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The Impact of Everyday Stressors on the Immune System and Health

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Stress Challenges and Immunity in Space

Abstract

Research over the past three decades has clearly established that psychological stress in daily life affects clinically relevant immune outcomes including inflammatory processes, wound healing, and responses to infectious agents and other immune challenges (e.g., vaccination). It is notable that these effects are seen even in young, healthy people experiencing relatively mild stressors, such as medical students undertaking routine academic exams. In this chapter, we provide an overview of key models and findings linking everyday stressors to immune function and health. Research examining stressors in everyday life has implications for understanding effects of more extreme stressors, such as those encountered during space flight which presents an exceptional and intense combination of physical and psychological challenges. Here we provide an overview of key models and findings linking daily life stress to immune dysregulation.

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Acknowledgment

Funding: Work on this chapter was supported by grants R21-HD061644 and R21-HD067670 (LMC), the OSU CRC (UL1RR025755), the former OSU GCRC (M01-RR-00034), and the Kathryn & Gilbert Mitchell Endowment (RG). The content of this chapter is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.

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Authors and Affiliations

  1. Department of Psychiatry, The Ohio State University Medical Center, Columbus, OH, USA

    Lisa M. Christian

  2. Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, USA

    Lisa M. Christian & Ronald Glaser

  3. Department of Psychology, The Ohio State University, Columbus, OH, USA

    Lisa M. Christian

  4. Department of Obstetrics and Gynecology, The Ohio State University Medical Center, Columbus, OH, USA

    Lisa M. Christian

  5. Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH, USA

    Ronald Glaser

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  1. Lisa M. Christian
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Correspondence to Lisa M. Christian .

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  1. Klinikum Großhadern, Klinik für Anästhesiologie und, Universitätsklinikum München, Marchioninistr. 15, München, 81377, Germany

    Alexander Chouker

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Christian, L.M., Glaser, R. (2012). The Impact of Everyday Stressors on the Immune System and Health. In: Chouker, A. (eds) Stress Challenges and Immunity in Space. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22272-6_4

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