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VTE - Venöse Thromboembolien pp 243–283Cite as

Nichtoperative Therapie

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Zusammenfassung

Unter konservativer Therapie soll hier die Therapieform verstanden werden, die auf jede Art der aktiven invasiv manipulativen oder aktiv systemisch oder lokal lytischen Verminderung der Thrombusmenge bzw. Thrombusausdehnung verzichtet.

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Literatur

Zu 10.1.1

  • Aschwanden M, Labs KH, Engel H, Schwob A et al (2001) Acute deepvein thrombosis : early mobilisation does not increase the frequency of pulmonar embolism. Thromb Haemost 85:42–46

    Google Scholar 

  • Blättler W, Gerlach HE (2005) Implementation of outpatient treatment of deep-vein thrombosis in private practices in Germany. Eur J Vasc Endovasc Surg 30:319–324

    Google Scholar 

  • Blättler W, Borer M, Linder C, Bergan JJ (1997) Outpatient and conventional treatment of acute deep-vein thrombosis evaluated in a controlled single-center study. Sang Thrombose Vaissaux 9:315–319

    Google Scholar 

  • Blättler W, Kreis-Bovenzi N, Blättler IK (2000) Practicability and quality of outpatient management of acute deep venous thrombosis. J Vasc Surg 32:855–860

    Google Scholar 

  • Blättler W, Gerlach HE, Amsler F, Blättler I, Willenberg T (2011) Compression therapy for acute deep venous thrombosis - a double-edged intervention. J Thromb Haemost 9 (Suppl 2): Abstr P-TU–435

    Google Scholar 

  • Brandjes DPM, Buller HR, Heijboer H, Huisman MV, de Rijk M, Jagt H (1997) Randomized trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis. The Lancet 349:759–762

    Google Scholar 

  • Froehlicher JB, Prince MR, Greenfield LJ, Downing LJ, Shah NL, Wakefield TW (1997) „Bull’s-eye“ sign on gadolinium-enhanced magnetic resonance venography determines thrombus presence and age: a preliminary study. J Vasc Surg 26:809–816

    Google Scholar 

  • Hach-Wunderle V, Blättler W, Gerlach H, Konstantinides S et al (2010) Diagnostik und Therapie der Venenthrombose und Lungenembolie. Interdisziplinäre S2-Leitlinie. VASA 39(Suppl 78):1–S-31S

    Google Scholar 

  • Henke PK, Wakefield T (2009) Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes. Thromb Res 123(Suppl 4):72–S-78S

    Google Scholar 

  • Kearon C, Kahn S, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ (2008) Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th ed. Chest 133:454S–545S

    Google Scholar 

  • Keo HH, Amsler F, Rohr M, Blättler W (2011) Calf compartment syndrome in acute deep venous thrombosis assessed with magnetic resonance tomography. J Thromb Haemost 9 (Suppl 2): Abstr P-WE–293

    Google Scholar 

  • Partsch H, Blättler W (2000) Compression and walking versus bed rest in the treatment of proximal deep vein thrombosis with lowmolecular- weight heparin. J Vasc Surg 32:861–869

    Google Scholar 

  • Piovella F, Crippa L, Barone M, Vigano D’Angelo S et al (2002) Normalization rates of compression ultrasonography in patients with a first episode of deep vein thrombosis of the lower limbs: association with recurrence and new thrombosis. Haematologica 87:515–522

    Google Scholar 

  • Prandoni P, Lensing AWA, Prins MH, Frulla M et al (2004) Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial. Ann Intern Med 141:249–256

    Google Scholar 

  • Prandoni P, Frulla M, Sartori D, Concolato A, Girolami A (2005) Vein abnormalities and the post-thrombotic syndrome. J Thromb Haemost 3:401–402

    Google Scholar 

  • Roberts LN, Patel RK, Bonner L, Arya R (2011) Early use of compression stockings following deep vein thrombosis is associated with reduced early incidence of post-thrombotic syndrome and improved quality of life. J Thromb Haemost 9 (Suppl 2): Abstr P-WE–430

    Google Scholar 

  • Roumen-Klappe EM, Janssen MC, Van Rossum J et al (2009) Inflammation in deep vein thrombosis and the development of postthrombotic syndrome: a prospective study. J Thromb Haemost 7:582–587

    Google Scholar 

  • Seem E, Stranden E (1990) Transcapillary forces in muscle compartments of lower limbs with deep venous thrombosis. Scand J Clin Lab Invest 50:325–330

    Google Scholar 

  • Wojcik BM, Wrobleski SK, Hawley AE, Wakefield TW et al (2011) Interleukin- 6: A potential target for post-thrombotic syndrome. Ann Vasc Surg 25:229–239

