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Light-Triggered Peptide Dynamics

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Protein Folding and Misfolding

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Photoswitches suitably connected to model peptides allow to apply light as trigger for folding initiation. Time-resolved infrared spectroscopy provides a certain degree of structural information and allows to follow the kinetics of photoinduced conformational changes by investigating the transient, interconverting structures. Several secondary structure elements have been studied in detail with this approach. The recent development of light-responsive tertiary structures yields the next generation of model peptides on the way toward an understanding of protein folding.

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References

  1. A. Cattani-Scholz, C. Renner, C. Cabrele, R. Behrendt, D. Oesterhelt, L. Moroder, Angew. Chem. Int. Ed. 41, 289 (2002)

    Article  Google Scholar 

  2. R.H. Kramer, D.L. Fortin, D. Trauner, Curr. Opin. Neurobiol. 19, 1 (2009)

    Article  Google Scholar 

  3. C. Renner, L. Moroder, Chembiochem 7, 869 (2006)

    Article  Google Scholar 

  4. T. Nägele, R. Hoche, W. Zinth, J. Wachtveitl, Chem. Phys. Lett. 272, 489 (1997)

    Article  Google Scholar 

  5. T. Cordes, C. Elsner, T.T. Herzog, C. Hoppmann, T. Schadendorf, W. Summerer, K. Rück-Braun, W. Zinth, Chem. Phys. 358, 103 (2009)

    Article  ADS  Google Scholar 

  6. T. Cordes, D. Weinrich, S. Kempa, K. Riesselmann, S. Herre, C. Hoppmann, K. Rück-Braun, W. Zinth, Chem. Phys. Lett. 428, 167 (2006)

    Article  ADS  Google Scholar 

  7. T. Cordes, T. Schadendorf, B. Priewisch, K. Rück-Braun, W. Zinth, J. Phys. Chem. A 112, 581 (2008)

    Article  Google Scholar 

  8. T. Cordes, T.T. Herzog, S. Malkmus, S. Draxler, T. Brust, J.A. DiGirolamo, W.J. Lees, M. Braun, Photochem. Photobiol. Sci. 8, 528 (2009)

    Article  Google Scholar 

  9. H. Port, P. Gärtner, M. Hennrich, I. Ramsteiner, T. Schöck, Mol. Cryst. Liq. Cryst. 430, 15 (2005)

    Article  Google Scholar 

  10. T. Brust, S. Malkmus, S. Draxler, S.A. Ahmed, K. Rück-Braun, W. Zinth, M. Braun, J. Photochem. Photobiol. A 207, 209 (2009)

    Article  Google Scholar 

  11. T. Brust, S. Draxler, J. Eicher, W.J. Lees, K. Rück-Braun, W. Zinth, M. Braun, Chem. Phys. Lett. 489, 175 (2010)

    Article  ADS  Google Scholar 

  12. S. Draxler, T. Brust, S. Malkmus, J.A. Di Girolamo, W.J. Lees, W. Zinth, M. Braun, Phys. Chem. Chem. Phys. 11, 5019 (2009)

    Article  Google Scholar 

  13. A. Fissi, O. Pieroni, F. Ciardelli, Biopolymers 26, 1993 (1987)

    Article  Google Scholar 

  14. A. Fissi, O. Pieroni, E. Balestreri, C. Amato, Macromolecules 29, 4680 (1996)

    Article  ADS  Google Scholar 

  15. O. Sadovski, A.A. Beharry, F.Z. Zhang, G.A. Woolley, Angew. Chem. Int. Ed. 48, 1484 (2009)

    Article  Google Scholar 

  16. R. Behrendt, C. Renner, M. Schenk, F. Wang, J. Wachtveitl, D. Oesterhelt, L. Moroder, Angew. Chem. Int. Ed. 38, 2771 (1999)

    Article  Google Scholar 

  17. R. Denschlag, W. Schreier, B. Rieff, T. Schrader, F.O. Koller, L. Moroder, W. Zinth, P. Tavan, Phys. Chem. Chem. Phys. 12, 6204 (2010)

    Article  Google Scholar 

  18. S.-L. Dong, M. Löweneck, T.E. Schrader, W.J. Schreier, W. Zinth, L. Moroder, C. Renner, Chem. Eur. J. 12, 1114 (2006)

    Article  Google Scholar 

  19. C. Hoppmann, S. Seedorff, A. Richter, H. Fabian, P. Schmieder, K. Rück-Braun, M. Beyermann, Angew. Chem. Int. Ed. 48, 6636 (2009)

    Article  Google Scholar 

  20. R. Behrendt, C. Renner, M. Schenk, F.Q. Wang, J. Wachtveitl, D. Oesterhelt, L. Moroder, Angew. Chem. Int. Ed. 38, 2771 (1999)

    Article  Google Scholar 

  21. S. Spörlein, H. Carstens, H. Satzger, C. Renner, R. Behrendt, L. Moroder, P. Tavan, W. Zinth, J. Wachtveitl, Proc. Natl. Acad. Sci. U.S.A. 99, 7998 (2002)

    Article  ADS  Google Scholar 

  22. T.E. Schrader, W.J. Schreier, T. Cordes, F.O. Koller, G. Babitzki, R. Denschlag, C. Renner, M. Löweneck, S.-L. Dong, L. Moroder, P. Tavan, W. Zinth, Proc. Natl. Acad. Sci. U.S.A. 104, 15729 (2007)

