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Selenoproteins and Atherosclerosis

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Book cover Selenoproteins and Mimics

Part of the book series: Advanced Topics in Science and Technology in China ((ATSTC))

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Abstract

Atherosclerosis is a chronic inflammatory disease of the arterial wall which is a serious hazard to human health. This review focuses on the role and mechanism of selenium in cytoprotection against cholesterol oxide-induced vascular damage in rats. Selenium, as an essential nutritional trace element for humans, exerts its biological effect through selenoproteins and plays an important role in the inhibition of vascular oxidative damage and in the prevention of atherosclerosis induced by oxysterols. The mechanism may be related to: (i) the effect of selenium on the antioxidative capacity of the arterial wall; (ii) the regulation of selenium on oxysterols-induced abnormality of prostacyclin and thromboxane; (iii) the inhibiting effect of selenium on oxysterols-induced apoptosis of vascular smooth muscle cells.

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  1. Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 430074, Wuhan, China

    Kaixun Huang & Huibi Xu

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  1. Kaixun Huang
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Huang, K., Xu, H. (2011). Selenoproteins and Atherosclerosis. In: Selenoproteins and Mimics. Advanced Topics in Science and Technology in China. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22236-8_10

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