Zusammenfassung
Die Synthetische Biologie ist eine hochdynamische neue Disziplin, die sich in den Natur-und Ingenieurwissenschaften rasch entfaltet. Die Auswirkungen der Synthetischen Biologie beschränken sich nicht allein auf die Forschung und die Arbeitswelt in den Labors, denn sie könnte künftig in vielen gesellschaftlichen Bereichen relevant werden. Forscher aus der Synthetischen Biologie können unter anderem künstliche Moleküle nutzen, um emergente Phänomene aus der Natur nachzuahmen. Ihr Ziel ist es, künstliches Leben zu erschaffen oder biologischen Bausteine zu entwickeln, die sich so zusammensetzen lassen, dass komplexe Systeme entstehen - und zwar mit völlig neuartigen Funktionen, wie sie in der Natur nicht vorkommen.1
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Literaturv erzeichnis
Anderson, J. C. et al.: An expanded genetic code with a functional quadruplet codon. In: Proceedings of the National Academy of Sciences of the United States (2004), Nr. 101, S. 7566–7571.
Anonymous: Hacking the Genome. In: 2600 The Hacker Quarterly (2003), Nr. 20, S. 6–9.
Bedau, M. A. et al.: Social and ethical checkpoints for bottom-up synthetic biology, or protocells. In: Systems and Synthetic Biology (2009), Vol. 3, Nr. 1–4, S. 65–75.
Benner, S. A./Sismour, A. M.: Synthetic biology. In: Nat Rev Genet (2005), Nr. 6, S. 533–443.
Bennett et al.: From synthetic biology to biohacking: are we prepared? In: Nat Biotech (2009), Vol. 27, Nr. 12, S. 1109–1111.
Bernauer, H. et al.: Technical solutions for biosecurity in synthetic biology. IASB Industry Association Synthetic Biology (2008). URL: http://www.ia-sb.eu/tasks/sites/ synthetic-biology/assets/File/pdf/iasb_report_biosecurity_syntheticbiology.pdf [Stand: 07.06.2010].
Budisa, N.: Prolegomena to future efforts on genetic code engineering by expanding its amino acid repertoire. In: Angew Chem Int. (2004), Nr. 43, S. 3387–3428.
Bügl, H. et al.: DNA synthesis and biological security. In: Nature Biotechnology (2007), Nr. 25, S. 627–629.
Buller, M.: The potential use of genetic engineering to enhance orthopoxviruses as bioweapons. International Conference Smallpox Biosecurity: Preventing the Unthinkable, Genf, Schweiz 2003.
Carr, P./Church, C.: Genome engineering. In: Nat Biotech Volume 27 (2009), Nr. 12, S. 1151–1162.
Cello, J. et al.: Chemical synthesis of poliovirus cDNA: generation of infectious virus in the absence of natural template. In: Science (2002), Nr. 297, S. 1016–1018.
Chin, J. W.: Modular approaches to expanding the functions of living matter. In: Nat Chem Biol (2006), Nr. 2, S. 304–311.
Church, G: A Synthetic Biohazard Nonproliferation Proposal (2004). URL: http://arep. med.harvard.edu/SBP/Church_Biohazard04c.htm [Stand: 07.06.2010].
Church, G. M.: A synthetic biohazard non-proliferation proposal (2005). URL: http:// arep.med.harvard.edu/SBP/Church_Biohazard04c.html [Stand: 07.06.2010].
de Vriend, H.: Constructing Life: Early social reflections on the emerging field of SB, The Hague: Rathenau Instituut, 2006.
Endy, D.: Foundations for engineering biology. In: Nature (2005), Nr. 438, S. 449–453.
FAO: Report of the Expert Consultation on Biosecurity in Food and Agriculture, Rome: FAO, 2002.
Fink et al.: Biotechnology Research In An Age Of Terrorism: Confronting The Dual Use Dilemma, Washington D.C.: The National Academies Press, 2004.
Fleming, D. O.: Risk Assessment of Synthetic Genomics: A Biosafety and Biosecurity Perspective. In: Working Papers for Synthetic Genomics: Risks and Benefits for Science and Society (2007), S. 105–164.
Garfinkel, M./Endy, D./Epstein, G. L./Friedman, R.: Synthetic Genomics: Options for Governance, CSIS-MIT-Venter report 2007. URL: http://www.jcvi.org/cms/research/projects/ syngen-options/overview/ [Stand 23.05.2011].
Glass, J. I. et al.: Essential genes of a minimal bacterium. In: Proceedings of the National Academy of Sciences of the United States (2006), Nr. 103, S. 425–430.
Graham et al.: World at Risk, New York: Random House, 2008.
Heinemann, M./Panke, S.: Synthetic biology-putting engineering into biology. In: Bioinformatics (2006), Nr. 22, S. 2790–2799.
Herdewijn, P./Marliere, P.: Toward safe genetically modified organisms through the chemical diversification of nucleic acids. In: Chem Biodivers (2009), Nr. 6, S. 791–808.
IASB: The IASB Code of Conduct for Best Practices in Gene Synthesis Cambridge (2009). URL: http://www.ia-sb.eu/tasks/sites/synthetic-biology/assets/File/pdf/iasb_code_of_ conduct_final.pdf [Stand: 07.06.2010].
IGSC (International Gene Synthesis Consortium): Harmonized Screening Protocol: Gene Sequence & Customer Screening to Promote Biosecurity (2009). URL: http://www.genesynthesisconsortium. org/Harmonized_Screening_Protocol.html [Stand: 07.06.2010].
Jackson, R. J. et al.: Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. IN: Journal of Virology (2001), Nr. 75, S. 1205–1210.
