Abstract
Selenoprotein T (SelT) has been recently identified as a member of the redoxin protein family, based on the occurrence in its primary structure of a “thioredoxinlike fold” containing a selenocystein. Few studies have been reported on the distribution of SelT, showing its low expression in adult tissues and its abundance during embryogenesis. A pangenomic microarray analysis allowed us to identify SelT as a gene stimulated by a trophic neuropeptide, the pituitary adenylate cyclase-activating polypeptide, during neuronal differentiation. It was shown that SelT is mainly localized in the endoplasmic reticulum and participates actively to intracellular Ca2+ homeostasis. Other genomic studies revealed that SelT gene expression is stimulated upon tissue injury, suggesting that the selenoprotein could also play an important role in protection against oxidative stress.
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© 2011 Zhejiang University Press, Hangzhou and Springer-Verlag Berlin Heidelberg
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Tanguy, Y. et al. (2011). Selenoprotein T. In: Selenoproteins and Mimics. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22236-8_6
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DOI: https://doi.org/10.1007/978-3-642-22236-8_6
Publisher Name: Springer, Berlin, Heidelberg
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