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Coronary Sclerosis, Myocardial Infarction, Myocarditis, Cardiomyopathy, Coronary Anomalies, and the Cardiac Conduction System

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Forensic Histopathology

Abstract

Sudden unexpected deaths occur frequently in forensic autopsy practice. In such cases, pathological findings in the heart can often explain the acuteness of death (Fineschi et al. 2006; Fineschi and Pomara 2004). In addition to ruptured myocardial infarcts, these pathological changes include rare diseases, such as a primary heart tumor (atrial myxoma, rhabdomyosarcoma) or pericardial tamponade in the case of a ­dissecting aortic aneurysm.

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References

  • Abbate A, Sinagra G, Bussani R, Hoke NN, Merlo M, Varma A, Toldo S, Salloum FN, Biondi-Zoccai GG, Vetrovec GW, Crea F, Silvestri F, Baldi A (2009) Apoptosis in patients with acute myocarditis. Am J Cardiol 104:995–1000

    PubMed  Google Scholar 

  • Adams JE, Bodor GS, Dávila-Román VG et al (1993) Cardiac troponin I: a marker with high specificity for cardiac injury. Circulation 88:101–106

    PubMed  Google Scholar 

  • Akashi YJ, Goldstein DS, Barbaro G, Ueyama T (2008) Takotsubo cardiomyopathy. A new form of acute, reversible heart failure. Circulation 118:2754–2762

    PubMed  Google Scholar 

  • Albalooshi Y, Hagemeier L, Doberentz E et al (2008) Abgang der rechten Herzkranzarterie aus einem Aneurysma des Sinus Valsalvae. Rechtsmedizin 18:437–440

    Google Scholar 

  • Alexander RW, Griffith GC (1956) Anomalies of the coronary arteries and their clinical significance. Circulation 14:800–805

    PubMed  CAS  Google Scholar 

  • Al-Rufaie HK, Elorio RA, Olsen EGJ (1983) Comparison of the haematoxylin basic fuchsin picric acid method and the fluorescence of haematoxylin and eosin stained sections for the identification of early myocardial infarction. J Clin Pathol 36:646–649

    PubMed  CAS  Google Scholar 

  • Althoff H (1983) Zur Morphologie des akuten Koronartodes jüngerer Frauen. Z Rechtsmed 91:85–99

    PubMed  CAS  Google Scholar 

  • Amberg R (1995) Immunmorphologische Reaktionsmuster des Myokard bei kardialen und nicht-kardialen Perfusions­störungen. In: Bratzke H, Schröter A (eds) Immunhistochemie in der Rechtsmedizin. Hänsel-Hohenhausen, Egelsbach, pp 101–116

    Google Scholar 

  • Andrews RE, Fenton MJ, Ridout DA, Burch M (2008) British congenital cardiac association. New onset heart failure due to heart muscle disease in childhood: a prospective study in the United Kingdom and Ireland. Circulation 117:79–84

    PubMed  Google Scholar 

  • Angelini A, Thiene G, Boffa GM et al (1993) Endomyocardial biopsy in right ventricular cardiomyopathy. Int J Cardiol 40:273–282

    PubMed  CAS  Google Scholar 

  • Angelini A, Basso C, Nava A, Thiene G (1996) Endomyocardial biopsy in arrhythmogenic right ventricular cardiomyopathy. Am Heart J 132:203–206

    PubMed  CAS  Google Scholar 

  • Aoki Y, Nata M, Hashiyada M, Sagisaka K (1996) Sudden unexpected death in childhood due to eosinophilic myocarditis. Int J Legal Med 108:221–224

    PubMed  CAS  Google Scholar 

  • Aoki Y, Saigusa K, Nakayama Y (1999) Sudden infant death with anomalous origin of the left coronary artery from the pulmonary artery. Leg Med 1:250–253

    CAS  Google Scholar 

  • Aretz HT (1987) Myocarditis: the Dallas criteria. Hum Pathol 18:619–624

    PubMed  CAS  Google Scholar 

  • Aretz HT, Billingham ME, Edwards W, Factor SM, Falllon JT, Fenoglio JJ et al (1987) Myocarditis: a histopathologic definition and classification. Am J Cardiovasc Pathol 1:5–14

    Google Scholar 

  • Arnold G, Kaiser C, Fischer R (1985) Myofibrilläre degeneration – a common type of myocardial lesion and its selective identification by a modified Luxol fast blue stain. Pathol Res Pract 180:405–415

    PubMed  CAS  Google Scholar 

  • Arola A, Jokinen E, Ruuskanen O, Saraste M, Pesonen E, Kuusela AL, Tikanojja T, Paavilainen T, Simell O (1997) Epidemiology of idiopathic cardiomyopathies in children and adolescents. A nationwide study in Finland. Am J Epidemiol 146:385–393

    PubMed  CAS  Google Scholar 

  • Arola A, Kallajoki M, Ruuskanen O, Hyypia T (1998) Detection of enteroviral RNA in end-stage dilated cardiomyopathy in children and adolescents. J Med Virol 56:364–371

    PubMed  CAS  Google Scholar 

  • Azzawi M, Hasleton PS, Kann SW, Hillier VF, Quigley A, Hutchinson IV (1997) Distribution of myocardial macrophages in the normal human heart. J Anat 191:417–423

    PubMed  Google Scholar 

  • Baasner A, Dettmeyer R, Graebe M, Madea B (2003a) PCR-based diagnosis of enterovirus and parvovirus B19 in paraffin-embedded heart tissue. In: Brinkmann B, Carracedo A (Hrsg.) Progress in Forensic Genetics 9, 19th International ISFG Congress, 28.08–01.09.2001, Münster, Germany; International Congress Series 1239:715–717

    Google Scholar 

  • Baasner A, Dettmeyer R, Graebe M, Rissland J, Madea B (2003b) PCR-based diagnosis of Enterovirus and Parvovirus B19 in paraffin embedded heart tissue of children with suspected sudden infant death syndrome. Lab Invest 83:1451–1455

    PubMed  CAS  Google Scholar 

  • Badir B, Knight B (1987) Fluorescence microscopy in the detection of early myocardial infarction. Forensic Sci Int 34:99–102

    PubMed  CAS  Google Scholar 

  • Badorff C, Lee GH, Lamphear BJ, Martone ME, Campbell KP, Rhoads RE, Knowlton KU (1999) Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy. Nat Med 5:320–326

    PubMed  CAS  Google Scholar 

  • Badorff C, Berkeley N, Mehrotrar S, Talhouk JW, Rhoads RE, Knowlton KU (2000a) Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based analogue. J Biol Chem 275:1191–1197

    Google Scholar 

  • Badorff C, Lee GH, Knowlton KU (2000b) Enteroviral cardiomyopathy: bad news for the dystrophin-glycoprotein-complex. Herz 25:227–232

    PubMed  CAS  Google Scholar 

  • Baldassarre S, Unger P, Renard M (1996) Acute myocardial infarction and myocardial bridging: a case report. Acta Cardiol 51:461–465

    PubMed  CAS  Google Scholar 

  • Baroldi G, Mittleman RE, Parolini M, Silver MD, Fineschi V (2001) Myocardial contraction bands. Definition, quantification and significance in forensic pathology. Int J Legal Med 115:142–151

    PubMed  CAS  Google Scholar 

  • Barriales R, Moris C, Lopz Muniz A, Hernandez LC, San Roman L, Barriales Alvarez V, Testa A, de la Hara J, Sammartin JC, Cortina A (2001) Anomalías congénitas de las arterias ­coronarias del adulto descritas en 31 años de estudios coronariográficos en el Principado de Asturias: principales ­características angiográficas y clínicas. Rev Esp Cardiol 54:269–281

    Google Scholar 

  • Basso C, Thiene G (2005) Adipositas cordis, fatty infiltration of the right ventricle, and arrhythmogenic right ventricular cardiomyopathy. Just a matter of fat? Cardiovasc Pathol 14:37–41

    PubMed  Google Scholar 

  • Basso C, Ronco F, Marcus F et al (2008) Quantitative assessment of endomyocardial biopsy in arrythmogenic right ­ventricular cardiomyopathy/dysplasia: an in vitro validation of diagnostic criteria. Eur Heart J 29:2760–2771

    PubMed  Google Scholar 

  • Basso C, Corrado D, Marcus F et al (2009) Arrhythmogenic right ventricle cardiomyopathy. Lancet 373:1289–1300

    PubMed  Google Scholar 

  • Ben m’rad M, Leclerc-Mercier S, Blanche P, Franck N, Rozenberg F, Fulla Y, Guesmi M, Rollot F, Dehoux M, Guillevin L, Moachon L (2009) Drug-induced hypersensitivity syndrome: clinical and biologic disease patterns in 24 patients. Medicine Baltimore 88:131–140

    PubMed  Google Scholar 

  • Bendig JWA, O’Brien PS, Muir P, Porter HJ, Caul EO (2001) Enterovirus sequences resembling coxsackievirus A2 detected in stool and spleen from a girl with fatal myocarditis. J Med Virol 64:482–486

    PubMed  CAS  Google Scholar 

  • Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS et al (1997) Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 275:1320–1323

    PubMed  CAS  Google Scholar 

  • Bernstein M, Konzelman FW, Sidlick DM (1929) Boeck’s sarcoid: a report of a case with visceral involvement. Arch Intern Med 4:721–734

    Google Scholar 

  • Bestetti RB, Finzi LA, Amaral FTV (1987) Myocardial bridging of coronary arteries associated with an impending acute myocardial infarction. Clin Cardiol 10:129–131

    PubMed  CAS  Google Scholar 

  • Bezerra AJC, Prates JC, DiDio LJA (1987) Incidence and clinical significance of bridges of myocardium over the coronary arteries and their branches. Surg Radiol Anat 9:273–280

    PubMed  CAS  Google Scholar 

  • Bharati S, Lev M (1995) Cardiac conduction system involvement in sudden death of obese young people. Am Heart J 129:273–281

    PubMed  CAS  Google Scholar 

  • Biggs MJ, Swift B, Sheppard MN (2008) Myocardial bridging: is it really a cause of sudden cardiac death? In: Tsokos M (ed) Forensic pathology reviews, vol 5. Humana, Totawa, pp 115–127

    Google Scholar 

  • Binz G, Knirsch W, Lewin MA, Haas NA, Koch W, Kandolf R, Uhlemann F (2003) Isolated myocardial noncompaction in childhood – case report and review of the literature. Z Kardiol 92:1039–1044

    PubMed  CAS  Google Scholar 

  • Blauwet LA, Cooper LT (2010) Myocarditis. Prog Cardiovasc Dis 52:274–288

    PubMed  Google Scholar 

  • Bleyl SB, Mumford BR, Brown-Harrison MC, Pagotto LT, Carey JC, Pysher TJ, Ward K, Chin TK (1997a) Xq28-linked noncompaction of the left ventricular myocardium: prenatal diagnosis and pathologic analysis of affected individuals. Am J Med Genet 72:257–265

    PubMed  CAS  Google Scholar 

  • Bleyl SB, Mumford BR, Thompson V, Carey JC, Pysher JT, Chin TK, Ward K (1997b) Neonatal, lethal noncompaction of the left ventricular myocardium is allelic with Barth syndrome. Am J Hum Genet 61:868–872

