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Experimental and Numerical Investigation on the Flow-Induced Stresses on the Alveolar-Epithelial-Surfactant-Air Interface

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Part of the book series: Notes on Numerical Fluid Mechanics and Multidisciplinary Design ((NNFM,volume 116))

Abstract

To develop new protective artificial respiration strategies a profound knowledge of the lung functionality is required. Still unknown are the dominating effects on the alveolar level and the exact geometry of the alveolar structure itself. We try to fill this gap with our multi-disciplinary research, where on the one hand we are interested in visualization techniques to reconstruct the three-dimensional structure of the alveoli and on the other hand develop a numerical tool to simulate the complex physics at the surfactant enriched liquid-lining layer interface.

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References

  1. Adami, S., Hu, X.Y., Adams, N.A.: A conservative SPH method for surfactant dynamics. J. Comput. Phys. 229(5), 1909–1926 (2010)

    Article  MATH  MathSciNet  Google Scholar 

  2. Antoci, C., Gallati, M., Sibilla, S.: Numerical simulation of fluid-structure interaction by SPH. Comput. & Structures 85(11–14), 879–890 (2007)

    Article  Google Scholar 

  3. ARDS Clinical Trials Network, Higher vs. Lower End-Expiratory Pressures in Patients with the Acute Respiratory Distress Syndrome. N. Engl. J. Med. 351(4), 327–336 (2004)

    Google Scholar 

  4. ARDS Network, Effect of a Protective-Ventilation Strategy on Mortality in the Acute Respiratory Distress Syndrome. N. Engl. J. Med. 338, 347–354 (1998)

    Google Scholar 

  5. ARDS Network, Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N. Engl. J. Med. 342(18), 1301–1308 (2000)

    Google Scholar 

  6. Borwankar, R.P., Wasan, D.T.: The kinetics of adsorption of surface active agents at gas-liquid surfaces. Chem. Engrg. Sci. 38(10), 1637–1649 (1983)

    Article  Google Scholar 

  7. Chang, C., Franses, E.: Adsorption dynamics of surfactants at the air/water interface: a critical review of mathematical models, data, and mechanisms. Colloids Surf. A 100, 1–45 (1995)

    Article  Google Scholar 

  8. Fercher, A.F., Drexler, W., Hitzenberger, C.K., Lasser, R.: Optical coherence tomography- principles and applications. Reports on Progress in Physics 66(2), 239–303 (2003)

    Article  Google Scholar 

  9. Frank, J.A., Matthay, M.A.: Science review: mechanisms of ventilator induced injury. Crit. Care. 7, 233–241 (2003)

    Article  Google Scholar 

  10. Ghadiali, S.N., Gaver, D.P.: The influence of non-equilibrium surfactant dynamics on the flow of a semi-infinite bubble in a rigid cylindrical capillary tube. J. Fluid Mech. 478, 165–196 (2003)

    Article  MATH  Google Scholar 

  11. Gingold, R.A., Monaghan, J.J.: Smoothed particle hydrodynamics, Theory and application to non-spherical stars. Mon. Not R. Astron. Soc. 181, 375 (1977)

    MATH  Google Scholar 

  12. Hu, X.Y., Adams, N.A.: A multi-phase SPH method for macroscopic and mesoscopic flows. J. Comput. Phys. 213(2), 844–861 (2006)

    Article  MATH  MathSciNet  Google Scholar 

  13. Huang, D., Swanson, E.A., Lin, C.P., Schuman, J.S., Stinson, W.G., Chang, W., Hee, M.R., Flotte, T., Gregory, K., Puliafito, C.A., Fujimoto, J.G.: Optical coherence tomography. Science 254, 1178–1181 (1991)

    Article  Google Scholar 

  14. James, A., Lowengrub, J.: A surfactant-conserving volume-of-fluid method for interfacial flows with surfactant. J. Comput. Phys. 212(2), 590–616 (2006)

