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Bio-Medical Applications of Elastomeric Blends, Composites

  • Valentine KanyantaEmail author
  • Alojz Ivankovic
  • Neal Murphy
Chapter
Part of the Advanced Structured Materials book series (STRUCTMAT, volume 12)

Abstract

Elastomeric blends and composites are now extensively used for biomedical applications. Some of these applications include medical devices and utilities such as blood bags and cardiac assist pumps, and chronic medical implants such as heart valves and vascular grafts. These materials demonstrate superior biocompatibility, biostability and good mechanical properties, and as a result are now preferred over the use of metals and ceramics in most chronic medical implants applications. In addition, the chemical composition of these elastomeric blends and composites offers substantial opportunities for synthetic polymer chemists to tailor the structures to meet specific requirements. The current chapter discusses some of the recent developments in the use of elastomeric blends and composites for biomedical applications. The chapter also discusses the essential properties that materials used in these applications should possess in order to reduce the risk of severe allergic reactions in patients, implants being rejected by the host environment and premature failure of device and/or implants. An overview of the commonly used elastomer based products in biomedical applications and their fabrication/synthesis techniques is also presented.

Keywords

Medical Device Heart Valve Medical Application Vascular Graft Mould Cavity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Gogolewski, S.: In vitro and in vivo molecular stability of medical polyurethanes: A review. Trends Polym. Sci. 1, 47–61 (1991)Google Scholar
  2. 2.
    Christenson, E.M., Wiggins, M.J., Anderson, J.M., Hiltner, A.: Surface modification of poly(ether urethane urea with modified dehydroepiandros-terone for improved in vivo biostability). J. Biomed. Mater. Res. 73A, 108–115 (2005)CrossRefGoogle Scholar
  3. 3.
    Lelah, M.D., Cooper, S.L.: Polyurethanes in medicine. CRC Press, Boca Raton (1986)Google Scholar
  4. 4.
    Szycher, M.: Polyurethanes in vascular grafts. Elastomer World 218, p44 (1998) Google Scholar
  5. 5.
    Szycher, M., Reed, A.: Biostable polyurethane elastomers. Med. Device Technol. 3, 42–51 (1992)Google Scholar
  6. 6.
    Stokes, K., McVenes, R.: Polyurethane elastomer biostability. J. Biomater. Appl. 9, 321–354 (1995)Google Scholar
  7. 7.
    Gunatillake, P.A., Martin, D.J., Meijs, G.F., et al.: Designing biostable polyurethane elastomers for biomedical implants. Aust. J. Chem. 56, 545–557 (2003)CrossRefGoogle Scholar
  8. 8.
    Ripple, W.S., Simons, J.: Thermoplastic elastomers in medical devices. Technical contribution for MedPlast Supplement (2007)Google Scholar
  9. 9.
    Khorasani, M.T., Zaghiyan, M., Mirzadeh, H.: Ultra high molecular weight polyethylene and polydimethylsiloxane blend as acetabular cup material. Colloids Surf. B 41, 169–174 (2005)CrossRefGoogle Scholar
  10. 10.
    Onatea, J.I., Cominb, M., Bracerasa, I., et al.: Wear reduction effect on ultra-high-molecular-weight polyethylene by application of hard coatings and ion implantation on cobalt chromium alloy, as measured in a knee wear simulation machine. Surf. Coat. Technol. 142–144, 1056–1062 (2001)CrossRefGoogle Scholar
  11. 11.
    Brandon, H.J., Young, V.L., Jerina, K.L., et al.: Variability in the properties of silicone gel breast implants. Plast. Reconstr. Surg. 108(3), 647–655 (2001)CrossRefGoogle Scholar