    PubMed  CAS  Google Scholar 

  • Bock CT, Klingel K, Aberle S, Duechting A, Lupescu A, Lang F, Kandolf R (2005) Human parvovirus B19: a new emerging pathogen of inflammatory cardiomyopathy. J Vet Med B Infect Dis Vet Public Health 52:340–343

    PubMed  CAS  Google Scholar 

  • Bock CT, Klingel K, Kandolf R (2010) Human parvovirus B19-associated myocarditis. N Engl J Med 362:1248–1249

    PubMed  CAS  Google Scholar 

  • Bouchardy B, Majno G (1974) Histopathology of early myocardial infarcts. A new approach. Am J Pathol 74:301–330

    PubMed  CAS  Google Scholar 

  • Bowles NE, Richardson PJ, Olsen EGJ, Archard LC (1986) Detection of coxsackie-B-virus-specific RNA sequences in myocardial biopsy samples from patients with myocarditis and dilated cardiomyopathy. Lancet 17:1120–1122

    Google Scholar 

  • Bowles NE, Rose ML, Taylor P, Banner NR, Morgan-Capner P, Cunningham L et al (1989) End-stage dilated cardiomyopathy. Persistence of enterovirus RNA in myocardium at cardiac transplantation and lack of immune response. Circulation 80:1128–1136

    PubMed  CAS  Google Scholar 

  • Bowles NE, Ni J, Marcus F, Towbin JA (2002) The detection of cardiotropic viruses in the myocardium of patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy. J Am Coll Cardiol 39:892–895

    PubMed  Google Scholar 

  • Braun R, Hassler D, Kimmig P (2002) Myokarditis durch Enteroviren in Griechenland – und bei uns? Dtsch Med Wochenschr 127:1364

    PubMed  Google Scholar 

  • Brinkmann B, Sepulchre MA, Fechner G (1993) The application of selected histochemical and immunohistochemical markers and procedures to the diagnosis of early myocardial damage. Int J Legal Med 106:135–141

    PubMed  CAS  Google Scholar 

  • Brodsky SV, Roh L, Ashar K, Braun A, Ramaswamy G (2008) Myocardial bridging of coronary arteries: a risk factor for myocardial fibrosis? Int J Cardiol 124:391–392

    PubMed  Google Scholar 

  • Bryant RM (1999) Hypertrophic cardiomyopathy in children. Cardiol Rev 7:92–100

    PubMed  CAS  Google Scholar 

  • Büchner F (1975) Strukturveränderungen durch allgemeinen Sauerstoffmangel, insbesondere bei der Höhenkrankheit. In: Grundmann E (ed) Hypoxie. Springer, Berlin, Heidelberg, New York

    Google Scholar 

  • Büchner F, Onishi S (1968) Der Herzmuskel bei akuter Coronarinsuffizienz im elektronenmikroskopischen Bild. Urban & Schwarzenberg, München, Berlin, Wien

    Google Scholar 

  • Bulloch RT, Pearce MB, Murphy ML, Jenkins BJ, Davis JL (1972) Myocardial lesions in idiopathic and alcoholic cardiomyopathy. Study by ventricular septal biopsy. Am J Cardiol 29:15

    PubMed  CAS  Google Scholar 

  • Bültmann BD, Klingel K, Sotlar K, Bock CT, Baba HA, Sauter M, Kandolf R (2003a) Fatal parvovirus B19-associated myocarditis clinically mimicking ischemic heart disease: an endothelial cell-mediated disease. Hum Pathol 34:92–95

    PubMed  Google Scholar 

  • Bültmann BD, Klingel K, Sotlar K, Bock CT, Kandolf R (2003b) Parvovirus B19: a pathogen responsible for more than hematologic disorders. Virchows Arch 442:8–17

    PubMed  Google Scholar 

  • Burke AP, Saenger J, Mulick F, Virmani R (1991) Hypersensitivity myocarditis. Arch Pathol Lab Med 115:764–769

    PubMed  CAS  Google Scholar 

  • Burke A, Mont E, Kutys R, Virmani R (2005) Left ventricular noncompaction: a pathological study of 14 cases. Hum Pathol 36:403–411

    PubMed  Google Scholar 

  • Buschmann C, Schäfer HJ, Püschel K, Schulz F (2006) Innate heart deformation as a cause of sudden death in a 7-year-old girl. Rechtsmedizin 16:64–68

    Google Scholar 

  • Bux R, Bratzke H, Rothschild MA, Lutz FU (2002) Plötzlicher Tod einer 12-Jährigen mit klinisch inapparenter Myokarditis unter psychischer und physischer Belastung. Rechtsmedizin 12:229–232

    Google Scholar 

  • Byard RW (2002) Unexpected death due to infectious mononucleosis. J Forensic Sci 47:202–204

    PubMed  Google Scholar 

  • Byard RW, Manton N, Tsokos M (2008) Sarcoidosis and mechanism of unexpected death. J Forensic Sci 53:460–464

    PubMed  Google Scholar 

  • Bybee KA, Prasad A (2008) Stress-related cardiomyopathy syndromes. Circulation 118:397–409

    PubMed  Google Scholar 

  • Carle BN (1981) Autofluorescence in the identification of myocardial infarcts. Hum Pathol 12:643–646

    PubMed  CAS  Google Scholar 

  • Casscells W, Kimura H, Sanchez J, Yu Z, Ferrans VJ (1990) Immunohistochemical study of fibronectin in experimental myocardial infarction. Am J Pathol 137:801–810

    PubMed  CAS  Google Scholar 

  • Cassinotti P, Weitz M, Siegl G (1993) Human parvovirus B 19 infections: Routine diagnosis by a new nested polymerase chain reaction assay. J Med Virol 40:228–234

    PubMed  CAS  Google Scholar 

  • Cassling RS, Linder J, Sears TD, Waller BF, Rogler WC, Wilson JE, Kugler JD, Kay DH, Dillon JC, Slack JD et al (1985) Quantitative evaluation of inflammation in biopsy specimen from idiopathically failing or irritable hearts: experience in 80 pediatric and adult patients. Am Heart J 110:713–720

    PubMed  CAS  Google Scholar 

  • Cebelin MS, Hirsch CS (1980) Human stress cardiomyopathy. Myocardial lesions in victims of homicidal assaults without internal injuries. Hum Pathol 11:123–132

    PubMed  CAS  Google Scholar 

  • Cecchi R, Bajanowski T, Kahl B, Wiegand P (1995) CMV-DNA detection in parenchymatous organs in cases of SIDS. Int J Legal Med 107:291–295

    PubMed  CAS  Google Scholar 

  • Chandrasiri N (1985) Histopathological re-study of the human cardiac conduction system. Med Sci Law 25:29–43

    PubMed  CAS  Google Scholar 

  • Charlton I, Williams R (1990) Cardiac conducting tissue: a simplified technique for examination of the SA and AV nodes. Am J Forensic Med Pathol 11:213–218

    PubMed  CAS  Google Scholar 

  • Chen X, Zhang Y (2006) Myocardial Cx43 expression in the cases of sudden death due to dilated cardiomyopathy. Forensic Sci Int 162:170–173

    PubMed  CAS  Google Scholar 

  • Chia JKS, Jackson B (1996) Myopericarditis due to parvovirus B19 in an adult. Clin Infect Dis 23:200–201

    PubMed  CAS  Google Scholar 

  • Chin TK, Perloff JK, Vuillemin M, Thompson RP, Anderson RH (1990) Isolated noncompaction of left ventricular myocardium. A study of eight cases. Circulation 82:507–513

    PubMed  CAS  Google Scholar 

  • Chow LH, Ye Y, Linder J, McManus BM (1989) Phenotypic analysis of infiltrating cells in human myocarditis. Arch Pathol Lab Med 113:1357–1362

    PubMed  CAS  Google Scholar 

  • Chrysohoou C, Tsiamis E, Brili S, Barbetseas J, Stefanadis C (2009) Acute myocarditis from coxsackie infection, mimi­cking subendocardial ischaemia. Hellenic J Cardiol 50:147–150

    PubMed  Google Scholar 

  • Chumachenko PV, Vikkert AM (1991) Immunomorphologic diagnosis of early myocardial necrosis using monoclonal antibodies to desmin and vimentin. Arkh Patol 53:16–19 (Russian)

    PubMed  CAS  Google Scholar 

  • Cohle SD, Lie JT (1998) Histopathologic spectrum of the cardiac tissue in traumatic and noncardiac sudden death patients under 30 years of age: an analysis of 100 cases. Anat Pathol 3:53–76

    PubMed  CAS  Google Scholar 

  • Cohle SD, Graham MA, Pounder DJ (1986) Nonatherosclerotic sudden coronary death. Pathol Ann 21:217–249

    Google Scholar 

  • Cremer U, Althoff H (1991) Nachweis und Inzidenz von Zytomegalievirusinfektionen bei plötzlichen Kindstodesfällen (SIDS). Rechtsmedizin 1:25–28

    Google Scholar 

  • Curca GC, Dermengiu D, Ceausu M, Francisc A, Rusu MC, Hostiuc S (2011) Cardiac lesions associated with cardiopulmonary resuscitation. Rom J Legal Med 19:1–6

    Google Scholar 

  • D’Ambrosio A, Patti G, Manzoli A, Sinagra G, Di Lenarda A, Silvestri F, Di Sciascio G (2001) The fate of acute myocarditis between spontaneous improvement and evolution to dilated cardiomyopathy: a review. Heart 85:499–504

    PubMed  Google Scholar 

  • Daar AS, Fuggle SV, Fabre JW, Ting A, Morris J (1984a) The detailed distribution of HLA-A, B, C antigens in normal human organs. Transplantation 38:287–292

    PubMed  CAS  Google Scholar 

  • Daar AS, Fuggle SV, Fabre JW, Ting A, Morris PJ (1984b) The detailed distribution of MHC class II antigens in normal human organs. Transplantation 38:293–298

    PubMed  CAS  Google Scholar 

  • Dada MA, Lazarus NG, Kharsany ABM, Sturm AW (2000) Sudden death caused by myocardial tuberculosis. Am J Forensic Med Pathol 21:385–388

    PubMed  CAS  Google Scholar 

  • Dalal P, Fujisic K, Hupart P, Schweizer P (1994) Arrhythmogenic right ventricular dysplasia: a review. Cardiology 85:361–369

    PubMed  CAS  Google Scholar 

  • Davies JM, Pomerance A, Lamb D (1975) Techniques in examination and anatomy of the heart. In: Pomerance A, Davies MJ (eds) The pathology of the heart. Blackwell, Oxford, London, Melbourne

    Google Scholar 

  • Dermengiu D, Ceausu M, Rusu MC, Dermengiu S, Curca GC, Hostiuc S (2010a) Sudden death with borderline hypertrophic cardiomyopathy and multiple coronary anomalies. Case report and literature review. Rom J Legal Med 18:3–12

    Google Scholar 

  • Dermengiu D, Vovolis I, Hostiuc S, Curca GC, Rusu MC, Luca L (2010b) Morphological features in myocardial bridging. Rom J Legal Med 18:163–170

