Skip to main content

Hybrid (Generalization-Correlation) Method for Feature Selection in High Dimensional DNA Microarray Prediction Problems

  • Conference paper

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 6692))

Abstract

Microarray data analysis is attracting increasing attention in computer science because of the many applications of machine learning methods in prediction problems. The process typically involves a feature selection step, important in order to increase the accuracy and speed of the classifiers. This work analyzes the characteristics of the features selected by two wrapper methods, the first one based on artificial neural networks (ANN) and the second in a novel constructive neural network (CNN) algorithm, to later propose a hybrid model that combines the advantages of wrapper and filter methods. The results obtained in terms of the computational costs involved and the prediction accuracy reached show the feasibility of the hybrid model proposed here and indicate an interesting research line for the near future.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Huda, S., Yearwood, J., Strainieri, A.: Hybrid Wrapper-Filter Approaches for Input Feature Selection Using Maximum Relevance and Artificial Neural Network Input Gain Measurement Approximation (ANNIGMA). In: 4th International Conference on Network and System Security, pp. 442–449 (2010)

    Google Scholar 

  2. Inza, I., Larrañaga, P., Blanco, R., Cerrolaza, A.J.: Filter versus wrapper gene selection approaches in DNA microarray domains. Artificial Intelligence in Medicine 31, 91–103 (2004)

    Article  Google Scholar 

  3. Kohavi, R., John, G.: The Wrapper approach. In: Feature Extraction, Construction and Selection: a data mining perspective, pp. 33–51 (1998)

    Google Scholar 

  4. Lancashire, L.J., Rees, R.C., Ball, G.R.: Identification of gene transcript signatures predictive for er and lymph node status using a stepwise forward selection ann modelling approach. Artif. Intell. Med. 43, 99–111 (2008)

    Article  Google Scholar 

  5. Pirooznia, M., Yang, J., Yang, M.Q., Deng, Y.: A comparative study of different machine learning methods on microarray gene expression data. BMC Genomics 9, S13 (2008)

    Google Scholar 

  6. Sebban, M., Nock, R.: A hybrid filter/wrapper approach of feature selection using information theory. Pattern Recognition 35, 835–846 (2002)

    Article  MATH  Google Scholar 

  7. Subirats, J.L., Jerez, J.M., Gómez, I., Franco, L.: Multiclass Pattern Recognition Extension for the New C-Mantec Constructive Neural Network Algorithm. Cognitive Computation 2, 285–290 (2010)

    Article  Google Scholar 

  8. Urda, D., Subirats, J.L., Franco, L., Jerez, J.M.: Constructive neural networks to predict breast cancer outcome by using gene expression profiles. In: García-Pedrajas, N., Herrera, F., Fyfe, C., Benítez, J.M., Ali, M. (eds.) IEA/AIE 2010. LNCS, vol. 6096, pp. 317–326. Springer, Heidelberg (2010)

    Chapter  Google Scholar 

  9. West, M.: Bayesian factor regression models in the “large p, small n” paradigm. Bayesian statistics 7, 723–732 (2003)

    Google Scholar 

  10. West, M., Blanchette, C., Dressman, H., Huang, E., Ishida, S., Spang, R., Zuzan, H., Olson, J.A., Marks, J.R., Nevins, J.R.: Predicting the clinical status of human breast cancer by using gene expression profiles. PNAS 98, 11462–11467 (2001)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Couce, Y., Franco, L., Urda, D., Subirats, J.L., Jerez, J.M. (2011). Hybrid (Generalization-Correlation) Method for Feature Selection in High Dimensional DNA Microarray Prediction Problems. In: Cabestany, J., Rojas, I., Joya, G. (eds) Advances in Computational Intelligence. IWANN 2011. Lecture Notes in Computer Science, vol 6692. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21498-1_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-21498-1_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-21497-4

  • Online ISBN: 978-3-642-21498-1

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics