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Ribonucleases pp 35–53Cite as

Vertebrate Secretory (RNase A) Ribonucleases and Host Defense

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Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC))

Abstract

Bovine pancreatic ribonuclease, also known as RNase A, is the prototype of an extensive, multi-lineage family of vertebrate secretory proteins that share elements of structure and catalytic activity despite substantial functional divergence. In this review, we feature the RNase A family and its members that are implicated in promoting host defense – activities that include sustaining mucosal barriers, as well as participating in various aspects of innate and acquired immunity – and explore relationships linking gene evolution, enzymatic activity, and physiologic function.

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Acknowledgments

Ongoing work in our laboratory is supported by funds from the NIAID Division of Intramural Research, Project AI000942.

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  1. Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Helene F. Rosenberg

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  1. Helene F. Rosenberg
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Correspondence to Helene F. Rosenberg .

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  1. Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA

    Allen W. Nicholson

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Rosenberg, H.F. (2011). Vertebrate Secretory (RNase A) Ribonucleases and Host Defense. In: Nicholson, A. (eds) Ribonucleases. Nucleic Acids and Molecular Biology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-21078-5_2

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