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Altersabhängige Makuladegeneration pp 125–141Cite as

Geographische Atrophie

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Zusammenfassung

Die geographische Atrophie (GA) stellte die atrophische Spätform der trockenen AMD dar. Sie imponiert funduskopisch am Augenhintergrund als scharf demarkierte, depigmentierte Areale. Innerhalb von Atrophiearealen werden typischerweise choroidale Gefäße sichtbar (◚ Abb. 8.1).

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Literatur

  1. Algvere PV, Marshall J, Seregard S (2006) Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol Scand 84 (1):4–15

    PubMed  CAS  Google Scholar 

  2. Allikmets R, Bergen AA, Dean M, Guymer RH, Hageman GS, Klaver CC, Stefansson K, Weber BH (2009) Geographic atrophy in age-related macular degeneration and TLR3). N Engl J Med 360 (21):2252–2254; author reply 2255–2256

    PubMed  CAS  Google Scholar 

  3. Anderson DH, Mullins RF, Hageman GS, Johnson LV (2002) A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 134 (3):411–431

    PubMed  CAS  Google Scholar 

  4. AREDS (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8) Arch Ophthalmol 119 (10):1417–1436

    Google Scholar 

  5. Arnold JJ, Sarks SH, Killingsworth MC, Sarks JP (1995) Reticular pseudodrusen. A risk factor in age-related maculopathy. Retina 15 (3):183–191

    PubMed  CAS  Google Scholar 

  6. Bearelly S, Chau FY, Koreishi A, Stinnett SS, Izatt JA, Toth CA (2009) Spectral domain optical coherence tomography imaging of geographic atrophy margins. Ophthalmology 116 (9):1762–1769

    PubMed  Google Scholar 

  7. Bellman, C, Holz FG, Schapp O, Volcker HE, Otto TP (1997) Topography of fundus autofluorescence with a new confocal scanning laser ophthalmoscope]. Ophthalmologe 94 (6):385–391

    Google Scholar 

  8. Bellmann C, Jorzik J, Spital G, Unnebrink K, Pauleikhoff D, Holz FG (2002) Symmetry of bilateral lesions in geographic atrophy in patients with age-related macular degeneration. Arch Ophthalmol 120 (5):579–584

    PubMed  Google Scholar 

  9. Bissell AJ, Yalcinbayir O, Akduman L (2005) Bilateral geographic atrophy: spontaneous visual improvement after loss of vision in the fellow eye. Acta Ophthalmol Scand 83 (4):514–515

    PubMed  Google Scholar 

  10. Blair CJ (1975) Geographic atrophy of the retinal pigment epithelium. A manifestation of senile macular degeneration. Arch Ophthalmol 93 (1):19–25

    PubMed  CAS  Google Scholar 

  11. Booij JC, Baas DC, Beisekeeva J, Gorgels TG, Bergen AA (2010) The dynamic nature of Bruch’s membrane. Prog Retin Eye Res 29 (1):1–18

    PubMed  CAS  Google Scholar 

  12. Boulton M, Dayhaw-Barker P (2001) The role of the retinal pigment epithelium: topographical variation and ageing changes. Eye (Lond) 15 (Pt 3):384–389

    CAS  Google Scholar 

  13. Brar M, Kozak I, Cheng L, Bartsch DU, Yuson R, Nigam N, Oster SF, Mojana F, Freeman WR (2009) Correlation between spectraldomain optical coherence tomography and fundus autofluorescence at the margins of geographic atrophy. Am J Ophthalmol 148 (3):439–444

    PubMed  Google Scholar 

  14. Charbel Issa P, Scholl HP, Holz FG, Knolle P, Kurts C (2005) [The complement system and its possible role in the pathogenesis of age-related macular degeneration (AMD)]. Ophthalmologe 102 (11):1036–1042

    PubMed  CAS  Google Scholar 

  15. Chew E Y, Sperduto RD, Milton RC, Clemons TE, Gensler GR, Bressler SB, Klein R, Klein BE, Ferris FL, 3rd (2009) Risk of advanced age-related macular degeneration after cataract surgery in the Age-Related Eye Disease Study: AREDS report 25) Ophthalmology 116 (2):297–303

