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Evidence and Significance of Biofilms in Chronic Wounds in Horses

  • Samantha J. WestgateEmail author
  • Steven L. Percival
  • Peter D. Clegg
  • Derek C. Knottenbelt
  • Christine A. Cochrane
Chapter
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Part of the Springer Series on Biofilms book series (BIOFILMS, volume 6)

Abstract

Equine wounds have a high risk of becoming infected due to their environment. Infected wounds encompass diverse populations of microorganisms that fail to respond to antibiotic treatment, resulting in chronic non-healing wounds. In human wounds this has been attributed to the ability of bacteria to survive in a biofilm phenotypic state. Biofilms are known to delay wound healing, principally due to their recalcitrance towards antimicrobial therapies and components of the innate immune response. The presence of biofilms in equine wounds partly explains the reluctance of many lower limb wounds to heal. Non-healing limb wounds in horses are a well documented welfare and economic concern. Therefore, there is a need to develop future treatments in order to increase the healing rate, decrease the cost of treatment and reduce suffering associate with equine wounds.

Keywords

Minimum Inhibitory Concentration Chronic Wound Wound Healing Process Fluid Channel Bacterial Attachment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Samantha J. Westgate
    • 1
    Email author
  • Steven L. Percival
    • 2
  • Peter D. Clegg
    • 3
  • Derek C. Knottenbelt
    • 1
  • Christine A. Cochrane
    • 4
  1. 1.Faculty of Health and Life Sciences, Department of musculoskeletal BiologyUniversity of LiverpoolNestonUK
  2. 2.Department of Pathology, Medical SchoolWest Virginia UniversityMorgantownUSA
  3. 3.Department of Musculoskeletal BiologyUniversity of LiverpoolNestonUK
  4. 4.Faculty of Health and Life Sciences, Institute of Ageing and Chronic DiseaseUniversity of LiverpoolNestonUK

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