Advertisement

The Dynamic of Electroporation in Dilute Cell Suspension: A Numerical and Experimental Study

  • D. O. H. SuzukiEmail author
  • A. Ramos
  • L. H. Cazarolli
  • F. R. M. B. Silva
  • J. L. B. Marques
Part of the IFMBE Proceedings book series (IFMBE, volume 33)

Abstract

The electroporation is utilized in the gene therapy, DNA vaccination protocols, cancer treatment and introduce substances into cells. Nowadays, the experimental results are not completely understood and explained by a theory or mathematical model. This work proposed the compatibility between experimental and numerical results. The assymptotic model presented error less than 1%. The simulation provides information about the alteration of transmembrane potential and membrane conductance during electroporation pulse. The simulation of rest potential effect does not cause the electroporation asymmetry described experimentally.

Keywords

Electroporation mathematical model cell suspension experiments 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer Berlin Heidelberg 2013

Authors and Affiliations

  • D. O. H. Suzuki
    • 1
    Email author
  • A. Ramos
    • 2
  • L. H. Cazarolli
    • 3
  • F. R. M. B. Silva
    • 3
  • J. L. B. Marques
    • 1
  1. 1.Instituto de Engenharia Biomédica, Departamento de Engenharia Elétrica, CTCUFSCFlorianópolisBrasil
  2. 2.Grupo de Engenharia Biomédica, Departamento de Engenharia Elétrica, CCTUDESCJoinvilleBrasil
  3. 3.Departamento de Bioquímica, CCBUFSCFlorianópolisBrasil

Personalised recommendations