    Article  MathSciNet  Google Scholar 

  15. Lucy, L.B.: A numerical approach to the testing of the fission hypothesis. Astron. J. 82, 1013 (1977)

    Article  Google Scholar 

  16. McGough, P., Basaran, O.: Repeated formation of fluid threads in breakup of a surfactant-covered jet. Phys. Rev. Lett. 96(5) (2006)

    Google Scholar 

  17. Meissner, S., Knels, L., Krueger, A., Koch, T., Koch, E.: Simultaneous 3D Optical Coherence Tomography and intravital microscopy for imaging subpleural pulmonary alveoli in isolated rabbit lungs. J. Biomed. Opt. 14(5), 054020 (2009)

    Article  Google Scholar 

  18. Meissner, S., Knels, L., Koch, E.: Improved 3D Fourier Domain Optical Coherence Tomography by index matching in alveolar structures. J. Biomed. Opt. 14(6), 064037 (2009)

    Article  Google Scholar 

  19. Mertens, M., Tabuchi, A., Meissner, S., Krueger, A., Kertzscher, U., Pries, A.R., Affeld, K., Slutsky, A.S., Koch, E., Kuebler, W.M.: Alveolar dynamics in acute lung injury: heterogeneous distension rather than cyclic recruitment. Crit. Care. Med. 37(9), 2604–2611 (2009)

    Article  Google Scholar 

  20. Monaghan, J.J.: Simulating free surface flows with SPH. J. Comput. Phys. 110, 399–399 (1994)

    Article  MATH  Google Scholar 

  21. Morris, J.P., Fox, P.J., Zhu, Y.: Modeling low Reynolds number incompressible flows using SPH. J. Comput. Phys. 136(1), 214–226 (1997)

    Article  MATH  Google Scholar 

  22. Muradoglu, M., Tryggvason, G.: A front-tracking method for computation of interfacial flows with soluble surfactants. J. Comput. Phys. 227(4), 2238–2262 (2008)

    Article  MATH  Google Scholar 

  23. Novak, I.I., Gao, F., Choi, Y., Resasco, D., Schaff, J.C., Slepchenko, B.M.: Diffusion on curved surface coupled to diffusion in the volume: Application to cell biology. J. Comput. Phys. 226, 1271–1290 (2007)

    Article  MATH  MathSciNet  Google Scholar 

  24. Otis, D.R., Ingenito, E.P., Kamm, R.D., Johnson, M.: Dynamic surface tension of surfactant TA: experiments and theory. J. Appl. Physiol. 77(6), 2681–2688 (1994)

    Google Scholar 

  25. Pawar, Y., Stebe, K.: Marangoni effects on drop deformation in an extensional flow: The role of surfactant physical chemistry. Phys. Fluids 8, 476–480 (1996)

    Article  Google Scholar 

  26. Popp, A., Wendel, M., Knels, L., Koch, T., Koch, E.: Imaging of the Three-Dimensional Alveolar Structure and the Alveolar Mechanics of a Ventilated and Perfused Isolated Rabbit Lung with Fourier Transform Optical Coherence Tomography. J. Biomed. Opt. 11(1) (2006)

    Google Scholar 

  27. Yon, S., Pozrikidis, C.: A finite-volume/boundary-element method for flow past interfaces in the presence of surfactants, with application to shear flow past a viscous drop. Computers & Fluids 27(8), 879–902 (1998)

    Article  MATH  Google Scholar 

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Meissner, S. et al. (2011). Experimental and Numerical Investigation on the Flow-Induced Stresses on the Alveolar-Epithelial-Surfactant-Air Interface. In: Klaas, M., Koch, E., Schröder, W. (eds) Fundamental Medical and Engineering Investigations on Protective Artificial Respiration. Notes on Numerical Fluid Mechanics and Multidisciplinary Design, vol 116. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20326-8_4

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  • DOI: https://doi.org/10.1007/978-3-642-20326-8_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-20325-1

  • Online ISBN: 978-3-642-20326-8

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