Abstract
Stem cells, which can self-renew and produce different cell types, are regulated by both extrinsic signals and intrinsic factors. Fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by the functional loss of fragile X mental retardation protein (FMRP). FMRP is a selective RNA-binding protein that forms a messenger ribonucleoprotein (mRNP) complex that associates with polyribosomes. Recently, the role of Fmrp in stem cell biology has been explored in both Drosophila and the mouse. In this chapter, we discuss the role of FMRP in regulating the proliferation and differentiation of stem cells.
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Acknowledgments
P.J. is supported by National Institutes of Health. P.J. is a recipient of the Beckman Young Investigator Award and the Basil O′Connor Scholar Research Award, as well as an Alfred P. Sloan Research Fellow in Neuroscience. X.L. is supported in part by FRAXA Research Foundation.
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Qurashi, A., Li, X., Jin, P. (2012). Fragile X Mental Retardation Protein and Stem Cells. In: Denman, R. (eds) Modeling Fragile X Syndrome. Results and Problems in Cell Differentiation, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21649-7_8
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DOI: https://doi.org/10.1007/978-3-642-21649-7_8
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