    Google Scholar 

Zu 10.1.2

  • Aschwanden M, Labs KH, Engel H et al (2001) Acute deep vein thrombosis: early mobilization does not increase the frequency of pulmonary embolism. Thromb Haemost 85:42–46

    Google Scholar 

  • Fischer H (1910) Eine neue Therapie der Phlebitis. Med Klin 30:1172–1180

    Google Scholar 

  • Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuünemann HJfor the American College of Chest Physicians Antithrombotic herapy and Prevention of Thrombosis Panel (2012) Executive Summary: Antithrombotic Therapy and Prevention of Thrombosis, 9thed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141:7S–47S

    Google Scholar 

  • Partsch H, Blättler W (2000) Compression and walking versus bed-rest in the treatment of proximal deep venous thrombosis with lowmolecularweight heparin. J Vasc Surg 32:861–869

    Google Scholar 

  • Partsch H (2001) Therapy of deep vein thrombosis with low molecular weight heparin, leg compression and immediate ambulation. VASA 30:195–204

    Google Scholar 

  • Partsch H (2002) Bed rest versus ambulation in the initial treatment of patients with proximal deep vein thrombosis. Curr Opin Pulm Med 8:389–393

    Google Scholar 

  • Schraibman IG, Milne AA, Royle EM (2001) Home versus in-patient treatment for deep vein thrombosis (Cochrane Review). Cochrane Database Syst Rev 2: Art No CD003076, 2001

    Google Scholar 

  • Sigg K (1962) Varizen, Ulcus cruris und Thrombosen. Springer, Heidelberg

    Google Scholar 

Zu 10.1.3

  • Arcelus JI, Caprini JA, Monreal M, Sua´rez C, Gonza´lez-Fajardo J (2003) The management and outcome of acute venous thromboembolism: A prospective registry including 4011 patients. J Vasc Surg 38:916–922

    Google Scholar 

Zu 10.2.1

  • Alban S (2010) Heparine und andere Glykoantikoagulantien. In: Pötzsch B, Madlener K (Hrsg) Hämostaseologie. Springer, Heidelberg

    Google Scholar 

  • Bauersachs R, and the EINSTEIN Investigators (2010) Oral Rivaroxaban for Symptomatic Venous Thromboembolism. N Engl J Med 363:2499–2510

    Google Scholar 

  • Brandjes DP, Heijboer H, Büller HR, de Rijk M, Jagt H, ten Cate JW (1992) Acenocoumarol and heparin compared with acenocoumarol alone in the initial treatment of proximal-vein thrombosis. N Engl J Med 327:1485–1489

    Google Scholar 

  • Büller HR, Davidson BL, Decousus H, Gallus A, Gent M, Piovella F, Prins MH, Raskob G, Segers AE, Cariou R, Leeuwenkamp O, Lensing AW; Matisse Investigators (2004) Fondaparinux or enoxaparin for the initial treatment of symptomatic deep venous thrombosis: a randomized trial. Ann Intern Med 140:867–873

    Google Scholar 

  • Erkens PM, Prins MH (2010) Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism. Cochrane Database Syst Rev

    Google Scholar 

  • Hach-Wunderle V, Blättler W, Gerlach H, Konstantinides St, Noppeney T, Pillny M, Riess H, Schellong S, Stiegler H, Wildberger JE (2010) Diagnostik und Therapie der Venenthrombose und der Lungenembolie. Interdisziplinäre S2 Leitlinie. VASA (Suppl) S78/2010

    Google Scholar 

  • Hirsh J, Bauer KA, Donati MB, Gould M, Samama MM, Weitz JI (2008) Parenteral anticoagulants. American College of Chest Physicans Evidence Based Clinical Practice Guidelines, 8th ed. Chest 133:141S–159S

    Google Scholar 

  • Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ; American College of Chest Physicians (2008) Antithrombotic therapy for venous thromboembolic disease American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th ed. Chest: 133 (6 Suppl): 454S–545S

    Google Scholar 

  • Siguret V, Pautas E, Fevier M, Wipff C, Durant-Gasselin B, Laurent M, Andreux JP, d’Urso M, Gaussem P (2000) Elderly Patients Treadet with Tinzaparin (innohep®) Administrated once Daily (175 Anti- Xa-IU/kg): Anti-Xa and Anti-IIa Activities over 10 Days. Thromb Haemost 84:800–804

    Google Scholar 

  • Siguret V, Gouin-Thibault I, Pautas E, Leizorovicz A (2011) Kein Anstieg der Anti-Faktor-Xa-Spitzenspiegel unter Tinzaparin bei älteren Patienten mit moderater bis schwerer Nierenfunktionsstörung: die IRIS-Substudie. J Thromb Haemost 9:1966–1972

