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Genetic Engineering of Probiotic Microorganisms

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Probiotics

Part of the book series: Microbiology Monographs ((MICROMONO,volume 21))

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Abstract

With the advent of the era of genomics and proteomics, the molecular mechanisms of beneficial characteristics of probiotics are gradually being elucidated. These studies while paving the way for concrete evidence of the beneficial effects of probiotics have also lead to the idea of improved probiotics through genetic modification. Genetically Modified (GM) probiotics are mainly concerned with the improved survival and persistence of probiotics within the human and animal gut, tolerance of packing and storage conditions of food and the delivery of therapeutics by live probiotics. With the identification of genetic elements that confer tolerance to increased osmolarity, bile salt and reduced water activity, the improvement of probiotics for survival has become a reality. With the expression of various molecules such as antigens, enzymes, and molecules of immunological importance within probiotic microbes, the use of GM probiotics in the field of therapeutics looks promising. However, the safety issues of GM probiotics and the consumer perceptions need to be addressed properly in order to reap their full benefits.

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Authors and Affiliations

  1. Faculty of Applied Sciences, Department of Biological Sciences, Rajarata University, Mihintale, Sri Lanka

    T. C. Bamunuarachchige

  2. Faculty of Agriculture, Department of Agricultural Biology, University of Peradeniya, Peradeniya, Sri Lanka

    H. A. M. Wickramasinghe

  3. Teaching hospital, Anuradhapura, Sri Lanka

    D. M. J. C. Dissanayaka

  4. University of Alberta, Edmonton, AB, Canada

    N. A. D. Wickramarathna

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  1. T. C. Bamunuarachchige
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  2. H. A. M. Wickramasinghe
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  3. D. M. J. C. Dissanayaka
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  4. N. A. D. Wickramarathna
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Correspondence to T. C. Bamunuarachchige .

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  1. , School of Industrial Technology, University Sains Malaysia, Penang, 11800, Malaysia

    Min-Tze Liong

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Bamunuarachchige, T.C., Wickramasinghe, H.A.M., Dissanayaka, D.M.J.C., Wickramarathna, N.A.D. (2011). Genetic Engineering of Probiotic Microorganisms. In: Liong, MT. (eds) Probiotics. Microbiology Monographs, vol 21. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20838-6_5

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