    PubMed  Google Scholar 

  16. Cruickshanks KJ, Klein R, Klein BE (1993) Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol 111 (4):514–518

    PubMed  CAS  Google Scholar 

  17. Csaky KG, Richman EA, Ferris FL, 3rd (2008) Report from the NEI/ FDA Ophthalmic Clinical Trial Design and Endpoints Symposium. Invest Ophthalmol Vis Sci 49 (2):479–489

    PubMed  Google Scholar 

  18. De Jong PT, Klaver CC, Wolfs RC, Assink JJ, Hofman A (1997) Familial aggregation of age-related maculopathy. Am J Ophthalmol 124 (6):862–863

    PubMed  Google Scholar 

  19. Deckert A, Schmitz-Valckenberg S, Jorzik J, Bindewald A, Holz FG, Mansmann U (2005) Automated analysis of digital fundus autofluorescence images of geographic atrophy in advanced age-related macular degeneration using confocal scanning laser ophthalmoscopy (cSLO). BMC Ophthalmol 5:8

    PubMed  CAS  Google Scholar 

  20. Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ (1995) In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci 36 (3):718–729

    PubMed  CAS  Google Scholar 

  21. Dreyhaupt J, Mansmann U, Pritsch M, Dolar-Szczasny J, Bindewald A, Holz FG (2005) Modelling the natural history of geographic atrophy in patients with age-related macular degeneration. Ophthalmic Epidemiol 12 (6):353–362

    PubMed  CAS  Google Scholar 

  22. Edwards AO, Ritter R, 3rd, Abel KJ, Manning A, Panhuysen C, Farrer LA (2005) Complement factor H polymorphism and agerelated macular degeneration. Science 308 (5720):421–424

    PubMed  CAS  Google Scholar 

  23. Fagerness JA, Maller JB, Neale BM, Reynolds RC, Daly MJ, Seddon JM (2009) Variation near complement factor I is associated with risk of advanced AMD. Eur J Hum Genet 17 (1):100–104

    PubMed  CAS  Google Scholar 

  24. Ferris FL, Davis MD, Clemons TE, Lee LY, Chew EY, Lindblad AS, Milton RC, Bressler SB, Klein R (2005) A simplified severity scale for age-related macular degeneration: AREDS Report No. 18) Arch Ophthalmol 123 (11):1570–1574

    PubMed  Google Scholar 

  25. Fleckenstein M, Charbel Issa P, Helb HM, Schmitz-Valckenberg S, Finger RP, Scholl HP, Loeffler KU, Holz FG (2008) High-resolution spectral domain-OCT imaging in geographic atrophy associated with age-related macular degeneration. Invest Ophthalmol Vis Sci 49 (9):4137–4144

    PubMed  Google Scholar 

  26. Fleckenstein M, Adrion C, Schmitz-Valckenberg S, Gobel AP, Bindewald-Wittich A, Scholl HP, Mansmann U, Holz FG (2010a) Concordance of disease progression in bilateral geographic atrophy due to AMD. Invest Ophthalmol Vis Sci 51 (2):637–642

    Google Scholar 

  27. Fleckenstein M, Schmitz-Valckenberg S, Adrion C, Kramer I, Eter N, Helb HM, Brinkmann CK, Charbel Issa P, Mansmann U, Holz FG (2010b) Tracking progression with spectral-domain optical coherence tomography in geographic atrophy caused by agerelated macular degeneration. Invest Ophthalmol Vis Sci 51 (8):3846–3852

    Google Scholar 

  28. Freeman EE, Munoz B, West SK, Tielsch JM, Schein OD (2003) Is there an association between cataract surgery and age-related macular degeneration? Data from three population-based studies. Am J Ophthalmol 135 (6):849–856

    PubMed  Google Scholar 

  29. Friedman DS, O’Colmain BJ, Munoz B, Tomany SC, McCarty C, de Jong PT, Nemesure B, Mitchell P, Kempen J (2004) Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol 122 (4):564–572

    PubMed  Google Scholar 

  30. Gass JD (1973) Drusen and disciform macular detachment and degeneration. Arch Ophthalmol 90 (3):206–217

    PubMed  CAS  Google Scholar 

  31. Gold B, Merriam JE, Zernant J, Hancox LS, Taiber AJ, Gehrs K, Cramer K, Neel J, Bergeron J, Barile GR, Smith RT, Hageman GS, Dean M, Allikmets R (2006) Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration. Nat Genet 38 (4):458–462

