diagnosis of thyroid nodules. Br J Surg 81:1151–1154
Taneri F, Poyraz A, Tekin E, Ersoy E, Dursun A (1998) Accuracy and significance of fine-needle aspiration cytology and frozen section in thyroid surgery. Endocr Regul 32:187–191
Shaha AR, DiMaio T, Webber C, Jaffe BM (1990) Intraoperative decision making during thyroid surgery based on the results of preoperative needle biopsy and frozen section. Surgery 108:964–967; discussion 970–961
Shaha A, Gleich L, Di Maio T, Jaffe BM (1990) Accuracy and pitfalls of frozen section during thyroid surgery. J Surg Oncol 44:84–92
Basolo F, Baloch ZW, Baldanzi A, Miccoli P, LiVolsi VA (1999) Usefulness of ultrafast Papanicolaou-stained scrape preparations in intraoperative management of thyroid lesions. Mod Pathol 12:653–657
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Baloch, Z.W., LiVolsi, V.A. (2012). Thyroid Pathology. In: Oertli, D., Udelsman, R. (eds) Surgery of the Thyroid and Parathyroid Glands. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23459-0_21
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