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Tolerance of Normal Tissues to Ion Beam Therapy

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Ion Beam Therapy

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL,volume 320))

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Abstract

This review from the radiation oncology literature provides tolerance doses of normal tissues, mainly late responding. It reports toxicity data for main organs based on the experience with photons, and similar data for various modes of ion beam therapy (protons, light ions, single or multifractionated). Although these data can help compare toxicity of both types of radiations, it should be remembered that clinical historical series are generally not strictly comparable.

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References

  1. International Commission on Radiation Units and Measurements. Report 78: Prescribing, recording and reporting proton-beam therapy. J. ICRU 7, 49–81 (2007)

    Google Scholar 

  2. Y.R. Lawrence, X.A. Li, I. El Naqa, et al., Radiation dose-volume effects in the brain. Int. J. Radiat. Oncol. Biol. Phys. 76, S20–S27 (2010)

    Article  Google Scholar 

  3. J. Kirkpatrick, A.J. van der Kogel, T.E. Schultheiss, Radiation dose-volume effects in the spinal cord. Int. J. Radiat. Oncol. Biol. Phys. 76, S42–S49 (2010)

    Article  Google Scholar 

  4. C. Mayo, M.K. Martel, L.B. Marks, et al., Radiation dose-volume effects of optic nerves and chiasm. Int. J. Radiat. Oncol. Biol. Phys. 76, S28–S35 (2010)

    Article  Google Scholar 

  5. C. Mayo, E. Yorke, T. Merchant, Radiation associated brainstem injury. Int. J. Radiat. Oncol. Biol. Phys. 76, S36–S41 (2010)

    Article  Google Scholar 

  6. N. Bhandare, A. Jackson, A. Eisbruch, et al., Radiation therapy and hearing loss. Int. J. Radiat. Oncol. Biol. Phys. 76, S50–S57 (2010)

    Article  Google Scholar 

  7. L.B. Marks, S.M. Bentzen, J.O. Deasy, et al., Radiation dose-volume effects in the lung. Int. J. Radiat. Oncol. Biol. Phys. 76, S70–S76 (2010)

    Article  Google Scholar 

  8. C.C. Pan, B.D. Kavanagh, L.A. Dawson, et al., Radiation associated liver injury. Int. J. Radiat. Oncol. Biol. Phys. 76, S94–S100 (2010)

    Article  Google Scholar 

  9. J.M. Michalski, H. Gay, A. Jackson, et al., Radiation dose-volume effects in radiation-induced rectal injury. Int. J. Radiat. Oncol. Biol. Phys. 76, S123–129 (2010)

    Article  Google Scholar 

  10. B.D. Kavanagh, C.C. Pan, L.A. Dawson, et al., Radiation dose-volume effects in the stomach and small bowel. Int. J. Radiat. Oncol. Biol. Phys. 76, S101–S107 (2010)

    Article  Google Scholar 

  11. A.N. Viswanathan, E.D. Yorke, L.B. Marks, et al., Radiation dose-volume effects of the urinary bladder. Int. J. Radiat. Oncol. Biol. Phys. 76, S116–S122 (2010)

    Article  Google Scholar 

  12. B. Emami, J. Lyman, A. Brown, et al, Tolerance of normal tissue to therapeutic irradiation. Int. J. Radiat. Oncol. Biol. Phys. 21, 109–122 (1991)

    Google Scholar 

  13. J.R. Castro, D.H. Char, P.L. Petti, et al, 15 years experience with helium ion for uveal melanomas. Int. J. Radiat. Oncol. Biol. Phys. 39, 989–996 (1997)

    Article  Google Scholar 

  14. A. Courdi, J.P. Caujolle, J.D. Grange, et al., Results of proton therapy of uveal melanomas treated in Nice. Int. J. Radiat. Oncol. Biol. Phys. 45, 5–11 (1999)

