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Heparin - A Century of Progress pp 403–422Cite as

Semi-synthetic Heparinoids

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 207))

Abstract

New chemical-enzymatic technology based on the modification of the bacterial polysaccharide K5 from Escherichia coli leads to the synthesis of a number of heparin/heparan sulfate-like molecules with different biological activities. With this technology, two families of sulfated compounds were synthesized, which differ in their uronic acid content. The first group contains only glucuronic acid, whereas the second group contains about 50% iduronic acid following epimerization by immobilized recombinant C5 epimerase. This has led to the development of various anticoagulant and nonanticoagulant K5 derivatives endowed with different – and sometimes highly specific – antitumor, antiviral, and/or anti-inflammatory activities.

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Acknowledgments

The authors thank all the participants in the research and, in particular, Dr. Crisafulli, Dr. Lembo, Dr. Rusnati, and Dr. Presta for the critical revision of the manuscript.

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  1. Glycores 2000 S.r.l., Milan, Italy

    P. Oreste & G. Zoppetti

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  1. P. Oreste
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Correspondence to P. Oreste .

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  1. School of Pharmacy, University of London, Brunswick Square 29-39, London, WC1N 1AX, United Kingdom

    Rebecca Lever

  2. Standards and Control, National Institute for Biological, Blanche Lane, Potters Bar, Herts., EN6 3QG, United Kingdom

    Barbara Mulloy

  3. King's College London, Sackler Inst. Pulmonary Pharmacology, Waterloo Campus, London, SE1 9NH, United Kingdom

    Clive P. Page

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Oreste, P., Zoppetti, G. (2012). Semi-synthetic Heparinoids. In: Lever, R., Mulloy, B., Page, C. (eds) Heparin - A Century of Progress. Handbook of Experimental Pharmacology, vol 207. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23056-1_18

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