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Small Supernumerary Marker Chromosomes (sSMC) pp 21–29Cite as

Formation of Small Supernumerary Marker Chromosomes

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Abstract

In general, not much is known about the exact mode of small supernumerary marker chromosome (sSMC) formation. Especially, when, why, and how during gametogenesis or embryogenesis an sSMC evolves is unclear. Nonetheless, for all kinds of sSMC shapes there are models for how they could be formed. These ideas are based in part on the finding that uniparental disomy and sSMC can show up together and on the observation that sSMC can evolve by incomplete trisomic rescue. Overall, an sSMC is formed by the combination of one or more rare events happening during gametogenesis or embryogenesis. This chapter sumarizes what is known on the formation of multiple sSMC compared with single sSMC, on inverted duplicated, centric minute-shaped, and ring-shaped sSMC evolution, on the mixtures of different sSMC shapes, and on centromeric activity of dicentric sSMC and breakpoint characteristics of sSMC.

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  1. Institut für Humangenetik, Universitätsklinikum Jena, Kollegiengasse 10, 07743, Jena, Germany

    Dr. Thomas Liehr

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  1. Dr. Thomas Liehr
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© 2012 Springer-Verlag Berlin Heidelberg

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Liehr, T. (2012). Formation of Small Supernumerary Marker Chromosomes. In: Small Supernumerary Marker Chromosomes (sSMC). Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20766-2_3

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