    Google Scholar 

  15. E. Egger, L. Zografos, A. Schalenbourg, et al., Eye retention after proton beam radiotherapy for uveal melanoma. Int. J. Radiat. Oncol. Biol. Phys. 55, 867–880 (2003)

    Article  Google Scholar 

  16. J.E. Munzenrider, Uveal melanomas. Conservation treatment. Hematol. Oncol. Clin. North Am. 15, 389–402 (2001)

    Article  Google Scholar 

  17. R. Dendale, L. Lumbroso-Le Rouic, G. Noël, et al., Proton beam radiotherapy for uveal melanoma: results of Curie-Institute-Orsay Proton Therapy Center (ICPO). Int. J. Radiat. Oncol. Biol. Phys. 65, 780–787 (2006)

    Article  Google Scholar 

  18. G. Simonova, R. Liscak, J. Novotny, Ocular and Orbital Lesions, in Principles and Practice of Stereotactic Radiosurgery, ed. by L.S. Chin, W.R. Regine. (Springer, New York, 2008), pp. 593–610

    Chapter  Google Scholar 

  19. B. Damato, A. Kacperek, M. Chopra, et al., Proton beam radiotherapy of iris melanoma. Int. J. Radiat. Oncol. Biol. Phys. 63, 109–115 (2005)

    Article  Google Scholar 

  20. L. Lumbroso-Le Rouic, S. Delacroix, R. Dendale, et al., Proton beam therapy for iris melanomas. Eye 20, 1300–1305 (2006)

    Article  Google Scholar 

  21. H. Wuestemeyer, W. Sauerwein, D. Meller, et al., Proton radiotherapy as an alternative to exenteration in the management of extended conjunctival melanoma. Graefes Arch. Clin. Exp. Ophtalmol. 244, 438–446 (2006)

    Article  Google Scholar 

  22. L. Desjardins, L. Lumbroso-Le Rouic, C. Levy-Gabriel, et al., Combined proton beam radiotherapy and transpupillary thermotherapy for large uveal melanomas: a randomized study of 151 patients. Ophthalmic Res. 38, 255–260 (2006)

    Article  Google Scholar 

  23. E.S. Gragoudas, A.M. Lane, S. Regan, et al., A randomized controlled trial of varying radiation doses in the treatment of choroidal melanoma. Arch. Ophthalmol. 118, 773–778 (2000)

    Google Scholar 

  24. E.S. Gragoudas, W. Li, A.M. Lane, et al., Risk factors for radiation maculopathy and papillopathy after intraocular irradiation. Ophthalmology 106, 1571–1578 (1999)

    Article  Google Scholar 

  25. D.H. Char, S. Kroll, J. Castro, Ten-year follow up of helium ion therapy for uveal melanoma. Am. J. Ophthalmol. 125, 81–89 (1998)

    Article  Google Scholar 

  26. D.H. Char, J.M. Quivey, J.R. Castro, et al., Helium ions versus 125-I brachytherapy in the management of uveal melanoma: a prospective randomized dynamically balanced trial. J. Ophthalmol. 100, 1547–1554 (1993)

    Google Scholar 

  27. E.B. Hug, L.N. Loredo, J.D. Slater, et al., Proton radiation therapy for chordomas and chondrosarcomas of the skull base. J. Neurosurg. 91, 432–439 (1999)

    Article  Google Scholar 

  28. J.E. Munzenrider, N.J. Liebsch, Proton therapy for tumors of the skull base. Strahlenther Onkol. 175, 57–63 (1999)

    Article  Google Scholar 

  29. H. Igaki, K. Tokuuye, T. Okumura, et al., Clinical results of proton beam therapy for skull base chordoma. Int. J. Radiat. Oncol. Biol. Phys. 60, 1120–1126 (2004)

    Article  Google Scholar 

  30. G. Noël, L. Feuvret, V. Calugaru, et al., Chordomas of the base of the skull and cervical spine. One hundred patients irradiated by a 3D conformal technique combining photon and proton beams. Acta Oncol. 44, 700–708 (2005)

