Abstract
Experimental and clinical data suggest that reactive oxygen species, which cause no damage under physiological conditions, can cause cellular damage at high concentrations and may play key roles in carcinogenesis. The aim of this study was to evaluate the activities of catalase, superoxide dismutase, and glutathione peroxidise, as well as the production of malondialdheyde and nitric oxide, in bitches suffering adenocarcinoma, histiocytoma, and hemangiopericytoma. Data showed that the levels of both malondialdheyde and nitric oxide were significantly increased in both plasma and tissues. The decreased activities of antioxidant enzymes and increased oxidative stress observed could be attributed to a reduction in antioxidant defenses of the organism because of depleted defenses over time.
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Abbreviations
- CAT:
-
Catalase
- GPx:
-
Glutathione peroxidase
- MDA:
-
Malondialdehyde
- ROS:
-
Reactive oxygen species
- SOD:
-
Superoxide dismutase
References
Armstrong D, Hiramitsu T, Ueda T (1998) In vitro screening for antioxidant activity. Methods Mol Biol 108:315–323
Arnold RS, Shi J, Murad E, Whalen AM, Sun CQ, Polavarapu R, Parthasarathy S, Petros JA, Lambeth JD (2001) Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc Natl Acad Sci USA 98:5550–5555
Baker AM, Oberley LW, Cohen MB (1997) Expression of antioxidant enzymes in human prostatic adenocarcinoma. Prostate 32:229–233
Borek C (1983) Epithelial in vitro cell systems in carcinogenesis studies. Ann NY Acad Sci 407:284–290
Ciarcia R, d’Angelo D, Pacilio C, Pagnini D, Galdiero M, Fiorito F, Damiano S, Mattioli E, Lucchetti C, Florio S, Giordano A (2010) Dysregulated calcium homeostasis and oxidative stress in chronic myeloid leukemia (CML) cells. J Cell Physiol 224:443–453
Ding M, Bressler SL, Yang W, Liang H (2000) Short-window spectral analysis of cortical event-related potentials by adaptive multivariate autoregressive modeling: data preprocessing, model validation, and variability assessment. Biol Cybernet 83:35–45
Jung K, Seidel B, Rudolph B, Lein M, Cronauer MV, Henke W, Hampel G, Schnorr D, Loening SA (1997) Antioxidant enzymes in malignant prostate cell lines and in primary cultured prostatic cells. Free Radic Biol Med 23:127–133
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265–275
Mannervik B, Alin P, Guthenberg C, Jensson H, Tahir MK, Warholm M, Jörnvall H (1985) Identification of three classes of cytosolic glutathione transferase common to several mammalian species: correlation between structural data and enzymatic properties. Proc Natl Acad Sci USA 21:7202–7206
Mayo JC, Tan DX, Sainz RM, Lopez-Burillo S, Reiter RJ (2003) Oxidative damage to catalase induced by peroxyl radicals: functional protection by melatonin and other antioxidants. Free Radic Res 37:543–553
Moncada S (1992) The 1991 Ulf von Euler Lecture. The L-arginine: nitric oxide pathway. Acta Physiol Scand 145:201–227
Pejić S, Todorović A, Stojiljković V, Kasapović J, Pajović SB (2009) Antioxidant enzymes and lipid peroxidation in endometrium of patients with polyps, myoma, hyperplasia and adenocarcinoma. Reprod Biol Endocrinol 23:7–149
Portakal O, Ozkaya O, Erden Inal M, Bozan B, Koşan M, Sayek I (2000) Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 33:279–284
Suh YA, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, Chung AB, Griendling KK, Lambeth JD (1999) Cell transformation by the superoxide-generating oxidase Mox1. Nature 401:79–82
Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem 34:497–500
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Ciarcia, R., Navas, L., Granato, G.E., Fiorito, F., Russo, R., Florio, S. (2012). Increased Oxidative/Nitrosative Stress in Bitches with Several Tumors. In: Pugliese, A., Gaiti, A., Boiti, C. (eds) Veterinary Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23271-8_14
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DOI: https://doi.org/10.1007/978-3-642-23271-8_14
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