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Risks and Benefits of Aggressive and Conservative Approaches to the Management of the Patent Ductus Arteriosus in Premature Infants

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Controversies around treatment of the open duct

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Abstract

During fetal life, the ductus arteriosus (DA) connects the pulmonary artery to the aorta and provides a channel through which the majority of pulmonary blood flow is shunted into the systemic circulation. Persistent patency of the DA during the first few days after birth might represent a normal physiologic adaptation by allowing shunting from pulmonary to systemic circulation as the left ventricle adapts to its role as the dominant pumping chamber. However, in the vast majority of infants, the DA closes by three days of life [1]. In some infants, especially preterm infants with lung disease, there is a delayed closure of the DA [2]. Approximately 65% of infants born at less than 28 weeks’ gestation will have a diagnosis of a patent ductus arteriosus (PDA) at some time during the early neonatal period [3].

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Authors and Affiliations

  1. School of Medicine, Division of Neonatal-Perinatal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC

    Sofia Aliaga MD, MPH & Matthew M. Laughon MD, MPH

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  1. Sofia Aliaga MD, MPH
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  2. Matthew M. Laughon MD, MPH
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Aliaga, S., Laughon, M.M. (2011). Risks and Benefits of Aggressive and Conservative Approaches to the Management of the Patent Ductus Arteriosus in Premature Infants. In: Controversies around treatment of the open duct. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20623-8_8

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  • DOI: https://doi.org/10.1007/978-3-642-20623-8_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-20622-1

  • Online ISBN: 978-3-642-20623-8

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