    Google Scholar 

  • Van Dongen CJ, Mac Gillavry MR, Prins MH (2011) Once versus twice daily LMWH for the initial treatment of venous thromboembolism. Cochrane Database Syst Rev

    Google Scholar 

  • Vardi M, Zittan E, Bitterman H (2009). Subcutaneous unfractionated heparin for the initial treatment of venous thromboembolism (Review). Cochrane Database Syst Rev

    Google Scholar 

Zu 10.2.2

  • Bounameaux H, Perrier A (2008) Duration of anticoagulation therapy for venous thromboembolism. Hematology Am Soc Hematol Educ Program 252–258

    Google Scholar 

  • East AT, Wakefield TW (2010) What is the optimal duration of treatment for DVT? An update on evidence-based medicine of treatment for DVT. Semin Vasc Surg 23:182–191

    Google Scholar 

  • Hach-Wunderle V, Blättler W, Gerlach G, Konstantinides St, Noppeney T et al. (2010) Diagnostik und Therapie der Venenthrombose und der Lungenembolie. Interdisziplinäre S2-Leitlinie. VASA 39: S/78

    Google Scholar 

  • Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ; American College of Chest Physicians (2008) Antithrombotic therapy for venous thromboembolic disease American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8thEdition). Chest 133 (6 Suppl): 454S–545S

    Google Scholar 

  • Matchar DB, Jacobson A, Dolor R, Edson R, Uyeda L, Phibbs CS, Vertrees JE, Shih MC, Holodniy M, Lavori P; THINRS Executive Committee and Site Investigators (2010) Effect of home testing of international normalized ratio on clinical events. N Engl J Med 363:1608–1620

    Google Scholar 

  • van der Heijden JF, Hutten BA, Büller HR, Prins MH (2002) Vitamin K antagonists or low-molecular-weight heparin for the long term treatment of symptomatic venous thromboembolism (Review). Cochrane Database Syst Rev

    Google Scholar 

Zu 10.2.3

  • Schulman S, Kearon C, Kakkar AK et al (2009) Dabigatran versus warfarin in the tratment of acute venous thromboembolism. N Engl J Med 361:2342–2352

    Google Scholar 

  • The EINSTEIN Investigators (2010) Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 363:2499–2510

    Google Scholar 

Zu 10.2.4

  • Boutitie F, Pinede L, Schulman S, Agnelli G, Raskob G, Julian J, Hirsh J, Kearon C (2011) Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants’ data from seven trials. BMJ 342:d303–6

    Google Scholar 

  • Campbell IA, Bentley DP, Prescott RJ, Routledge PA, Shetty HG, Williamson IJ (2007) Anticoagulation for three versus six months in patients with deep vein thrombosis or pulmonary embolism, or both: randomised trial. BMJ 334: 674

    Google Scholar 

  • Hach-Wunderle V, Blättler W, Gerlach G, Konstantinides St, Noppeney T et al. (2010) Diagnostik und Therapie der Venenthrombose und der Lungenembolie. Interdisziplinäre S2-Leitlinie. VASA 39: S/78

    Google Scholar 

  • Hutten BA, Prins MH (2006) Duration of treatment with vitamin K antagonists in symptomatic venous thromboembolism. Cochrane Database Syst Rev

    Google Scholar 

  • Kearon C (2009) Balancing risks and benefits of extended anticoagulant therapy for idiopathic venous thrombosis. J Thromb Haemost (Suppl) 7:296–300

    Google Scholar 

  • Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ; American College of Chest Physicians (2008) Antithrombotic therapy for venous thromboembolic disease American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8thed. Chest 133 (6 Suppl): 454S–545S

    Google Scholar 

  • Pinede L, Duhaut P, Cucherat M, Ninet J, Pasquier J, Boissel JP (2000) Comparison of long versus short duration of anticoagulant therapy after a first episode of venous thromboembolism a meta-analysis of randomized, controlled trials. J Intern Med 47:553–562

    Google Scholar 

  • Pinede L, Ninet J, Duhaut P, Chabaud S, Demolombe-Rague S, Durieu I, Nony P, Sanson C, Boissel JP; Investigators of the „Durée Optimale du Traitement AntiVitamines K“ (DOTAVK) Study (2001) Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis. Circulation 103:2453–2460

    Google Scholar 

  • van Dongen CJ, Vink R, Hutten BA, Büller HR, Prins MH (2003) The incidence of recurrent venous thromboembolism after treatment with vitamin K antagonists in relation to time since first event a meta-analysis. Arch Intern Med 163:1285–1293

