Abstract
Derivatives of propofol (2, 6-diisopropylphenol) were prepared by coupling with 12-hydroxy-octadec-Z-9-enoic acid and Z-9-octadecenoic acid (oleic acid) with the C1-α-hydroxy function of propofol. Spectroscopic studies confirmed the formation of the desired product. The compounds were then investigated for its in-vitro anticancer activity against a panel of solid human tumor cell lines including human malignant melanoma, human leukemia cells. Their cytotoxicity was also determined against non-cancerous mammalian cells (VERO cells). The analogs were cytotoxic against all cancer cell lines whereas no effect was observed against normal cells. The compounds showed good antimicrobial activity against E. coli and S. albus.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
T. Mammoto, M. Mukai, A. Mammoto, Y. Yamanaka, Y. Hayashi, T. Mashimo, Y. Kishi and H. Nakamura; Cancer Lett. 184 (2002) 165.
R.A. Siddiqui, M. Zerouga, M. Wu, A. Castillo, K. Harvey, G.P. Zaloga and W. Stillwell; Breast Cancer Res. 7 (2005) 645.
D.D. Ross, P.J. Wooten, Y. Tong, B. Cornblatt, C. Levy, R. Sridhara, E.J. Lee and C.A. Schiffer; Blood. 83 (1994) 1337.
F.D. Gunstone; J. Chem. Soc. (1954) 1611.
A. Mohammad, F.B. Faruqi and J. Mustafa; J. Adv. Sci. Res. 1 (2010) 12.
E. Borenfreund, H. Babich and N. Martin-Alguacil; In vitro Dev. Cell. Biol. 26 (1990) 1030.
A.L. Barry, P.D. Hoeprich and M.A. Saubolle. Eds. 4th. LBS, Lea & Febiger, Philadelphia, (1976) p. 180–193.
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Mohammad, A., Faruqi, F., Mustafa, J. (2012). Synthesis, Characterization, Anti-Tumor and Anti-Microbial Activity of Fatty Acid Analogs of Propofol. In: Khemani, L., Srivastava, M., Srivastava, S. (eds) Chemistry of Phytopotentials: Health, Energy and Environmental Perspectives. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23394-4_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-23394-4_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-23393-7
Online ISBN: 978-3-642-23394-4
eBook Packages: Earth and Environmental ScienceEarth and Environmental Science (R0)