    PubMed  CAS  Google Scholar 

  32. Green WR, Enger C (1993) Age-related macular degeneration histopathologic studies. The 1992 Lorenz E. Zimmerman Lecture. Ophthalmology 100 (10):1519–1535

    PubMed  CAS  Google Scholar 

  33. Green WR, Key SN, 3rd (1977) Senile macular degeneration: a histopathologic study. Trans Am Ophthalmol Soc 75:180–254

    PubMed  CAS  Google Scholar 

  34. Grimm C, Wenzel A, Williams T, Rol P, Hafezi F, Reme C (2001) Rhodopsin-mediated blue-light damage to the rat retina: effect of photoreversal of bleaching. Invest Ophthalmol Vis Sci 42 (2):497–505

    PubMed  CAS  Google Scholar 

  35. Haas P, Steindl K, Schmid-Kubista KE, Aggermann T, Krugluger W, Hageman GS, Binder S (2009) Complement factor H gene polymorphisms and Chlamydia pneumoniae infection in age-related macular degeneration. Eye (Lond) 23 (12):2228–2232

    CAS  Google Scholar 

  36. Hageman GS, Anderson DH, Johnson LV et al. (2005) A common haplotype in the complement regulatory gene factor H (HF1/ CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 102 (20):7227–7232

    PubMed  CAS  Google Scholar 

  37. Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, Spencer KL, Kwan SY, Noureddine M, Gilbert JR, Schnetz-Boutaud N, Agarwal A, Postel EA, Pericak-Vance MA (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308 (5720):419–421

    PubMed  CAS  Google Scholar 

  38. Heiba IM, Elston RC, Klein BE, Klein R (1994) Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study. Genet Epidemiol 11 (1):51–67

    PubMed  CAS  Google Scholar 

  39. Helb HM, Issa PC, Fleckenstein M, Schmitz-Valckenberg S, Scholl HP, Meyer CH, Eter N, Holz FG (2009) Clinical evaluation of simultaneous confocal scanning laser ophthalmoscopy imaging combined with high-resolution, spectral-domain optical coherence tomography. Acta Ophthalmol DOI: 10.1111/j.1755-3768- .2009.01602.x

    Google Scholar 

  40. Henkind P, Gartner S (1983) The relationship between retinal pigment epithelium and the choriocapillaris. Trans Ophthalmol Soc UK 103 ( Pt 4):444–447

    PubMed  Google Scholar 

  41. Holz FG, Bellman C, Staudt S, Schutt F, Volcker HE (2001) Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci 42(5):1051–1056

    PubMed  CAS  Google Scholar 

  42. Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl H, Schmitz-Valckenberg S (2007a) Progression of geographic atrophy and impact of fundus autofluorescence patterns in agerelated macular degeneration. Am J Ophthalmol 143:463–472

    Google Scholar 

  43. Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HP, Schmitz-Valckenberg S (2007b) Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol 143 (3):463–472

    Google Scholar 

  44. Holz FG, Wolfensberger TJ, Piguet B, Gross-Jendroska M, Wells JA, Minassian DC, Chisholm IH, Bird AC (1994) Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors. Ophthalmology 101 (9):1522–1528

    PubMed  CAS  Google Scholar 

  45. Klaver CC, Wolfs RC, Vingerling JR, Hofman A, de Jong PT (1998) Age-specific prevalence and causes of blindness and visual impairment in an older population: the Rotterdam Study. Arch Ophthalmol 116 (5):653–658

    PubMed  CAS  Google Scholar 

  46. Klein ML, Ferris FL, 3rd, Armstrong J, Hwang TS, Chew EY, Bressler SB, Chandra SR (2008a) Retinal precursors and the development of geographic atrophy in age-related macular degeneration. Ophthalmology 115 (6):1026–1031

    Google Scholar 

  47. Klein ML, Ferris FL, 3rd, Francis PJ, Lindblad AS, Chew EY, Hamon SC, Ott J (2010) Progression of Geographic Atrophy and Genotype in Age-Related Macular Degeneration. Ophthalmology 117(8):1554–1559

    PubMed  Google Scholar 

  48. Klein R, Klein BE, Knudtson MD, Meuer SM, Swift M, Gangnon RE (2007) Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology 114(2):253–262

    PubMed  Google Scholar 

  49. Klein R, Klein BE, Tomany SC, Meuer M, Huang GH (2002) Tenyear incidence and progression of age-related maculopathy: The Beaver Dam eye study. Ophthalmology 109 (10):1767–1779

