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Genomics on Pretreatment Inhibitor Tolerance of Zymomonas mobilis

Chapter
Part of the Microbiology Monographs book series (MICROMONO, volume 22)

Abstract

The development and use of robust ethanologenic microorganisms resistant to industrially relevant pretreatment inhibitors will be a critical component in the successful generation of biofuel on the industrial scale. Recent progress to understand the genetic basis of pretreatment inhibitor tolerance using genomics and systems biology tools for metabolic engineering for the model ethanologenic bacterium Zymomonas mobilis is reviewed in this chapter. The importance of accurate genome annotations and the integration of systems biology data for annotation improvement are highlighted, and case studies that describe the identification and characterization of the Z. mobilis nhaA, hfq, and himA inhibitor tolerance related gene targets are presented.

Keywords

Zymomonas Mobilis Final Cell Density Comparative Genome Sequencing Inhibitor Tolerance System Biology Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors would like to thank Meghan M. Drake for her careful review and suggestions. The BioEnergy Science Center is a US Department of Energy Bioenergy Research Center supported by the Office of Biological and Environmental Research in the DOE Office of Science. This manuscript has been authored by UT-Battelle, LLC, under Contract No. DE-AC05-00OR22725 with the US Department of Energy.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Biosciences Division and BioEnergy Science Center, Oak Ridge National LaboratoryOak RidgeUSA

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