Abstract
Facing the deluge of protein sequences generated in the post-genomic age, it is necessary to develop useful machine learning tools to predict the type of a hetero-oligomer. In this paper, a new method for the prediction of hetero-oligomeric protein types is proposed. Firstly, we constructed a high-quality benchmark data set. We collect as much desired information as possible, but meanwhile ensure a high quality for the working data sets, the data were screened strictly. Based on such a stringent data set, an effective sequence encoding scheme for truly representing the protein samples is used. Finally, a powerful prediction algorithm is introduced to identify the types of the given hetero-oligomers.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Price, N.C.: Assembly of multi-subunit structures. In: Pain, R.H. (ed.) Mechanisms of Protein Folding, pp. 160–193. Oxford University Press, New York (1994)
Garian, R.: Prediction of quaternary structure from primary structure. Bioinformatics 17, 551–556 (2001)
Xiao, X., Wang, P., Chou, K.C.: Quat-2L: a web-server for predicting protein quaternary structural attributes. Molecular Diversity (2010) (in press)
Lin, H., Li, Q.Z.: Using pseudo amino acid composition to predict protein structural class: approached by incorporating 400 dipeptide components. J. Comput. Chem. 28, 1463–1466 (2007)
He, X., Cai, D., Yan, S., Zhang, H.-J.: Neighborhood Preserving Embedding. In: IEEE International Conference on Computer Vision (ICCV), Beijing, China (2005)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Wang, T., Hu, L., Wang, J. (2011). Application of NPE Algorithm in Prediction of Oligomeric Proteins. In: Lin, S., Huang, X. (eds) Advances in Computer Science, Environment, Ecoinformatics, and Education. CSEE 2011. Communications in Computer and Information Science, vol 217. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23339-5_45
Download citation
DOI: https://doi.org/10.1007/978-3-642-23339-5_45
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-23338-8
Online ISBN: 978-3-642-23339-5
eBook Packages: Computer ScienceComputer Science (R0)