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Cyclodextrin-based Mimics of Selenoproteins

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Selenoproteins and Mimics

Part of the book series: Advanced Topics in Science and Technology in China ((ATSTC))

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Abstract

The two most important factors, substrate recognition and intermolecular catalysis in enzyme catalysis play vital roles in enzyme imitation. Glutathione peroxidase (GPx, EC 1.11.1.9) is one of the key antioxidant enzymes involved in scavenging reactive oxygen species (ROS) in biological systems. Due to its biological importance and structural specificity, chemists and biologists attempt to mimic its function using different ways. Cyclodextrins have been widely investigated as enzyme models since their hydrophobic cavities are capable of binding small organic molecules. Thus, cyclodextrins have been widely used as scaffolds for constructing artificial selenoenzymes. In this chapter, we will focus on the introduction of the design and preparation of cyclodextrin-based mimics of GPx, including their catalytic mechanisms and substrate recognitions.

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Authors and Affiliations

  1. Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, 130012, Changchun, China

    Fei Yan & Guimin Luo

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  1. Fei Yan
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  2. Guimin Luo
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© 2011 Zhejiang University Press, Hangzhou and Springer-Verlag Berlin Heidelberg

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Yan, F., Luo, G. (2011). Cyclodextrin-based Mimics of Selenoproteins. In: Selenoproteins and Mimics. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22236-8_15

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