    Google Scholar 

Zu 10.2.5

  • Baglin T, Luddington R, Brown K, Baglin C (2003) Incidence of recurrent venous thromboembolism in relation to clinical and thrombophilic risk factors: prospective cohort study. The Lancet 362:523–526

    Google Scholar 

  • Bauer KA (2010) Duration of anticoagulation: applying the guidelines and beyond. Hematology Am Soc Hematol Educ Program 210–215

    Google Scholar 

  • Carrier M, Le Gal G, Wells PS, Rodger MA (2010) Systematic review: case-fatality rates of recurrent venous thromboembolism and major bleeding events among patients treated for venous thromboembolism. Ann Intern Med 152:578–589

    Google Scholar 

  • Carrier M, Rodger MA, Wells PS, Righini M, Le Gal G (2011) Residual vein obstruction to predict the risk of recurrent venous thromboembolism in patients with deep vein thrombosis: a systematic review and meta-analysis. J Thromb Haemost 9:1119–1125

    Google Scholar 

  • Christiansen SC, Cannegieter SC, Koster T, Vandenbroucke JP, Rosendaal FR (2005) Thrombophilia, clinical factors, and recurrent venous thrombotic events. JAMA 293:2352–2361

    Google Scholar 

  • Cosmi B, Legnani C, Iorio A, Pengo V, Ghirarduzzi A, Testa S, Poli D, Tripodi A, Palareti G; PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics) (2009) Residual venous obstruction, alone and in combination with D-dimer, as a risk factor for recurrence after anticoagulation withdrawal following a first idiopathic deep vein thrombosis in the prolong study. Eur J Vasc Endovasc Surg 39:356–365

    Google Scholar 

  • Cosmi B, Legnani C, Tosetto A, Pengo V, Ghirarduzzi A, Testa S, Prisco D, Poli D, Tripodi A, Marongiu F, Palareti G; PROLONG Investigators (on behalf of Italian Federation of Anticoagulation Clinics) (2010) Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism the PROLONG II prospective study. Blood 115:481–488

    Google Scholar 

  • Cosmi B, Legnani C, Cini M, Guazzaloca G, Palareti G (2011) D-dimer and residual vein obstruction as risk factors for recurrence during and after anticoagulation withdrawal in patients with a first episode of provoked deep-vein thrombosis. Thromb Haemost 105:837–845

    Google Scholar 

  • Douketis J, Tosetto A, Marcucci M, Baglin T, Cushman M, Eichinger S, Palareti G, Poli D, Tait RC, Iorio A (2010) Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism. Ann Intern Med 153:523–531

    Google Scholar 

  • East AT, Wakefield TW (2010) What is the optimal duration of treatment for DVT? An update on evidence-based medicine of treatment for DVT. Semin Vasc Surg 23:182–191

    Google Scholar 

  • Hach-Wunderle V, Blättler W, Gerlach G, Konstantinides St, Noppeney T et al. (2010) Diagnostik und Therapie der Venenthrombose und der Lungenembolie. Interdisziplinäre S2-Leitlinie. VASA 39: S/78

    Google Scholar 

  • Ho WK, Hankey GJ, Quinlan DJ, Eikelboom JW (2006) Risk of recurrent venous thromboembolism in patients with common thrombophilia: a systematic review. Arch Intern Med 166:729–736

    Google Scholar 

  • Kearon C, Ginsberg JS, Kovacs MJ, Anderson DR, Wells P, Julian JA, MacKinnon B, Weitz JI, Crowther MA, Dolan S, Turpie AG, Geerts W, Solymoss S, van Nguyen P, Demers C, Kahn SR, Kassis J, Rodger M, Hambleton J, Gent M (2003) Extended Low-Intensity Anticoagulation for Thrombo-Embolism Investigators. Comparison of low-intensity warfarin therapy with conventional-intensity warfarin therapy for long-term prevention of recurrent venous thromboembolism. N Engl J Med 349:631–639

    Google Scholar 

  • Landefeld CS, Beyth RJ (1993) Anticoagulant-related bleeding: clinical epidemiology, prediction, and prevention. Am J Med 95:315–328

    Google Scholar 

  • Le Gal G, Carrier M, Kovacs MJ, Betancourt MT, Kahn SR, Wells PS, Anderson DA, Chagnon I, Solymoss S, Crowther M, Righini M, Delluc A, White RH, Vickars L, Rodger M (2011) Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: data from the REVERSE cohort study. J Thromb Haemost 9:1126–1132

    Google Scholar 

  • Lijfering WM, Brouwer JL, Veeger NJ, Bank I, Coppens M, Middeldorp S, Hamulyák K, Prins MH, Büller HR, van der Meer J (2009) Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives. Blood 113:5314–5322