Keasling, J. D.: Synthetic Biology for Synthetic Chemistry. IN: ACS Chem Biol (2008), Nr. 3, S. 64–76.
Kelle, A.: Synthetic Biology and Biosecurity Awareness in Europe, Vienna: IDC, 2007. URL: http://www.synbiosafe.eu/uploads/pdf/Synbiosafe-Biosecurity_awareness_in_Europe_ Kelle.pdf [Stand: 07.06.2010].
Leconte, A. M. et al.: Discovery, characterisation, and optimisation of an unnatural base pair for expansion of the genetic alphabet. In: J. Am. Chem. Soc. (2008), Nr. 130, S. 2336–2343.
Lemon-Relman Committee: Globalization, Biosecurity and the Future of the Life Sciences, Report by the Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare Threats, Washington D.C: The National Academies Press, 2006.
Luisi, P. L.: Chemical Aspects of Synthetic Biology. In: Chemistry and Biodiversity (2007), Nr. 4, S. 603–621.
MacKenzie, D.: US develops lethal new viruses. In: New Scientist (2003), Nr. 180.
Marliere, P.: The farther, the safer: a manifesto for securely navigating synthetic species away from the old living world. In: Syst Synth Biol (2009), Nr. 3, S. 77–84.
Neumann, H. et al.: Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. In: Nature (2010) Nr. 464, S. 441–444.
NIH (US Department of Health and Human Services): Screening Framework Guidance for Synthetic Double-Stranded DNA Providers (2009). URL: http://edocket.access.gpo. gov/2009/pdf/E9-28328.pdf [Stand: 07.06.2010].
Nowak, R.: Disaster in the making. An engineered mouse virus leaves us one step away from the ultimate bioweapon. IN: New Scientist 13. Januar 2001, S. 4–5.bl]References
NSABB: Roundtable on Synthetic Biology, National Science Advisory Board for Biosecurity, Bethesda 2007. URL: http://oba.od.nih.gov/biosecurity/pdf/Annotated%20Agenda% 20Website.pdf [Stand: 07.06.2010].
NSABB: Addressing biosecurity concerns related to the synthesis of selected agents (2008). URL: http://oba.od.nih.gov/biosecurity/pdf/Final_NSABB_Report_on_Synthetic_ Genomics.pdf [Stand: 07.06.2010].
O’Malley, M. et al.: Knowledge-making distinctions in synthetic biology. IN: BioEssays (2008), Nr. 30, S. 57.
Qiang, W.: Efforts to Strengthen Biosafety and Biosecurity in China (chapter 6). In: Smithson AE (ed.): Beijing on Biohazards: Chinese Experts on Bioweapons Nonproliferation Issues, James Martin Center for Nonproliferation Studies, Monterey Institute of International Studies, Monterey.
Ro, D. K. et al.: Production of the antimalarial drug precursor artemisinic acid in engineered yeast. In: Nature (2006), Nr. 440, S. 940–943.
Rosengard, A. M. et al.: Variola virus immune evasion design: expression of a highly efficient inhibitor of human complement. In: Proceedings of the National Academy of Sciences USA (2002) Nr. 99, S. 8808–8813.
Sarasin P.: Anthrax. Bioterror als Phantasma. Frankfurt am Main: Suhrkamp Verlag, 2004.
Schmidt, M.: Public will fear biological accidents, not just attacks. In: Nature (2006), Nr. 441, S. 1048.
Schmidt, M.: Diffusion of synthetic biology: a challenge to biosafety. Systems and Synthetic Biology (2008). DOI: 10.1007/s11693-008-9018-z.
Schmidt, M.: Do I understand what I can create? Biosafety issues in synthetic biology. Kapitel 6 in: Schmidt, M. et al.: Synthetic Biology. The Technoscience and its Societal Consequences, Springer Academic Publishing, 2009.
Schmidt, M. et al.: A priority paper for the societal and ethical aspects of synthetic biology. In: Syst Synth Biol (2009), Nr. 3, S. 3–7.
Schmidt M.: Xenobiology: A new form of life as the ultimate biosafety tool.In: BioEssays Vol. 32 (2010), Nr. 4, S. 322–331.
Serrano, L.: Synthetic biology: promises and challenges. In: Mol Syst Biol (2007), Nr. 3, S. 158.
Steinbruner, J. D./Harris, E. D.: When science breeds nightmares. In: International Herald Tribune 3. Dezember 2003.
Steinbrunner, J./Harris, E. D./Gallagher, N./Okutani, S. M.: Controlling Dangerous Pathogens. A Prototype Protective Oversight System, 2007, College Park: University of Maryland. URL: http://www.cissm.umd.edu/papers/files/pathogens_project_monograph. pdf [Stand 23.05.2011].
Tucker, J. B./Zilinskas, R. A.: The Promise and Perils of Synthetic Biology. The New Atlantis (2006). URL: http://www.thenewatlantis.com/archive/12/tuckerzilinskas.htm [Stand: 07.06.2010].
WHO (World Health Organization): Laboratory biosafety manual, 3. Aufl. Geneva: World Health Organization, 2004.
Yang, Z. et al.: Artificially expanded genetic information system: a new base pair with an alternative hydrogen bonding pattern. In: Nucleic Acids Res (2006), Nr. 34, S. 6095–6101.
Yang, Z. et al.: Enzymatic incorporation of a third nucleobase pair. In: Nucleic Acids Res (2007), Nr. 35, S. 4238–4249.
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Schmidt, M. (2011). Biosicherheit und Synthetische Biologie. In: Pühler, A., Müller-Röber, B., Weitze, MD. (eds) Synthetische Biologie. acatech DISKUSSION. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22354-9_11
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