Abstract
This chapter provides an overview of how the basal metazoan Hydra serves as model for untangling and dissecting the fundamental principles underlying complex host–microbe interactions.
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References
Augustin R, Siebert S, Bosch TCG (2009a) Identification of a kazal-type serine protease inhibitor with potent anti-staphylococcal activity as part of Hydra’s innate immune system. Dev Comp Immunol 33:830–837
Augustin R, Anton-Erxleben F, Jungnickel S, Hemmrich G, Spudy B, Podschun R, Bosch TCG (2009b) Activity of the novel peptide arminin against multiresistant human pathogens shows the considerable potential of phylogenetically ancient organisms as drug sources. Antimicrob Agents Chemother 53:5245–5250
Bosch TCG, Augustin R, Anton-Erxleben F, Fraune S, Hemmrich G et al (2009) Uncovering the evolutionary history of innate immunity: the simple metazoan Hydra uses epithelial cells for host defence. Dev Comp Immunol 33:559–569
Chapman JA, Kirkness EF, Simakov O, Hampson SE, Mitros T et al (2010) The dynamic genome of Hydra. Nature 464:592–596
Cheesman SE, Neal JT, Mittge E, Seredick BM, Guillemin K (2010) Microbes and Health Sackler Colloquium: epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88. Proc Natl Acad Sci USA. doi:10.1073/pnas.1000072107
Fraune S, Bosch TCG (2007) Long-term maintenance of species-specific bacterial microbiota in the basal metazoan Hydra. Proc Natl Acad Sci USA 104:13146–13151
Fraune S, Bosch TCG (2010) Why bacteria matter in animal development and evolution. Bioessays 32:571–580
Fraune S, Abe Y, Bosch TCG (2009) Disturbing epithelial homeostasis in the metazoan Hydra leads to drastic changes in associated microbiota. Environ Microbiol 11:2361–2369
Fraune S, Augustin R, Anton-Erxleben F, Wittlieb J, Gelhaus C et al (2010) In an early branching metazoan, bacterial colonization of the embryo is controlled by maternal antimicrobial peptides. Proc Natl Acad Sci USA 107:18067–18072
Gee L, Hartig J, Law L, Wittlieb J, Khalturin K et al (2010) Beta-catenin plays a central role in setting up the head organizer in hydra. Dev Biol 340:116–124
Hemmrich G, Bosch TCG (2008) Compagen, a comparative genomics platform for early branching metazoan animals, reveals early origins of genes regulating stem-cell differentiation. Bioessays 30:1010–1018
Jung S, Dingley AJ, Augustin R, Anton-Erxleben F, Stanisak M et al (2009) Hydramacin-1, structure and antibacterial activity of a protein from the basal metazoan Hydra. J Biol Chem 284:1896–1905
Kortschak RD, Samuel G, Saint R, Miller DJ (2003) EST analysis of the cnidarian Acropora millepora reveals extensive gene loss and rapid sequence divergence in the model invertebrates. Curr Biol 13:2190–2195
Lange C, Hemmrich G, Klostermeier UC, López-Quintero JA, Miller DJ et al (2011) Defining the origins of the NOD-like receptor system at the base of animal evolution. Mol Biol Evol. doi:10.1093/molbev/msq349
Miller DJ, Ball EE, Technau U (2005) Cnidarians and ancestral genetic complexity in the animal kingdom. Trends Genet 21:536–539
Ochman H, Worobey M, Kuo C-H, Ndjango J-BN, Peeters M et al (2010) Evolutionary relationships of wild hominids recapitulated by gut microbial communities. Proc Natl Acad Sci USA. doi:10.1371/journal.pbio.1000546
Putnam NH, Srivastava M, Hellsten U, Dirks B, Chapman J et al (2007) Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization. Science 317:86–94
Srivastava M, Begovic E, Chapman J, Putnam NH, Hellsten U et al (2008) The Trichoplax genome and the nature of placozoans. Nature 454:955–960
Steele RE, David CN, Technau U (2011) A genomic view of 500 million years of cnidarian evolution. Trends Genet 27(1):7–13
Technau U, Rudd S, Maxwell P, Gordon PM, Saina M et al (2005) Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians. Trends Genet 21:633–639
Trembley A (1744) Mémoires, Pour Servir à l´Histoire d´un Genre de Polypes d´Eau Douce, à Bras en Frome de Cornes. Verbeek, Leiden
Wittlieb J, Khalturin K, Lohmann JU, Anton-Erxleben F, Bosch TCG (2006) Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis. Proc Natl Acad Sci USA 103:6208–6211
Steele RE, David CN, Technau U (2011) A genomic view of 500 million years of cnidarian evolution. Trends Genet. Jan 27(1):7–13
Acknowledgment
Research in our laboratory is supported in parts by grants from the Deutsche Forschungsgemeinschaft (DFG) and grants from the DFG Cluster of Excellence programs “The Future Ocean” and “Inflammation at Interfaces.”
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Bosch, T.C.G., Anton-Erxleben, F., Augustin, R., Franzenburg, S., Fraune, S. (2012). Hydra Go Bacterial. In: Rosenberg, E., Gophna, U. (eds) Beneficial Microorganisms in Multicellular Life Forms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21680-0_23
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DOI: https://doi.org/10.1007/978-3-642-21680-0_23
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