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Ätiologie

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Adipositas

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Zusammenfassung

Obwohl die Erblichkeit der Ausprägung des Körpergewichts hoch ist, konnten molekulargenetische Faktoren bislang nur einen kleinen Anteil davon erklären. Es wurden wenige monogene Formen der Adipositas identifiziert, bei denen der Ausfall eines einzelnen Genproduktes bereits zu einer extremen Adipositas führt. So haben funktionell relevante Mutationen im Leptin - oder Leptinrezeptorgen einen monogenen Effekt hinsichtlich der Entwicklung einer Adipositas. Sie finden sich nur bei wenigen Familien weltweit. Funktionell relevante Mutationen im Melanokortin-4-Rezeptorgen (MC4R) finden sich dagegen bei bis zu 6% der extrem adipösen Kinder und Jugendlichen sowie Erwachsenen

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  1. Department für Frauen- und Kindermedizin/IFB AdipositasErkrankungen, Universität Leipzig, Philipp-Rosenthal-Straße 27, 4103, Leipzig, Deutschland

    S. Blüher

  2. Department für Innere Medizin, Klinik für Endokrinologie und Nephrologie, Universität Leipzig, Liebigstraße 20, 4103, Leipzig, Deutschland

    M. Blüher

  3. Klinik für Kinder- und Jugendmedizin, Department für Frauen- und Kindermedizin, Universitätsklinikum Leipzig AöR, Liebigstraße 20a, 4103, Leipzig, Deutschland

    W. Kiess

  4. Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, Molekulargenetisches Labor, LVR-Klinikum Essen, Kliniken und Institut der Universität Duisburg-Essen, Virchowstraße 171, 45147, Essen, Deutschland

    A. Hinney

  5. Institut für Soziale Pädiatrie und Jugendmedizin, Ludwig-Maximilians-Universität, Heiglhofstraße 63, 81377, München, Deutschland

    I. Nehring

  6. Abteilung Epidemiologie, Ludwig-Maximilians-Universität, Heiglhofstraße 63, 81377, München, Deutschland

    R. von Kries

  7. Dr. von Haunersches Kinderspital, Ludwig-Maximilians-Universität, Lindwurmstr. 4, 80337, München, Deutschland

    R. Ensenauer

  8. Labor für Physiologie und Verhalten, ETH-Zürich, Schorenstraße 16, CH – 8603, Schwerzenbach, Der Schweiz

    W. Langhans

  9. Institut für Diabetes und Adipositas (IDO), Business Campus Garching-Hochbrück, Helmholtz Zentrum MünchenDeutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Parkring 13, München, Deutschland

    S.C. Schriever

  10. Institut für Diabetes und Adipositas (IDO), Business Campus Garching-Hochbrück, Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Parkring 13, 85748, Garching, Deutschland

    C.X. Yi, P.T. Pfluger & M.H. Tschöp

  11. Institut für Humanernährung und Lebensmittelkunde, Christian-Albrechts-Universität zu Kiel, Düsternbrooker Weg 17, 24105, Kiel, Deutschland

    T.D. Müller

  12. Klinikum rechts der Isar, Kompetenznetz Adipositas & Lehrstuhl für Ernährungsmedizin Technische Universität München, Georg-Brauchle-Ring 60/62, 80992, München, Deutschland

    C. Holzapfel

  13. Sonnenhang 1a, 49214, Bad Rothenfelde, Deutschland

    A. Wirth

  14. Klinik für Psychosomatische Medizin und Psychotherapie, LWL-Universitätsklinikum der Ruhr-Universität Bochum, Alexandrinenstraße 1–3, 44791, Bochum, Deutschland

    S. Herpertz

  15. Institut für Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    S. Engeli

Authors
  1. S. Blüher
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  2. M. Blüher
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  3. W. Kiess
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  4. A. Hinney
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  5. I. Nehring
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  6. R. von Kries
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  7. R. Ensenauer
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  8. W. Langhans
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  9. S.C. Schriever
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  10. C.X. Yi
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  11. P.T. Pfluger
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  12. M.H. Tschöp
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  13. T.D. Müller
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  14. C. Holzapfel
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  15. A. Wirth
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  16. S. Herpertz
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  17. S. Engeli
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Editor information

Editors and Affiliations

  1. Teutoburger-Wald-Klinik, Bad Rothenfelde, Germany

    Alfred Wirth

  2. für Ernährung, Technische Universität München Else-Kröner-Fresenius-Zentrum, Freising-Weihenstephan, Bayern, Germany

    Hans Hauner

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© 2013 Springer-Verlag Berlin Heidelberg

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Blüher, S. et al. (2013). Ätiologie. In: Wirth, A., Hauner, H. (eds) Adipositas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22855-1_3

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  • DOI: https://doi.org/10.1007/978-3-642-22855-1_3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-22854-4

  • Online ISBN: 978-3-642-22855-1

  • eBook Packages: Medicine (German Language)

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