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Pediatric Clinical Pharmacology pp 203–217Cite as

Sample Collection, Biobanking, and Analysis

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 205))

Abstract

Pediatric pharmacokinetic studies require sampling of biofluids from neonates and children. Limitations on sampling frequency and sample volume complicate the design of these studies. In addition, strict guidelines, designed to guarantee patient safety, are in place. This chapter describes the practical implications of sample collection and their storage, with special focus on the selection of the appropriate type of biofluid and withdrawal technique. In addition, we describe appropriate measures for storage of these specimens, for example, in the context of biobanking, and the requirements on drug assay methods that they pose. Pharmacokinetic studies in children are possible, but they require careful selection of an appropriate sampling method, specimen volume, and assay method. The checklist provided could help prospective researchers with the design of an appropriate study protocol and infrastructure.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Erasmus MC, Rotterdam, The Netherlands

    Maurice J. Ahsman & Ron A. A. Mathot

  2. Intensive Care and Department of Pediatric Surgery, Erasmus MC Sophia Children’s Hospital, Dr. Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands

    Dick Tibboel & Saskia N. de Wildt

Authors
  1. Maurice J. Ahsman
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  2. Dick Tibboel
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  3. Ron A. A. Mathot
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  4. Saskia N. de Wildt
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Corresponding author

Correspondence to Saskia N. de Wildt .

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Editors and Affiliations

  1. Klinik für Kinder- und Jugendmedizin, Univ.Klinikum Marburg, Baldingerstr. 12, Marburg, 35043, Germany

    Hannsjörg W. Seyberth

  2. Karolinska Institutet, Dept. Laboratory Medicine, Karolinska University Hostpital, Stockholm, 141 86, Sweden

    Anders Rane

  3. für Klinische Pharmakologie (IKP), Dr. Margarete Fischer-Bosch Institut, Auerbachstr. 112, Stuttgart, 70376, Germany

    Matthias Schwab

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Ahsman, M.J., Tibboel, D., Mathot, R.A.A., de Wildt, S.N. (2011). Sample Collection, Biobanking, and Analysis. In: Seyberth, H., Rane, A., Schwab, M. (eds) Pediatric Clinical Pharmacology. Handbook of Experimental Pharmacology, vol 205. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20195-0_10

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