    Google Scholar 

  31. D.C. Weber, H.P. Rutz, E.S. Pedroni, et al., Results of spot-scanning proton radiation therapy for chordoma and chondrosarcoma of the skull base: the Paul Scherrer Institute experience. Int. J. Radiat. Oncol. Biol. Phys. 63, 401–409 (2005)

    Article  Google Scholar 

  32. D. Schulz-Ertner, C.P. Karger, A. Feuerhake, et al., Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas. Int. J. Radiat. Oncol. Biol. Phys. 68, 449–457 (2007)

    Article  Google Scholar 

  33. D. Schulz-Ertner, A. Nikoghosyan, H. Hof, et al., Carbon ion radiotherapy of skull base chondrosarcomas. Int. J. Radiat. Oncol. Biol. Phys. 67, 171–177 (2007)

    Article  Google Scholar 

  34. J.E. Mizoe, H. Tsujii, T. Kamada, et al., Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 60, 358–364 (2004)

    Article  Google Scholar 

  35. P. Pommier, N. Liebsch, D.G. Deschler, et al., Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch. Otolaryngol. Head Neck Surg. 132, 1242–1249 (2006)

    Article  Google Scholar 

  36. M.M. Fitzek, A.F. Thornton, J.D. Rabinov, et al., Accelerated fractionated proton/photon irradiation to 90-cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial. J. Neurosurg. 91, 251–260 (1999)

    Article  Google Scholar 

  37. M.M. Fitzek, A.F. Thornton, G. Harsh IV, et al., Dose-escalation with proton/photon irradiation for Daumas-Duport lower grade glioma: results of an institutional phase I/II trial. Int. J. Radiat. Oncol. Biol. Phys. 51, 131–137 (2001)

    Google Scholar 

  38. H. Tatsuzaki, M.M. Urie, R. Linggood, Comparative treatment planning: proton vs. x-ray beams against glioblastoma multiforme. Int. J. Radiat. Oncol. Biol. Phys. 22, 265–273 (1992)

    Google Scholar 

  39. J. Debus, D. Schultz-Ertner, L. Schad, et al., Stereotactic fractionated radiotherapy for chordomas and chondrosarcomas of the skull base. Int. J. Radiat. Oncol. Biol. Phys. 47, 591–596 (2000)

    Article  Google Scholar 

  40. B.G. Baumert, A.J. Lomax, V. Miltchev, J.B. Davis, A comparison of dose distributions of proton and photon beams in stereotactic conformal radiotherapy of brain lesions. Int. J. Radiat. Oncol. Biol. Phys. 49, 1439–1449 (2001)

    Article  Google Scholar 

  41. R. Santoni, N. Liebsch, D.M. Finkelstein, et al., Temporal lobe (TL) damage following surgery and high-dose photon and proton irradiation in 96 patients affected by chordomas and chondrosarcomas of the base of the skull. Int. J. Radiat. Oncol. Biol. Phys. 41, 59–68 (1998)

    Article  Google Scholar 

  42. J. Debus, E.B. Hug, N. Liebsch, et al., Dose-volume tolerance of the brainstem after high dose radiotherapy. Front. Radiat. Ther. Oncol. 33, 305–314 (1999)

    Article  Google Scholar 

  43. L. Marucci, A. Niemierko, N. Liebsch, et al., Spinal cord tolerance to high dose fractionated 3D conformal proton-photon irradiation as evaluated by equivalent uniform dose and dose-volume histogram analysis. Int. J. Radiat. Oncol. Biol. Phys. 59, 551–555 (2004)

    Article  Google Scholar 

  44. G. Glosser, P. McManus, J. Munzenrider, et al., Neuropsychological function in adults after high dose fractionated radiation therapy of skull base tumors. Int. J. Radiat. Oncol. Biol. Phys. 38, 231–239 (1997)