    Google Scholar 

  • McRae S, Tran H, Schulman S, Ginsberg J, Kearon C (2006) Effect of patient’s sex on risk of recurrent venous thromboembolism: a meta-analysis. The Lancet 68:371–378

    Google Scholar 

  • Prandoni P, Lensing AW, Prins MH, Bernardi E, Marchiori A, Bagatella P, Frulla M, Mosena L, Tormene D, Piccioli A, Simioni P, Girolami A (2002) Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern Med 137:955–960

    Google Scholar 

  • Prandoni P, Noventa F, Ghirarduzzi A, Pengo V, Bernardi E, Pesavento R, Iotti M, Tormene D, Simioni P, Pagnan A (2007) The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients. Haematologica 92:199–205

    Google Scholar 

  • Prandoni P, Prins MH, Lensing AW, Ghirarduzzi A, Ageno W, Imberti D, Scannapieco G, Ambrosio GB, Pesavento R, Cuppini S, Quintavalla R, Agnelli G (2009) AESOPUS Investigators. Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomised trial. Ann Intern Med 150:577–585

    Google Scholar 

  • Ridker PM, Goldhaber SZ, Danielson E, Rosenberg Y, Eby CS, Deitcher SR, Cushman M, Moll S, Kessler CM, Elliott CG, Paulson R, Wong T, Bauer KA, Schwartz BA, Miletich JP, Bounameaux H, Glynn RJ (2003) PREVENT Investigators. Long-term, low-intensity warfarin therapy for the prevention of recurrent venous thromboembolism. N Engl J Med 348:1425–1434

    Google Scholar 

  • Rodger M, Carrier M, Gandara E, Le Gal G (2010) Unprovoked venous thromboembolism: Short term or indefinite anticoagulation? Balancing long-term risk and benefit. Blood Rev 24:171–178

    Google Scholar 

  • Ruíz-Giménez N, Suárez C, González R, Nieto JA, Todolí JA, Samperiz AL, Monreal M; RIETE Investigators (2008) Predictive variables for major bleeding events in Patients presenting with documented acute venous thromboembolism. Findings from the RIETE Registry. Thromb Haemost 100:26–31

    Google Scholar 

  • Scarvelis D, Wells PS (2006) Diagnosis and treatment of deep-vein thrombosis. CMAJ 175:1087–1092

    Google Scholar 

  • Siragusa S, Malato A, Anastasio R, Cigna V, Milio G, Amato C, Bellisi M, Attanzio MT, Cormaci O, Pellegrino M, Dolce A, Casuccio A, Bajardi G, Mariani G (2008) Residual vein thrombosis to establish duration of anticoagulation after a first episode of deep vein thrombosis: the duration of anticoagulation based on compression ultrasonography (DACUS) study. Blood 112:511–515

    Google Scholar 

  • Tan M, Mos IC, Klok FA, Huisman MV (2011) Residual venous thrombosis as predictive factor for recurrent venous thromboembolim in patients with proximal deep vein thrombosis: a sytematic review. Br J Haematol 153:168–178

    Google Scholar 

  • van der Meer FJ, Rosendaal FR, Vandenbroucke JP, Briët E (1993) Bleeding complications in oral anticoagulant therapy. An analysis of risk factors. Arch Intern Med 153:1557–1562

    Google Scholar 

  • Vítovec M, Golán L, Roztocil K, Linhart A (2009) The development of persistent thrombotic masses in patients with deep venous thrombosis randomized to long-term anticoagulation treatment. Vasa 38:238–244

    Google Scholar 

Zu 10.2.6

  • Ahrens I, Lip GY, Peter K (2010) New oral anticoagulant drugs in cardiovascular disease. Thromb Haemost 104:49–60

    Google Scholar 

  • AWMF-Leitlinien-Register Nr. 003/001 (finale Version vom 18. März 2009) Prophylaxe der venösen Thromboembolie (VTE). www.uni-duesseldorf.de/AWMF/ll/003-001.htm

  • Harenberg J et al (2010) Anticoagulation in the elderly. Internist (Berl) 51:1446–1455

    Google Scholar 

  • Harenberg J et al (2012) New anticoagulants - promising and failed developments. Br J Pharmacol 165:363–372

    Google Scholar 

  • Harenberg J, Marx S, Giese C (2012) Determination of the anticoagulant effects of new oral anticoagulants - an unmet need. Expert Review Haematology 5:107–113

    Google Scholar 

  • Ogilvie IM et al (2010) Underuse of oral anticoagulants in atrial fibrillation: A systematic review. Am J Med 123(638–645):e63–4