    PubMed  Google Scholar 

  50. Klein R, Meuer SM, Knudtson MD, Iyengar SK, Klein BE (2008b) The epidemiology of retinal reticular drusen. Am J Ophthalmol 145 (2):317–326

    Google Scholar 

  51. Klein R, Meuer SM, Knudtson MD, Klein BE (2008c) The epidemiology of progression of pure geographic atrophy: the Beaver Dam Eye Study. Am J Ophthalmol 146 (5):692–699

    Google Scholar 

  52. Klein R, Moss SE, Meuer SM, Klein BE (2008d) The 15-year cumulative incidence of retinal vein occlusion: the Beaver Dam Eye Study. Arch Ophthalmol 126 (4):513–518

    Google Scholar 

  53. Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, SanGiovanni JP, Mane SM, Mayne ST, Bracken MB, Ferris FL, Ott J, Barnstable C, Hoh J (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308(5720):385–389

    PubMed  CAS  Google Scholar 

  54. Knudtson MD, Klein R, Klein BE, Lee KE, Meuer SM, Tomany SC (2004) Location of lesions associated with age-related maculopathy over a 10-year period: the Beaver Dam Eye Study. Invest Ophthalmol Vis Sci 45 (7):2135–2142

    PubMed  Google Scholar 

  55. Li M, Atmaca-Sonmez P, Othman M, Branham KE, Khanna R, Wade MS, Li Y, Liang L, Zareparsi S, Swaroop A, Abecasis GR (2006) CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration. Nat Genet 38 (9):1049–1054

    PubMed  CAS  Google Scholar 

  56. Lindblad AS, Lloyd PC, Clemons TE, Gensler GR, Ferris FL, 3rd, Klein ML, Armstrong JR (2009) Change in area of geographic atrophy in the Age-Related Eye Disease Study: AREDS report number 26) Arch Ophthalmol 127 (9):1168–1174

    PubMed  Google Scholar 

  57. Lujan BJ, Rosenfeld PJ, G Gregori, Wang F, Knighton RW, Feuer WJ, Puliafito CA (2009) Spectral domain optical coherence tomographic imaging of geographic atrophy. Ophthalmic Surg Lasers Imaging 40 (2):96–101

    PubMed  Google Scholar 

  58. Maguire P, Vine AK (1986) Geographic atrophy of the retinal pigment epithelium. Am J Ophthalmol 102 (5):621–625

    PubMed  CAS  Google Scholar 

  59. Maller J, George S, Purcell S, Fagerness J, Altshuler D, Daly MJ, Seddon JM (2006) Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nat Genet 38 (9):1055–1059

    PubMed  CAS  Google Scholar 

  60. Maller JB, Fagerness JA, Reynolds RC, Neale BM, Daly MJ, Seddon JM (2007) Variation in complement factor 3 is associated with risk of age-related macular degeneration. Nat Genet 39 (10):1200–1201

    PubMed  CAS  Google Scholar 

  61. Mata NL, Vogel R (2010) Pharmacologic treatment of atrophic age-related macular degeneration. Curr Opin Ophthalmol 21 (3):190–196

    PubMed  Google Scholar 

  62. McLeod DS, Grebe R, Bhutto I, Merges C, Baba T, Lutty GA (2009) Relationship between RPE and choriocapillaris in age-related macular degeneration. Invest Ophthalmol Vis Sci 50 (10):4982–4991

    PubMed  Google Scholar 

  63. Mitchell P, Smith W, Attebo K, Wang JJ (1995) Prevalence of agerelated maculopathy in Australia. The Blue Mountains Eye Study. Ophthalmology 102 (10):1450–1460

    PubMed  CAS  Google Scholar 

  64. Neale BM, Fagerness J, Reynolds R et al. (2010) Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci USA 107 (16):7395–7400

    PubMed  CAS  Google Scholar 

  65. Pollack A, Marcovich A, Bukelman A, Oliver M (1996) Age-related macular degeneration after extracapsular cataract extraction with intraocular lens implantation. Ophthalmology 103 (10):1546–1554

    PubMed  CAS  Google Scholar 

  66. Pollack A, Marcovich A, Bukelman A, Zalish M, Oliver M (1997) Development of exudative age-related macular degeneration after cataract surgery. Eye (Lond) 11 ( Pt 4):523–530

