Long Term Modulation and Control of Neuronal Firing in Excitable Tissue Using Optogenetics

  • L. Humphreys
  • J. M. Ferrández
  • E. Fernández
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6686)


Since the initial demonstration of nerve excitation and the subsequent action potential generation by Hodgkin and Huxley in 1952, most efforts in modulating or restoring neural activity to cure diseases or injury have concentrated on using neural interfaces for electrical stimulation with electrodes. However, it was soon appreciated that repeated chronic stimulations necessary for lasting rehabilitation could have its drawbacks. Namely, the eventual degradation of tissue and electrodes, issues of biocompatibility and immune responses to foreign objects. Nevertheless, new innovative methods are emerging which can improve the quality and duration of neural stimulations. Here we review and suggest an alternative approach to modulate activity using optogenetics in therapy.


Deep Brain Stimulation Cochlear Implant Neuronal Firing Microelectrode Array Chronic Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • L. Humphreys
    • 1
    • 3
  • J. M. Ferrández
    • 1
    • 2
  • E. Fernández
    • 1
    • 3
  1. 1.Instituto de BioingenieríaUniversidad Miguel HernándezAlicante
  2. 2.Dpto. Electrónica, Tecnología de ComputadorasUniv. Politécnica de CartagenaSpain
  3. 3.CIBER-BBNSpain

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