    Article  Google Scholar 

  45. D.C. Weber, A.W. Chan, S. Lessell, et al., Visual outcome of accelerated fractionated radiation for advanced sinonasal malignancies employing photons/protons. Radiother. Oncol. 81, 243–249 (2006)

    Article  Google Scholar 

  46. R.N. Kjellberg, T. Hanamura, K.R. Davis, et al., Bragg-peak proton-beam therapy for arteriovenous malformations of the brain. N. Engl. J. Med. 309, 269–274 (1983)

    Article  Google Scholar 

  47. S. Amin-Hanjani, C.S. Ogilvy, G.J. Candia, Stereotactic radiosurgery for cavernous malformations: Kjellberg’s experience with proton beam therapy in 98 cases at the Harvard Cyclotron. Neurosurgery 42, 1229–1236 (1998)

    Article  Google Scholar 

  48. J.C. Flickinger, Radiobiology of Stereotactic Radiosurgery, in Intracranial Stereotactic Radiosurgery, ed. by L.D. Lunsford, J.P. Sheehan, 2nd edn. (Thieme Medical, New York, 2009), pp. 5–12

    Google Scholar 

  49. H.A. Shih, P.H. Chapman, M.R. Bussière, et al., Central Nervous System, in Proton and Charged Particle Radiotherapy, ed. by T.F. DeLaney, H.M. Kooy (Lippincott, Williams & Wilkins, Philadelphia, 2008), pp. 140–150

    Google Scholar 

  50. J.R. Castro, D.E. Linstadt, J.P. Bahary, et al., Experience in charged particle irradiation of tumors of the skull base: 1977–1992. Int. J. Radiat. Oncol. Biol. Phys. 29, 647–655 (1994)

    Article  Google Scholar 

  51. I. Schlampp, C.P. Karger, O. Jäkel, et al., Temporal lobe reactions after radiotherapy with carbon ions: incidence and estimation of the relative biological effectiveness by the local effect model. Int. J. Radiat. Oncol. Biol. Phys. 80, 815–823 (2011)

    Article  Google Scholar 

  52. J. Kim, J.E. Munzenrider, A. Maas, et al., Optic neuropathy following combined proton and photon radiotherapy for base of skull tumors. Int. J. Radiat. Oncol. Biol. Phys. 39, 272, Abstr 2064 (1997)

    Google Scholar 

  53. J.L. Habrand, M. Austin-Seymour, S. Birnbaum, et al., Neurovisual outcome following proton radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 16, 1601–1606 (1989)

    Article  Google Scholar 

  54. E.B. Hug, J.D. Slater, Proton radiation therapy for chordomas and chondrosarcomas of the skull base. Neurosurg. Clin. N. Am. 11, 627–638 (2000)

    Google Scholar 

  55. R. Schoenthaler, B. Fullerton, A. Maas, et al., Relationship between dose to auditory pathways and audiological outcomes in skull-base tumor patients receiving high-dose proton-photon radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 36, 291, Abstr 2026 (1996)

    Google Scholar 

  56. M.M. Urie, B. Fullerton, H. Tatsuzaki, et al., A dose response analysis of injury to cranial nerves and/or nuclei following proton beam radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 23, 27–39 (1992)

    Article  Google Scholar 

  57. G.R. Harsh, A.F. Thornton, P.H. Chapman, et al., Proton beam stereotactic radiosurgery of vestibular schwannomas. Int. J. Radiat. Oncol. Biol. Phys. 54, 35–44 (2002)

    Google Scholar 

  58. D.C. Weber, A.W. Chan, M.R. Bussière, et al., Proton beam radiosurgery for vestibular schwannoma: tumor control and cranial nerve toxicity. Neurosurgery 53, 577–586 (2003)

    Article  Google Scholar 

  59. Y. Demizu, M. Murakami, D. Miyawaki, et al., Analysis of vision loss caused by radiation-induced optic neuropathy after particle therapy for head-and-neck and skull-base tumors adjacent to optic nerves. Int. J. Radiat. Oncol. Biol. Phys. 75, 1487–1492 (2009)

