Finding Bicliques in Digraphs: Application into Viral-Host Protein Interactome

  • Malay Bhattacharyya
  • Sanghamitra Bandyopadhyay
  • Ujjwal Maulik
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6744)


We provide the first formalization true to the best of our knowledge to the problem of finding bicliques in a directed graph. The problem is addressed employing a two-stage approach based on an existing biclustering algorithm. This novel problem is useful in several biological applications of which we focus only on analyzing the viral-host protein interaction graphs. Strong and significant bicliques of HIV-1 and human proteins are derived using the proposed methodology, which provides insights into some novel regulatory functionalities in case of the acute immunodeficiency syndrome in human.


Gene Ontology Bipartite Graph Human Protein Interaction Matrix Biclustering Algorithm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Malay Bhattacharyya
    • 1
  • Sanghamitra Bandyopadhyay
    • 1
  • Ujjwal Maulik
    • 2
  1. 1.Machine Intelligence UnitIndian Statistical InstituteKolkataIndia
  2. 2.Department of Computer Science and EngineeringJadavpur UniversityKolkataIndia

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