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Muscarinic Receptor Agonists and Antagonists: Effects on Inflammation and Immunity

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Muscarinic Receptors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 208))

Abstract

In this chapter, we will review what is known about muscarinic regulation of immune cells and the contribution of immune cell muscarinic receptors to inflammatory disease and immunity. In particular, immune cell expression of cholinergic machinery, muscarinic receptor subtypes and functional consequences of agonist stimulation will be reviewed. Lastly, this chapter will discuss the potential therapeutic effects of selective antagonists on immune cell function and inflammatory disease in recent animal studies and human clinical trials.

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Authors and Affiliations

  1. School of Public Health, Harvard University, 665 Huntington Avenue, Boston, MA, 02115, USA

    Norah G. Verbout

  2. Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA

    David B. Jacoby

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  1. Norah G. Verbout
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  2. David B. Jacoby
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Correspondence to Norah G. Verbout .

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Editors and Affiliations

  1. UHN67, Department of Pulmonary and Critical Ca, Oregon Health & Science University, SW Sam Jackson Park Road 3181, Portland, 97239, Oregon, USA

    Allison D. Fryer

  2. , Department of Pharmacology, Monash Institute of Pharmaceutical Scien, Royal Parade 381, Parkville, 3052, Victoria, Australia

    Arthur Christopoulos

  3. , Department of Pharmacology, University of Washington, Seattle, 98195-7750, Washington, USA

    Neil M. Nathanson

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Verbout, N.G., Jacoby, D.B. (2012). Muscarinic Receptor Agonists and Antagonists: Effects on Inflammation and Immunity. In: Fryer, A., Christopoulos, A., Nathanson, N. (eds) Muscarinic Receptors. Handbook of Experimental Pharmacology, vol 208. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23274-9_17

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