    Article  Google Scholar 

  60. H.H. Pai, A. Thornton, L. Katznelson, et al., Hypothalamic/pituitary function following high-dose conformal radiotherapy to the base of the skull: demonstration of a dose-effect relationship using dose-volume histogram analysis. Int. J. Radiat. Oncol. Biol. Phys. 49, 1079–1092 (2001)

    Article  Google Scholar 

  61. W.U. Shipley, L.J. Verhey, J.E. Munzenrider, et al., Advanced prostate cancer: the results of a randomized comparative trial of high dose irradiation boosting with conformal protons compared with conventional dose irradiation using photons alone. Int. J. Radiat. Oncol. Biol. Phys. 32, 3–12 (1995)

    Article  Google Scholar 

  62. J.D. Slater, C.J. Rossi, L.T. Yonemoto, et al., Proton therapy for prostate cancer: the initial Loma Linda University experience. Int. J. Radiat. Oncol. Biol. Phys. 59, 348–352 (2004)

    Article  Google Scholar 

  63. A.I. Zietman, M.L. DeSilvio, J.D. Slater, et al., Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate. A randomized control trial. J. Am. Med. Assoc. 294, 1233–1239 (2005)

    Google Scholar 

  64. D.A. Bush, J.D. Slater, B.B. Shin, et al., Hypofractionated proton beam radiotherapy for stage I lung cancer. Chest 126, 1198–1203 (2004)

    Article  Google Scholar 

  65. M. Hata, K. Tokuuye, K. Kagei, et al., Hypofractionated high-dose proton beam therapy for stage I non small cell lung cancer: preliminary results of a phase I/II clinical study. Int. J. Radiat. Oncol. Biol. Phys. 68, 786–793 (2007)

    Article  Google Scholar 

  66. T. Ogino, K. Nihei, M. Onozawa, et al., Updated results of high dose proton beam therapy (PBT) for stage I non-small-cell lung cancer (NSCLC), in Proceedings of Particle Therapy Cooperative Group, Abstract 12, PTCOG 46, Zibo, China, 18–23 May 2007

    Google Scholar 

  67. S. Sugahara, K. Tokuuye, T. Okumura, et al., Clinical results of proton beam therapy for cancer of the esophagus. Int. J. Radiat. Oncol. Biol. Phys. 61, 76–84 (2005)

    Article  Google Scholar 

  68. T. Chiba, K. Tokuuye, Y. Matsuzaki, et al., Proton beam therapy for hepatocellular carcinoma: a retrospective review of 162 patients. Clin. Cancer Res. 11, 3799–3805 (2005)

    Article  Google Scholar 

  69. M. Kawashima, J. Furuse, T. Nishio, et al., Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma. J. Clin. Oncol. 23, 1839–1846 (2005)

    Article  Google Scholar 

  70. K.R. Kozak, B.L. Smith, J. Adams, et al., Accelerated partial breast irradiation using proton beams: initial clinical experience. Int. J. Radiat. Oncol. Biol. Phys. 66, 691–698 (2006)

    Article  Google Scholar 

  71. A. Al-Mamgani, W.L. van Putten, W.D. Heemsberger, et al., Update of Dutch multicenter dose-escalation trial of radiotherapy for localized prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 71, 1028–1033 (2008)

    Article  Google Scholar 

  72. M.J. Zelefsky, E.J. Levin, M. Hunt et al., Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 70, 1124–1129 (2008)

    Article  Google Scholar 

  73. H. Tsujii, J. Mizoe, T. Kamada, et al., Clinical results of carbon ion radiotherapy at NIRS. J. Radiat. Res. 48(Suppl A), A1–A13 (2007)

    Google Scholar 

  74. M. Werner-Wasik, E. Yorke, J. Deasy, et al., Radiation dose-volume effects in the esophagus. Int. J. Radiat. Oncol. Biol. Phys. 76, S86–S93 (2010)