    Google Scholar 

  67. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E and beta carotene for age-related cataract and vision loss: AREDS report no. 9 (2001) Arch Ophthalmol 119 (10):1439–1452

    Google Scholar 

  68. Rivera A, Fisher SA, Fritsche LG, Keilhauer CN, Lichtner P, Meitinger T, Weber BH (2005) Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet 14 (21):3227–3236

    PubMed  CAS  Google Scholar 

  69. Sarks JP, Sarks SH, Killingsworth MC (1988a) Evolution of geographic atrophy of the retinal pigment epithelium. Eye (Lond) 2 ( Pt 5):552–577

    Google Scholar 

  70. Sarks JP, Sarks SH, Killingsworth MC (1988b) Evolution of geographic atrophy of the retinal pigment epithelium. Eye 2 (5):552–577

    Google Scholar 

  71. Sarks SH (1976) Ageing and degeneration in the macular region: a clinico-pathological study. Br J Ophthalmol 60 (5):324–341

    PubMed  CAS  Google Scholar 

  72. Schatz H, McDonald HR (1989) Atrophic macular degeneration. Rate of spread of geographic atrophy and visual loss. Ophthalmology 96 (10):1541–1551

    PubMed  CAS  Google Scholar 

  73. Schmitz-Valckenberg S, Bindewald-Wittich A, Dolar-Szczasny J, Dreyhaupt J, Wolf S, Scholl HP, Holz FG (2006) Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD. Invest Ophthalmol Vis Sci 47 (6):2648–2654

    PubMed  Google Scholar 

  74. Schmitz-Valckenberg S, Bultmann S, Dreyhaupt J, Bindewald A, Holz FG, Rohrschneider K (2004) Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci 45 (12):4470–4476

    PubMed  Google Scholar 

  75. Schmitz-Valckenberg S, Fleckenstein M, Helb HM, Charbel P Issa, Scholl HP, Holz FG (2009a) In vivo imaging of foveal sparing in geographic atrophy secondary to age-related macular degeneration. Invest Ophthalmol Vis Sci 50 (8):3915–3921

    Google Scholar 

  76. Schmitz-Valckenberg S, Fleckenstein M, Scholl HP, Holz FG (2009b) Fundus autofluorescence and progression of age-related macular degeneration. Surv Ophthalmol 54 (1):96–117

    Google Scholar 

  77. Schmitz-Valckenberg S, Jorzik J, Unnebrink K, Holz FG (2002) Analysis of digital scanning laser ophthalmoscopy fundus autofluorescence images of geographic atrophy in advanced agerelated macular degeneration. Graefes Arch Clin Exp Ophthalmol 240 (2):73–78

    PubMed  Google Scholar 

  78. Schmitz-Valckenberg S, Steinberg JS, Fleckenstein M, Visvalingam S, Brinkmann CK, Holz FG (2010) Combined Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography Imaging of Reticular Drusen Associated with Age- Related Macular Degeneration. Ophthalmology 117(6):1169–76

    PubMed  Google Scholar 

  79. Scholl HP, Bellmann C, Dandekar SS, Bird AC, Fitzke FW (2004) Photopic and scotopic fine matrix mapping of retinal areas of increased fundus autofluorescence in patients with age-related maculopathy. Invest Ophthalmol Vis Sci 45 (2):574–583

    PubMed  Google Scholar 

  80. Scholl HP, Charbel Issa P, Walier M, Janzer S, Pollok-Kopp B, Borncke F, Fritsche LG, Chong NV, Fimmers R, Wienker T, Holz FG, Weber BH, Oppermann M (2008) Systemic complement activation in age-related macular degeneration. PLoS ONE 3 (7):e2593

    PubMed  Google Scholar 

  81. Scholl HP, Fleckenstein M, Fritsche LG, Schmitz-Valckenberg S, Gobel A, Adrion C, Herold C, Keilhauer CN, Mackensen F, Mossner A, Pauleikhoff D, Weinberger AW, Mansmann U, Holz FG, Becker T, Weber BH (2009) CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. PLoS One 4 (10):e7418

    PubMed  Google Scholar 

  82. Schutt F, Davies S, Kopitz J, Holz FG, Boulton ME (2000) Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin. Invest Ophthalmol Vis Sci 41 (8):2303–2308

