Abstract
Movement disorders in patients with Parkinson’s disease may require functional surgery, when medical therapy isn’t effective. In Deep Brain Stimulation (DBS), electrodes are implanted within the brain to stimulate deep structures such as SubThalamic Nucleus (STN). This paper describes successive steps for constructing digital atlases gathering patient’s location of electrode contacts and clinical scores. Three motor and three neuro-psychological scores were integrated in the study. Correlations between active contacts localization and clinical data were carried out using an adapted Hierarchical Ascendant Classification and have enabled the extraction of clusters aiming to suggest optimum sites for therapeutic STN DBS. The postero-superior region has been found to be effective for motor score improvement whereas the antero-inferior region revealed noticeable neuro-psychological scores deterioration. Comparison with existing results has shown that such atlases are very promising for understanding phenomena better.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Benabid, A.L., Krack, P., Benazzouz, A., Limousin, P., Koudsie, A., Pollak, P.: Deep brain stimulation of the subthalamic nucleus for Parkinson’s disease: methodologic aspects and clinical criteria. Neurology 55, 40–44 (2000)
Rodriguez-Oroz, M.C., Rodriguez, M., Guridi, J., Mewes, K., Chockkman, V., Vitek, J., DeLong, M.R., Obeso, J.A.: The subthalamic nucleus in parkinson’s disease: somatotopic organization and physiological. Brain 124(9), 1777–1790 (2001)
Parsons, T.D., Rogers, S.A., Braayen, A.J., Woods, S.P., Troster, A.I.: Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson’s disease: a meta-analysis. Lancet. Neurol. 5, 578–588 (2006)
Biseul, I., Sauleau, P., Haegelen, C., Trebon, P., Drapier, D., Raoul, S., Drapier, S., Lallement, F., Rivier, I., Lajat, Y., Verin, M.: Fear recognition is impaired by subthalamic nucleus stimulation in Parkinson’s disease. Neuropsychologia 43, 1054–1059 (2005)
Houeto, J., Mesnage, V., Mallet, L., Pillon, B., Gargiulo, M., du Moncel, S., Bonnet, A., Pidoux, B., Dormont, D., Cornu, P., Agid, Y.: Behavioural disorders, Parkinson’s disease and subthalamic stimulation. J. Neurol. Neurosurg. Psychiatry 72, 701–707 (2002)
St-Jean, P., Sadikot, A.F., Collins, L., Clonda, D., Kasrai, R., Evans, A.C., Peters, T.M.: Automated atlas integration and interactive three-dimensional visualization tools for planning and guidance in functional neurosurgery. IEEE Trans. on Med. Imaging 17(5), 854–866 (1998)
D’Haese, P.F., Cetinkaya, E., Konrad, P.E., Kao, C., Dawant, B.M.: Computer-aided placement of deep brain stimulators: From planning to intraoperative. IEEE TMI 24(11), 1469–1478 (2005)
D’Haese, P.F., Pallavaram, S., Li, R., Remple, M.S., Kao, C., Neimat, J.S., Konrad, P.E., Dawant, B.M.: CranialVault and its CRAVE tools: A clinical computer assistance system for deep brain stimulation (DBS) therapy. Med. Image Anal., Ahead of print (2010)
Guo, T., Parrent, A.G., Peters, T.M.: Surgical targeting accuracy analysis of six methods for subthalamic nucleus deep brain stimulation. Computer Aided Surgery 12(6), 325–334 (2007)
Pallavaram, S., Dawant, B.M., Remple, M., Neimat, J.S., Kao, C., Konrad, P.E., D’Haese, P.F.: Effect of brain shift on the creation of functional atlases for deep brain stimulation surgery. Int. J. Comp. Assist Radiol. Surg. 5(3), 221–228 (2009)
Coupe P, Yger P, Prima S, Hellier P, Kervrann C, Barillot C. An Optimized Blockwise Non Local Means Denoising Filter for 3D Magnetic Resonance Images. IEEE TMI 24(4), 425-441 (2008)
Mangin, J.F.: Entropy minimization for automatic correction of intensity non uniformity. In: Proc. of the IEEE Workshop on Math. Method in Biomed. Image Analysis, MMBIA 2000, Hilton Head Island, pp. 162–169 (2000)
Pollo, C., Villemure, J.G., Vingerhoets, F., Ghika, J., Maeder, P., Meuli, R.: Magnetic resonance artefact induced by the electrode activa 3389: an in vitro and in vivo study. Acta Neurochirurgica 146(2), 161–164 (2004)
Lalys, F., Haegelen, C., Ferre, J.C., El-Ganaoui, O., Jannin, P.: Construction and assessment of a 3T MRI brain template. NeuroImage 49, 345–354 (2010)
Lalys, F., Haegelen, C., Abadie, A., Jannin, P.: Post-operative assessment in Deep Brain Stimulation based on multimodal images: registration workow and validation. In: Proceedings of SPIE, vol. 7261 (2009)
Fahn, Y., Elton, R.: Unified Parkinson’s disease rating scale. In: Fahn, S., Marsden, C., Calne, D., Goldstein, M. (eds.) Recent Developments in Parkinson’s Disease, vol. 2, pp. 153–163. Macmillan, Florham Park (1987)
Schwab, R.S., England Jr., A.: Projection techniques for evaluating surgery in Parkinson’s Disease, pp. 152–157 (1968)
Hoehn, M., Yahr, M.: Parkinsonism: onset, progression and mortality. Neurology 17(5), 427–442 (1967)
Stroop, J.R.: Studies of interference in serial verbal reactions. Journal of Experimental Psychology 18, 643–661 (1935)
Troyer, A.K., Moscovitch, M., Winocur, G., Leach, L., Freedman, M.: Clustering and switching on verbal fluency tests in Alzheimer’s and Parkinson’s disease. J. Int. Neuropsycholog. Soc. 4(2), 137–143 (1998)
Lanotte, M.M., Rizzone, M., Bergamasco, B., Faccani, G., Melcarne, A., Lopiano, L.: Deep Brain Stimulation of the subthalamic nucleus: anatomical, neurophysiological, and outcome correlations with the effects of stimulation. J. Neurol Neurosurg. Psychiatry 72, 53–58 (2002)
Theodosopoulos, P.V., Marks, W.J., Christine, C., Starr, P.A.: Locations of movement-related cells in the human subthalamic nucleus in parkinson’s disease. Movement Disorders 18(7), 791–798 (2003)
Saint-Cyr, J.A., Trépanier, L.L., Kumar, R., Lozano, A.M., Lang, A.E.: Neuropsychological consequences of chronic stimulation of the subthalamic nucleus in Parkinson’s disease. Brain 123, 2091–2108 (2000)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Lalys, F., Haegelen, C., Abadie, A., Jannin, P. (2011). Correlating Clinical Scores with Anatomical Electrodes Locations for Assessing Deep Brain Stimulation. In: Taylor, R.H., Yang, GZ. (eds) Information Processing in Computer-Assisted Interventions. IPCAI 2011. Lecture Notes in Computer Science, vol 6689. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21504-9_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-21504-9_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-21503-2
Online ISBN: 978-3-642-21504-9
eBook Packages: Computer ScienceComputer Science (R0)