    Article  Google Scholar 

  75. T. Hashimoto, K. Tokuuye, N. Fukumitsu, et al., Repeated proton beam therapy for hepatocellular carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 65, 196–202 (2006)

    Article  Google Scholar 

  76. S. Liu, J. Li, Q. Sun, et al., Preliminary results of proton radiotherapy for esophageal carcinoma, in Proceedings of Particle Therapy Cooperative Group, Abstract 13, PTCOG 46, Zibo, China, 18–23 May 2007

    Google Scholar 

  77. H. Kato, H. Tsujii, T. Miyamoto, et al., Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis. Int. J. Radiat. Oncol. Biol. Phys. 59, 1458–1476 (2004)

    Google Scholar 

  78. H. Kato, S. Yamada, S. Yasuda, et al., Four-fraction carbon ion radiotherapy for hepatocellular carcinoma. J. Clin. Oncol. 22(Suppl), S335 (2004)

    Google Scholar 

  79. J.Y. Chang, X. Zhang, X. Wang, et al., Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in stage I or stage III non small cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 65, 1087–1096 (2006)

    Article  Google Scholar 

  80. K. Nihei, T. Ogino, S. Ishikura, H. Nishimura, High-dose proton beam therapy for Stage I non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 65, 107–111 (2006)

    Article  Google Scholar 

  81. Y. Shioyama, K. Tokuuye, T. Okumura, et al., Clinical evaluation of proton radiotherapy for non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 56, 7–13 (2003)

    Article  Google Scholar 

  82. J.S.A. Belderbos, K. De Jaeger, W.D. Heemsbergen, et al., First results of phase I/II dose-escalation trial in non-small cell lung cancer using three dimensional conformal radiotherapy. Radiother. Oncol. 66, 119–126 (2003)

    Article  Google Scholar 

  83. B. Jeremic, Y. Shibamoto, B. Milicic, et al., Impact of treatment interruptions due to toxicity on outcome of patients with early stage (I/II) non-small cell lung cancer (NSCLC) treated with hyperfractionated radiation therapy alone. Lung Cancer 40, 317–323 (2003)

    Article  Google Scholar 

  84. R. Komaki, S.V. Sejpal, X. Wei, et al., Reduction of bone marrow suppression for patients with stage III NSCLC treated with proton and chemotherapy compared with IMRT and chemotherapy, in Proceedings of Particle Therapy Cooperative Group, Abstract 010, PTCOG 47, Jacksonville, 19–24 May 2008

    Google Scholar 

  85. H. Nishimura, T. Miyamoto, N. Yamamoto, et al., Radiographic pulmonary and pleural changes after carbon ion irradiation. Int. J. Radiat. Oncol. Biol. Phys. 55, 861–866 (2003)

    Article  Google Scholar 

  86. T. Miyamoto, M. Baba, N. Yamamoto, et al., Curative treatment of stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen. Int. J. Radiat. Oncol. Biol. Phys. 67, 750–758 (2007)

    Article  Google Scholar 

  87. T. Miyamoto, M. Baba, T. Sugane, et al., Carbon ion radiotherapy in stage I non-small-cell lung cancer using a regimen of four fractions during one week. J. Thorac. Oncol. 2, 907–926 (2007)

    Article  Google Scholar 

  88. T. Yanagi, T. Kamada, H. Tsuji et al., Dose-volume histogram and dose- surface histogram analysis for skin reactions to carbon ion radiotherapy for bone and soft tissue sarcoma. Radiother. Oncol. 95, 60–65 (2010)

    Article  Google Scholar 

  89. B. McAllister, J.O. Archambeau, M.C. Nguyen, et al., Proton therapy for pediatric cranial tumors: preliminary report on treatment and disease-related morbidities. Int. J. Radiat. Oncol. Biol. Phys. 39, 455–460 (1997)