    PubMed  CAS  Google Scholar 

  83. Seddon JM, Ajani UA, Mitchell BD (1997) Familial aggregation of age-related maculopathy. Am J Ophthalmol 123 (2):199–206

    PubMed  CAS  Google Scholar 

  84. Seddon JM, Reynolds R, Maller J, Fagerness JA, Daly MJ, Rosner B (2009) Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci 50 (5):2044–2053 S

    PubMed  Google Scholar 

  85. Smith W, Assink J, Klein R, Mitchell P, Klaver CC, Klein BE, Hofman A, Jensen, Wang JJ, de Jong PT (2001) Risk factors for age-related macular degeneration: Pooled findings from three continents. Ophthalmology 108 (4):697–704

    PubMed  CAS  Google Scholar 

  86. Solbach U, Keilhauer C, Knabben H, Wolf S (1997) Imaging of retinal autofluorescence in patients with age-related macular degeneration. Retina 17 (5):385–389

    PubMed  CAS  Google Scholar 

  87. Sparrow JR, Nakanishi K, Parish CA (2000) The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 41 (7):1981–1989

    PubMed  CAS  Google Scholar 

  88. Sunness JS, Applegate CA (2005) Long-term follow-up of fixation patterns in eyes with central scotomas from geographic atrophy that is associated with age-related macular degeneration. Am J Ophthalmol 140 (6):1085–1093

    PubMed  Google Scholar 

  89. Sunness JS, Applegate CA, Bressler NM, Hawkins BS (2007a) Designing clinical trials for age-related geographic atrophy of the macula: enrollment data from the geographic atrophy natural history study. Retina 27 (2):204–210

    Google Scholar 

  90. Sunness JS, Applegate CA, Gonzalez-Baron J (2000) Improvement of visual acuity over time in patients with bilateral geographic atrophy from age-related macular degeneration. Retina 20 (2):162–169

    PubMed  CAS  Google Scholar 

  91. Sunness JS, Gonzalez-Baron J, Applegate CA, Bressler NM, Tian Y, Hawkins B, Barron Y, Bergman A (1999a) Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. Ophthalmology 106 (9):1768–1779

    CAS  Google Scholar 

  92. Sunness JS, Gonzalez-Baron J, Bressler NM, Hawkins B, Applegate CA (1999b) The development of choroidal neovascularization in eyes with the geographic atrophy form of age-related macular degeneration. Ophthalmology 106 (5):910–919

    CAS  Google Scholar 

  93. Sunness JS, Margalit E, Srikumaran D, Applegate CA, Tian Y, Perry D, Hawkins BS, Bressler M (2007b)The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and implications for interventional clinical trials. Ophthalmology 114 (2):271–277

    Google Scholar 

  94. Sunness JS, Rubin GS, Broman A, Applegate CA, Bressler NM, Hawkins BS (2008a) Low luminance visual dysfunction as a predictor of subsequent visual acuity loss from geographic atrophy in age-related macular degeneration. Ophthalmology 115 (9):1480–1488, 1488 e1481–1482

    Google Scholar 

  95. Sunness JS, Rubin GS, Zuckerbrod A, Applegate CA (2008b) Foveal-Sparing Scotomas in Advanced Dry Age-Related Macular Degeneration. J Vis Impair Blind 102 (10):600–610

    Google Scholar 

  96. Taylor HR, S West, Munoz B, Rosenthal FS, Bressler SB, Bressler NM (1992) The long-term effects of visible light on the eye. Arch Ophthalmol 110 (1):99–104

    PubMed  CAS  Google Scholar 

  97. von Ruckmann A, Fitzke FW, Bird AC (1995) Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. BrJ Ophthalmol 79 (5):407–412

    CAS  Google Scholar 

  98. von Ruckmann A, Fitzke FW, Bird AC (1997) Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci 38 (2):478–486

    PubMed  CAS  Google Scholar 

  99. Weiter J, Fine BS (1977) A histologic study of regional choroidal dystrophy. Am J Ophthalmol 83 (5):741–750

    PubMed  CAS  Google Scholar 

  100. West SK, Rosenthal FS, NM Bressler, Bressler SB, Munoz B, Fine SL, Taylor HR (1989) Exposure to sunlight and other risk factors for age-related macular degeneration. Arch Ophthalmol 107 (6):875–879

