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Linked Landscapes and Conformational Conversions: How Proteins Fold and Misfold

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Book cover Protein Folding and Misfolding

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Polypeptide chains must make a vast, complex array of interactions in order to fold to their correct structures. The mechanisms by which they do so, and the consequences when this process fails, are the subject of intense study. A key conceptual development has been the idea that proteins fold and misfold on linked, funnelled energy landscapes, where rarely populated states (such as folding intermediates) can provide access to misfolded and sometimes aggregation-prone ensembles. Advances in experimental methodologies and computer simulations are driving an increased understanding of the forces involved in folding and aggregation. This knowledge is beginning to be used to stabilise proteins for new biological functions as well as to develop treatments for diseases of misfolding. In this introductory chapter, we focus on the array of experimental methods that are being applied to the key questions of how the folding, misfolding and aggregation of proteins are linked, both in vitro and in the more complex environment of the cell.

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  1. University of Leeds, Mount Preston Street, Leeds, LS2 9JT, UK

    Gareth J. Morgan & Sheena E. Radford

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    Dieter Naumann

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Morgan, G.J., Radford, S.E. (2012). Linked Landscapes and Conformational Conversions: How Proteins Fold and Misfold. In: Fabian, H., Naumann, D. (eds) Protein Folding and Misfolding. Biological and Medical Physics, Biomedical Engineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22230-6_1

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