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Carbon Ion Radiotherapy for Peripheral Stage I Non-Small Cell Lung Cancer

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Ion Beam Therapy

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL,volume 320))

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Abstract

The National Institute of Radiological Sciences in Chiba, Japan (NIRS) has the highest number of patients with lung cancer treated with carbon ion beams in the world. This report describes the techniques and clinical trials that have been undertaken at NIRS and preliminary results of a current study on single-fraction irradiation. The data are compared to recent results for the treatment of peripheral stage I lung cancer from the literature.

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References

  1. H. Asamura, T. Goya, Y. Koshiishi, et al., A Japanese Lung Cancer Registry study: prognosis of 13,010 resected lung cancers. J. Thorac. Oncol. 3, 46–52 (2008)

    Article  Google Scholar 

  2. W.R. Smythe, American College of Chest Physicians. Treatment of stage I non-small cell lung carcinoma. Chest 123, 181S–187S (2003)

    Google Scholar 

  3. B. Jeremic, J. Classen, M. Bamberg, Radiotherapy alone in technically operable, medically inoperable, early-stage (I/II) non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 54, 119–130 (2002)

    Google Scholar 

  4. F.B. Zimmermann, M. Bamberg, M. Molls, et al., Radiation therapy alone in early stage non-small cell lung cancer. Semin. Surg. Oncol. 21, 91–97 (2003)

    Article  Google Scholar 

  5. Y. Nagata, M. Hiraoka, T. Mizowaki, et al., Survey of stereotactic body radiation therapy in Japan by the Japan 3-D Conformal External Beam Radiotherapy Group. Int. J. Radiat. Oncol. Biol. Phys. 75, 343–347 (2009)

    Article  Google Scholar 

  6. F.B. Zimmermann H. Geinitz, S. Schill, et al., Stereotactic hypofractionated radiation therapy for stage I non-small cell lung cancer. Lung Cancer 48, 107–114 (2005)

    Article  Google Scholar 

  7. H. Onishi, T. Araki, H. Shirato, et al., Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study. Cancer 101, 1623–1631 (2004)

    Article  Google Scholar 

  8. S. Senan, F. Lagerwaard, Stereotactic radiotherapy for stage I lung cancer: current results and new developments. Cancer Radiother. 14, 115–118 (2010)

    Article  Google Scholar 

  9. H. Onishi, H. Shirato, Y. Nagata, et al., Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study. J. Thorac. Oncol. 2(Suppl 3), S94–S100 (2007)

    Article  Google Scholar 

  10. Y. Nagata, K. Takayama, Y. Matsuo, et al., Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame. Int. J. Radiat. Oncol. Biol. Phys. 63, 1427–1431 (2005)

    Article  Google Scholar 

  11. T. Miyamoto, N. Yamamoto, H. Nishimura, et al., Carbon ion radiotherapy for stage I non-small cell lung cancer. Radiother. Oncol. 66, 127–140 (2003)

    Article  Google Scholar 

  12. T. Miyamoto, M. Baba, N. Yamamoto, et al., Curative treatment of Stage I non-small-cell lung cancer with carbon ion beams using a hypo-fractionated regimen. Int. J. Radiat. Oncol. Biol. Phys. 67, 750–758 (2007)

    Article  Google Scholar 

  13. T. Miyamoto, M. Baba, T. Sugane, et al., Carbon ion radiotherapy for stage I non-small cell lung cancer using a regimen of four fractions during 1 week. J. Thorac. Oncol. 2, 916–926 (2007)

    Article  Google Scholar 

  14. T. Sugane, M. Baba, R. Imai, et al., Carbon ion radiotherapy for elderly patients 80 years and older with stage I non-small cell lung cancer. Lung Cancer 64, 45–50 (2009)

    Article  Google Scholar 

  15. T. Kanai, M. Endo, S. Minohara, et al., Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 44, 201–210 (1999)

    Article  Google Scholar 

  16. T. Yasukawa, Y. Yamaguchi, H. Aoyagi et al., Diagnosis of hilar and mediastinal lymph node metastasis of lung cancer by positron emission tomography using 11C-methionine. Jpn. J. Lung Cancer 36, 919–926 (1996)

