Abstract
One of the biggest challenges for nowadays biologist is the identification, characterization and gene-gene interactions detection for common human diseases such as cancer and diabetes. This challenge is partly due to the explosion of biological information. The multifactor dimensionality reduction (MDR) method can be used to address this problem. This method can be computationally intensive, especially when more than ten polymorphisms need to be evaluated. The Grid is a promising architecture for genomics problems providing high computing capabilities. In this paper, we describe a framework for supporting the MDR method on Grid environments. This framework helps biologists to automate the execution of multiple tests of gene-gene interactions detection.
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Ben Haj Hmida, M., Slimani, Y. (2011). Grid-Enabled Framework for Large-Scale Analysis of Gene-Gene Interactions. In: Özcan, A., Zizka, J., Nagamalai, D. (eds) Recent Trends in Wireless and Mobile Networks. CoNeCo WiMo 2011 2011. Communications in Computer and Information Science, vol 162. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21937-5_33
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DOI: https://doi.org/10.1007/978-3-642-21937-5_33
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