    Google Scholar 

  • Dermengiu D, Curcă GC, Sãrbu N, Hostiuc S, Ceauşu M (2010c) Sudden cardiac death in non-atherosclerotic and non-inflammatory intimal cellular proliferations. A case report. Rom J Legal Med 18:183–188

    Google Scholar 

  • Dettmeyer R, Kandolf R (2009) Cardiomyopathies – misdiagnosed as Sudden Infant Death Syndrome (SIDS). Forensic Sci Int 194:e21–e24

    Google Scholar 

  • Dettmeyer R, Madea B (2002) Myokarditis durch Enteroviren in Griechenland – und bei uns? Leserbrief zum Beitrag aus Dtsch Med Wochenschr 127:1364 (2002). Dtsch Med Wochenschr 27:2467–2468

    Google Scholar 

  • Dettmeyer R, Madea B (2003) Commentary to the letter of Arya SC and Agarval N to our report “Fatal parvovirus B19 myocarditis in an 8-year-old boy”, J Forensic Sci 2003; 48:183–186 – authors response. J Forensic Sci 48:1205

    Google Scholar 

  • Dettmeyer R, Madea B (2004) Sudden, unexpected death related to viral myocarditis. A survey of histological, immunohistochemical, and molecularpathological methods for the postmortem diagnosis. In: Tsokos M (ed) Forensic pathology reviews, vol 2. Humana Press, Totowa, pp 169–186

    Google Scholar 

  • Dettmeyer R, Haag C, Madea B (2002a) Leserbrief zum Beitrag “Plötzlicher Tod einer 12-jährigen mit klinisch inapparenter Myokarditis unter psychischer und physischer Belastung”. Rechtsmedizin 12:229–232 (2002). Rechtsmedizin 12:395–396

    Google Scholar 

  • Dettmeyer R, Reith K, Madea B (2002b) Alcoholic cardiomyopathy versus chronic myocarditis – immunohistological investigations with LCA, CD3, CD68 and tenascin. Forensic Sci Int 126:57–62

    PubMed  CAS  Google Scholar 

  • Dettmeyer R, Kandolf R, Baasner A, Banaschak S, Eis-Hübinger AM, Madea B (2003) Fatal parvovirus B19 myocarditis in an 8-year-old boy. J Forensic Sci 48:183–186

    PubMed  Google Scholar 

  • Dettmeyer R, Padosch SA, Baasner A, Madea B (2004a) PCR-based diagnosis of adenovirus and Epstein-Barr virus in paraffin-embedded heart tissue. In: Doutremépuich C, Morling N (eds.) Progress in Forensic Genetics 10. Proceedings of the 20th International ISFG Congress, Arcachon, 9.-13. September 2003, France. International Congress Series 1261:605–607

    Google Scholar 

  • Dettmeyer R, Schmidt P, Kandolf R, Madea B (2004b) Evolution of dilated cardiomyopathy (DCM) from idiopathic hypertrophic cardiomyopathy (IHCM) vs. inflammatory dilated cardiomyopathy (DCMi): a rare case of sudden death in an 8-year-old boy. Pathol Res Pract 200:411–415

    PubMed  Google Scholar 

  • Dettmeyer R, Stiel M, Madea B (2006a) Heatshockprotein 60 (cHSP60) as a marker for chronic infection with Chlamydiae pneumopniae in atherosclerosis – investigation of atherosclerotic coronary arteries by immunocytochemistry. Forensic Sci Med Pathol 2:173–178

    CAS  Google Scholar 

  • Dettmeyer R, Strehler M, Winkelmann S, Madea B (2006b) Myokarditis. Rechtsmedizin 16:138–142

    Google Scholar 

  • Dettmeyer R, Padosch SA, Madea B (2006c) Lethal enterovirus-induced myocarditis and pancreatitis in a 4-month-old boy. Forensic Sci Int 156:51–54

    PubMed  CAS  Google Scholar 

  • Dettmeyer R, Müller J, Poster S, Madea B (2006d) PCR-based diagnosis of cytomegaloviruses in paraffin-embedded heart tissue in cases of suspected sudden infant death syndrome (SIDS). In: Progress in Forensic Genetics11. Proceedings of the 21st international ISFG congress, 13.-16. Sept 2005, Portugal. Int Congr Series 1288:771–773

    Google Scholar 

  • DiMaio VJM, Dana SE (2007) Handbook of Forensic Pathology. CRC Taylor & Francis, Boca Raton

    Google Scholar 

  • Doerr W (1959) Histopathologie des Reizbildungs- und Reizlei­tungssystems des Herzens. Verh Dtsch Ges Inn Med 65:459–495

    PubMed  CAS  Google Scholar 

  • Doerr W (1969) Normale und pathologische Anatomie des reizbildenden und erregungsleitenden Gewebes. Verh Dtsch Ges Herz Kreislauffors 35:1–36

    CAS  Google Scholar 

  • Doerr W (1975) Morphologische Äquivalente bei Rhythmus­störungen des Herzens. Verh Dtsch Ges Inn Med 81:36–69

    PubMed  CAS  Google Scholar 

  • Doerr W (1980) Sekundenherztod. Beitr Gerichtl Med 39:1–25

    Google Scholar 

  • Drescher JZP, Verhagen W, Flik J, Milbradt H (1987) Recent influenza virus A infections in forensic cases of sudden unexplained death. Arch Virol 92:63–76

    PubMed  CAS  Google Scholar 

  • Drory TY, Hiss Y (1991) Sudden unexpected death in persons less than 40 years of age. Am J Cardiol 68:1388–1392

    PubMed  CAS  Google Scholar 

  • Druyts-Voets E, van Renterghem L, Gerniers S (1993) Epidemiology. Coxsackie B virus epidemiology and neonatal infection in Belgium. J Infect 27:311–316

    PubMed  CAS  Google Scholar 

  • Eber B, Kilzer K, Luha O, Schumacher M, Fruhwald FM, Gasser R, Klein W (1991) Coronary artery anomalies in adulthood. Wien Med Wochenschr 141:406–411

    PubMed  CAS  Google Scholar 

  • Edston E, Perskvist N (2009) Histiocytoid cardiomyopathy and ventricular non-compaction in a case of sudden death in a female infant. Int J Legal Med 123:47–53

    Google Scholar 

  • Edston E, Grontoft L, Johnsson J (2002) TUNEL: a useful screening method in sudden cardiac death. Int J Legal Med 116:22–26

    PubMed  Google Scholar 

  • Edwards WD, Holmes DR Jr, Reeder GS (1982) Diagnosis of active lymphocytic myocarditis by endomyocardial biopsy. Quantitative criteria for light microscopy. Mayo Clin Proc 57:419–425

    PubMed  CAS  Google Scholar 

  • Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, Dubourg O, Kühl U, Maisch B, McKenna WJ, Montserrat L, Pankuweit S, Rapezzi C, Seferovic P, Tavazzi L, Keren A (2008) Classification of the cardiomyopathies; a position statement from the European Society of Cardiology Working Group on myocardial and pericardial diseases. Eur Heart J 29:270–277

    PubMed  Google Scholar 

  • Enders G, Dotsch J, Bauer J et al (1998) Life-threatening parvovirus B19-associated myocarditis and cardiac transplantation as possible therapy: two case reports. Clin Infect Dis 26:355–358

    PubMed  CAS  Google Scholar 

  • Engberding S, Bender F (1984) Identification of a rare congenital anomaly of the myocardium by two dimensional echocardiography: persistence of isolated myocardial sinusoids. Am J Cardiol 53:1733–1734

    PubMed  CAS  Google Scholar 

  • Eston E, Perskvist N (2009) Histiocytoid cardiomyopathy and ventricular non-compaction in a case of sudden death in a female infant. Int J Legal Med 123:47–53

    Google Scholar 

  • Fairley CK, Ryan M, Wall PG, Weinberg J (1996) The organisms reported to cause infective myocarditis and pericarditis in England and Wales. J Infect 32:223–225

    PubMed  CAS  Google Scholar 

  • Fechner GG, Sivaloganathan S (1987) Demonstration of myocardial infarction in putrefying bodies. J Clin Pathol 40:922–929

    PubMed  CAS  Google Scholar 

  • Feldmann AM, McNamara D (2000) Myocarditis. N Engl J Med 343:1388–1398

    Google Scholar 

  • Ferrans VJ, McAllister HA, Haese WH (1976) Infantile cardiomyopathy with histiocytoid change in cardiac muscle cells. Report of six patients. Circulation 53:708–719

    PubMed  CAS  Google Scholar 

  • Ferreira AG, Trotter SE, König B, Décourt LV, Fox K, Olsen EG (1991) Myocardial bridges: morphological and functional aspects. Br Heart J 66:364–367

    PubMed  Google Scholar 

  • Figulla HR (2004) Transformation of myocarditis and inflammatory cardiomyopathy to idiopathic dilated cardiomyopathy: facts and fiction. Med Microbiol Immunol 193:61–64

    PubMed  Google Scholar 

  • Fineschi V, Pomara C (2004) A forensic pathological approach to sudden cardiac death. In: Tsokos M (ed) Forensic pathology reviews, vol 5. Humana, Totawa, pp 139–168

    Google Scholar 

  • Fineschi V, Neri M, Riezzo I, Turillazzi E (2004) Sudden cardiac death due to hypersensitivity myocarditis during clozapine treatment. Int J Legal Med 118:307–309

    PubMed  Google Scholar 

  • Fineschi V, Baroldi G, Silver MA (2006) Pathology of the heart and sudden death in forensic medicine. CRC press, Boca Raton

    Google Scholar 

  • Fineschi V, Michalodimitrakis M, D’Errico S, Neri M, Pomara C, Turillazzi E (2010) Insight into stress-induced cardiomyopathy and sudden cardiac death due to stress. A forensic cardio-pathologist point of view. Forensic Sci Int 194:1–8

    PubMed  Google Scholar 

  • Finsterer J (2008) Histiocytoid cardiomyopathy: a mitochondrial disorder. Clin Cardiol 31:225–227

    PubMed  Google Scholar 

  • Finsterer J, Stöllberger C (2009) Is mitochondrial disease the common cause of histocytoid cardiomyopathy and non-compaction? Int J Legal Med 123:507–508

    PubMed  Google Scholar 

  • Finsterer J, Stöllberger C, Karner J, Keller H, Feichtinger F (2007) Left ventricular hypertrabeculation (noncompaction) with prominent calcifications in a patient with mannose-binding lectin deficiency and unclassified myopathy. Cardiovasc Pathol 16:310–312

    PubMed  CAS  Google Scholar 

  • Fischbein MC, Kulber D, Stancl M, Edwalds G (1986) Distribution of fibrinogen and albumin in normal, ischaemic, and necrotic myocardium during the evolution of myocardial infarction: an immunohistochemical study. Cardiovasc Res 20:36–41

    Google Scholar 

  • Fraser WJ, Haffejee Z, Cooper K (1995) Rheumatic Aschoff nodules revisited: an immunohistological reappraisal of the cellular component. Histopathology 27:457–461