  12. 12.
    Koo, N.: The fabrication of a flexible mold for high resolution soft ultraviolet nano-imprint lithography. Nanotechnology 19, 1–4 (2008)Google Scholar
  13. 13.
    Barr, S., Bayat A.: Current implant surface technology: An examination of their nanostructure and their influence on fibroblast alignment and biocompatibility. Eplasty 9, e22 (2009)Google Scholar
  14. 14.
    Barr, S., Hill, E., Bayat, A.: Patterning of novel breast implant surfaces by enhancing silicone biocompatibility, using biomimetic topographies. Eplasty 10, 246–268 (2010)Google Scholar
  15. 15.
    Shanshan L., Daniel, M.D., Yi, C., et al.: Designed biomaterials to mimic the mechanical properties of muscles. Nature 465(7294), 69–73 (2010)Google Scholar
  16. 16.
    Lysaght, M.J., O’Loughlin, J.A.: Demographic scope and economic magnitude of contemporary organ replacement therapies. ASAIO J. 46(5), 515–521 (2000)CrossRefGoogle Scholar
  17. 17.
    Ratner, B.D.: An introduction to biomaterials. University of Washing-ton Engineered Biomaterials. http://www.uweb.engr.washington.edu/research/tutorials
  18. 18.
    Bettinger, C.J.: Biodegradable elastomers for tissue engineering and cell biomaterial interactions. Macromol. Biosci. (2011). doi: 10.1002/mabi.201000397 Google Scholar
  19. 19.
    Kurtz Steven, M.: UHMWPE Biomaterials Handbook-Ultra-High Molecular Weight Polyethylene in Total Joint Replacement and Medical Devices (2nd edn), Elsevier, pp. 543 (2009) SBN: 978-0-12-374721-1Google Scholar
  20. 20.
    Tilak M.S.: Dip molding of polyurethane and silicone for latex-free, nonallergic products. Medical device and diagnostic Industry (2001)Google Scholar
  21. 21.
    Kanyanta, V., Ivankovic, A.: Mechanical characterisation of polyurethane elastomer for biomedical applications. J. Mech. Behav. Biomater. 3, 51–62 (2010)CrossRefGoogle Scholar
  22. 22.
    Colas, A., Curtis, J.: Biomaterials science. High Molecular Weight Polyethylene in Total Joint Replacement and Medical Devices. Academic Press, Elsevier (2009)Google Scholar
  23. 23.
    Kanyanta, V.: Towards early diagnosis of atherosclerosis -accurate prediction of wall shear stress. PhD thesis, University College Dublin, Ireland (2009)Google Scholar
  24. 24.
    Kang, J., Erdodi, G., Brendel, M.C., et al.: Polyisobutylene-based polyurethanes. v. oxidative-hydrolytic stability and biocompatibility. J. Polym. Sci. Part A: Polym. Chem. 48(10), 2194–2203 (2010)CrossRefGoogle Scholar
  25. 25.
    Dibra, A., Kastrati, A., Mehilli, J., et al.: Paclitaxel-eluting or sirolimus-eluting stents to prevent restenosis in diabetic patients. N. Engl. J. Med. 353, 663–670 (2005)CrossRefGoogle Scholar
  26. 26.
    Holvoet, S., Chevallier, P., Turgeon, S., Mantovani, D.: Toward high-performance coatings for biomedical devices: Study on plasma-deposited fluorocarbon films and ageing in pbs. Materials 3, 1515–1532 (2010)CrossRefGoogle Scholar
  27. 27.
    Nwankire, C.E., Ardhaoui, M., Dowling, D.P.: The effect of plasma-polymerised silicon hydride-rich polyhydrogenmethylsiloxane on the adhesion of silicone elastomers. Polym. Int. 58(9), 996–1001 (2009)CrossRefGoogle Scholar
  28. 28.
    Nwankire, C.E., ONeill, L., Byrne, G., Dowling, D.P.: The effect of plasma polymerised si-h rich polymethylhydrogen siloxane (phms) on the adhesion of silicone elastomer. In: Proceedings of the 31st Annual Meeting of the Adhesion Society, pp. 436 (2008)Google Scholar
  29. 29.
