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Sistemas de Liberación Controlada de Fármacos a Partir de Materiales para la Restauración del Tejido Óseo

  • G. FuentesEmail author
  • Y. Campos
  • E. Peón
  • V. C. A. Martins
  • A. M. G. Plepis
  • M. L. Rojas
  • A. Almirall
  • J. A. Delgado
  • C. X. Resende
  • G. D. A. Soares
Part of the IFMBE Proceedings book series (IFMBE, volume 33)

Abstract

Nowadays, two of the most important problems are the high incidence of bone infections and the inflammatory response of the human organism when an implant is used. For this reason, the inclusion of drugs in materials for bone restoration is an interesting and promising approach to solve this problem. On this paper, drug delivery systems from bone restoration materials making little modifications to classic materials such as calcium phosphate cements, PMMA acrylic cements and coating metals were prepared, characterized and evaluated. All the prepared matrixes showed no-interaction between main components of formulation allowing the composition to lead the behavior of drug profile. The modifications made to classic bone materials on hydrophilicity and porosity, two important characteristics, helped to improve the drug delivery capacity. The ending results of delivery moved between 40-95 % in different time ranges according to composition which allows different possible application of these materials.

Palabras claves

Liberación controlada composites metales recubiertos cefalosporinas 

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Copyright information

© Springer Berlin Heidelberg 2013

Authors and Affiliations

  • G. Fuentes
    • 1
    Email author
  • Y. Campos
    • 1
  • E. Peón
    • 1
  • V. C. A. Martins
    • 2
  • A. M. G. Plepis
    • 2
  • M. L. Rojas
    • 3
  • A. Almirall
    • 1
  • J. A. Delgado
    • 1
  • C. X. Resende
    • 4
  • G. D. A. Soares
    • 4
  1. 1.Departamento de Cerámicas y Composites, Centro de BiomaterialesUniversidad de La HabanaLa HabanaCuba
  2. 2.Grupo de Bioquímica y Biomateriales, Instituto de Química de San CarlosUniversidad de Sao PauloSan CarlosBrasil
  3. 3.Dpto. Química Inorgánica y Química Técnica, Fac. CienciasUniversidad Nacional de Educación a DistanciaMadridEspaña
  4. 4.COPPE/PEMMUniversidad Federal de Río de JaneiroRío de JaneiroBrasil

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