    Article  Google Scholar 

  90. E.B. Hug, M.W. Muenter, J.O. Archambeau et al., Conformal proton radiation therapy for pediatric low grade astrocytomas. Strahlenther Onkol. 178, 10–17 (2002)

    Article  Google Scholar 

  91. E.B. Hug, R.A. Sweeney, P.M. Nurre, et al., Proton radiotherapy in management of pediatric base of skull tumors. Int. J. Radiat. Oncol. Biol. Phys. 52, 1017–1024 (2002)

    Article  Google Scholar 

  92. G. Noël, J.L. Habrand, S. Helfre, et al., Proton beam therapy in the management of central nervous system tumors in childhood: the preliminary experience of the Centre de Protonthérapie d’Orsay. Med. Pediatr. Oncol. 40, 309–315 (2003)

    Article  Google Scholar 

  93. G.E. Yuh, L.N. Loredo, L.T. Yonemoto, et al., Reducing toxicity from craniospinal irradiation: using proton beams to treat medulloblastoma in young children. Cancer J. 10, 386–390 (2004)

    Article  Google Scholar 

  94. T. Yock, R. Schneider, A. Friedmann, et al., Proton radiotherapy for orbital rhabdomyosarcoma: clinical outcome and dosimetric comparison with photons. Int. J. Radiat. Oncol. Biol. Phys. 63, 1161–1168 (2005)

    Article  Google Scholar 

  95. Q.T. Luu, L.N. Loredo, J.O. Archambeau, et al, Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report. Cancer J. 12, 155–159 (2006)

    Google Scholar 

  96. B. Timmermann, A. Schuck, F. Niggli, et al., Spot-scanning proton therapy for malignant soft tissue tumors in childhood: first experiences at the Paul Scherrer Institute. Int. J. Radiat. Oncol. Biol. Phys. 67, 497–504 (2007)

    Article  Google Scholar 

  97. J.L. Habrand, R. Schneider, C. Alapetite, et al., Proton therapy in pediatric skull base and cervical canal low-grade bone malignancies. Int. J. Radiat. Oncol. Biol. Phys. 71, 672–678 (2008)

    Article  Google Scholar 

  98. S.M. MacDonald, S. Safai, A. Trofimov, et al., Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons. Int. J. Radiat. Oncol. Biol. Phys. 71, 979–986 (2008)

    Article  Google Scholar 

  99. D.L. Friedman, L.S. Constine, Late Effects of Cancer Treatment, in Pediatric Radiation Oncology, ed. by E.C. Halperin, L.S. Constine, N.J. Tarbell, L.E. Kun. 4th edn. (Lippincott, Williams & Wilkins, Philadelphia, 2005), pp. 523–611

    Google Scholar 

  100. A.C. Paulino, L.S. Constine, P. Rubin, J.P. Williams, Normal tissue development, homeostasis, senescence and the sensitivity to radiation injury across the age spectrum. Semin. Radiat. Oncol. 20, 12–20 (2010)

    Article  Google Scholar 

  101. R.G. Steen, B.S.M. Coury, C.I. Granja, et al., Effect of ionizing radiation on the human brain: white matter and grey matter T1 in pediatric brain tumor patients treated with conformal radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 49, 79–91 (2001)

    Article  Google Scholar 

  102. B.M. Seddon, A.M. Cassoni, M.J. Galloway, et al., Fatal radiation myelopathy after busulfan and melphalan chemotherapy and radiotherapy for Ewing’s sarcoma: a review of the literature and implications for practice. Clin. Oncol. 17, 385–390 (2005)

    Article  Google Scholar 

  103. T.E. Merchant, C.J. Gould, X. Xiong, et al., Early neuro-otologic effects of three-dimensional irradiation in children with primary brain tumors. Int. J. Radiat. Oncol. Biol. Phys. 58, 1194–1207 (2004)