    PubMed  CAS  Google Scholar 

  • Frenzel H, Schwartzkopff B, Reinecke P, Kamino K, Lösse B (1987) Evidence for muscle fiber hyperplasia in the septum of patients with hypertrophic obstructive cardiomyopathy (HOCM). Quantitative examination of endomyocardial ­biopsies (EMCB) and myectomy specimens. Z Kardiol 76(suppl 3):14–19

    PubMed  Google Scholar 

  • Friman G, Fohlman J (1993) The epidemiology of viral heart disease. Scand J Infect Dis 88(suppl):7–10

    CAS  Google Scholar 

  • Friman G, Wesslen L, Fohlman J, Karjalainen J, Rolf C (1995) The epidemiology of infectious myocarditis, lymphocytic myocarditis and dilated cardiomyopathy. Eur Heart J 16(suppl O):36–41

    PubMed  Google Scholar 

  • Grady KL, Costanzo-Nordin MR (1989) Myocarditis: review of a clinical enigma. Heart Lung 18:347–354

    PubMed  CAS  Google Scholar 

  • Greve G, Rotevath S, Svendby K, Grong K (1990) Early morphologic changes in cat heart muscles cells after acute coronary artery occlusion. Am J Pathol 136:273–283

    PubMed  CAS  Google Scholar 

  • Hagemeier L, Madea B (2009) Ursprungsanomalie der rechten Koronararterie und Roemhild-Syndrom – Ursache eines plötzlichen Todes. Rechtsmedizin 19:30–33

    Google Scholar 

  • Hagemeier L, Mohr C, Schyma C et al (2010) Diagnose der arrythmogenen rechtsventrikulären Kardiomyopathie. Histomorphometrisches Verfahren zum postmortalen Nachweis. Rechtsmedizin 20:13–18

    Google Scholar 

  • Hamilton RA, Sullivan L, Wolf BC (2007) Sudden cardiac death due to giant cell inflammatory porcesses. J Forensic Sci 52:943–948

    PubMed  Google Scholar 

  • Hansen PR (2007) Takotsubo cardiomyopathy: an under-recognized myocardial syndrome. Eur J Intern Med 18:561–565

    PubMed  Google Scholar 

  • Hansen SH, Rossen K (1999) Evaluation of cardiac troponin I immunoreaction in autopsy hearts: a possible marker of early myocardial infarction. Forensic Sci Int 99:189–196

    PubMed  CAS  Google Scholar 

  • Hauck AJ, Kearney DL, Edwards W (1989) Evaluation of postmortem endomyocardial biopsy specimens from 38 patients with lymphocytic myocarditis: implications for role of sampling error. Mayo Clin Proc 64:1235–1245

    PubMed  CAS  Google Scholar 

  • Hayes MA, Russell RG, Babiuk LA (1979) Sudden death in young dogs with myocarditis caused by parvovirus. J Am Vet Med Assoc 174:1197–1203

    PubMed  CAS  Google Scholar 

  • Hebert MM, Yu C, Towbin JA, Rogers BB (1995) Fatal Epstein-Barr Virus myocarditis in a child with repetitive myocarditis. Pediatr Pathol Lab Med 15:805–812

    PubMed  CAS  Google Scholar 

  • Hermido-Prieto M, Montserrat L, Castro-Beiras A, Laredo R, Soler R, Peteiro J, Rodriguez E, Bouzasa B, Alvarez N, Muniz J et al (2004) Familial dilated cardiomyopathy and isolated left ventricular noncompaction associated with lamin A/C gene mutations. Am J Cardiol 94:50–54

    Google Scholar 

  • Herzum M, Maisch B (1988) Humoral and cellular immune response in human myocarditis and dilated cardiomyopathy. Pathol Immunopathol Res 7:240–250

    PubMed  CAS  Google Scholar 

  • Holczabek W (1970) Über das histologische Bild der ischämischen Schädigung des Herzfleisches bei Anwendung der Weinsteinsäure-Kresylechtviolett-Einschlußfärbung. Beitr Gericht Med 27:275

    CAS  Google Scholar 

  • Holczabek W (1973) Nachweis von Isoprotenerol-bedingten Herzmuskelschäden an der Ratte mittels der Weinsteinsäure-Kresylechtviolett-Einschlußfärbung. Beitr Gerichtl Med 30:175

    PubMed  CAS  Google Scholar 

  • Hort W (1965) Ventrikeldilatation und Muskelfaserdehnung als früheste morphologische Befunde beim Herzinfarkt. Virchows Arch 339:72

    CAS  Google Scholar 

  • Hort W (ed) (2000) Pathologische Anatomie des Herzens und seiner Hüllen II. Pathologie des Endokard, der Kranzarterien und des Myokard. Springer, Berlin, Heidelberg, New York, Tokio

    Google Scholar 

  • Hu BJ, Chen YC, Zhu JZ (2002) Study on the specificity of fibronectin for post-mortem diagnosis of early myocardial infarction. Med Sci Law 42:195–199

    PubMed  Google Scholar 

  • Huber SA, Gauntt CJ, Sakkinen P (1999) Enteroviruses and myocarditis: viral pathogenesis through replication, cytokine induction, and immunopathogenicity. Adv Virus Res 51:35

    Google Scholar 

  • Huckenbeck W, Papadomanolakis A (2005) Right and left ventricular Arrythmogenic Dysplasia. Pathological features and medicolegal significance. In: Tsokos M (ed) Forensic pathology reviews, vol 3. Humana Press, Totowa, pp 253–165

    Google Scholar 

  • Hudson REB (1960) The human pacemaker and its pathology. Br Heart J 22:153–167

    PubMed  CAS  Google Scholar 

  • Hudson REB (1963) The human conducting-system and its examination. J Clin Pathol 16:492–499

    PubMed  CAS  Google Scholar 

  • Hufnagel G, Maisch B (1991) Expression of MHC class I and II antigens and the IL-2 receptor in rejection, myocarditis and dilated cardiomyopathy. Eur Heart J 12(suppl D):137–140

    PubMed  Google Scholar 

  • Ichida F, Tsubata S, Bowles KR, Haneda N, Uese K, Miyawaki T, Dreyer WJ, Messina J, Li H, Bowles NE et al (2001) Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome. Circulation 103:1256–1263

    PubMed  CAS  Google Scholar 

  • Iino M, Kimura T, Abiru H, Kaszynski RH, Yuan QH, Tsuruyama T, Tamaki K (2007) Unexpected sudden death resulting from anomalous origin of the right coronary artery from the left sinus of Valsalva: a case report involving identical twins. Leg Med 9:25–29

    Google Scholar 

  • Ishikawa T, Zhu BL, Li DR, Zhao D, Maeda H (2005) Epstein-Barr virus myocarditis as a cause of sudden death: two autopsy cases. Int J Legal Med 119:231–235

    PubMed  Google Scholar 

  • Ishiyama I, Kamiya M, Rose M, Komuro E, Takatsu A (1982) Fulminant deletion of myoglobin from myocardial fibers in state of acute cardiac failure including sudden cardiac arrest. Lancet 2:1468–1469

    PubMed  CAS  Google Scholar 

  • Jääskeläinen AJ (1968) Enzymhistochemischer Nachweis des frischen Myokardinfarkts bei Fällen von vermutetem gewaltsamem Tod. Dtsch Z Gerichtl Med 64:1–8

    Google Scholar 

  • James TN, Marshall TK (1976) Multifocal stenosis due to fibromuscular dysplasia of the sinus node artery. Circulation 53:736–742

    PubMed  CAS  Google Scholar 

  • Janssen W (1968) Zur Arteriosklerose der Coronararterien jugendlicher Menschen. Morphologische und forensische Bedeutung. Dsch Zschr Gerichtl Med 62:39–50

    CAS  Google Scholar 

  • Janssen W (1975) Todesfälle im Rahmen emotionaler Belastung. Beitr Gerichtl Med 33:97–102

    PubMed  CAS  Google Scholar 

  • Janssen W (1977) Forensische histologie. Schmidt-Römhild, Lübeck

    Google Scholar 

  • Janssen W (1984) Forensic histopathology. Springer, Berlin, Heidelberg, New York, Tokio, pp 187–190

    Google Scholar 

  • Jenni R, Wyss CA, Eochslin EN, Kaufmann PA (2002) Isolated ventricular noncompaction is associated with coronary microcirculatory dysfunction. J Am Coll Cardiol 39:450–454

    PubMed  Google Scholar 

  • Jiang WX, Gao C, Sun J, Bunai Y (2009) Sudden cardiac death caused by a primary intimal sarcoma of the left coronary artery. Int J Legal Med 123:503–506

    PubMed  Google Scholar 

  • Jin O, Sole M, Butany JW, Chia WK, McLaughlin PR, Liu P et al (1990) Detection of enterovirus RNA in myocardial biopsies from patients with myocarditis and cardiomyopathy using gene amplification by polymerase chain reaction. Circulation 82:8–16

    PubMed  CAS  Google Scholar 

  • Joswig BC, Warren SE, Vieweg WV, Hagan AD (1978) Transmural myocardial infarction in the absence of coronary arterial luminal narrowing in a young man with single coronary arterial anomaly. Cathet Cardiovasc Diagn 4:297–304

    PubMed  CAS  Google Scholar 

  • Kandolf R (1995a) Molekulare Pathogenese der Entero­virusmyokarditits. Viruspersistenz und chronische Entzün­dung. Internist 36:430–438

    PubMed  CAS  Google Scholar 

  • Kandolf R (1995b) Molekulare Pathogenese der Enterovirus­myokarditis. Viruspersistenz und chronische Entzündung. Internist 36:438

    Google Scholar 

  • Kandolf R, Ameis D, Kirschner P, Canu A, Hofschneider PH (1987) In situ detection of enteroviral genomes in myocardial cells by nucleic acid hybridization: an approach to the diagnosis of viral heart disease. Proc Natl Acad Sci USA 84:6272–6276

    PubMed  CAS  Google Scholar 

  • Kandolf R, Klingel K, Zell R, Canu A, Fortmuller U, Hohenadl C et al (1993a) Molecular mechanisms in the pathogenesis of enteroviral heart disease: acute and persistent infections. Clin Immunol Immunopathol 68:153–158

    PubMed  CAS  Google Scholar 

  • Kandolf R, Klingel K, Zell R, Canu A, Fortmuller U, Hohenadl C et al (1993b) Molecular mechanisms in the pathogenesis of enteroviral heart disease: acute and persistent infections. Clin Immunol Immunopathol 68:153–158

    PubMed  CAS  Google Scholar 

  • Karch SB (2009) Karch’s pathology of drug abuse, 4th edn. CRC Press, Boca Raton, p 101

    Google Scholar 

  • Karch SB, Billingham ME (1986) Myocardial contraction band revisited. Hum Pathol 17:9–13

    PubMed  CAS  Google Scholar 

  • Karjalainen J, Heikkila J (1999) Incidence of three presentations of acute myocarditis in young men in military service. A 20-year experience. Eur Heart J 20:1120–1125

    PubMed  CAS  Google Scholar 

  • Karjalainen J, Nieminen M, Heikkila J (1980) Influenza A1 myocarditis in conscripts. Acta Med Scand 207:27–30

    PubMed  CAS  Google Scholar 

  • Kauferstein S, Kiehne N, Neumann T, Pitschner HF, Bratzke H (2009) Cardiac gene defects can cause sudden cardiac death in young people. Dtsch Arztebl Int 106:41–47

