Abstract
This study presents a novel microfabricated polymerase chain reaction (PCR) chip based on silicon. A microheater utilizing doped semiconductors as heating resistors and a temperature sensor made of Pt are integrated on the chip to make up a thermal module. The micro-stationary PCR chip is fabricated on a silicon wafer using photolithography, wet etching and ion implantation technology. The package is created without complex processes. Three types of configurations for the microheater are designed and simulated to analyze the temperature distribution by the finite element analysis so as to enhance the temperature uniformity in the reaction chamber. With this approach, the microheater is optimized. Finally, the simulation results are validated by infrared images from experiments.
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© 2011 Springer-Verlag Berlin Heidelberg
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Nie, J., Zhao, Y., Liu, Y., Liu, K., Peng, N. (2011). The Design and Manufacture of Functional Micro-stationary PCR Chip. In: Stephanidis, C. (eds) Universal Access in Human-Computer Interaction. Context Diversity. UAHCI 2011. Lecture Notes in Computer Science, vol 6767. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21666-4_44
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DOI: https://doi.org/10.1007/978-3-642-21666-4_44
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-21665-7
Online ISBN: 978-3-642-21666-4
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