    Article  Google Scholar 

  17. International Union Against Cancer (UICC), TNM Classification of Malignant Tumors, 6th edn., ed. by L.H. Sobin, Ch. Wittekint (Wiley-Liss, NewYork, 2002)

    Google Scholar 

  18. T. Sugane, M. Baba, N. Yamamoto, et al., Treatment planning in carbon ion radiotherapy for lung cancer. Paper presented at Proceedings of NIRS-MD Anderson Symposium on Clinical Issues for Particle Therapy, NIRS-M-210, Houston, TX, 20–21 Mar 2008, pp. 30–35

    Google Scholar 

  19. S. Minohara, T. Kanai, M. Endo, et al., Respiratory gated irradiation system for heavy-ion radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 47, 1097–1103 (2000)

    Article  Google Scholar 

  20. T. Kanai, Y. Furusawa, K. Fukutsu, et al., Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy. Radiat. Res. 147, 78–85 (1997)

    Article  Google Scholar 

  21. M. Endo, H. Koyama-Ito, S. Minohara, et al., HIPLAN-a heavy ion treatment planning system at HIMAC. J. Jpn. Soc. Ther. Radiol. Oncol. 8, 231–238 (1996)

    Google Scholar 

  22. T. Miyamoto, M. Baba, K. Kagei, et al., Carbon ion radiotherapy in hypofraction regimen for stage I non-small cell lung cancer. Paper presented at Proceedings of NIRS-MedAustron Joint Symposium on Carbon ion Therapy in Cancer, NIRS-M-188, Chiba, 25–26 Feb 2006, pp. 25–28

    Google Scholar 

  23. J.D. Cox, J. Stetz, T.F. Pajak, Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int. J. Radiat. Oncol. Biol. Phys. 31, 1341–1346 (1995)

    Article  Google Scholar 

  24. D.A. Bush, J.D. Slater, R. Bonnet, et al., Proton-beam radiotherapy for early-stage lung cancer. Chest 116, 1313–1319 (1999)

    Article  Google Scholar 

  25. D.A. Bush, J.D. Slater, B.B. Shin, et al., Hypofractionated proton beam radiotherapy for stage I lung cancer. Chest 126, 1198–1203 (2004)

    Article  Google Scholar 

  26. Y. Shioyama, K. Tokuuye, T. Okumura, et al., Clinical evaluation of proton radiotherapy for non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 56, 7–13 (2003)

    Article  Google Scholar 

  27. M. Hata, K. Tokuuye, K. Kagei, et al., Hypofractionated high-dose proton beam therapy for stage I non-small-cell lung cancer: preliminary results of a phase I/II clinical study. Int. J. Radiat. Oncol. Biol. Phys. 68, 786–93 (2007)

    Article  Google Scholar 

  28. H. Nakayama, S. Sugahara, M. Tokita, et al., Proton beam therapy for patients with medically inoperable Stage I non-small-cell lung cancer at the University of Tsukuba. Int. J. Radiat. Oncol. Biol. Phys. 78, 467–471 (2010)

    Article  Google Scholar 

  29. K. Nihei, T. Ogino, S. Ishikura et al., High-dose proton therapy and carbon-ion therapy for stage I nonsmall cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 65, 107–111 (2006)

    Article  Google Scholar 

  30. H. Iwata, M. Murakami, Y. Demizu, et al., High-dose proton therapy and carbon-ion therapy for stage I non-small cell lung cancer. Cancer 116, 2476–2485 (2010)

    Google Scholar 

  31. K. Tsujino, S. Hirota, M. Endo, et al., Predictive value of dose-volume histogram parameters for predicting radiation pneumonitis after concurrent chemoradiation for lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 55, 110–115 (2003)

    Article  Google Scholar 

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Correspondence to Tadashi Kamada .

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Kamada, T., Yamamoto, N., Baba, M. (2012). Carbon Ion Radiotherapy for Peripheral Stage I Non-Small Cell Lung Cancer. In: Linz, U. (eds) Ion Beam Therapy. Biological and Medical Physics, Biomedical Engineering, vol 320. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21414-1_14

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  • DOI: https://doi.org/10.1007/978-3-642-21414-1_14

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  • Print ISBN: 978-3-642-21413-4

  • Online ISBN: 978-3-642-21414-1

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