Abstract
Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n − mer statistics with different classification algorithms namely Alternating Decision (AD) Tree, Best First (BF) Tree, Random Tree and Adaptive (Ada) Boost. On BaCello dataset [1], NcPred improves about 20% accuracy with Random Tree and about 10% sensitivity with Ada Boost for Animal proteins compared to existing techniques. It also increases the accuracy of Fungal protein prediction by 20% and recall by 4% with AD Tree. In case of Human protein, the accuracy is improved by about 25% and sensitivity about 10% with BF Tree. Performance analysis of NcPred clearly demonstrates its suitability over the contemporary in-silico nuclear protein classification research.
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Islam, M.S., Kabir, A., Sakib, K., Hossain, M.A. (2011). NcPred for Accurate Nuclear Protein Prediction Using n-mer Statistics with Various Classification Algorithms. In: Rocha, M.P., Rodríguez, J.M.C., Fdez-Riverola, F., Valencia, A. (eds) 5th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2011). Advances in Intelligent and Soft Computing, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19914-1_38
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DOI: https://doi.org/10.1007/978-3-642-19914-1_38
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