    Google Scholar 

Zu 10.2.7

  • Bates S, Greer I, Pabinger I, Sofaer S, Hirsh J (2008) Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, 8th ed. Chest 133:844S–886S

    Google Scholar 

  • Casele H, Haney E, James A, Rosene-Montella K, Carson M (2006) Bone density changes in women who receive thromboprophylaxis in pregnancy. Am J Obstet Gynecol 195:1109–1113

    Google Scholar 

  • Clark P, Bates SM (2009) North American and British guidelines for anti-thrombotic therapy: are we reaching consensus? Thromb Res 123(Suppl 2):S111–S123

    Google Scholar 

  • Encke A, Haas S, Sauerland S, Abholz HH, Beckmann MW et al. (2009) Prophylaxe der venösen Thromboembolie (VTE). VASA 38, Suppl 76 (S3-Leitlinie)

    Google Scholar 

  • Gogarten W, van Aken H (2007) The use of antithrombotic drugs during various surgical procedures. Chirurg 78:119–120

    Google Scholar 

  • Greer IA, Nelson-Piercy C (2005) Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood 106:401–407

    Google Scholar 

  • Guideline (2005) AWMF-S2-Leitlinie 065/002: Diagnostik und Therapie der Bein- und Beckenvenenthrombose und Lungenembolie. http://leitlinien.net/ 1–31

  • Guideline (2007) Royal College of Obstetcians and Gynaecologists: Gree-top- guideline no. 28: Thromboembolic disease in pregnancy and puerperium: Acute management.1–17

    Google Scholar 

  • Guideline (2009) AWMF-S3-Leitlinie 003/001: Prophylaxe der venösen Thromboembolie (VTE). www.arztbibliothek.de/mdb/downloads/dgch/prophylaxe-vte-lang.pdf

  • Guideline (2009) Royal College of Obstetricians and Gynaecologists: Green-top Guideline no. 37: Reducing the risk of thromboembolism during pregnancy, birth and the puerperium. www.rcog.org.uk/files/rcog-corp/GT37ReducingRisk:1-17

  • Hovens MM, Snoep JD, Tamsma JT, Huisman MV (2006) Aspirin in the prevention and treatment of venous thromboembolism. J Thromb Haemost 4:1470–1475

    Google Scholar 

  • James A (2007) Prevention and management of venous thromboembolism in pregnancy. Am J Med 120: S26–34

    Google Scholar 

  • Kher A, Bauersachs R, Nielsen JD (2007) The management of thrombosis in pregnancy: role of low-molecular-weight heparin. Thromb Haemost 97:505–513

    Google Scholar 

  • Kuipers S, Schreijer A, Cannegieter S, Buller H, Rosendaal F, Middeldorp S (2007) Travel and venous thrombosis: a systematic review. J Intern Med 262:615–634

    Google Scholar 

  • Pettila V, Kaaja R, Leinonen P, Ekblad U, Kataja M, Ikkala E (1999) Thromboprophylaxis with low molecular weight heparin (dalteparin) in pregnancy. Thromb Res 96:275–282

    Google Scholar 

  • Scharf RE (2009) Management of bleeding in patients using antithrombotic agents Prediction, prevention, protection and problem- oriented intervention. Hamostaseologie 29:38–8

    Google Scholar 

  • Schobersberger W, Toff Wd, Eklof B, Fraedrich G, Gunga H, Haas S, Landgraf H, Lapostolle F, Partsch H, Perschler F, Schnapka J, Schobersberger B, Scurr Jh, Watzke H (2008) Traveller’s thrombosis: international consensus statement. Vasa 37:311–317

    Google Scholar 

Zu 10.3

  • Brandjes DP, Buller HR, Heijboer H, Huisman MV, de Rijk M, Jagt H et al (1997) Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis. The Lancet 349(9054):759–762

    Google Scholar 

  • Földi M, Kubik S (1999) Lehrbuch der Lymphologie. Fischer, Stuttgart

    Google Scholar 

  • Genzel I, Wienert V (1991) Kompressionskniestrumpf oder Kompressionsstrumpfhose verordnen? Phlebol 20:157–160

    Google Scholar 

  • Ginsberg JS, Hirsh J, Julian J, Vander Laan de Vries M, Magier D, MacKinnon B, et al (2001) Prevention and treatment of postphlebitic syndrome: results of a 3-part study. Arch Int Med 161:2105–2109

    Google Scholar 

  • Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schünemann HJ, for the American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel (2012) Executive Summary: Antithrombotic Therapy and Prevention of Thrombosis, 9thed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141:7S–47S

    Google Scholar 

  • Hach-Wunderle V, Blättler W, Gerlach H, Konstantinides S et al (2010) Diagnostik und Therapie der Venenthrombose und Lungenembolie. Interdisziplinäre S2-Leitlinie. VASA 39(Suppl 78):1–S-31S

    Google Scholar 

  • Kolbach DN, Sandbrink MWC, Hamulyak K, Prins MH, Neumann MHAM (2008) Non-pharmaceutical measures for prevention of post-thrombotic syndrome. Cochrane Database Syst Rev, Issue 3. Art. No.: CD004174. DOI: 10.1002/14651858.CD004174. pub2.