    PubMed  Google Scholar 

  • Kawai C (1999) From myocarditis to cardiomyopathy: Mechanisms of inflammation and cell death. Circulation 99:1091–1100

    PubMed  CAS  Google Scholar 

  • Kawai C, Matsumori A, Fujiwara H (1987) Myocarditis and dilated cardiomyopathy. Annu Rev Med 38:221–239

    PubMed  CAS  Google Scholar 

  • Kawano H, Okada R, Kawano Y, Sueyoshi N, Shirai T (1994) Apoptosis in acute and chronic myocarditis. Jpn Heart J 35:745–750

    PubMed  CAS  Google Scholar 

  • Kenton AB, Sanchez X, Coveler KJ, Kavar KA, Jiminez S, Ichida F, Murphy RT, Elliott PM, McKenna W, Bowles NE et al (2004) Isolated left ventricular noncompaction is rarely caused by mutations in G4.5, alpha-dystrobrevin and FK Binding Protein-12. Mol Genet Metab 82:162–166

    PubMed  CAS  Google Scholar 

  • Kittulwatte ID, Kim PJH, Pollanen MS (2010) Sudden death related myocarditis: a study of 56 cases. Forensic Sci Med Pathol 6:13–19

    Google Scholar 

  • Klages U, Gerken F (1972) Eine Methode zur Objektivierung fraglicher entzündlicher Zellvermehrung im Interstitium des Herzmuskels. Beitr Z Gerichtl Med 14:429

    Google Scholar 

  • Klein RM, Vester EG, Perings C, Strauer BE (1995) Arrhythmien bei Myokarditis. Internist 36:458–468

    PubMed  CAS  Google Scholar 

  • Klein RM, Vester EG, Brehm MU et al (2000) Entzündung des Myokards als Arrhythmietrigger. Z Kardiol 89(suppl 3):24–35

    PubMed  Google Scholar 

  • Klingel K, Kandolf R (2009) Virale Myokarditis im Kindesalter. Stellenwert der modernen kardiopathologischen Diagnostik. Rechtsmedizin 18:349–358

    Google Scholar 

  • Klingel K, Albrecht M, Canu A, Hofschneider PH, Kandolf R (1992a) Molekulare Pathogenese der Myokarditis: Viruspersistenz und chronische Herzmuskelentzündung. Verh Dtsch Ges Path 76:394

    Google Scholar 

  • Klingel K, Hohenadl C, Canu A et al (1992b) Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage and inflammation. Proc Natl Acad Sci USA 89:314–318

    PubMed  CAS  Google Scholar 

  • Klingel K, Selinka HC, Huber M, Sauer M, Leube M, Kandolf R (2000) Molecular pathology and structural features of enteroviral replication. Towards understanding the pathogenesis of viral heart disease. Heart 25:216–220

    CAS  Google Scholar 

  • Klingel K, Sauer M, Bock CT, Szalay G, Schnorr JJ, Kandolf R (2004) Molecular pathology of inflammatory cardiomyopathy. Med Microbiol Immunol 193:101–107

    PubMed  CAS  Google Scholar 

  • Klump WM, Bergmann I, Muller BC, Ameis D, Kandolf R (1990) Complete nucleotide sequence of infectious Coxsackievirus B3 cDNA: two initial 5′ uridine residues are regained during plus-strand RNA syntheses. J Virol 64:1573–1583

    PubMed  CAS  Google Scholar 

  • Knight B (1967) Early myocardial infarction: practical methods for its postmortem demonstration. J Forensic Med 14:101–107

    PubMed  CAS  Google Scholar 

  • Korb G, Knorr G (1962) Vergleichende licht- und fluoreszenzmikroskopische Untersuchungen frischer Herzmuskelschäden beim Menschen. Virchows Arch 335:159

    CAS  Google Scholar 

  • Kühl U, Daun B, Seeberg B, Schultheiss HP, Strauer BE (1992) Dilatative Kardiomyopathie – eine chronische Myokarditits? Herz 17:97–106

    PubMed  Google Scholar 

  • Kühl U, Noutsias M, Seeberg B, Schannwell M, Welp LB, Schultheiss HP (1994) Chronic inflammation in the myocardium of patients with clinically suspected dilated cardiomyopathy. J Card Fail 1:13–25

    PubMed  Google Scholar 

  • Kühl U, Noutsias M, Seeberg B, Schultheiß HP (1996) Immunohistochemical analysis of the chronic inflammatory process in dilated cardiomyopathy. Heart 75:295–300

    PubMed  Google Scholar 

  • Kühl U, Pauschinger M, Schultheiss HP (1997) Neue Konzepte zur Diagnostik der entzündlichen Herzmuskelerkrankung. Dtsch Med Wochenschr 122:690–698

    PubMed  Google Scholar 

  • Kühl U, Pauschinger M, Bock T, Klingel K, Schwimmbeck CPL, Seeberg B, Krautwurm L, Poller W, Schultheiss HP, Kandolf R (2003) Parvovirus B19 infection mimicking acute myocardial infarction. Circulation 108:945–950

    PubMed  Google Scholar 

  • Kytö V, Vuorinen T, Saukko P, Lautenschlager I, Lignitz E, Saraste A, Voipio-Pulkki LM (2005) Cytomegalovirus infection of the heart is common in patients with fatal myocarditis. Clin Infect Dis 40:683–688

    PubMed  Google Scholar 

  • Lang C, Sauter M, Szalay G, Racchi G, Grassi G, Rainaldi G, Mercantanti A, Lang F, Kandolf R, Klingel K (2008) Connective tissue growth factor: a crucial cytokine-mediating cardiac fibrosis in ongoing enterovirus myocarditis. J Mol Med 86:49–60

    PubMed  CAS  Google Scholar 

  • Langlois NE (2009) Sudden adult death. Forensic Sci Med Pathol 5:210–232

    PubMed  Google Scholar 

  • Lau RCH (1983) Coxsackie B Virus infections in New Zealand patients with cardiac and non-cardiac diseases. J Med Virol 11:131–137

    PubMed  CAS  Google Scholar 

  • Lau G (1994) Acute fulminant fatal coxsackie B virus infection: a report of two cases. Ann Acad Med Singapore 23:917–920

    PubMed  CAS  Google Scholar 

  • Lauer B, Schulze K, Kühl U, Pauschinger M, Schwimmbeck PL, Strauer BE, Schultheiss HP (1998) Biphasischer Verlauf der linksventrikulären Funktion bei einer 22 jährigen Patientin mit akuter Myokarditis. Dtsch Med Wochenschr 123:74–80

    PubMed  CAS  Google Scholar 

  • Lazaros GA, Stefanaki KS, Panayiotides IG, Tzardi MN, Vlachonikolis IG, Kanavaros PE, Delides GS (1998) Nuclear morphometry of the myocardial cells as a diagnostic tool in cases of sudden death due to coronary thrombosis. Forensic Sci Int 96:173–180

    PubMed  CAS  Google Scholar 

  • Leadbetter S, Wawman HM, Jasani B (1989) Immunocytochemical diagnosis of early myocardial ischaemic/hypoxic damage. Forensic Sci Int 40:171–180

    Google Scholar 

  • Leadbetter S, Wawman HM, Jasani B (1990) Further evaluation of immunocytochemical staining in the diagnosis of early myocardial ischaemic/hypoxic damage. Forensic Sci Int 45:135–141

    Google Scholar 

  • Lenègre J, Chevalier H (1951) Note technique préliminaire concernant l’étude histologique de la cloison du cœur. Arch Mal Cœur 44:512–524

    PubMed  Google Scholar 

  • Lentini S, Klingel K, Skowasch R, Kandolf R, Bauriedel G (2001) Epstein-Barr Virus assoziierte Perikarditis. Dtsch Med Wochenshr 126:1043–1046

    CAS  Google Scholar 

  • Lev M, Kinave SG, Pick A (1970) The pathogenesis of atrioventricular block in coronary disease. Circulation 42:409–426

    PubMed  CAS  Google Scholar 

  • Lev M, Nordenberg A, Carvalho AG, Bharati S, Rosen K, Varghese JP, Bauernfeind RA (1979) The anatomic substrate for the sick sinus syndrome in adolescence. Circulation 59/60(suppl II):437

    Google Scholar 

  • Li Y, Bourlet T, Andreoletti L, Mosnier JF, Peng T, Yang Y, Archard LC, Pozzetto B, Zhang H (2000) Enteroviral capsid protein is present in myocardial tissues from some patients with myocarditis or dilated cardiomyopathy. Circulation 101:231–234

    PubMed  CAS  Google Scholar 

  • Lie JT (1968) Detection of early myocardial infarction by the acid fuchsin staining technic. Am J Clin Pathol 50:317–319

    PubMed  CAS  Google Scholar 

  • Lie JT, Holley KE, Kampa WR, Titus IL (1971) New histochemical method for morphologic diagnosis of early stages of myocardial ischemia. Mayo Clin Proc 46:319–327

    PubMed  CAS  Google Scholar 

  • Lin YT, Chen CH, Ding PY (1998) Evolution of dilated cardiomyopathy from hypertrophic obstructive cardiomyopathy in a child. J Formos Med Assoc 97:416–419

    PubMed  CAS  Google Scholar 

  • Linder J, Cassling RS, Rogler WC, Wilson JE, Markin RS, Sears TD, McManus BM (1985) Immunohistochemical characterization of lymphocytes in uninflamed ventricular myocardium. Arch Pathol Lab Med 109:917–920

    PubMed  CAS  Google Scholar 

  • Lipsett J, Cohle SD, Berry PJ, Russell G, Byard RW (1994) Anomalous coronary arteries: a multicenter pediatric autopsy study. Pediatr Pathol 14:287–300

    PubMed  CAS  Google Scholar 

  • Liu PP, Mason JW (2001) Advances in the understanding of myocarditis. Circulation 104:1076–1082

    PubMed  CAS  Google Scholar 

  • Lobo FV, Ha H, Butany J et al (1992) Right ventricular dys­plasia: morphological findings in 13 cases. Can J Cardiol 8:261–268

    PubMed  CAS  Google Scholar 

  • Löffler W (1936) Endocarditis parietalis fibroplastica mit Bluteosinophilie. Ein eigenartiges Krankheitsbild. Schweiz Med Wochenschr 66:817

    Google Scholar 

  • Lozinski GM, Davis GG, Krous HF, Billman GF, Shimizu H, Burns JC (1994) Adenovirus myocarditis: retrospective diagnosis by gene amplification from formalin-fixed, paraffin-embedded tissues. Hum Pathol 25:831–834

    PubMed  CAS  Google Scholar 

  • Madea B, Dettmeyer R (1998) Sudden death in cases with anomalous origin of the left coronary artery. Forensic Sci Int 96:91–100

    PubMed  CAS  Google Scholar 

  • Maisch B (1994) Myokarditis. Internist 35:91–93

    PubMed  CAS  Google Scholar 

  • Maisch B, Schönian U, Crombach M, Wendl I, Bethge C, Herzum M et al (1993) Cytomegalovirus associated inflammatory heart muscle disease. Scand J Infect Dis Suppl 88:135–148