    Article  ADS  Google Scholar 

  23. V. Schultheis, R. Reichold, B. Schropp, P. Tavan, J. Phys. Chem. B 112, 12217 (2008)

    Article  Google Scholar 

  24. B. Fierz, H. Satzger, C. Root, P. Gilch, W. Zinth, T. Kiefhaber, Proc. Natl. Acad. Sci. U.S.A. 104, 2163 (2007)

    Article  ADS  Google Scholar 

  25. O. Bieri, T. Kiefhaber, Biol. Chem. 380, 923 (1999)

    Article  Google Scholar 

  26. J. Bredenbeck, J. Helbing, J. Kumita, G. Woolley, P. Hamm, Proc. Natl. Acad. Sci. U.S.A. 102, 2379 (2005)

    Article  ADS  Google Scholar 

  27. M. Towrie, A. Gabrielsson, P. Matousek, A. Parker, A. Rodriguez, A. Vlcek, Appl. Spectrosc. 59, 467 (2005)

    Article  ADS  Google Scholar 

  28. H. Satzger, C. Root, C. Renner, R. Behrendt, L. Moroder, J. Wachtveitl, W. Zinth, Chem. Phys. Lett. 396, 191 (2004)

    Article  ADS  Google Scholar 

  29. J. Wachtveitl, S. Spörlein, H. Satzger, B. Fonrobert, C. Renner, R. Behrendt, D. Oesterhelt, L. Moroder, W. Zinth, Biophys. J. 86, 2350 (2004)

    Article  ADS  Google Scholar 

  30. J. Bredenbeck, J. Helbing, C. Kolano, P. Hamm, ChemPhysChem 8, 1747 (2007)

    Article  Google Scholar 

  31. P. Hamm, J. Helbing, J. Bredenbeck, Annu. Rev. Phys. Chem. 59, 291 (2008)

    Article  ADS  Google Scholar 

  32. V. Botan, E.H.G. Backus, R. Pfister, A. Moretto, M. Crisma, C. Toniolo, P.H. Nguyen, G. Stock, P. Hamm, Proc. Natl. Acad. Sci. U.S.A. 104, 12749 (2007)

    Article  ADS  Google Scholar 

  33. M. Löweneck, A.G. Milbradt, C. Root, H. Satzger, W. Zinth, L. Moroder, C. Renner, Biophys. J. 90, 2099 (2006)

    Article  Google Scholar 

  34. J. Bredenbeck, J. Helbing, A. Sieg, T. Schrader, W. Zinth, C. Renner, R. Behrendt, L. Moroder, J. Wachtveitl, P. Hamm, Proc. Natl. Acad. Sci. U.S.A. 100, 6452 (2003)

    Article  ADS  Google Scholar 

  35. S. Rehm, M.O. Lenz, S. Mensch, H. Schwalbe, J. Wachtveitl, Chem. Phys. 323, 28 (2006)

    Article  ADS  Google Scholar 

  36. D.E. Robertson, R.S. Farid, C.C. Moser, J.L. Urbauer, S.E. Mulholland, R. Pidikiti, J.D. Lear, A.J. Wand, W.F. DeGrado, P.L. Dutton, Nature 368, 425 (1994)

    Article  ADS  Google Scholar 

  37. H.P. Bächinger, J. Engel, in Protein Folding Handbook, vol Part II, ed. by J. Buchner, T. Kiefhaber (Wiley-VCH, Weinheim, 2005), p. 1059

    Google Scholar 

  38. U. Kusebauch, S.A. Cadamuro, H.J. Musiol, L. Moroder, C. Renner, Chem. Eur. J. 13, 2966 (2007)

    Article  Google Scholar 

  39. U. Kusebauch, S.A. Cadamuro, H.J. Musiol, M.O. Lenz, J. Wachtveitl, L. Moroder, C. Renner, Angew. Chem. Int. Ed. 45, 7015 (2006)

    Article  Google Scholar 

  40. Y.A. Lazarev, B.A. Grishkovsky, T.B. Khromova, Biopolymers 24, 1449 (1985)

    Article  Google Scholar 

  41. K.J. Payne, A. Veis, Biopolymers 27, 1749 (1988)

    Article  Google Scholar 

  42. A. Bachmann, T. Kiefhaber, S. Boudko, J. Engel, H.P. Bachinger, Proc. Natl. Acad. Sci. U.S.A. 102, 13897 (2005)

    Article  ADS  Google Scholar 

  43. S.W. Englander, N.R. Kallenbach, Q. Rev. Biophys. 16, 521 (1983)

    Article  Google Scholar 

  44. J. Backmann, C. Schultz, H. Fabian, U. Hahn, W. Saenger, D. Naumann, Proteins 24, 379 (1996)

    Article  Google Scholar 

  45. T.M. Raschke, S. Marqusee, Curr. Opin. Biotechnol. 9, 80 (1998)

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biomolecular Optics, Ludwig-Maximilians-University Munich, Oettingenstr. 67, 80538, Munich, Germany

    Wolfgang Zinth (Faculty of Physics)

  2. Institute for Physical and Theoretical Chemistry, Goethe-University Frankfurt, Max von Laue-Straße 7, 60438, Frankfurt am Main, Germany

    Josef Wachtveitl

Authors
  1. Wolfgang Zinth
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  2. Josef Wachtveitl
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Corresponding authors

Correspondence to Wolfgang Zinth or Josef Wachtveitl .

Editor information

Editors and Affiliations

  1. Robert Koch Institut, Nordufer 20, Berlin, 13353, Germany

    Heinz Fabian

  2. Robert Koch Institut, Nordufer 20, Berlin, 13353, Germany

    Dieter Naumann

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Zinth, W., Wachtveitl, J. (2012). Light-Triggered Peptide Dynamics. In: Fabian, H., Naumann, D. (eds) Protein Folding and Misfolding. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22230-6_7

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  • DOI: https://doi.org/10.1007/978-3-642-22230-6_7

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