    Google Scholar 

  • Mosti G, Partsch H (2010) Inelastic bandages maintain their hemodynamic effectivness over time despite significant pressure loss. J Vasc Surg 52:925–931

    Google Scholar 

  • Nüllen H, Noppeney T (2010) Kompressionstherapie. In: Noppeney T, Nüllen H (Hrsg) Varikose. Springer, Heidelberg, S 230ff

    Google Scholar 

  • Nüllen H, Noppeney T (2011) Kompressionstherapie - Theoretische Grundlagen. Phlebologie 40:3–8

    Google Scholar 

  • Partsch H (1984) Do we need firm compression stockings exerting high pressure. VASA 13:52–57

    Google Scholar 

  • Partsch H (2011) Kompression - wie viel Druck ist genug? Vasomed 23:2–2

    Google Scholar 

  • Partsch H, Blättler W (2000) Compression and walking versus bedrest in the treatment of proximal deep venous thrombosis with low molecular weight heparin. J Vasc Surg 32:861–869

    Google Scholar 

  • Partsch H, Menzinger G, Mostbeck A (1999) Inelastic leg compression is more effectiv ti reduce deep venous refluxes than elastic bandages. Dermatol Surg 25:695–700

    Google Scholar 

  • Partsch H, Rabe E, Stemmer R (1999) Kompressionstherapie der Extremitäten. Editions Phlebologiques Francaises, Paris

    Google Scholar 

  • Prandoni P, Lensing AW, Prins MH, Frulla M, Marchiori A, Bernardi E et al (2004) Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial. Ann Intern Med 141:249–256

    Google Scholar 

  • Weidinger P (1989) Kompressionsstrumpf - Hilfe oder Trauma - Patientenstatistik. In: Denk, van Dongen: Therapie der Venenerkrankungen. TM Verlag, Hameln, S 131–134

    Google Scholar 

Zu 10.4

  • Arneson H (1983) The late results of treatment with streptokinase or heparin in patients with acute deep vein thrombosis. Thromb Haemost 50: Abstract No. 1039

    Google Scholar 

  • Arneson H, Heilo A, Jakobsen E et al (1978) A prospective study of streptokinase and heparin in the treatment of deep vein thrombosis. Acta Med Scand 203:457–463

    Google Scholar 

  • Browse NL, Burnand KG, Lea TM (1999) Deep vein thrombosis: pathology, diagnosis and treatment. In: Browse NL (ed) Diseases of the veins, 2nd edn. Edward Arnold, London, pp 443–474

    Google Scholar 

  • Enden T, Klow NE, Sandvik L et al (2009) Catheter-directed thrombolysis vs. anticoagulant therapy alone in deep vein thrombosis: results of an open randomized, controlled trial reporting on short-term patency. J Thromb Haemost 7:1268–1275

    Google Scholar 

  • Enden T, Haig Y, Klow NE et al (2012) Long-term outcome after additionalcatheter-directed thrombolysis versus standard treatment for acute iliofemoral deep vein thrombosis (the CaVenT study): a randomized controlled trial. The Lancet 379:31–38

    Google Scholar 

  • Guyatt GH et al for the American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel (2012) American College of Chest Physicians Evidenced-based Clinical Practice Guidelines, 9th ed. Chest 141 (Suppl): 7S–47S

    Google Scholar 

  • Hach-Wunderle V et al (2010) Interdisziplinäre S2-Leitlinie: Diagnostik und Therapie der Bein- und Beckenvenenthrombose und der Lungenembolie. VASA 39:3–24

    Google Scholar 

  • Hach-Wunderle V, Bauersachs R, Gerlach HE et al (2013) Postthrombotic Syndrome Three Years after Deep Venous Thrombosis in the TULIPA PLUS Registry. J Vasc Surg 57:5–12

    Google Scholar 

  • Haig Y, Enden T, Slagsvold CE et al (2013) Determinants of Early and Long-term Efficacy of Catheter-directed thrombolysis in Proximal Deep Vein Thrombosis. J Vasc Interv Radiol 24:17–24