    PubMed  CAS  Google Scholar 

  • Maisch B, Schönian U, Herzum M, Hufnagel G (1995) Immunserologische und immunhistologische Untersuchungen bei Myokarditis und Perikarditis. Internist 36:448–457

    PubMed  CAS  Google Scholar 

  • Maisch B, Portig I, Ristic A, Hufnagel G, Pankuweit S (2000) Definition of inflammatory cardiomyopathy (myocarditis): on the way to consensus. Herz 25:200–209

    PubMed  CAS  Google Scholar 

  • Mall G (1995) Morphologie der myokarditis. Internist 36:426–429

    PubMed  CAS  Google Scholar 

  • Mallory GK, White PD, Salcedo Salgar J (1939) The speed of healing of myocardial infarction. A study of the pathologic anatomy in seventy-two cases. Am Heart J 18:647

    Google Scholar 

  • Maron BJ (2002) Hypertrophic cardiomyopathy: a systemic review. JAMA 287:1308–1320

    PubMed  Google Scholar 

  • Maron BJ, Bonow RO, Cannon RO, Leon MB, Epstein SE (1997) Hypertrophic cardiomyopathy: interrelations of clinical manifestations, pathophysiology, and therapy: parts 1 and 2. N Engl J Med 316:780–789, 844–852

    Google Scholar 

  • Maron BJ, Towbin JA, Thiene G, Antzelevith C, Corrado D, Arnett D, Moss AJ, Seidman CE, Young JB (2006) Contem­porary definitions and classifications of the cardiomyopathies: an American heart association scientific statement from the council on clinical cardiology, heart failure and transplantation committee; quality of care and outcomes research and functional genomics and translational biology interdisciplinary working group; and council on epidemiology and prevention. Circulation 113:1807–1816

    PubMed  Google Scholar 

  • Martin AB, Webber S, Fricker FJ, Jaffe R, Demmler G, Kearney D et al (1994) Acute myocarditis: rapid diagnosis by PCR in children. Circulation 90:330–339

    PubMed  CAS  Google Scholar 

  • Martino TA, Liu P, Sole MJ (1994) Viral infection and the pathogenesis of dilated cardiomyopathy. Circ Res 74:182–188

    PubMed  CAS  Google Scholar 

  • Martino TA, Liui P, Petric M, Sole MJ (1995) Enteroviral myocarditis and dilated cardiomyopathy: a review of clinical and experimental studies. In: Rothbard HA (ed) Human enterovirus infections. American Society for Microbiology, Washingtin DC, pp 291–350

    Google Scholar 

  • Matejic D, Schönfeld C, Tsokos M (2010) Plötzlicher Tod bei akuter idiopathischer Riesenzellmyokarditis. Rechtsmedizin 20:275–277

    Google Scholar 

  • McCaffrey FM, Braden DS, Strong WB (1991) Sudden cardiac death in young athletes. Am J Dis Child 145:177–183

    PubMed  CAS  Google Scholar 

  • McConnell SE, Collins KA (1998) Sudden unexpected death from an anomalous hypoplastic left coronary artery. J Forensic Sci 43:708–711

    PubMed  CAS  Google Scholar 

  • McConnell MV, Ganz P, Selwyn AP, Li W, Edelmann RR, Manning WJ (1995) Identification of anomalous coronary arteries and their anatomic course by magnetic resonance coronary angiography. Circulation 92:3158–3162

    PubMed  CAS  Google Scholar 

  • McKenna WJ, Thiene G, Nava A et al (1994) Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Br Heart J 71:215–218

    PubMed  CAS  Google Scholar 

  • McVie JG (1970) Postmortem detection of inapparent myocardial infarction. J Clin Pathol 23:203–209

    PubMed  CAS  Google Scholar 

  • Metze K, Meves R, Moreira PRS (1993) Seasonal variation in rheumatic heart disease – letter to the editor. Int J Cardiol 38:01–102

    Google Scholar 

  • Michaud K, Romain N, Taroni F, Horisberger B, Mangin P (2002) Evaluation of a simplified method of the conduction system analysis in 110 forensic cases. Forensic Sci Int 130:13–24

    PubMed  Google Scholar 

  • Michaud K, Mangin P, Elger BS (2011) Genetic analysis of sudden cardiac death victims: a survey of current forensic autopsy practices. Int J Legal Med 125:359–366

    PubMed  Google Scholar 

  • Mihatsch MJ (1988) Die Morphologie des Myokardinfarkts. Schweiz Med Wochenschr 118:1688–1691

    PubMed  CAS  Google Scholar 

  • Milei J, Bortman G, Fernandez-Alonso G, Grancelli H, Beigelman R (1990) Immunohistochemical staining of ­lymphocytes for the reliable diagnosis of myocarditis in endomyocardial biopsies. Cardiology 77:77–85

    PubMed  CAS  Google Scholar 

  • Miller R, Ward C, Amsterdam E (1973) Focal mononucleosis myocarditis simulating myocardial infarction. Chest 63:102–105

    PubMed  CAS  Google Scholar 

  • Möhlenkamp S, Wort W, Ge J, Erbel R (2002) Update on myocardial bridging. Circulation 106:2616–2622

    PubMed  Google Scholar 

  • Moral GL, Rubio-Calduch EM, Broto-Escapa P, Caballero-Requero E, Calico-Bosch I, Bertran-Sangues JM (1993) Enteroviral infections in children: clinical and epidemiological findings in 530 patients (1984–1991). An Esp Pediatr 39:521–527

    Google Scholar 

  • Mounts AW, Amr S, Jamshidi R, Graves C, Dwyer D, Guarner J et al (2001) A cluster of fulminant myocarditis cases in children, Baltimore, Maryland, 1997. Pediatr Cardiol 22:34–39

    PubMed  CAS  Google Scholar 

  • Muir P (1993) Enteroviruses and heart disease. Br J Biomed Sci 50:258–271

    PubMed  CAS  Google Scholar 

  • Mund MT, Hailemariam S, Gathomas G (2002) Die arrhythmogene rechtsventrikuläre Kardiomyopathie als Ursache des plötzlichen Herztodes. Rechtsmedizin 12:371–374

    Google Scholar 

  • Murry CE, Jerome KR, Reichenbach DD (2001) Fatal parvovirus myocarditis in an 5-year-old girl. Hum Pathol 32:342–345

    PubMed  CAS  Google Scholar 

  • Murty OP (2008) Giant cell myocarditis with cardiac tamponade. Am J Forensic Med Pathol 29:245–248

    PubMed  CAS  Google Scholar 

  • Narula J, Haider N, Virmani R, DiSalvo TG, Kolodgie FD, Hajjar RJ et al (1996) Apoptosis in myocytes in end-stage heart failure. N Engl J Med 335:1182–1189

    PubMed  CAS  Google Scholar 

  • Nishida N, Ikeda N, Kudo K, Tsuji A, Kiyoshima A (2002) Forensic significance of conduction system abnormalities as a precise cause of accidental death. Int J Legal Med 116:344–349

    PubMed  CAS  Google Scholar 

  • Noutsias M, Seeberg B, Schultheiß HP (1996) Immunohistological evidence for a chronic intramyocardial process in dilated cardiomyopathy. Heart 75:295–300

    PubMed  Google Scholar 

  • Noutsias M, Seeberg B, Schultheiss HP, Kühl U (1999) Expression of cell adhesion molecules in dilated cardiomyopathy. Evidence for endothelial activation in inflammatory cardiomyopathy. Circulation 99:2124–2131

    PubMed  CAS  Google Scholar 

  • Noutsias M, Fechner H, de Jonge H, Wand X, Dekkers D, Houtsmuller AB, Pauschinger M, Bergelson JM, Warraich R, Yacoub M et al (2001) Human coxsackie-adenoviruses receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. Circulation 104:275–280

    PubMed  CAS  Google Scholar 

  • Noutsias M, Pauschinger M, Kühl U, Schultheiss HP (2002) Myokarditis und dilatative Kardiomyopathie. Neue Wege in Diagnostik und Therapie. Münch Med Wochenschr 144:36–40

    CAS  Google Scholar 

  • Oechslin EN, Attenhofer JCH, Rojas JR, Kaufmann PA, Jenni R (2000) Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct cardiomyopathy with poor prognosis. J Am Coll Cardiol 36:493–500

    PubMed  CAS  Google Scholar 

  • Oehmichen M, Pedal I, Hofmann P (1990a) Diagnostic significance of myofibrillar degeneration of cardiocytes in forensic pathology. Forensic Sci Int 48:163–173

    PubMed  CAS  Google Scholar 

  • Oehmichen M, Pedal I, Hohmann P (1990b) Myofibrilläre Degeneration der Herzmuskulatur: Diagnostische Wertigkeit am ausgesuchten forensisch-pathologischen Fallmaterial. Beitr Gerichtl Med 48:245–249

    PubMed  CAS  Google Scholar 

  • Ogbuihi S (1989) Zum forensischen Stellenwert von Läsionen des Sinusknotens bei unklaren plötzlichen Todesfällen. Z Rechtsmed 102:315–322

    PubMed  CAS  Google Scholar 

  • Ogbuihi S, Fechner G, Brinkmann B (1993) Sudden death due to cardiac sarcoidosis in a case of suspected homicide. Int J Legal Med 106:99–102

    PubMed  CAS  Google Scholar 

  • Okada R, Kawai S (1983) Histopathology of the conduction system in sudden cardiac death. Jpn Circ J 47:573–580

    PubMed  CAS  Google Scholar 

  • Orth T, Herr W, Spahn T et al (1997) Human parvovirus B19 infection associated with severe acute perimyocarditis in an 34-year-old man [letter]. Eur Heart J 18:524–525

    PubMed  CAS  Google Scholar 

  • Osuna E, Perez Carceles MD, Jakobson SW, Luna A (1990) Biochemical and morphological markers in the post mortem diagnosis of ischemic heart distress. Acta Med Leg Soc 40:275–283

    CAS  Google Scholar 

  • Oyer CE, Ongeapin EH, Ni J, Bowles NE, Towbin JA (2000) Fatal intrauterine adenoviral endomyocarditis with aortic and pulmonary valve stenosis: diagnosis by polymerase chain reaction. Hum Pathol 31:1433–1435

    PubMed  CAS  Google Scholar 

  • Pampín JB, Aranzazu García Rivero S, Cepeda JLO, Vázquez Boquete A, Forteza Vila J, Fonseca RH (2006) Immunohistochemical expression of HIF-1-alpha in response to early myocardial ischemia. J Forensic Sci 51:120–124

    Google Scholar 

  • Patel J, Sheppard MN (2011) Cystic tumour of the atrioventricular node: three cases of sudden death. Int J Legal Med 125:139–142

    PubMed  Google Scholar 

  • Pauschinger M, Meissner G, Preis S, Kühl U, Kandolf R, Schultheiss HP et al (1994) Detection of enteroviral RNA by polymerase chain reaction in patients with myocarditis and dilated cardiomyopathy. JACC 1994:880