    Ademovic, Z., Wei, J., Winther-Jensen, B., Hou, X., Kingshott, P.: Surface modification of pet films using pulsed ac plasma polymerisation aimed at preventing protein adsorption. Plasma Process. Polym. 2, 5363 (2005)CrossRefGoogle Scholar
  30. 30.
    Knoerr, K., HHomann, U.: Millable Polyurethane Elastomers, Hand-book of Elastomers, 2nd edn. Marcel Decker, Inc., New York (2001)Google Scholar
  31. 31.
    Recker, K.: Cast Polyurethane Elastomers, Handbook of Elastomers, 2nd edn. Marcel Decker, Inc., New York (2001)Google Scholar
  32. 32.
    Boretos, J.W., Pierce, S.W.: Segmented polyurethane: A new elastomer for biomedical applications. Science 158, 1481–1482 (1967)CrossRefGoogle Scholar
  33. 33.
    Lamba, N.M.K., Woodhouse, K.A., Cooper, S.L.: Polyurethanes in Biomedical Applications. CRC Press, Boca Raton (1997)Google Scholar
  34. 34.
    Lakshmi, P.D., Helene, A.S., Philippe, S., Ajit, P.Y.: Fluid mechanics of artificial heart valves. Clin. Exp. Pharmacol. Physiol. 36(2), 225–237 (2009)CrossRefGoogle Scholar
  35. 35.
    Bloomfield, P.: Choice of heart valve prosthesis. Heart 87(6), 583–589 (2002)CrossRefGoogle Scholar
  36. 36.
    Wiggins, M.J., Anderson, J.M., Hiltner, A.: Effect of strain and strain rate on fatique-accelerated biodegradation of polyurethane. Biomed. Mater. Res. 66A, 463–475 (2003)CrossRefGoogle Scholar
  37. 37.
    Kurtz S.M.: The UHMWPE Handbook. Academic Press, New York (2004)Google Scholar
  38. 38.
    Teoh, S.H., Tang, Z.G., Ramakrishna, S.: Development of thin elastomeric composite membranes for biomedical applications. J. Mater. Sci. Mater. Med. 10(6), 343–352 (1999)CrossRefGoogle Scholar
  39. 39.
    Noll, W.: Chemistry and Technology of Silicones. Academic Press, New York (1968)Google Scholar
  40. 40.
    Harmand, M.F., Briquet, F.: In-vitro comparative evaluation under static conditions of the hemocompatibility of four types of tubing of cardiopulmonary bypass. Biomaterials 20(17), 1561 (1999)CrossRefGoogle Scholar
  41. 41.
    Cronin, T.D., Gerow, F.J.: Augmentation mammaplasty: A newGoogle Scholar
  42. 42.
    John, L., Foster, R.: Biosynthesis, properties and potential of natural-synthetic hybrids of polyhydroxyalkanoates and polyethylene glycols. Appl. Microbiol. Biotechnol. 75, 1241–1247 (2007)CrossRefGoogle Scholar
  43. 43.
    Nijst, C.L., Bruggeman, J.P., Karp, J.M., Ferreira, L., Zumbuehl, A., et al.: Synthesis and characterization of photocurable elastomers from poly(glycerol-cosebacate). Biomacromolecules 8, 3067–3073 (2007)CrossRefGoogle Scholar
  44. 44.
    Bettingera, C.J., Bruggemanb, P., Borensteinc, J.T., Langerb, R.S.: Amino alcohol-based degradable poly(ester amide) elas-tomers. Biomaterials 29(15), 2315–2325 (2008)Google Scholar
  45. 45.
    Barrett, D.G., Luo, W., Yousaf, M.N.: Aliphatic polyester elastomers derived from erythritol and α, ω-diacids. Polym. Chem. 1, 296–302 (2010)CrossRefGoogle Scholar
  46. 46.
    Cui, W., Zhou, Y., Chang, J.: Electrospun nanofibrous materials for tissue engineering and drug delivery. Sci. Technol. Adv. Mater. 11 (2010). doi: 10.1088/1468-6996/11/1/014108
  47. 47.
    Liua, X., Wona, Y., Ma, P.: Porogen-induced surface modification of nano-fibrous poly(l-lactic acid) scaf-folds for tissue engineering. Biomaterials 27(21), 3980–3987 (2006)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Valentine Kanyanta
    • 1
    Email author
  • Alojz Ivankovic
    • 1
  • Neal Murphy
    • 1
  1. 1.School of mechanical and materials engineeringUniversity CollegeDublinIreland

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