Evaluación In Vitro de Composites Basados en Quitosana e Hidroxiapatita
The aim of the present work was to develop an in situ preparation of chitosan/apatite nanocomposites and evaluate their bioactivity, physiological stability and enzymatic biodegradation. Composites of different chitosan/hydroxyapatite ratios were prepared by wet chemistry using different kinds of chitosan. The method of preparation used to obtain composites in this work could be more attractive with respect to previous procedures because it allows more homogeneous systems and to control the composition and structure of the resulting materials. The bioactivity of the studied material was evidenced by the deposition in its surface of a calcium phosphate layer with apatite morphology after immersion in simulated body fluid (SBF). A higher biodegradation of composites with respect to apatite was obtained due to the presence of chitosan. Also the biodegradability of the composites increased with the chitosan content. Both, biodegradation and bioactivity could be controlled by the molecular weight of chitosan polymer matrix Along the different kinds of chitosan used, a better in vitro biological result was obtained using a chitosan with lower molecular weight. The in vitro biological characteristics of composites indicate that they are promising materials for bone substitution in guided bone regeneration.
Palabras clavesnanocomposites apatite chitosan bioactivity enzymatic biodegradation
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