The Dynamic of Electroporation in Dilute Cell Suspension: A Numerical and Experimental Study
The electroporation is utilized in the gene therapy, DNA vaccination protocols, cancer treatment and introduce substances into cells. Nowadays, the experimental results are not completely understood and explained by a theory or mathematical model. This work proposed the compatibility between experimental and numerical results. The assymptotic model presented error less than 1%. The simulation provides information about the alteration of transmembrane potential and membrane conductance during electroporation pulse. The simulation of rest potential effect does not cause the electroporation asymmetry described experimentally.
KeywordsElectroporation mathematical model cell suspension experiments
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