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Ribonucleases pp 167–192Cite as

5′-3′ Exoribonucleases

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Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC))

Abstract

The 5′-3′ exoribonucleases have important functions in RNA processing, RNA degradation, RNA interference, transcription, and other cellular processes. The Xrn1 and Xrn2/Rat1 family of enzymes are the best characterized 5′-3′ exoribonucleases, and there has been significant recent progress in the understanding of their structure and function. Especially, the first structural information on Rat1 just became available. Other 5′-3′ exoribonucleases have been identified recently, including yeast Rrp17 and B. subtilis RNase J1, the first enzyme with 5′-3′ exoribonuclease activity found in prokaryotes. This review will summarize our current understanding of these enzymes, focusing on their sequence conservation, molecular structure, biochemical and cellular functions.

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Acknowledgment

This research is supported in part by grants from the NIH to LT (GM077175).

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Authors and Affiliations

  1. Department of Biological Sciences, Columbia University, New York, NY, 10027, USA

    Jeong Ho Chang, Song Xiang & Liang Tong

  2. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, P.R. China

    Song Xiang

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  1. Jeong Ho Chang
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  2. Song Xiang
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  3. Liang Tong
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Corresponding author

Correspondence to Liang Tong .

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Editors and Affiliations

  1. Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA

    Allen W. Nicholson

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Chang, J.H., Xiang, S., Tong, L. (2011). 5′-3′ Exoribonucleases. In: Nicholson, A. (eds) Ribonucleases. Nucleic Acids and Molecular Biology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21078-5_7

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