The Reversal Potential of Inhibitory Synapses Strongly Impacts the Dynamics of Neural Networks

  • Santi Chillemi
  • Michele Barbi
  • Angelo Di Garbo
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6686)


The balance between inhibition and excitation is at the basis of the maintenance of stable and normal brain electrical activity. Experimental results revealed that inhibitory synapses can become depolarizing as the intracellular concentration of Cl  1 of the postsynaptic cells increases. In this work the dynamical behaviour of a network of pyramidal cells coupled to inhibitory Fast-Spiking interneurons was studied by simulations. In particular, in agreement to the experimental data, it was found that the increase of the reversal potential of inhibitory synapses strongly impacts the network dynamics.


Pyramidal Neuron Pyramidal Cell Reversal Potential Excitatory Synapse Inhibitory Synapse 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Santi Chillemi
    • 1
  • Michele Barbi
    • 1
  • Angelo Di Garbo
    • 1
  1. 1.Istituto di Biofisica CNR, Sezione di PisaPisaItaly

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