Abstract
Based on the obtained morphological and neurochemical evidence, at the moment three essentially different types of mechanoreceptors are described in lungs, sharing a nearly identical neurochemical coding and arising from myelinated nerve fibres. Although these three types of sensory nerve terminals in lungs reveal a somewhat different morphology, location and origin, it may be hypothesised that they share complementary mechanosensory roles in supporting normal lung function.
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References
Adriaensen D, Brouns I, Pintelon I, De Proost I, Timmermans J-P (2006) Evidence for a role of neuroepithelial bodies as complex airway sensors: comparison with smooth muscle-associated airway receptors. J Appl Physiol 101:960–970
Cutz E, Pan J, Yeger H (2009a) The role of NOX2 and ‘Novel oxidases’ in airway chemoreceptor O2 sensing. Adv Exp Med Biol 648:427–438
De Proost I, Pintelon I, Brouns I, Kroese ABA, Riccardi D, Kemp PJ, Timmermans J-P, Adriaensen D (2008) Functional live cell imaging of the pulmonary neuroepithelial body microenvironment. Am J Respir Cell Mol Biol 39:180–189
De Proost I, Pintelon I, Wilkinson WJ, Goethals S, Brouns I, Van Nassauw L, Riccardi D, Timmermans J-P, Kemp PJ, Adriaensen D (2009) Purinergic signaling in the pulmonary neuroepithelial body microenvironment unraveled by live cell imaging. FASEB J 23:1153–1160
Kratz JR, Yagui-Beltran A, Jablons DM (2010) Cancer stem cells in lung tumorigenesis. Ann Thorac Surg 89:S2090–S2095
Linnoila RI (2006) Functional facets of the pulmonary neuroendocrine system. Lab Invest 86:425–444
Pintelon I, De Proost I, Brouns I, Van Herck H, Van Genechten J, Van Meir F, Timmermans J-P, Adriaensen D (2005) Selective visualisation of neuroepithelial bodies in vibratome slices of living lung by 4-Di-2-ASP in various animal species. Cell Tissue Res 321:21–33
Rawlins EL, Hogan BL (2006) Epithelial stem cells of the lung: privileged few or opportunities for many? Development 133:2455–2465
Reynolds SD, Giangreco A, Power JH, Stripp BR (2000a) Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration. Am J Pathol 156:269–278
Roomans GM (2010) Tissue engineering and the use of stem/progenitor cells for airway epithelium repair. Eur Cell Mater 19:284–299
Snyder JC, Teisanu RM, Stripp BR (2009) Endogenous lung stem cells and contribution to disease. J Pathol 217:254–264
Sullivan JP, Minna JD, Shay JW (2010) Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Rev 29:61–72
Sutherland KD, Proost N, Brouns I, Adriaensen D, Song J-Y, Berns A (2011) Cells of origins of small cell lung cancer: inactivation of Trp53 and Rb1 in distinct cell types of adult mouse lung. Cancer Cell 19:754–764
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© 2012 Springer-Verlag Berlin Heidelberg
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Brouns, I., Pintelon, I., Timmermans, JP., Adriaensen, D. (2012). Concluding Remarks and Future Prospects. In: Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors. Advances in Anatomy, Embryology and Cell Biology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22772-1_7
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DOI: https://doi.org/10.1007/978-3-642-22772-1_7
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