    PubMed  CAS  Google Scholar 

  101. Wolf-Schnurrbusch UE, Enzmann V, Brinkmann CK, Wolf S (2008) Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination. Invest Ophthalmol Vis Sci 49 (7):3095–3099

    PubMed  Google Scholar 

  102. Wong WT, Kam W, Cunningham D, Harrington M, Hammel K, Meyerle CB, Cukras C, Chew EY, Sadda SR, Ferris FL (2010) Treatment of Geographic Atrophy by the Topical Administration of OT-551: Results of a Phase II Clinical Trial. Invest Ophthalmol Vis Sci 51 (12):6131–6139

    PubMed  Google Scholar 

  103. Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K (2006) A variant of the HTRA1 gene increases susceptibility to agerelated macular degeneration. Science 314 (5801):992–993

    PubMed  CAS  Google Scholar 

  104. Yang Z, Stratton C, Francis PJ et al. (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med 359 (14):1456–1463

    PubMed  CAS  Google Scholar 

  105. Yates JR, Sepp T, Matharu BK, Khan JC, Thurlby DA, Shahid H, Clayton DG, Hayward C, Morgan J, Wright AF, Armbrecht AM, Dhillon B, Deary IJ, Redmond E, Bird AC, Moore AT (2007) Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med 357 (6):553–561

    PubMed  CAS  Google Scholar 

  106. Young RW (1988) Solar radiation and age-related macular degeneration. Surv Ophthalmol 32 (4):252–269

    PubMed  CAS  Google Scholar 

  107. Zweifel SA, Spaide RF, Curcio CA, Malek G, Imamura Y (2010) Reticular pseudodrusen are subretinal drusenoid deposits. Ophthalmology 117 (2):303–312 e301

    PubMed  Google Scholar 

  108. Schmitz-Valckenberg S, Jaffe GJ, Fleckenstein M, Kozma P, Hohman T, Holz FG and GAP-Study Group (2009) Lesion Characteristics and Progression in the Natural History of Geographic Atrophy (GAP)-Study. ARVO Meeting Abstracts 50:3914

    Google Scholar 

  109. Holz, FG, Schmitz-Valckenberg S, Fleckenstein M, Jaffe GJ, Hohman T (2010) Lesion Characteristics and Progression in the Natural History of Geographic Atrophy (GAP)-Study. ARVO Meeting Abstracts 51:94

    Google Scholar 

  110. J. S. Sunness, JS, Schmitz-Valckenberg S, Applegate CA, Fleckenstein M, Bressler NM, Holz FG (2009) Impact of Cataract Surgery on Progression of Geographic Atrophy in Age-Related Macular Degeneration. ARVO Meeting Abstract 50:3916

    Google Scholar 

  111. Schmitz-Valckenberg S, Alten F, Steinberg JS, Jaffe GJ, Fleckenstein M, Mukesh BN, Hohman TC, Holz FG; for the GAP-Study Group (2011) Reticular drusen associated with geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci [Epub ahead of print]

    Google Scholar 

  112. Schmitz-Valckenberg S, Adrion C, Fleckenstein M, Göbel A, Scholl HPN, Mansmann U, Holz FG für die FAM-Studiengruppe (2008) Progression of age-related geographic atrophy: Role of the fellow eye. 106. DOG-Kongress, Berlin. Abstract und Poster

    Google Scholar 

  113. Sunness JS, Rubin GS, Applegate CA, Bressler NM, Marsh MJ, Hawkins BS, Haselwood D (1997) Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity. Ophthalmology 104(10):1677–91

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Klinik für Augenheilkunde, Universitätsklinikum Bonn, Ernst-Abbe-Strasse 2, 53127, Bonn

    Dr. Monika Fleckenstein, PD Dr. Steffen Schmitz-Valckenberg & Prof. Dr. F. G. Holz

  2. Hoover Low Vision Rehabilitation Services, Greater Baltimore Medical Center, 6569 North Charles St, PPW305, 21204, Baltimore, USA

    Dr. J. S. Sunness

Authors
  1. Dr. Monika Fleckenstein
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  2. PD Dr. Steffen Schmitz-Valckenberg
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  3. Dr. J. S. Sunness
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  4. Prof. Dr. F. G. Holz
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Fleckenstein, M., Schmitz-Valckenberg, S., Sunness, J.S., Holz, F.G. (2011). Geographische Atrophie. In: Altersabhängige Makuladegeneration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20870-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-20870-6_8

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