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Prevention of Bone Metastases pp 1–31Cite as

Preclinical Models that Illuminate the Bone Metastasis Cascade

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 192))

Abstract

In this chapter currently available preclinical models of tumor progression and bone metastasis, including genetically engineered mice that develop primary and metastatic carcinomas and transplantable animal models, will be described. Understanding the multistep process of incurable bone metastasis is pivotal to the development of new therapeutic strategies. Novel technologies for imaging molecules or pathologic processes in cancers and their surrounding stroma have emerged rapidly and have greatly facilitated cancer research, in particular the cellular behavior of osteotropic tumors and their response to new and existing therapeutic agents. Optical imaging, in particular, has become an important tool in preclinical bone metastasis models, clinical trials and medical practice. Advances in experimental and clinical imaging will—in the long run—result in significant improvements in diagnosis, tumor localization, enhanced drug delivery and treatment.

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Acknowledgments

The authors wish to thank Mr. Henry Cheung (Leiden Univ. Med. Ctr., dept. Urology, Leiden, the Netherlands) and Mr. Ivo Que (Leiden Univ. Med. Ctr., Dept. Endocrinology, Leiden, the Netherlands) for real-time optical imaging of osteotropic cancer cells in vivo.

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  1. Department of Urology, Leiden University Medical Centre, J3-100, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands

    Geertje van der Horst & Gabri van der Pluijm

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  1. Geertje van der Horst
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  2. Gabri van der Pluijm
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Correspondence to Gabri van der Pluijm .

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  1. , Dept. of Medical Oncology, Kantonsspital St. Gallen, Rorschacherstr. 95, St. Gallen, 9007, Switzerland

    Markus Joerger

  2. Chirurgische Klinik, Abt. Allgemeine Chirurgie, Universitätsklinikum Wien, Währinger Gürtel 18-20, Wien, 1090, Austria

    Michael Gnant

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van der Horst, G., van der Pluijm, G. (2012). Preclinical Models that Illuminate the Bone Metastasis Cascade. In: Joerger, M., Gnant, M. (eds) Prevention of Bone Metastases. Recent Results in Cancer Research, vol 192. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21892-7_1

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