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Mechanostimulation and Mechanics Analysis of Lung Cells, Lung Tissue and the Entire Lung Organ

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Fundamental Medical and Engineering Investigations on Protective Artificial Respiration

Part of the book series: Notes on Numerical Fluid Mechanics and Multidisciplinary Design ((NNFM,volume 116))

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Abstract

Analysis of respiratory mechanics under mechanical ventilation is crucial for a lung-protective ventilation setting. However, under the conditions of mechanostimulation caused by mechanical ventilation, only the global components of mechanical impedance can be determined. These include the airflow resistance, compliance, and inertance. Whereas in the case of conventionalmechanical ventilation, the organ integrity of the lung is certainly preserved, it is practically impossible to obtain quantitative information about the local pulmonary mechanics, for instance at the alveolar level. Analysis of pulmonary mechanics at a local level requires sophisticated experimental techniques for the mechanostimulation of anatomical subunits of the lung. In this chapter, we summarize our investigations in the field of experimental mechanostimulation and mechanics analysis of lung cells, lung tissue and entire lung organ.

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Authors and Affiliations

  1. University Medical Center Freiburg, Germany

    Stefan Schumann, Katharina Gamerdinger, Caroline Armbruster, Constanze Dassow, David Schwenninger & Josef Guttmann

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  1. Stefan Schumann
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  2. Katharina Gamerdinger
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  3. Caroline Armbruster
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  4. Constanze Dassow
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  5. David Schwenninger
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  6. Josef Guttmann
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  1. Lehrstuhl für Strömungslehre und Aerodynamisches Institut , RWTH Aachen, Wüllnerstr. 5a, 52062, Aachen, Germany

    Michael Klaas  & Wolfgang Schröder  & 

  2. Arbeitsgruppe Klinisches Sensoring und Monitoring Medizinische Fakultät Carl Gustav Carus, TU Dresden, Fetscherstr. 74, 01307, Dresden, Germany

    Edmund Koch

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Schumann, S., Gamerdinger, K., Armbruster, C., Dassow, C., Schwenninger, D., Guttmann, J. (2011). Mechanostimulation and Mechanics Analysis of Lung Cells, Lung Tissue and the Entire Lung Organ. In: Klaas, M., Koch, E., Schröder, W. (eds) Fundamental Medical and Engineering Investigations on Protective Artificial Respiration. Notes on Numerical Fluid Mechanics and Multidisciplinary Design, vol 116. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20326-8_8

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  • DOI: https://doi.org/10.1007/978-3-642-20326-8_8

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