    Google Scholar 

  • Pauschinger M, Kühl U, Dörner A, Schieferecke K, Petschauer S, Rauch U, Schwimmbeck PL, Kandolf R, Schultheiss HP (1998) Nachweis enteroviraler RNA in endomyokardialen Biopsien bei inflammatorischer Kardiomyopathie und ­idiopathischer dilatativer Kardiomyopathie. Z Kardiol 87:443–452

    PubMed  CAS  Google Scholar 

  • Pedal I (1976) Ursprungsanomalie einer Koronararterie. Dtsch Med Wochenschr 101:1601–1604

    PubMed  CAS  Google Scholar 

  • Pedal I, Oehmichen M (1990) Myofibrilläre Degeneration der Herzmuskulatur: Histologisches Bild und pathophysiologische Bedeutung. Beitr Gerichtl Med 48:237–244

    PubMed  CAS  Google Scholar 

  • Pedal I, Teufel M (1993) Plötzlicher Herztod im Kindesalter durch eine Ursprungsanomalie der Koronararterie. Dtsch Med Wochenschr 118:861–866

    PubMed  CAS  Google Scholar 

  • Pedersen PK (1980) Poor results in attempting to demonstrate the cause of death by examination of the conduction system of the heart in cases of sudden death. Forensic Sci Int 16:281–282

    PubMed  CAS  Google Scholar 

  • Philipps CA, Aronson MD, Tomkow J, Philipps ME (1980) Enteroviruses in Vermont, 1969–1978: an important cause of illness throughout the year. J Infect Dis 141:162–164

    Google Scholar 

  • Philips M, Robiniwitz M, Higgins JR, Boran KJ, Reed T, Virmani R (1986) Sudden cardiac death in air force recruits. JAMA 256:2696–2699

    Google Scholar 

  • Pichotka J (1942) Tierexperimentelle Untersuchungen zur pathologischen Histologie des akuten Höhentodes. Beitr Pathol Anat 197:117

    Google Scholar 

  • Piercecchi-Marti MD, Lepidi H, Leonetti G, Vire O, Cianfarani F, Pellissier JF (2001) Immunostaining by complement C9: a tool for early diagnosis of myocardial infarction and application in forensic medicine. J Forensic Sci 46:328–334

    PubMed  CAS  Google Scholar 

  • Piercecchi-Marti MD, Mohamed H, Chau C, Liprandi A, Fredouille C (2003) Congenital atrioventricular block: histological aspects. Forensic Sci Int 136:12–15

    PubMed  CAS  Google Scholar 

  • Prasad A, Lerman A, Rihal CS (2008) Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J 155:408–417

    PubMed  Google Scholar 

  • Priemer F, Keil W, Kandolf R (1999) Hydrocution in a case of Coxsackie virus infection. Int J Legal Med 112:368–371

    PubMed  CAS  Google Scholar 

  • Raza-Ahmad A (1994) Fibrinogen: a diagnostic marker for early ischemia. Biotech Histochem 69:268–272

    PubMed  CAS  Google Scholar 

  • Richardson P, McKenna W, Bristow M, Maisch B, Mautner B, O’Connell J, Olsen E, Thiene G, Goodwin J, Gyarfas I, Martin I, Nordet P (1996) Report on the 1995 world health organization/international society and federation of cardiology task force on the definition and classification of cardiomyopathies. Circulation 93:841–842

    PubMed  CAS  Google Scholar 

  • Riedel J, Neudorf U, Schmaltz AA (1997) Rasche Progredienz einer hypertrophen Kardiomyopathie in eine dilatative Form – Ungewöhnlicher Verlauf bei einem jugendlichen Patienten. Eine Fallbeschreibung. Z Kardiol 88:427–432

    Google Scholar 

  • Riezzo I, Ventura F, D’Errico S, Neri M, Turillazzi E, Fineschi V (2009) Arrhythmogenesis and diagnosis of cardiac sarcoidosis. An immunohistochemical study in a sudden cardiac death. Forensic Sci Int 183:e1–e5

    PubMed  CAS  Google Scholar 

  • Riße M, Weiler G (1985) Die koronare Muskelbrücke und ihre Beziehungen zu lokaler Koronarsklerose, regionaler Myokar­dischämie und Koronarspasmus. Eine morphometrische Studie. Z Kardiol 74:700–705

    PubMed  Google Scholar 

  • Riße M, Verhoff MA, Dettmeyer R (2008) Kardiale sarkoidose. Rechtsmedizin 18:267–268

    Google Scholar 

  • Roberts WC (1986) Major anomalies of coronary arterial origin seen in adulthood. Am Heart J 111:941–963

    PubMed  CAS  Google Scholar 

  • Roberts WC, Shirami J (1992) The four subtypes of anomalous origin of the left main coronary artery from the right aortic sinus (or from the right coronary artery). Am J Cardiol 70:119–123

    PubMed  CAS  Google Scholar 

  • Rodríguez-Calvo MS, Brion M, Alleque C, Concheiro L, Carracedo A (2008) Molecular genetics of sudden cardiac death. Forensic Sci Int 182:1–12

    PubMed  Google Scholar 

  • Rohayem J, Dinger J, Fischer R et al (2001) Fatal myocarditis associated with acute parvovirus B19 and human herpesvirus 6 coinfection. J Clin Microbiol 39:4585–4587

    PubMed  CAS  Google Scholar 

  • Roynard JL, Cattan S, Artigou JY (1994) Anomalous course of the left anterior descending coronary artery between the aorta and pulmonary trunk: a rare cause of myocardial ischaemia at rest. Br Heart J 72:397–399

    PubMed  CAS  Google Scholar 

  • Ruszkiewicz AR, Vernon-Roberts E (1993) Sudden death in an infant due to histiocytoid cardiomyopathy. A light-microscopic, ultrastructural and immunohistochemical study. Am J Forensic Med Pathol 16:74–80

    Google Scholar 

  • Sahai VB (1976) The post-mortem detection of early myocardial infarction by a simple fluorescent method. Med Sci Law 16:17–20

    PubMed  CAS  Google Scholar 

  • Sandritter W, Thomas C (eds) (1977) Histopathologie. F.K. Schattauer, Stuttgart, New York

    Google Scholar 

  • Santer R (2004) Metabolische Kardiomyopathien. Monatsschrift Kinderheilkd 152:639–648

    Google Scholar 

  • Sasse-Klaassen S, Gerull B, Oechslin E, Jenni R, Thierfelder L (2003) Isolated noncompaction of the left ventricular myocardium in the adult is an autosomal dominant disorder in the majority of patients. Am J Med Genet A 119:162–167

    Google Scholar 

  • Sasse-Klaassen S, Probst S, Gerull B, Oechslin E, Nurnberg P, Heuser A, Jenni R, Hennies HC, Thierfelder L (2004) Novel gene locus for autosomal dominant left ventricular nonc­ompaction maps to chromosome 11p15. Circulation 109:2720–2723

    PubMed  CAS  Google Scholar 

  • Saukko P, Knight B (1989) Evaluation of eosin-fluorescence in the diagnosis of sudden cardiac death. Forensic Sci Int 40:285–290

    PubMed  CAS  Google Scholar 

  • Schäfer H, Mathey D, Hugo F, Bhakdi S (1986) Deposition of the terminal C5b-9 complement complex in infarcted areas of human myocardium. J Immunol 137:1945–1949

    PubMed  Google Scholar 

  • Schaper J, Lorenz-Meyer S, Suzuku K (1999) The role of apoptosis in dilated cardiomyopathy. Herz 24:219–224

    PubMed  CAS  Google Scholar 

  • Schnitt SJ, Ciano PS, Schoen FJ (1987) Quantitation of lymphocytes in endomyocardial biopsies: use and limitations of antibodies to leukocyte common antigen. Hum Pathol 18:796–800

    PubMed  CAS  Google Scholar 

  • Schultheiß HP (1993) Die dilatative Kardiomyopathie – eine chronische Myokarditis? Neue Aspekte zur Diagnostik und Therapie. Z Kardiol 82(suppl 4):25–33

    PubMed  Google Scholar 

  • Schwartz DA, Finkelstein SD, Lumb GD (1988) Fat embolism to the cardiac conduction system associated with sudden death. Hum Pathol 19:116–119

    PubMed  CAS  Google Scholar 

  • Schwartz ML, Cox GF, Lin AE, Korson MS, Perez-Atayde A, Lacro RV, Lishultz SE (1996) Clinical approach to genetic cardiomyopathy in children. Circulation 94:2021–2038

    PubMed  CAS  Google Scholar 

  • Schwartzkopff B, Klein RM, Strauer BE (1995) Diagnostik und Therapie der Myokarditis. Internist 36:469–483

    PubMed  CAS  Google Scholar 

  • Schwartzkopff B, Klein RM, Strauer BE (1998) Evidence of endothelial dysfunction of epicardial coronary arteries in patients with immunohistochemically proven myocarditis. Am Heart J 136:389–397

    PubMed  Google Scholar 

  • Seidman CD, McKenna WJ, Watkins HC, Seidman JG (1992) Molecular genetic approaches to diagnosis and management of hypertrophic cardiomyopathy. In: Braunwald E (ed) Heart disease. A textbook of cardiovascular medicine. W.B. Saunders Co, New York, pp 77–83

    Google Scholar 

  • Seko Y, Tsuchimochi H, Nakamura T, Okumura K, Naito S, Imatako K (1990) Expression of major histocompatibility complex class I antigen in murine ventricular myocytes infected with Coxsackievirus B3. Circ Res 67:360–367

    PubMed  CAS  Google Scholar 

  • Shanes JG, Ghali J, Billingham ME, Ferrans VJ, Fenoglio JJ, Edwards WD, Tsai CC, Saffitz JE, Isner J, Furner S (1987) Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 75:401–405

    PubMed  CAS  Google Scholar 

  • Shekhonin BV, Guriev SB, Irgashev SB, Koteliansky VE (1990) Immunfluorescent identification of fibronection and fibrinogen/fibrin in experimental myocardial infarction. J Mol Cell Cardiol 22:533–541

    PubMed  CAS  Google Scholar 

  • Sigrist T, Germann U (1998) Morphological alterations in the conducting system for the diagnosis of sudden cardiac death. Rechtsmedizin 8:69–72

    Google Scholar 

  • Smith ET, Davis G (1997) Sudden cardiac death associated with hypoplasia of the coronary arteries and conduction system alteration. Am J Forensic Med Pathol 18:189–193

    PubMed  Google Scholar 

  • Song Y, Yao Q, Luo B, Zhu J, Liang S (1991) A simplified method for examining the human cardiac conduction system. Chin J Forensic Med 6:92–93

    Google Scholar 

  • Song Y, Zhu J, Laaksonen H, Saukko P (1997) A modified method for examining the cardiac conduction system. Forensic Sci Int 86:135–138

    PubMed  CAS  Google Scholar 

  • Song Y, Yao Q, Zhu J, Bin L, Shangyon L (1999) Age-related variation in the interstitial tissues of the cardiac conduction system; an autopsy study of 230 Han Chinese. Forensic Sci Int 104:133–142

    PubMed  CAS  Google Scholar 

  • Song Y, Laaksonen H, Saukko P, Toivonen S, Zhu J (2001) Histopathological findings of cardiac conduction system of 150 Finns. Forensic Sci Int 119:310–317