    Google Scholar 

  • Johnson BF, Manzo RA, Bergelin RO et al (1995) Relationship between changes in the deep venous system and the development of the postthrombotic syndrome after an acute episode of lower limb deep vein thrombosis: a one to six-year follow-up. J Vasc Surg 21:307–312

    Google Scholar 

  • Kim BJ, Chung HH, Lee SH et al (2010) Single-session endovascular treatment for lower symptomatic extremity deep vein thrombosis: a feasibility study. Acta Radiol 51:248–253

    Google Scholar 

  • Parikh S, Mortarjeme A, McNamara T et al (2008) Ultrasound-accelerated thrombolysis for the treatment of deep vein thrombosis: initial clinical experience. J Vasc Interv Radiol 19:521–528

    Google Scholar 

  • Patterson BO, Hinchliffe R, Loftus IM et al (2010) DVT: A New Era in Anticoagulant Therapy. Indications for Catheter-Directed Thrombolysis in the Management of Acute Proximal Deep Venous Thrombosis. Arterioscler Thromb Vasc Biol 30:669–674

    Google Scholar 

  • Sharifi M, Mehdipour M, Bay C et al (2010) Endovenous therapy for deep venous thrombosis: the TORPEDO trial. Cath Cardiovasc Int 76:316–325

    Google Scholar 

  • Torbicki A, Perrrier A, Konstantinidis S et al. (2008) Guidelines on the diagnosis and management of acute pulmonary embolism. The Task Force for the Diagnosis and Management of Acute Pulmonary

    Google Scholar 

  • Embolism of the European Society of Cardiology (ESC). Eur Heart J 29: 2276–2315

    Google Scholar 

  • Watson L, Armon MP (2010) Thrombolysis for acute deep venous thrombosis. Cochrane Database Syst Rev 2010, Issue 1, CD 002783

    Google Scholar 

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Authors and Affiliations

  1. Facharzt FMH für Innere Medizin und Angiologie, Einsiedlerstrasse 8, 8820 Wädenswil, Schweiz

    Dr. med. W. Blättler

  2. Facharzt für Allgemeinmedizin, Phlebologie, T6, 25, 68161, Mannheim

    Dr. med. H. Gerlach

  3. Praxis für Gefäßchirurgie & Gefäßmedizin, Mönchengladbach, Rheydter Straße 276, 41065

    Dr. med. H. Nüllen

  4. Versorgungszentrum für Gefäßmedizin, Nürnberg, Obere Turnstraße 8, 90429

    Dr. med. T. Noppeney

  5. Nibelungenweg 21, 50996, Köln

    Dr. med. C. Nüllen

  6. Klinische Pharmakologie Mannheim, Ruprecht-Karls-Universität Heidelberg, Maybachstraße 14, 68169, Mannheim

    Prof. Dr. med. J. Harenberg

  7. Frauenklinik des Universitätsklinikums der RWTH Aachen Spezielle Geburtshilfe und Perinatalmedizin, DEGUM II, Pauwelsstraße 30, 52074, Aachen

    Univ.-Prof.Dr. med. T. W. Goecke (Leiter der Abt. f. Pränatale Medizin und Spezielle Geburtshilfe)

  8. Universitätsklinikum Erlangen, Universitätsstraße 21–23, 91054, Erlangen

    Prof. Dr. med. M. W. Beckmann (Direktor der Frauenklinik)

  9. Gefäßzentrum, CA Angiologie Asklepios Westklinikum Hamburg, Suurheid 20, 22559, Hamburg

    Dr. med. H. Lawall

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  1. Dr. med. W. Blättler
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  2. Dr. med. F. Amsler
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  3. Dr. med. H. Gerlach
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  4. Dr. med. H. Nüllen
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  5. Dr. med. T. Noppeney
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  6. Dr. med. C. Nüllen
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  7. Prof. Dr. med. J. Harenberg
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  8. Univ.-Prof.Dr. med. T. W. Goecke
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  9. Prof. Dr. med. M. W. Beckmann
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  10. Dr. med. H. Lawall
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Editors and Affiliations

  1. Praxis für Gefäßchirurgie und Gefäßmedizin, Mönchengladbach

    Helmut Nüllen

  2. Versorgungszentrum für Gefäßmedizin, Nürnberg

    Thomas Noppeney

  3. Akademie für Gefäßkrankheiten, Karlsbad-Langensteinbach

    Curt Diehm

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Blättler, W. et al. (2014). Nichtoperative Therapie. In: Nüllen, H., Noppeney, T., Diehm, C. (eds) VTE - Venöse Thromboembolien. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21496-7_10

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  • DOI: https://doi.org/10.1007/978-3-642-21496-7_10

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