    Article  Google Scholar 

  104. M. Fuss, E.B. Hug, R.A. Schaefer, et al., Proton radiation therapy (PRT) for optic pathway gliomas: comparison with 3D planned photons and a standard photon technique. Int. J. Radiat. Oncol. Biol. Phys. 45, 1117–1126 (1999)

    Article  Google Scholar 

  105. W.H. St Clair, J.A. Adams, M. Bues, et al., Advantage of protons compared to conventional X-Ray or IMRT in the treatment of a pediatric patient with medulloblastoma. Int. J. Radiat. Oncol. Biol. Phys. 58, 727–734 (2004)

    Article  Google Scholar 

  106. M. Krengli, E.B. Hug, J.A. Adams, et al., Proton radiation therapy for retinoblastoma: comparison with various intraocular tumor locations and beam arrangements. Int. J. Radiat. Oncol. Biol. Phys. 61, 583–593 (2005)

    Article  Google Scholar 

  107. E.N. Hug, M. Nevinny-Stickel, M. Fuss, et al., Conformal proton radiation treatment for retroperitoneal neuroblastoma: introduction of a novel technique. Med. Pediatr. Oncol. 37, 36–41 (2001)

    Article  Google Scholar 

  108. E.J. Hall, Intensity-modulated radiotherapy, protons, and the risk of second cancers. Int. J. Radiat. Oncol. Biol. Phys. 65, 1–7 (2006)

    Article  ADS  Google Scholar 

  109. H. Paganetti, T. Bortfeld, T.F. Delaney, Neutron dose in proton radiation therapy: in regard to Eric J Hall. Int. J. Radiat. Oncol. Biol. Phys. 66, 1594–1595 (2006)

    Google Scholar 

  110. C.S. Chung, N. Keating, T. Yock, N. Tarbell, Comparative analysis of second malignancy risk in patients treated with proton therapy versus conventional photon therapy. Int. J. Radiat. Oncol. Biol. Phys. 72, S8 (2008)

    Article  Google Scholar 

  111. A. Wambersie, RBE, reference RBE and clinical RBE: applications of these concepts in hadron therapy. Strahlenther Onkol. 175 S39–S43 (1999)

    Article  Google Scholar 

  112. H. Engels, H.G. Menzel, P. Pihet, A. Wambersie, Risk assessment for cancer induction after low- and high-LET therapeutic irradiation. Strahlenther Onkol. 175, S47–S51 (1999)

    Article  Google Scholar 

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Acknowledgement

We extend special thanks to Mrs Lorna Sainte-Ange at IGR, for editing.

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Authors and Affiliations

  1. Department Radiation Oncology, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805, Villejuif, France

    Jean-Louis Habrand, Jean Datchary & Ismael Ghorbel

  2. ARCHADE - Centre François Baclesse, 3 av. Général Harris, 5026, 14076, Caen cedex 5, France

    Jean-Louis Habrand

  3. DepartmentRadiation Oncology, Centre Léon Berard, 28, rue Laennec, 69373, Lyon, France

    Pascal Pommier

  4. Clinical Division, Centre de Protonthérapie Institut Curie, Campus Universitaire, 91898, Orsay, France

    Stéphanie Bolle & Remi Dendale

  5. Department Radiation Oncology, Groupe Hospitalier Pitié-Salpétrière, 47-83, Blvd de l’Hôpital, 75013, Paris, France

    Loïc Feuvret

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  1. Jean-Louis Habrand
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  2. Jean Datchary
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  3. Pascal Pommier
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  7. Remi Dendale
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Correspondence to Jean-Louis Habrand .

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Editors and Affiliations

  1. Forschungszentrum Jülich, Jülich, 52425, Germany

    Ute Linz

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Habrand, JL. et al. (2012). Tolerance of Normal Tissues to Ion Beam Therapy. In: Linz, U. (eds) Ion Beam Therapy. Biological and Medical Physics, Biomedical Engineering, vol 320. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21414-1_18

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  • DOI: https://doi.org/10.1007/978-3-642-21414-1_18

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