    PubMed  CAS  Google Scholar 

  • Stahl J, Couper RTL, Byard RW (1997) Oncocytic cardiomyopathy: a rare cause of early childhood death associated with fitting. Med Sci Law 37:84–87

    PubMed  CAS  Google Scholar 

  • Steenbergen C, Kolbeck PC, Wolfe JA, Anthony RM, Sanfilippo FP, Jennings RB (1986) Detection of lymphocytes in endomyocardium using immunohistochemical techniques. Relevance to evaluation of endomyocardial biopsies in suspected cases of lymphocytic myocarditis. J Appl Cardiol 1:63–73

    Google Scholar 

  • Steenbergen C, Hill ML, Jennings RB (1987) Cytoskeletal damage during myocardial ischemia: changes in vinculin immunofluorescence staining during total in vitro ischemia in canine heart. Circ Res 60:478–486

    PubMed  CAS  Google Scholar 

  • Stöllberger C, Sporn R, Skala K, Schneider B, Finsterer J (2010) Assault-induced Takotsubo cardiomyopathy associated with persisting anterograde amnesia and myopathy. Int J Legal Med 124:467–470

    PubMed  Google Scholar 

  • Strauer B, Kandolf R, Mall G, Maisch B, Mertens T, Figulla HR et al (2001) Myokarditis – Kardiomyopathie. Update 2001. Med Klin 96:608–625

    CAS  Google Scholar 

  • Suarez-Mier MP, Aguilera B (1998) Histopathology of the conduction system in sudden infant death. Forensic Sci Int 93:143–154

    Google Scholar 

  • Suarez-Mier MP, Fernandez-Simón L, Gawallo C (1995) Pathologic changes of the cardiac conduction tissue in sudden cardiac death. Am J Forensic Med Pathol 16:193–202

    PubMed  CAS  Google Scholar 

  • Takahashi S, Kanetake J, Moriya T, Funayama M (2008) Sudden infant death from dilated cardiomyopathy with endocardial fibroelastosis. Leg Med 10:277–280

    Google Scholar 

  • Tamura A, Kusachi S, Nogami K, Yamanishi A, Kajikawa Y, Hirohata S, Tsuji T (1996) Tenascin expression in endomyocardial biopsy specimens in patients with dilated cardiomyopathy: distribution along margin of fibrotic lesions. Heart 75:291–294

    PubMed  CAS  Google Scholar 

  • Tansey DK, Aly Z, Sheppard MN (2005) Fat in the right ventricle of the normal heart. Histopathology 46:98–104

    PubMed  CAS  Google Scholar 

  • Tausch D (1974) Experimentelle Untersuchungen über den histologischen Nachweis frischer ischämischer Herzmuskelschädigungen mit der Methode nach Lie und Mitarb. Beitr Ger Med 32:274–278

    CAS  Google Scholar 

  • Taylor AJ, Rogan KM, Virman R (1992) Sudden cardiac death associated with isolated congenital coronary anomalies. J Am Coll Cardiol 20:640–647

    PubMed  CAS  Google Scholar 

  • Thierauf A, Dettmeyer R, Wollersen H, Madea B (2007) Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old man. Forensic Sci Int 173:178–181

    PubMed  Google Scholar 

  • Thomsen H, Held H (1995) Immunohistochemical detection of C5b-9 (m) in myocardium: an aid in distinguishing infarction-induced ischemic heart muscle necrosis from other forms of lethal myocardial injury. Forensic Sci Int 71:87–95

    PubMed  CAS  Google Scholar 

  • Thomsen H, Schulz A, Bhakdi S (1990) Immunohistochemische C5b-9-Komplement-Komplex-Darstellung in Frühstadien der Herzmuskelnekrosen am Paraffinschnitt. Z Rechtsmed 103:199–206

    PubMed  CAS  Google Scholar 

  • Titus JL, Daugherty GW, Kirklin JW, Edwards JE (1963) Lesions of the atrio-ventricular conduction system after repair of ventricular septal defect. Relation to heart block. Circulation 28:82–88

    PubMed  CAS  Google Scholar 

  • Todd GL, Baroldi G, Pieper GM, Clayton F, Eliot RS (1985a) Experimental catecholamine-induced myocardial necrosis. I Morphology, quantification and regional distribution of acute contraction band lesions. J Mol Cell Cardiol 17:317–338

    PubMed  CAS  Google Scholar 

  • Todd GL, Baroldi G, Pieper GM, Clayton F, Eliot RS (1985b) Experimental catecholamine-induced myocardial necrosis. II Temporal development of isoproterenol-induced contraction band lesions correlated with ECG, hemodynamic and biochemical changes. J Mol Cell Cardiol 17:647–656

    PubMed  CAS  Google Scholar 

  • Tsung SH, Huang TY, Chang HH (1982) Sudden death in young athletes. Arch Pathol Lab Med 106:168–170

    PubMed  CAS  Google Scholar 

  • Tyson AA, Hackshaw BT, Kutcher MA (1989) Acute Epstein-Barr virus myocarditis simulating myocardial infarction with cardiogenic shock. South Med J 82:1184–1187

    PubMed  Google Scholar 

  • Vallance HD, Jeven G, Wallace DC, Brown MD (2004) A case of sporadic infantile histiocytoid cardiomyopathy caused by the A8344G (MERRF) mitochondrial DNA mutation. Pediatr Cardiol 25:538–540

    PubMed  CAS  Google Scholar 

  • Veinot JP, Johnston B (1998) Cardiac sarcoidosis – an occult cause of sudden death: a case report and literature review. J Forensic Sci 43:715–717

    PubMed  CAS  Google Scholar 

  • Veinot JP, Johnston B, Acharya V, Healey J (2002) The spectrum of intramyocardial small vessel disease associacted with sudden death. J Forensic Sci 47:384–388

    PubMed  Google Scholar 

  • Ventéo L, Bourlet T, Renois F, Douche-Aourik F, Mosnier JF, Maison GL, Pluot M, Pozzetto B, Andreoletti L (2010) Enterovirus-related activation of the cardiomyocyte mitochondrial apoptotic pathway in patients with acute myocarditis. Eur Heart J 31:728–736

    PubMed  Google Scholar 

  • Voigt J (1976) Reflections on the value of histological examination of the cardiac conduction system in cases of natural unexpected death. Forensic Sci Int 8:29–31

    CAS  Google Scholar 

  • Walthard B (1942) Die Koronarsklerose der Jugendlichen. Schweiz Med Wochenschr 72:1261

    Google Scholar 

  • Weiler G, Knieriem HJ (1975) Beitrag zur Morphometrie der Coronarsklerose. Z Rechtsmed 75:241–254

    PubMed  CAS  Google Scholar 

  • Weiler G, Risse M (1981) Morphological examinations in cases of stenosing coronary sclerosis and their importance for evaluation of competing causes of death. Forensic Sci Int 18:131–139

    PubMed  CAS  Google Scholar 

  • Weiler G, Risse M (1994) New aspects concerning the morphology and significance of coronary muscle bridges. Cardiovasc Pathol 3:51–55

    Google Scholar 

  • Wick MR, Siegal GP (1988) Antibodies to desmin in diagnostic pathology. In: Wick MR (ed) Monoclonal antibodies in diagnostic immunohistochemistry. Marcel Dekker, New York, Basel, pp 93–114

    Google Scholar 

  • Wigle ED, Sasson Z, Henderson MA, Ruddy TD, Fulop J, Rakoski H, Williams WG (1985) Hypertrophic cardiomyopathy: the importance of the site and the extent of hypertrophy: a review. Prog Cardiovasc Dis 28:1–83

    PubMed  CAS  Google Scholar 

  • Wingenfeld L, Freislederer A, Schulze-Bahr E, Paul M, Bajanowski T (2010) Life-threatening hobbies in the youth? Two autoptic cases suggesting arrhythmogenic right ventricular cardiomyopathy. Forensic Sci Int 171:e1–e4

    Google Scholar 

  • Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC (2005) Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352:539–548

    PubMed  CAS  Google Scholar 

  • Wojnicz R, Nowalany-Kozielska E, Wodniecki J, Szczurek-Katanski K, Nożyński J, Zembala M, Rozek MM (1998) Immunohistological diagnosis of myocarditis – potential role of sarcolemmal induction of the MHC and ICAM-1 in the detection of autoimmune mediated myocyte injury. Eur Heart J 19:1564–1572

    PubMed  CAS  Google Scholar 

  • Woźniewicz B, Czarnowska E, Kubicka K, Ziólkowska L, Cielecka-Kuszyk J, Zaleska T (1998) Coexistence of arrhythmogenic right ventricular cardiomyopathy and chronic myocarditis in children. Ann Diagn Paediatr Pathol 2:13–17

    Google Scholar 

  • Xiaohong Z, Xiaorui C, Jun H, Qisheng Q (2002) The contrast of immunohistochemical studies of myocardial fibrinogen and myoglobin in early myocardial ischemia in rats. Leg Med 4:47–51

    Google Scholar 

  • Xu XH, Chen JG, Zhu JZ (2001) Primary study of vascular endothelial growth factor immunohistochemical staining in the diagnosis of early acute myocardial ischemia. Forensic Sci Int 118:11–14

    PubMed  CAS  Google Scholar 

  • Yamanaka O, Hobbs RE (1990) Coronary artery anomalies in 126 595 patients undergoing coronary angiography. Cath Cardiovasc Diagn 21:28–40

    CAS  Google Scholar 

  • Zack F, Wegener R (1994) Zur Problematik der Diagnose “rhythmogener Herztod” durch histologische Untersuchungen des Erregungsbildungs- und –leitungssystems. Rechtsmedizin 5:1–5

    Google Scholar 

  • Zell R, Klingel K, Bültmann B, Kandolf R (1995) Nachweis enteroviraler RNA aus Formalin-fixiertem Paraffin-eingebettetem Myokardgewebe durch nested RT-PCR. Verh Dtsch Ges Pathol 79:359

    Google Scholar 

  • Zhang JM, Riddick L (1996) Cytoskeleton immunohistochemical study of early ischemic myocardium. Forensic Sci Int 80:229–238

    PubMed  CAS  Google Scholar 

  • Zhu BL, Tanaka S, Ishikawa T, Zhao D, Li DR, Michiue T, Quan L, Maeda H (2008) Forensic pathological investigation of myocardial hypoxia-induced factor-1a, erythropoietin and vascular endothelial growth factor in cardiac death. Leg Med 10:11–19

    CAS  Google Scholar 

  • Zollinger U (1983) Die Chromotrop-Anilinblau-Färbung zur besseren Darstellung frischer Herzmuskelfaserschädigungen. Z Rechtsmed 90:269–275

    PubMed  CAS  Google Scholar 

  • Zugibe FT, Zugibe FT Jr, Costello JT, Breithaupt MK (1993) Hypoplastic coronary artery disease within the spectrum of sudden unexpected death in young and middle age adults. Am J Forensic Med Pathol 14:276–283

    PubMed  CAS  Google Scholar 

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Dettmeyer, R.B. (2011). Coronary Sclerosis, Myocardial Infarction, Myocarditis, Cardiomyopathy, Coronary Anomalies, and the Cardiac Conduction System. In: Forensic Histopathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20659-7_13

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