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Intelligent Clinical Decision Support Systems for Non-invasive Bladder Cancer Diagnosis

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Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 6685))

Abstract

The aim of this study was to find the set of biomarkers based on plasma microRNAs which can predict in a noninvasive way the diagnosis of bladder cancer. We presented here a methodology and the related concepts to develop intelligent molecular biomarkers using knowledge discovery in data and artificial intelligence methods. To the best of our knowledge, this is the first time when plasma miRNAs are combined using artificial intelligence and the prediction accuracy of the developed systems for medical decision support is the best published by now, some of them having even 100%.

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References

  1. ACS: American Cancer Society. Cancer Facts and Figures 2010. American Cancer Society, Atlanta (2010), http://www.cancer.org/acs/groups/content/@nho/documents/document/acspc-024113.pdf

    Google Scholar 

  2. Berner, E.S.: Clinical Decision Support Systems: Theory and Practice. Springer, New York (1998)

    Google Scholar 

  3. Bishop, C.M.: Neural Networks for Pattern Recognition. Oxford University Press, Inc., New York (1995)

    MATH  Google Scholar 

  4. Breiman, L.: Random forests. Machine Learning 45(1), 5–32 (2001)

    Article  MATH  Google Scholar 

  5. Floares, A., Balacescu, O., Floares, C., Balacescu, L., Popa, T., Vermesan, O.: Mining knowledge and data to discover intelligent molecular biomarkers: prostate cancer i-biomarkers. In: Proceedings of the 4th International Workshop on Soft Computing Applications, July 15–17 (2010)

    Google Scholar 

  6. Floares, A.G.: Toward Personalized Therapy Using Artificial Intelligence Tools to Understand and Control Drug Gene Networks. In: New Trends in Technologies. INTECH (2010), http://sciyo.com/articles/show/title/toward-personalized-therapy-using-artificial-intelligence-tools-to-understand-and-control-drug-gene-

  7. Floares, A.G.: Using computational intelligence to develop intelligent clinical decision support systems. In: Masulli, F., Peterson, L.E., Tagliaferri, R. (eds.) CIBB 2009. LNCS, vol. 6160, pp. 266–275. Springer, Heidelberg (2010)

    Chapter  Google Scholar 

  8. Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Thun, M.: Cancer statistics. CA Cancer J. Clin. 4(59), 225–249 (2009)

    Article  Google Scholar 

  9. Liu, C.G., Calin, G.A., Volinia, S., Croce, C.M.: Microrna expression profiling using microarrays. Nature Protocols 3, 563–578 (2008)

    Article  Google Scholar 

  10. Nisbet, R., Elder, J., Miner, G.: Handbook of Statistical Analysis and Data Mining Applications. Academic Press, London (2009)

    MATH  Google Scholar 

  11. Pounds, S., Morris, S.W.: Estimating the occurrence of false positives and false negatives in microarray studies by approximating and partitioning the empirical distribution of p-values. Bioinformatics 19(10), 1236–1242 (2003), http://bioinformatics.oxfordjournals.org/cgi/content/abstract/19/10/1236

    Article  Google Scholar 

  12. Schlkopf, B., Smola, A.J.: Learning with Kernels: Support Vector Machines, Regularization, Optimization, and Beyond (Adaptive Computation and Machine Learning), 1st edn. The MIT Press, Cambridge (2001)

    Google Scholar 

  13. Sidransky, D.: Emerging molecular markers of cancer. Nat. Rev. Cancer 2(3), 210–219 (2002)

    Article  Google Scholar 

  14. Tuma, R.S.: Biomarker developers face big hurdles. J. Natl. Cancer Inst. 100(7), 456–461 (2008), http://jnci.oxfordjournals.org

    Article  Google Scholar 

  15. Zhu, J., Hastie, T.: Classification of gene microarrays by penalized logistic regression. Biostat. 5(3), 427–443 (2004)

    Article  MATH  Google Scholar 

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© 2011 Springer-Verlag Berlin Heidelberg

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Floares, A.G. et al. (2011). Intelligent Clinical Decision Support Systems for Non-invasive Bladder Cancer Diagnosis. In: Rizzo, R., Lisboa, P.J.G. (eds) Computational Intelligence Methods for Bioinformatics and Biostatistics. CIBB 2010. Lecture Notes in Computer Science(), vol 6685. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21946-7_20

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  • DOI: https://doi.org/10.1007/978-3-642-21946-7_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-21945-0

  • Online ISBN: 978-3-642-21946-7

  • eBook Packages: Computer ScienceComputer Science (R0)

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